期刊
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
卷 30, 期 5, 页码 531-538出版社
WILEY-BLACKWELL
DOI: 10.1002/gps.4179
关键词
ADNI-1; ADNI-2; MRI; grey matter (GM); white matter (WM); cerebral spinal fluid (CSF)
资金
- NIHR Biomedical Research Centre for Mental Health
- NIHR Biomedical Research Unit for Dementia at South London
- Maudsley NHS Foundation Trust
- Institute of Psychiatry
- King's College London
- Alzheimer Research UK
- European Medical Information Framework
- MRC [MR/J008915/1] Funding Source: UKRI
- Medical Research Council [MR/J008915/1] Funding Source: researchfish
ObjectivesThe Alzheimer's Disease Neuroimaging Initiative 3.0T MRI image acquisition scheme changed between the original ADNI-1 grant and the two subsequent grants (ADNI-GO and ADNI-2). The aim of the current study was to investigate the compatibility of the 3.0T ADNI-1 and ADNI-2 T1-weighted volumes using voxel-based morphometry (VBM). MethodsT1-weighted images of 30 subjects were acquired using a 3T GE Signa HDx using the ADNI-1 and ADNI-2 T1-weighted volume sequences. Images were pre-processed and analysed using SPM8. Global grey matter (GM), white matter (WM) and cerebrospinal fluid (CSF) volumes were compared, as well as voxel-by-voxel differences in GM and WM. ResultsCorrelation coefficients and percentage differences for each tissue type between ADNI-1 and ADNI-2 were as follows: ((GM: intraclass correlation coefficient (ICC)=0.86, ADNI-1 3.09%ADNI-2) (CSF: ICC=0.90, ADNI-1 1.94%>ADNI-2)). For ADNI-2, widespread increases in GM were found relative to ADNI-1 (cerebellum and pre-central gyrus), with localised decreases along the midline and temporal lobes. For ADNI-1, widespread increases in WM were found relative to ADNI-2 (cerebellum and pre-central gyrus), together with localised decreases in the temporal gyrus. ConclusionsThe widespread increase in GM and localised decrease in WM in ADNI-2 compared to ADNI-1 images suggests that the image acquisition protocols are not directly comparable using SPM-8. Total volumes of GM, WM and CSF also differed between the protocols in the following order of magnitude: GM>WM>CSF. This has implications for studies aiming to analyse images acquired using the ADNI-1 and ADNI-2 protocols under VBM. (c) 2014 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.
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