Article
Infectious Diseases
Daniel Martak, Julia Guther, Tess D. Verschuuren, Benoit Valot, Nadine Conzelmann, Stefanie Bunk, M. Eugenia Riccio, Elena Salamanca, Alexandre Meunier, Charles P. Henriot, Caroline Pressacco Brossier, Xavier Bertrand, Ben S. Cooper, Stephan Harbarth, Evelina Tacconelli, Ad C. Fluit, Jesus Rodriguez-Bano, Jan A. J. W. Kluytmans, Silke Peter, Didier Hocquet
Summary: This study in five European cities found that food items were not the main source of ESBL-Ec and ESBL-Kp, as the strains from contaminated environments were genetically distinct from those in food. The findings suggest that human-to-human transmission is possibly the most frequent route of ESBL-Ec and ESBL-Kp transmission in high-income countries.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Immunology
Achiraya Siriphap, Thawatchai Kitti, Akachai Khuekankaew, Chalermchai Boonlao, Chonthida Thephinlap, Chutamas Thepmalee, Nittiya Suwannasom, Krissana Khoothiam
Summary: This study investigated the prevalence of ESBL-positive E. coli and K. pneumoniae isolates from hospitalized patients in Chiangrai Prachanukroh hospital, Thailand. The study found a high prevalence and emerging antibiotic resistance of ESBL-positive strains, indicating the need for carbapenems and aminoglycosides as the first-line drugs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Chonticha Romyasamit, Phoomjai Sornsenee, Siriphorn Chimplee, Sitanun Yuwalaksanakun, Dechawat Wongprot, Phanvasri Saengsuwan
Summary: The study found ESBL-producing E. coli and K. pneumoniae in raw vegetables, showing high resistance to beta-lactam antibiotics but good sensitivity to beta-lactam/carbapenem antibiotics. The genes carried by these bacteria may be associated with food chains and humans, suggesting that raw vegetables could serve as an important route for the transmission of ESBL-resistant bacteria to humans.
Article
Infectious Diseases
Shobha Giri, Vaishnavi Kudva, Kalidas Shetty, Veena Shetty
Summary: The study evaluated the potential burden of antibiotic-resistant E. coli and K. pneumoniae in emerging urban suburb of India where RTE street foods are rapidly establishing, finding a high prevalence of ESBL-producing strains isolated mostly from chutneys, salads, paani puri, and chicken. Antimicrobial resistance was observed towards various antibiotics with a majority of isolates showing high Multiple Antimicrobial Resistance (MAR) index.
Article
Infectious Diseases
Tyler J. Stone, Abdullah Kilic, John C. Williamson, Elizabeth L. Palavecino
Summary: The in vitro activity of omadacycline and comparator antibiotics against clinical ESBL-producing and non-ESBL-producing E. coli and K. pneumoniae urinary isolates was evaluated. Results showed that 54.9% of all ESBL-producing isolates and 74.5% of ESBL-producing E. coli isolates were susceptible to omadacycline. Overall, omadacycline and nitrofurantoin were the most active agents for treating UTI caused by ESBL-producing E. coli.
Article
Microbiology
Gopalan Krishnan Sivaraman, Vineeth Rajan, Ardhra Vijayan, Ravikrishnan Elangovan, Alison Prendiville, Till T. Bachmann
Summary: The study evaluated the prevalence of ESBL-producing Escherichia coli and Klebsiella pneumoniae in shrimp aquaculture farms in Kerala, South India. A low prevalence of ESBL producers was found, likely due to reduced antibiotic usage. The predominant ESBL genotype identified was CTX-M group 1. The findings suggest shrimp aquaculture environments can serve as reservoirs of multi-drug resistant strains.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Benti D. Gelalcha, Ruwaa I. Mohammed, Aga E. Gelgie, Oudessa Kerro Dego
Summary: This study investigates the presence of ESBL-producing E. coli and Klebsiella spp. in raw milk from dairy cattle farms. The results show a high prevalence of ESBL-producing bacteria, indicating a potential risk to human health. The detected strains were multidrug resistant and carried various resistance genes and virulence markers. These findings highlight the importance of milk safety and the need for monitoring and control measures.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Gabriel Lignieres, Andre Birgy, Camille Jung, Stephane Bonacorsi, Corinne Levy, Francois Angoulvant, Emmanuel Grimprel, Marie Aliette Dommergues, Yves Gillet, Irina Craiu, Alexis Rybak, Loic De Pontual, Francois Dubos, Emmanuel Cixous, Vincent Gajdos, Didier Pinquier, Isabelle Andriantahina, Valerie Soussan-Banini, Emilie Georget, Elise Launay, Olivier Vignaud, Robert Cohen, Fouad Madhi
Summary: The AC-cefixime combination is a viable treatment option for managing febrile urinary tract infections caused by ESBL-producing Enterobacteriaceae, with similar recurrence rates to cotrimoxazole and ciprofloxacin at 1 month post-treatment.
Article
Immunology
F. Morales-Leon, A. Opazo-Capurro, C. Caro, N. Lincopan, A. Cardenas-Arias, F. Esposito, V. Illesca, M. L. Rioseco, M. Dominguez-Yevenes, C. A. Lima, H. Bello-Toledo, Gerardo Gonzalez-Rocha
Summary: The convergence of virulence and multidrug-resistant phenotype is reported for the first time in Chile in Klebsiella pneumoniae complex isolates, indicating a clinical problem that requires special attention and continuous surveillance in South America. The detected hypervirulent isolates displayed resistance to broad-spectrum cephalosporins and carried multiple antibiotic-resistance genes, leading to a multidrug-resistant phenotype. In vivo virulence testing confirmed higher virulence of the isolates compared to the control strain.
Article
Agriculture, Dairy & Animal Science
Kwang-Won Seo
Summary: A simple and fast method for detecting ESBL- and pAmpC beta-lactamase-producing bacteria in samples with high bacterial load is important for clinical antimicrobial selection. The disk diffusion test, DDST, and multiplex PCR were used for phenotypic and genotypic detection of ESBL and pAmpC. The majority of isolates carried beta-lactamase genes, especially in samples grown on MacConkey agar containing cephalothin or ceftiofur.
Article
Infectious Diseases
Antonio Mandujano, Diana Veronica Cortes-Espinosa, Jose Vasquez-Villanueva, Paulina Guel, Gildardo Rivera, Karina Juarez-Rendon, Wendy Lizeth Cruz-Pulido, Guadalupe Aguilera-Arreola, Abraham Guerrero, Virgilio Bocanegra-Garcia, Ana Veronica Martinez-Vazquez
Summary: This study investigated the antimicrobial resistance profile of ESBL-producing E. coli among food-producing animals in Tamaulipas, Mexico. A total of 200 fecal samples were collected and 5.0% of the strains were confirmed as ESBL producers. High percentage of antimicrobial resistance was observed against gentamicin, tetracycline, and streptomycin. The study suggests that food-producing animals may serve as reservoirs and contribute to the spread of ESBL-producing bacteria.
Article
Microbiology
Wen-Chi Chen, Chih-Hsin Hung, Yao-Shen Chen, Jin-Shiung Cheng, Susan Shin-Jung Lee, Fan-Chen Tseng, Ming-Fang Cheng, Jiun-Ling Wang
Summary: This study found a higher frequency of ST 131 strains and longer hospital stay in patients with cirrhosis in the ESBLEC group compared to the NESBLEC group in bloodstream infections. The 30-day re-admission/mortality rates were similar between the two groups, but ST 131 strains were associated with 30-day re-admission.
Article
Multidisciplinary Sciences
Maria Muddassir, Almas Raza, Sadaf Munir, Ahmad Basirat, Muddassir Ahmed, Mazia Shahid Butt, Omair Arshad Dar, Syed Shoaib Ahmed, Saba Shamim, Syed Zeeshan Haider Naqvi
Summary: This study investigated the antibiogram and drug resistance genes of carbapenem-resistant Pseudomonas aeruginosa, as well as the potency of Silver Nanoparticles against multidrug-resistant strains. The results showed that the conjugated effect of silver nanoparticles with antibiotics effectively inhibited multidrug-resistant Pseudomonas aeruginosa.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Nguyen Thanh Viet, Vu Van Du, Nghiem Duc Thuan, Hoang Van Tong, Nguyen Linh Toan, Can Van Mao, Nguyen Van Tuan, Srinivas Reddy Pallerla, Dennis Nurjadi, Thirumalaisamy P. Velavan, Ho Anh Son
Summary: The study in Vietnam found that 30% of pregnant women had colonization of E. coli and Klebsiella species in their birth canals, with 47% of them producing ESBL. Carapenem resistance was low overall, but over 20% of Klebsiella species were resistant. This highlights the need for surveillance and molecular typing to combat the high rate of ESBL-producers and carbapenem resistance in Enterobacterales in Vietnam.
Article
Immunology
Jacqueline Findlay, Laurent Poirel, Julie Kessler, Andreas Kronenberg, Patrice Nordmann
Summary: The study in Switzerland found that NDM-positive CPE, primarily consisting of Klebsiella pneumoniae and Escherichia coli, were prevalent, with NDM-1 and NDM-5 variants being the most common. Some isolates also co-produced a second carbapenemase and a 16S rRNA methylase. Successful plasmids and global lineages were identified as major factors contributing to the increasing prevalence of NDMs in Switzerland.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Thermodynamics
Dong-Gun Lee, Padmini Pandey, Bhaskar Parida, Jun Ryu, SungWon Cho, Jae-Kwang Kim, Dong-Won Kang
Summary: Organic cations, particularly phenylethylammonium (PEA(+)), are found to improve the quality and crystallinity of all-inorganic cesium lead halide perovskite films. PEA(+) acts as an additive to control intermediate perovskite phase and promote pure phase perovskite crystal growth, leading to reduced pinholes and enhanced film quality. The presence of PEA(+) also helps in the uniform distribution of bromide ions, resulting in improved stability and performance of perovskite solar cells.
Article
Infectious Diseases
Ji-Yoon Jung, Dukhee Nho, Sung-Yeon Cho, Dong-Gun Lee, Su-Mi Choi, Hee-Je Kim, Myungshin Kim, Eun-Jee Oh
Summary: This article reports a case of a patient with acute myeloid leukemia and drug-resistant CMV infection, highlighting the challenges posed by drug-resistant mutations and intra-host diversity of CMV in treatment outcomes.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Giyeol Han, Dong Gun Lee
Summary: This study provides an initial investigation into the antibacterial mode of action of naringin in Escherichia coli. It was found that naringin can induce ROS accumulation, leading to cellular dysfunction and apoptosis-like death. Different ROS have varying degrees of damage to E. coli and contribute differently to cell death.
Article
Multidisciplinary Sciences
Jaeeun Yoo, Hyung Suk Cho, Jae-Ho Yoon, Byung Sik Cho, Hee-Je Kim, Dong-Gun Lee, Dong Wook Jekarl, Myungshin Kim, Eun-Jee Oh, Yeon-Joon Park, Yonggoo Kim
Summary: This study analyzed clinical and laboratory data from 219 patients with AML who underwent granulocyte transfusions (GT) and identified 8 score markers that reflect the response to GT. The study found that GT was significantly effective in the low-risk group of patients.
Article
Biology
Issam I. Raad, Ray Hachem, Nigo Masayuki, Tarcila Datoguia, Hiba Dagher, Ying Jiang, Vivek Subbiah, Bilal Siddiqui, Arnaud Bayle, Robert Somer, Ana Fernandez Cruz, Edward Gorak, Arvinder Bhinder, Nobuyoshi Mori, Nelson Hamerschlak, Samuel Shelanski, Tomislav Dragovich, Yee Elise Vong Kiat, Suha Fakhreddine, Abi Hanna Pierre, Roy F. Chemaly, Victor Mulanovich, Javier Adachi, Jovan Borjan, Fareed Khawaja, Bruno Granwehr, Teny John, Eduardo Yepez Yepez, Harrys A. Torres, Natraj Reddy Ammakkanavar, Marcel Yibirin, Cielito C. Reyes-Gibby, Mala Pande, Noman Ali, Raniv Dawey Rojo, Shahnoor M. Ali, Rita E. Deeba, Patrick Chaftari, Takahiro Matsuo, Kazuhiro Ishikawa, Ryo Hasegawa, Ramon Aguado-Noya, Alvaro Garcia Garcia, Cristina Traseira Puchol, Dong Gun Lee, Monica Slavin, Benjamin Teh, Cesar A. Arias, Dimitrios P. Kontoyiannis, Alexandre E. Malek, Anne-Marie Chaftari
Summary: This international multicenter study aimed to identify independent risk factors for increased 30-day mortality in COVID-19 patients with and without cancer. The study analyzed data from 16 international centers and found that cancer itself was not an independent risk factor for increased mortality. Older age and lymphopenia were the main predictors of 30-day mortality in all patients, and remdesivir was the only therapeutic agent associated with decreased mortality.
Review
Pediatrics
Ji Yoon Han, Seung Beom Han
Summary: Febrile seizure (FS) is the most common type of seizure disorder in children, and its pathogenesis is still debatable. The exact role of inflammatory mediators and the connection between inflammation and the central nervous system remain unclear. In most cases, FS is caused by mild respiratory virus infections, so there is no need for extensive efforts to identify the causative pathogen.
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2023)
Article
Chemistry, Physical
Jitendra Bahadur, Jun Ryu, Dong-Gun Lee, Jongin Hong, Shuzi Hayase, Jung Sang Cho, Sang Mun Jeong, Dong-Won Kang
Summary: In this study, small carbon chain molecules were introduced as liquid additives to improve the crystal growth and surface processing of CsPbI2Br perovskite. The additives could passivate surface defects by conducting with halide ions, leading to improved performance and stability of the photovoltaic devices. The addition of diiodo-methane was found to significantly enhance the power conversion efficiency of perovskite solar cells, reaching a record high of 16.42%.
APPLIED SURFACE SCIENCE
(2023)
Article
Medicine, General & Internal
Alberto Papi, Michael G. Ison, Joanne M. Langley, Dong-Gun Lee, Isabel Leroux-Roels, Federico Martinon-Torres, Tino F. Schwarz, Richard N. van Zyl-Smit, Laura Campora, Nancy Dezutter, Nathalie de Schrevel, Laurence Fissette, Marie-Pierre David, Marie Van der Wielen, Lusine Kostanyan, Veronica Hulstrom
Summary: A phase 3 clinical trial showed that a candidate vaccine for respiratory syncytial virus (RSV) infection has a high efficacy in preventing RSV-related respiratory infection and lower respiratory tract disease in older adults. The vaccine was effective against both RSV subtypes and in individuals with underlying conditions.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Chemistry, Analytical
Ae Sol Lee, Su Min Kim, Kyeong Rok Kim, Chulmin Park, Dong-Gun Lee, Hyung Joon Cha, Hye Ryoung Heo, Chang Sup Kim
Summary: To control SARS-CoV-2, early diagnosis of infected individuals is crucial. A colorimetric lateral flow immunoassay (LFIA) was developed in this study, enabling sensitive detection of cultured SARS-CoV-2 in 15 minutes with a detection limit of 5 x 10^4 copies/mL. Clinical evaluation showed that the LFIA accurately detected all positive and negative samples, achieving 100% accuracy.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Virology
Seungwan Chae, Hoon Seok Kim, Sung-Yeon Cho, Dukhee Nho, Raeseok Lee, Dong-Gun Lee, Myungshin Kim, Yonggoo Kim
Summary: This study aimed to identify variants associated with CMV drug resistance in HCT recipients and assess their clinical significance. The study found that 8.1% of patients had resistance variants, and 39.0% of patients had variants of uncertain significance. Patients with resistance variants had higher CMV viral load and higher risks of severe graft-versus-host disease and lower one-year survival rates.
Article
Biophysics
Juhwan Park, Minjun Park, Junbeom Kim, Youhee Heo, Bo Hoon Han, Nakwon Choi, Chulmin Park, Raeseok Lee, Dong-Gun Lee, Seok Chung, Ji Yoon Kang
Summary: Digital enzyme linked immunosorbent assays (ELISA) can detect SARS-CoV-2 antigens with higher sensitivity compared to conventional antigen tests. To improve detection sensitivity, researchers developed an oil-and bead-free single molecule counting assay with rolling circle amplification (RCA) on a substrate. This method showed more than 100-fold improvement in detecting the N protein of SARS-CoV-2 compared to conventional ELISA.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Immunology
Geon Young Ko, Jihyun Lee, Hyunjoo Bae, Ji Hyeong Ryu, Hye-Sun Park, Hyunhye Kang, Jin Jung, Ae-Ran Choi, Raeseok Lee, Dong-Gun Lee, Eun-Jee Oh
Summary: This prospective study evaluated immune responses and breakthrough infections in 235 infection-naive healthcare workers. The study found that both vaccine groups exhibited peak responses one to two months after the second or third dose, followed by gradual declines. The ChAd group showed a gradual increase in ELISPOT results, but their antibody levels declined more rapidly than the BNT group. Six months after the third dose, both groups had substantial cellular responses, with superior humoral responses in the BNT group.
Article
Pediatrics
Jeong Min Kim, Hyun Mi Kang, In Hyuk Yoo, Dong-Gun Lee, Nack-Gyun Chung, Bin Cho
Summary: Gastrointestinal bleeding is a rare adverse event of dasatinib, which can be caused by dasatinib-induced colitis, severe thrombocytopenia, and platelet dysfunction. We report two cases of pediatric patients who developed hematochezia during treatment with dasatinib after hematopoietic stem cell transplantation (HSCT). A colonic tissue biopsy was performed to differentiate the cause of GI bleeding. Both patients were diagnosed with proven cytomegalovirus (CMV) colitis, but only one received ganciclovir treatment. The patient who did not receive antiviral therapy experienced recurrent GI bleeding during dasatinib administration, leading to multiple treatment interruptions. Patients with GI bleeding and confirmed CMV colitis during dasatinib therapy after HSCT may benefit from antiviral therapy to reduce interruptions in dasatinib therapy.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jongmin Lee, Raeseok Lee, Kyongmin Sarah Beck, Dae Hee Han, Gi June Min, Suyon Chang, Jung Im Jung, Dong-Gun Lee
Summary: This study reported the clinical and radiological characteristics of patients with B-cell lymphoma and COVID-19, showing migratory airspace opacities on serial chest CT. The results showed that these patients exhibited multifocal patchy peripheral ground glass opacities (GGOs) with basal predominance in the baseline CTs, and clearance of previous opacities with the development of new peripheral and peribronchial GGO and consolidation in different locations. All patients demonstrated prolonged COVID-19 symptoms accompanied by positive polymerase chain reaction results throughout the follow-up period.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Infectious Diseases
Jing Chen, Ju-Young Shin, Sumitra Shantakumar, Sungho Bea, Byong Duk Ye, Dong-Gun Lee, Hyungwoo Kim, Won Suk Choi, Iain Kaan
Summary: The incidence rate of herpes zoster (HZ) is higher in individuals with immunocompromised conditions and autoimmune diseases (IC/AID) in the Republic of Korea (ROK), especially in women, those aged 50 years and above, and those who have undergone transplants and hemato-oncology treatment. HZ in IC/AID patients leads to higher medical costs.
INFECTIOUS DISEASES AND THERAPY
(2023)