Article
Medicine, General & Internal
Mario Herrera-Perez, David Gonzalez-Martin, Emilio J. Sanz, Jose L. Pais-Brito
Summary: With the aging of society, it is increasingly common to deal with ethical dilemmas that involve decision making in the elderly patient with a hip fracture. The study found that elderly patients may lose their principle of autonomy during their hospitalization and ageism may lead to surgical delay and increased mortality rate.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Mikel L. Saez de Asteasu, Tainara Steffens, Robinson Ramirez-Velez, Eduardo L. Cadore, Mikel Izquierdo
Summary: There is an association between muscle strength and adverse health outcomes related to cancer symptoms, specifically in frail elderly individuals. In this study, handgrip strength was found to be lower in older adults with cancer compared to those without a cancer diagnosis.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Orthopedics
Tao Wang, Shuo Yang, Zhiqian Wang, Junfei Guo, Zhiyong Hou
Summary: The purpose of this study was to identify the risk factors for admission deep venous thrombosis (aDVT) and proximal aDVT in nonagenarians and centenarians with intertrochanteric fracture (IF). By analyzing the statistics, it was found that female patients and a high level of D-dimer were risk factors for aDVT, while hypoproteinemia and a high level of D-dimer were risk factors for proximal aDVT. These findings are important for early targeted interventions and risk assessment.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Cell Biology
Qian Xu, Chunyan Wu, Qi Zhu, Renyuan Gao, Jianquan Lu, Mireia Valles-Colomer, Jian Zhu, Fang Yin, Linsheng Huang, Lulu Ding, Xiaohui Zhang, Yonghui Zhang, Xiao Xiong, Miaomiao Bi, Xiang Chen, Yefei Zhu, Lin Liu, Yongqiang Liu, Yongshen Chen, Jian Fan, Yan Sun, Jun Wang, Zhan Cao, Chunsun Fan, S. Dusko Ehrlich, Nicola Segata, Nan Qin, Huanlong Qin
Summary: A comparison of the gut microbiome and blood metabolome between long-lived individuals and their children reveals extensive remodeling in advanced age and a generational divergence in correlations with socioeconomic factors. Genetic associations with metagenomic and metabolomic features are largely generation-specific, but cross-generational associations are found for plasma metabolic quantitative traits.
Article
Nutrition & Dietetics
Silvana Mirella Aliberti, Richard H. W. Funk, Elena Ciaglia, Joseph Gonnella, Aldo Giudice, Carmine Vecchione, Annibale Alessandro Puca, Mario Capunzo
Summary: This study explored the association between tap drinking water and longevity in Cilento, Italy, and found that trace elements in tap water may have a positive influence on the lifespan and health of the local elderly population.
Article
Geriatrics & Gerontology
Suzuna Akema, Tomoaki Mameno, Takeshi Nakagawa, Hiroki Inagaki, Motoyoshi Fukutake, Kodai Hatta, Yuki Murotani, Yoshitaka Tsujioka, Hiromasa Hagino, Kotaro Higashi, Toshihito Takahashi, Masahiro Wada, Yoshinobu Maeda, Yasuyuki Gondo, Kei Kamide, Mai Kabayama, Tatsuro Ishizaki, Yukie Masui, Soshiro Ogata, Kazunori Ikebe
Summary: This study found an association between maximal occlusal force and psychological frailty among Japanese community-dwelling older adults.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Environmental Sciences
Yuebin Lv, Yuan Wei, Jinhui Zhou, Kai Xue, Yanbo Guo, Yang Liu, Aipeng Ju, Bing Wu, Feng Zhao, Chen Chen, Jiahui Xiong, Chengcheng Li, Heng Gu, Zhaojin Cao, John S. Ji, Xiaoming Shi
Summary: The study investigated the concentrations of toxic metals and essential metals in longevity among elderly individuals of different age groups. Men had higher concentrations of toxic metals and lower concentrations of essential metals compared to women, which may impact their lifespan. LASSO regression and random forest models identified significant metals associated with various diseases.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Donato Angelino, Francesca Pietrangeli, Mauro Serafini
Summary: This study investigated the meal timing and dietary habits of nonagenarians and centenarians in the Abruzzo region, Italy. The results showed an early dinner and a significant calorie restriction period between dinner and lunch. The participants had a high consumption of plant-based foods and were physically active throughout their lives.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Zhigao Sun, Xin Su, Xiaoqian Zhao, Yao Yao, Yali Zhao, Pei Zhang, Zhirui Li, Shihui Fu
Summary: This study investigated 1863 elderly individuals in Hainan, China, and found significant positive associations between constipation and overeating with depression. Therefore, interventions for constipation and overeating should be improved to enhance prevention and treatment for depression.
Article
Endocrinology & Metabolism
Min Jhon, Min-Ho Shin, Kyung Chul Yoon, Jeong-Sun Kim, Jeonghwa Lee, Kwangsung Park, Sang Chul Park
Summary: This study investigated factors related to subjective health among centenarians and near-centenarians in a rural area of South Korea. Depressive mood was found to be the only factor associated with subjective health, showing a negative correlation. The study highlights the importance of mental health at very advanced ages.
Article
Cell Biology
Paola Sebastiani, Anthony Federico, Melody Morris, Anastasia Gurinovich, Toshiko Tanaka, Kevin B. Chandler, Stacy L. Andersen, Gerald Denis, Katherine Costello, Luigi Ferrucci, Lori Jennings, David J. Glass, Stefano Monti, Thomas T. Perls
Summary: Using samples from the New England Centenarian Study, researchers characterized the serum proteome of centenarians, their offspring, and age-matched controls. They identified protein signatures associated with longer survival in centenarians and younger individuals and found similarities in aging markers between centenarians and short-lived cohorts. The study provides specific circulating biomarkers of healthy aging and longevity, suggesting potential mechanisms to prolong health and support longevity.
Review
Biochemistry & Molecular Biology
Natalia Frankowska, Ewa Bryl, Tamas Fulop, Jacek M. Witkowski
Summary: This study found that at least one intracellular proteolytic system in the peripheral blood lymphocytes of centenarians is as abundant as in young individuals, while the elderly population shows a significant decrease. The study aimed to investigate how different types of cells in long-lived people maintain the quality and quantity of their proteins. The results suggested that robust proteodynamics may contribute to longevity, as most aspects of cellular protein maintenance showed better performance in centenarians compared to the average elderly, approaching levels seen in young individuals, except for mitochondrial status and chaperone function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Chi Zhang, Hao Zhang, Minghao Zhao, Chen Chen, Zhongquan Li, Deping Liu, Yali Zhao, Yao Yao
Summary: This study evaluated the psychometric properties of the Geriatric Depression Scale (GDS) among a large representative longevous population in China. The original GDS-15 showed acceptable internal reliability, but some items may not be applicable for this population. A simplified GDS-10 model was proposed as a potentially more practical and comprehensible instrument for depression screening.
Article
Environmental Sciences
Silvana Mirella Aliberti, Francesco De Caro, Richard H. W. Funk, Luigi Schiavo, Joseph Gonnella, Giovanni Boccia, Mario Capunzo
Summary: This study investigated the phenomenon of regional longevity in Cilento and found that environmental factors such as altitude, climate, protected areas, and hinterland can directly or indirectly influence healthy living and lead to longevity. It was discovered that longevity is mainly concentrated in the central area of Cilento and extends towards the south-east, in the hilly area with altitudes between 400 and 700 meters above sea level. The towns in this area are part of the UNESCO heritage and have a transitional climate between Mediterranean and temperate climate. Furthermore, the study confirmed a linear relationship between the six indicators of longevity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Zhigao Sun, Ping Ping, Yulong Li, Long Feng, Fan Liu, Yali Zhao, Yao Yao, Pei Zhang, Shihui Fu
Summary: This study provides strong epidemiological evidence that Qi depression has a significant relationship with ARCD in Chinese centenarians, suggesting that regulating Qi depression may be a valuable method to prevent and treat ARCD in the elderly population.
FRONTIERS IN AGING NEUROSCIENCE
(2022)