Article
Biochemistry & Molecular Biology
Kamiya Bridges, Humphrey H-C Yao, Barbara Nicol
Summary: This study reveals the significance of the Runx1 gene in mouse ovarian development. Loss of Runx1 leads to an increased prevalence of ovarian tumors and also affects normal granulosa cell differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Peter Svajdler, Peter Vasovcak, Marian Svajdler, Monika Sedivcova, Veronika Urban, Michal Michal, Roman Mezencev
Summary: This study identified a specific germline mutation in the CHEK2 gene that is associated with an increased risk of developing adult-type granulosa cell tumors. Female carriers of this mutation were found to have a significantly higher proportion of ovarian adult-type granulosa cell tumors compared to the general population. These findings suggest potential avenues for the development of targeted interventions for this type of tumor.
Article
Pathology
Pauline Baillard, Catherine Genestie, Sabrina Croce, Francoise Descotes, Etienne Rouleau, Isabelle Treilleux, Sebastien Gouy, Philippe Morice, Isabelle Ray-Coquard, W. Glenn McCluggage, Mojgan Devouassoux-Shisheboran
Summary: FOXL2 mutations were not detected in JGCTs in this study, while only a small percentage of these neoplasms exhibited DICER1 mutations.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Endocrinology & Metabolism
Jin Zhang, Renwu Hua, Lishuang Ma, Chao Liu, Yanxia Zhang, Xuemin Lue, Tianren Wang, Naijun Wan
Summary: This study aimed to explore symptoms, treatment, and pathogenesis of ovarian juvenile granulosa cell tumors with Ollier's disease in children. Clinical data of one patient with this condition were retrospectively analyzed, and genetic mutations were detected in ovarian tumor and chondroma tissue. The mutation of the IDH1 gene was found to inhibit the phosphorylation of S6 ribosomal protein. Surgical operation was the main treatment, and regular investigations were recommended for patients with ovarian juvenile granulosa cell tumors and Ollier's disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Medicinal
Yi Wu, Zhong Zhang, Zuqiang Kou
Summary: Pentamidine inhibits proliferation and migration of human ovarian cancer cells by increasing PTEN protein expression, reducing phosphorylation levels of Akt, and modulating PTEN stability.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Oncology
Ayumu Matsuoka, Shinichi Tate, Kyoko Nishikimi, Tastuya Kobayashi, Satoyo Otsuka, Makio Shozu
Summary: This study found that preoperative serum follicle-stimulating hormone (FSH) levels are an extremely useful marker for differentiating granulosa cell tumors (GCTs) from other ovarian tumors. The GCT group had significantly lower serum FSH levels compared to the non-GCT group, while serum sex steroid hormone levels were significantly higher. Furthermore, serum FSH levels showed high sensitivity and specificity and served as a reliable indicator for distinguishing GCTs from other ovarian tumors.
Article
Oncology
Yasuhiko Ebina, Wataru Yamagami, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Takayuki Enomoto, Mikio Mikami
Summary: The study aimed to elucidate the clinicopathological features of ovarian granulosa cell tumors (GCTs) and identify prognostic factors. Lymph node metastasis rates increased with higher pathological stages in GCT patients, with residual disease after initial surgery and lymph node metastasis identified as independent risk factors for cancer-specific survival. Surgical strategies should be tailored based on pathological staging to optimize outcomes for GCT patients.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Oncology
Geertruid J. Brink, Jolijn W. Groeneweg, Lotty Hooft, Ronald P. Zweemer, Petronella O. Witteveen
Summary: Adult granulosa cell tumors (aGCTs) are a rare subtype of ovarian cancer. Surgery is the preferred treatment modality, with chemotherapy and anti-hormonal therapy as alternative options. Limited evidence exists on systemic therapy for aGCT, and the response rates for chemotherapy and anti-hormonal therapy are limited as well. However, including patients with stable disease in the analysis significantly increases the response rate. New approaches are needed to provide more evidence and standardize treatment for aGCT.
Article
Oncology
Helmut Plett, Enzo Ricciardi, Vlad Vacaru, Jan Phillip Ramspott, Nicoletta Colombo, Jalid Sehouli, Andreas du Bois, Annalisa Garbi, Rolf Richter, Beyhan Ataseven, Giovanni Aletti, Elena Braicu, Florian Heitz, Rosalba Portuesi, Mustafa-Zelal Muallem, Timoleon Dagres, Gabriella Parma, Eva Roser, Alexander Traut, Francesco Multinu, Philipp Harter
Summary: This study aimed to analyze the clinicopathological parameters and their impact on progression-free and overall survival in patients with primary adult granulosa cell tumors. The prognosis of patients with primary adult granulosa cell tumors is mainly determined by the FIGO stage. Fertility-sparing surgery seems to be a safe procedure in FIGO IA stage, while adjuvant chemotherapy is not supported in early and advanced stages of adult granulosa cell tumors.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
R. Tyler Hillman, Douglas Lin, Barrett Lawson, David M. Gershenson
Summary: The study aimed to determine the prevalence of predictive biomarkers associated with FDA-approved therapies in molecularly defined aGCTs. Potentially actionable variants including MTAP deletion and activating PIK3CA mutations were identified in the study's tumor profiles.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Reproductive Biology
Hao Yu, Jie Zhao, Xiaomeng Pei, Yuting Xia, Haolin Li, Wei Wang, Dagan Mao
Summary: This study aimed to investigate the role of NR4A1 in forskolin-induced granulosa cell differentiation and PGF2a-induced granulosa-lutein cell regression. The results showed that NR4A1 was up-regulated during granulosa cell differentiation and played a role in cell proliferation, apoptosis, steroidogenesis, and MAPK pathways. Furthermore, NR4A1 was also involved in the regression of granulosa-lutein cells and influenced several cellular processes. These findings provide a theoretical basis for further understanding the mechanism of porcine luteal formation and regression.
Article
Obstetrics & Gynecology
Jianfeng Yao, Rongfu Huang, Ming Li, Yi Jiang, Peiya Wu, Youzhu Li, Weilin Peng, Chengzhou Hua, Yanfang Huang, Huifang You, Yuanyuan Chen, Dianliang Lin, Xiaoyu Yang
Summary: The ovarian reserve, controlled by PTEN gene expression, is crucial for the success of IVF and embryo transfer treatment. Interestingly, PTEN levels were higher in poor responders and lower in high responders, indicating its role in ovarian response. Additionally, PTEN may be involved in follicular dysplasia and ovarian dysfunction, suggesting its importance in regulating follicular development.
REPRODUCTIVE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Massimo De Felici, Francesca Gioia Klinger
Summary: Several studies have demonstrated that the PI3K/PTEN/AKT signaling pathways play critical roles in regulating ovarian function, including primordial germ cell development and maintenance of the ovarian primordial follicle reserve. Dysregulation of these pathways may contribute to the development of certain types of germ cell tumors and ovarian dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Yuan Zhuang, Shushan Zhang, Yao Liu, Hua Yang
Summary: Adult granulosa cell tumors (aGCTs) are rare ovarian neoplasms with a relatively favorable prognosis. The use of adjuvant chemotherapy in aGCTs is still controversial, with lack of high-grade evidence to confirm the survival benefit. For inoperable disseminated disease or disease with suboptimal cytoreduction, adjuvant chemotherapy may be an option. Further research and prospective randomized controlled trials are needed to validate the role of adjuvant chemotherapy.
Article
Oncology
Nai-yu Li, Bin Shi, Yu-lan Chen, Pei-pei Wang, Chuan-bin Wang, Yao Chen, Ya-qiong Ge, Jiang-ning Dong, Chao Wei
Summary: This study explored the value of MRI and texture analysis in differentiating between ovarian granulosa cell tumors and thecoma-fibrothecoma. Results showed that texture features can reflect the microheterogeneity of the tumors and aid in clinical decision-making. The combination of MRI signs and texture features provide a more comprehensive and accurate basis for treatment differentiation.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Jun Yang, Peter J. Fuller, Michael Stowasser
MEDICAL JOURNAL OF AUSTRALIA
(2018)
Article
Oncology
Maria Alexiadis, Simone M. Rowley, Simon Chu, Dilys T. H. Leung, Colin J. R. Stewart, Kaushalya C. Amarasinghe, Ian G. Campbell, Peter J. Fuller
MOLECULAR CANCER RESEARCH
(2019)
Article
Oncology
Dilys T. H. Leung, Trang Nguyen, Edwina May Oliver, Juliana Matti, Maria Alexiadis, John Silke, Thomas W. Jobling, Peter J. Fuller, Simon Chu
MOLECULAR CANCER THERAPEUTICS
(2019)
Article
Endocrinology & Metabolism
Elizabeth K. Fletcher, Monica Kanki, James Morgan, David W. Ray, Lea M. Delbridge, Peter J. Fuller, Colin D. Clyne, Morag J. Young
JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Multidisciplinary Sciences
Peter J. Fuller, Yi-Zhou Yao, Ruitao Jin, Sitong He, Beatriz Martin-Fernandez, Morag J. Young, Brian J. Smith
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Endocrinology & Metabolism
Pravik Solanki, Stella May Gwini, James C. G. Doery, Kay Weng Choy, Jimmy Shen, Morag J. Young, Peter J. Fuller, Jun Yang
CLINICAL ENDOCRINOLOGY
(2020)
Review
Peripheral Vascular Disease
Renata Libianto, Peter J. Fuller, Morag J. Young, Jun Yang
JOURNAL OF HUMAN HYPERTENSION
(2020)
Review
Peripheral Vascular Disease
Peter J. Fuller, Yi-Zhou Yao, Jun Yang, Morag J. Young
Summary: The mineralocorticoid receptor plays a crucial role in sodium homeostasis by responding to aldosterone and cortisol, as well as progesterone with high affinity. The conformation of the receptor is determined by the ligand, which in turn regulates gene expression. Evolutionary studies of the MR suggest novel ways to achieve MR antagonism beyond current progesterone-based antagonists.
JOURNAL OF HUMAN HYPERTENSION
(2021)
Review
Peripheral Vascular Disease
Morag J. Young, Monica Kanki, Peter J. Fuller, Jun Yang
Summary: Recent studies have shown that the mineralocorticoid receptor (MR) plays a crucial role in various tissue types beyond renal epithelial cells, where its actions are mainly defined in the context of pathogenic signaling pathways leading to tissue injury and remodeling. Macrophages and cardiomyocytes are two cell types where the MR is central in the tissue response to factors like injury, renovascular hypertension, and oxidative stress. The dysfunction of MR in these cells contributes to the onset and progression of cardiovascular disease and heart failure.
JOURNAL OF HUMAN HYPERTENSION
(2021)
Article
Endocrinology & Metabolism
Renata Libianto, Serena Menezes, Amrina Kaur, Stella May Gwini, Jimmy Shen, Om Narayan, Peter J. Fuller, Jun Yang, Morag J. Young
Summary: Primary aldosteronism (PA) is a potentially curable cause of hypertension with worse cardiovascular prognosis than essential hypertension. This study compared ambulatory blood pressure monitoring (ABPM) parameters in hypertensive patients with and without PA, finding that PA patients had higher blood pressure levels despite similar antihypertensive medication use. ABPM alone may not reliably differentiate PA from other forms of hypertension, and routine biochemical screening remains the most reliable method for detecting PA.
CLINICAL ENDOCRINOLOGY
(2021)
Editorial Material
Oncology
Peter J. Fuller, Trang Nguyen, Maria Alexiadis, Simon Chu
Summary: Recent studies have suggested that the FOXL2(C134W) mutation is a gain-of-function mutation that enhances interactions with the SMAD transcription factor complex.
JOURNAL OF PATHOLOGY
(2022)
Article
Endocrinology & Metabolism
Elisabeth Ng, Stella May Gwini, Renata Libianto, Kay Weng Choy, Zhong X. Lu, Jimmy Shen, James C. G. Doery, Peter J. Fuller, Jun Yang
Summary: This retrospective cohort study investigated the intra-individual variability of plasma aldosterone concentration (PAC), direct renin concentration (DRC), and aldosterone-to-renin ratio (ARR) in patients with and without primary aldosteronism (PA), without interfering medications. The results demonstrated significant variability in PAC, DRC, and ARR, which was higher than the assays' analytical variability. A substantial proportion of PA patients had ARR values below the cut-off for first-line screening. These findings emphasize the need for multiple ARR measurements in the evaluation of PA.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Mendel Castle-Kirszbaum, Tony Goldschlager, Margaret D. Y. Shi, Peter Fuller
Summary: Water balance is regulated by the hypothalamic pituitary adrenal (HPA) axis, which involves the release of corticotropin releasing hormone (CRH) and cortisol, and their effects on arginine vasopressin (AVP) secretion, as well as the peripheral effects of cortisol on hemodynamics and renal water handling. This review examines the intricate relationship between glucocorticoids and water balance, with emphasis on hyponatremia and pituitary surgery.
NEUROENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Monica Kanki, Artika P. Nath, Ruidong Xiang, Stephanie Yiallourou, Peter J. Fuller, Timothy J. Cole, Rodrigo Canovas, Morag J. Young
Summary: Disrupted circadian rhythms have been found to be associated with an increased risk of hypertension and cardiovascular disease. This study reveals a U-shaped relationship between sleep length and SBP/DBP, and a positive association between poor sleep quality/night shift work and SBP/DBP.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Yin Yu Lim, Jimmy Shen, Peter J. Fuller, Jun Yang
AUSTRALIAN JOURNAL OF GENERAL PRACTICE
(2018)