Article
Multidisciplinary Sciences
Elizabeth T. Mansi, Samantha Banks, Alyson J. Littman, Noel S. Weiss
Summary: This study evaluated the association between sociodemographic factors and cholesterol-lowering medication use in high-risk individuals. It was found that only 61% of participants without healthcare coverage used the medication, while 85% of those with coverage used it. Older age and minimal variation by race and ethnicity were associated with higher medication use. Income, education level, and relationship status were weakly or not associated with medication use.
Article
Cardiac & Cardiovascular Systems
Adam C. Livori, Zanfina Ademi, Jenni Ilomaki, Derk Pol, Jedidiah Morton, J. Simon Bell
Summary: There is no clinically significant relationship between remoteness and the use of secondary prevention medications among myocardial infarction patients in Victoria, Australia.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Clara K. Chow, Harry Klimis, Aravinda Thiagalingam, Julie Redfern, Graham S. Hillis, David Brieger, John Atherton, Ravinay Bhindi, Derek P. Chew, Nicholas Collins, Michael Andrew Fitzpatrick, Craig Juergens, Nadarajah Kangaharan, Andrew Maiorana, Michele McGrady, Rohan Poulter, Pratap Shetty, Jonathon Waites, Christian Hamilton Craig, Peter Thompson, Sandrine Stepien, Amy Von Huben, Anthony Rodgers
Summary: A text message-based program did not improve medication adherence after acute coronary syndrome, but had small effects on lifestyle risk factors.
Article
Cardiac & Cardiovascular Systems
Catarina Schiborn, Daniela Weber, Tilman Grune, Ronald Biemann, Susanne Jager, Natascha Neu, Marie Muller von Blumencron, Andreas Fritsche, Cornelia Weikert, Matthias B. Schulze, Clemens Wittenbecher
Summary: This study found differences in the association of retinol and RBP4 (retinol binding protein 4) with cardiovascular diseases and type 2 diabetes. The association was modified by hypertension state, liver function, kidney function, and sex. These findings suggest a complex relationship between retinol, RBP4, and cardiometabolic risk.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Jennifer A. Rymer, Eileen Fonseca, Durgesh D. Bhandary, Deepa Kumar, Naeem D. Khan, Tracy Y. Wang
Summary: Medication adherence rates after myocardial infarction are low, with underuse of 90-day prescriptions. Patients filling 90-day prescriptions demonstrated higher adherence and fewer medication changes within one year post-discharge.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Ivana Skrlec, Zrinka Biloglav, Jasminka Talapko, Snjezana Dzijan, Danijela Daus-Sebedak, Vera Cesar
Summary: This study investigated the association between MTNR1B gene polymorphisms, chronotype, and susceptibility to myocardial infarction. The case-control study included 199 myocardial infarction patients and 198 control participants without previous cardiovascular diseases, who were genotyped for MTNR1B polymorphisms. Chi-square tests revealed no significant association between allele and genotype distribution in myocardial infarction patients and controls. Additionally, there was no association between MTNR1B polymorphisms and chronotype in myocardial infarction patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Marcelo Munoz, Cagla Eren Cimenci, Keshav Goel, Maxime Comtois-Bona, Mahir Hossain, Christopher McTiernan, Matias Zuniga-Bustos, Alex Ross, Brenda Truong, Darryl R. Davis, Wenbin Liang, Benjamin Rotstein, Marc Ruel, Horacio Poblete, Erik J. Suuronen, Emilio Alarcon
Summary: This article reports on the development and testing of a sprayable nanotherapeutic that can improve cardiac function and conductivity, reduce infarct size, and increase the number of blood vessels and cardiomyocytes in infarcted myocardium.
Article
Peripheral Vascular Disease
Zhongyu Jian, Chi Yuan, Yucheng Ma
Summary: This study reveals that higher levels of urinary uromodulin (uUMOD) are associated with an increased risk of myocardial infarction (MI), while no causal effects of uUMOD on other cardiovascular disease (CVD) outcomes were found. Blood pressure mediates the effect of uUMOD on MI risk.
Article
Peripheral Vascular Disease
Zegui Huang, Zekai Chen, Xianxuan Wang, Xiong Ding, Zefeng Cai, Weijian Li, Zhiwei Cai, Yulong Lan, Guanzhi Chen, Wei Fang, Shouling Wu, Youren Chen
Summary: In hypertensive patients, high-stable cardiovascular health score (CHS) or improvement in CHS is associated with a lower risk of incident myocardial infarction (MI), when compared with low-stable CHS trajectory over time.
Article
Rheumatology
Tsai-Hung Yen, Yun-Wen Chen, Tsu-Yi Hsieh, Yi-Ming Chen, Wen-Nan Huang, Yi-Hsing Chen, Hsin-Hua Chen
Summary: This study aimed to assess the incidence and risk factors of major adverse cardiovascular events (MACEs) in patients with systemic sclerosis (SSc). A nationwide cohort study was conducted in Taiwan, including 1379 SSc patients and 2758 non-SSc individuals. The study found that SSc was associated with increased risk of myocardial infarction and peripheral arterial occlusion disease, but not of ischaemic stroke. Age, gender, residential area, valvular heart disease, rheumatoid arthritis, and the use of clopidogrel and aspirin were identified as independent risk factors for MACEs in SSc patients. The findings of this study are clinically significant in understanding the risk factors for MACEs in SSc patients.
Article
Medicine, General & Internal
Nadezda Pupina, Annela Avarlaid, Helle Sadam, Arno Pihlak, Mariliis Jaago, Jurgen Tuvikene, Annika Rahni, Anu Planken, Margus Planken, Eija Kalso, Pentti J. Tienari, Janne K. Nieminen, Mikko R. J. Seppanen, Antti Vaheri, Dan Lindholm, Juha Sinisalo, Pirkko Pussinen, Tonis Timmusk, Kaia Palm
Summary: This study investigates the association between antibody-based immune response and severe cardiovascular conditions. The findings suggest that antibody response to the G-I-X-D epitope is associated with polio vaccinations. Low levels of antibody response to this epitope may be linked to severe cardiac disease complications.
Article
Nursing
Reza Hajialibeigloo, Seyed Reza Mazlum, Samira Mohajer, Donald E. Morisky
Summary: The study findings indicate that the self-administration of medication programme can significantly improve medication adherence levels in cardiovascular patients and increase nurse satisfaction.
Article
Multidisciplinary Sciences
Rodney Plat, Maria Vasile, Francois Roubille, Gregoire Mercier
Summary: Worldwide, there has been a decrease in hospitalizations for acute coronary syndrome (ACS) during the COVID-19 pandemic. ACS is known to be associated with socioeconomic status. This study aims to assess the impact of COVID-19 on ACS admissions in France during the first national lockdown and investigate the factors contributing to its spatial heterogeneity.
Article
Multidisciplinary Sciences
Camillo Rossi, Paolo Berta, Salvatore Curello, Pietro Giorgio Lovaglio, Mauro Magoni, Marco Metra, Aldo Maria Roccaro, Stefano Verzillo, Giorgio Vittadini
Summary: Despite the potential adverse effects of longer time to hospitalization and increased staff burden during the first wave of Covid-19, the mortality rates for AMI and stroke patients did not show statistically significant differences compared to before the pandemic. The study indicates that hospitals were able to manage the delivery of high-quality care to both Covid and non-Covid patients through a dual track organization.
Article
Multidisciplinary Sciences
Camillo Rossi, Paolo Berta, Salvatore Curello, Pietro Giorgio Lovaglio, Mauro Magoni, Marco Metra, Aldo Maria Roccaro, Stefano Verzillo, Giorgio Vittadini
Summary: This study examines the impact of Covid-19 on in-hospital mortality rates of AMI and stroke patients, finding that mortality rates during the pandemic were not statistically different from before the outbreak. This suggests that hospitals are capable of managing both types of patients effectively.
Article
Cell Biology
Sonja Langthaler, Jasmina Lozanovic Sajic, Theresa Rienmueller, Seth H. Weinberg, Christian Baumgartner
Summary: The mathematical modeling of ion channel kinetics is crucial for understanding electrophysiological mechanisms. In this paper, a new system theory-based approach is introduced, using transfer function characterization and patch clamp measurements, which shows exceptional accuracy and computational efficiency compared to traditional methods. This method has the potential to improve cell and organ model simulations and is a valuable tool for next-generation electrophysiology.
Article
Engineering, Biomedical
Christoph Leitner, Robert Jarolim, Bernhard Englmair, Annika Kruse, Karen Andrea Lara Hernandez, Andreas Konrad, Eric Yung-Sheng Su, Joerg Schroettner, Luke A. Kelly, Glen A. Lichtwark, Markus Tilp, Christian Baumgartner
Summary: Biomechanical and clinical gait research use machine learning to track muscle-tendon junctions, providing support in gait analysis. Extensive data collection and deep learning training showed that the model achieved similar performance in identifying junction position compared to human experts, and it is 100 times faster than manual labeling.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Review
Chemistry, Analytical
Yasmine Heyer, Daniela Baumgartner, Christian Baumgartner
Summary: Understanding the range and limits of human trans thoracic impedance (TTI) is crucial for cardiac defibrillator testing and design. A literature survey based on 71 selected articles revealed that TTI varied from 12 to 212 Ohms, with an average TTI of 76.7 Ohms. Factors such as shock waveforms and protocols, coupling devices, electrode characteristics, and patient characteristics were found to influence TTI, with coupling devices, electrode size, and pressure having the greatest impact.
Article
Computer Science, Information Systems
Jen Bichel-Findlay, Sabine Koch, John Mantas, Shabbir S. Abdul, Najeeb Al-Shorbaji, Elske Ammenwerth, Analia Baum, Elizabeth M. Borycki, George Demiris, Arie Hasman, William Hersh, Evelyn Hovenga, Ursula H. Huebner, Elaine S. Huesing, Andre Kushniruk, Kye Hwa Lee, Christoph U. Lehmann, Svein-Ivar Lillehaug, Heimar F. Marin, Michael Marschollek, Fernando Martin-Sanchez, Mark Merolli, Aurore Nishimwe, Kaija Saranto, Danielle Sent, Aviv Shachak, Jai Ganesh Udayasankaran, Martin C. Were, Graham Wright
Summary: The International Medical Informatics Association (IMIA) has published recommendations for biomedical and health informatics (BMHI) education to support educators, identify essential skills, provide an evaluation tool, and encourage the establishment and development of BMHI educational programs. IMIA's taskforce updated the recommendations, which cover various domains, programs, and levels of education in BMHI. Accreditation and information exchange on BMHI programs and courses are also provided.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Medical Informatics
Franziska Jahn, Elske Ammenwerth, Verena Dornauer, Konrad Hoeffner, Michelle Bindel, Thomas Karopka, Alfred Winter
Summary: In order to address the issue of inconsistent descriptions of libre/free and open-source software (LIFOSS) in the field of health informatics, researchers used Health Information Technology Ontology (HITO) to systematically describe LIFOSS. By using Linked Open Data (LOD), HITO provides a standardized terminology and accurate functionalities description, which helps healthcare and IT professionals select appropriate software products.
JMIR MEDICAL INFORMATICS
(2023)
Article
Education & Educational Research
Lisa -Maria Norz, Verena Dornauer, Werner O. Hackl, Elske Ammenwerth
Summary: The study aims to identify measures of social presence in online learning environments, which is challenging to measure. Through coding students' postings and using social network analysis and log data, the study conducted an exploratory path analysis to determine appropriate indicators for social presence. The size of the individual student's network, constraint, number of active forums, and number of solved learning activities were found to be indicators of social presence. Furthermore, the study found that four indicators for social presence in online-based courses can be readily obtained from routine data of learning management systems, and the focus will now be on the development of social presence in an ongoing course.
INTERNET AND HIGHER EDUCATION
(2023)
Article
Computer Science, Interdisciplinary Applications
A. Lara-Hernandez, T. Rienmueller, I. Juarez, M. Perez, F. Reyna, D. Baumgartner, V. N. Makarenko, O. L. Bockeria, M. Maksudov, R. Rienmueller, C. Baumgartner
Summary: This article introduces a deep learning-based deformable image registration method for quantitative myocardial perfusion CT examinations in dynamic cardiac cycles. The method addresses unique challenges such as low image quality, inaccurate anatomical landmarks, dynamic changes in contrast agent concentration, and misalignment caused by cardiac stress, respiration, and patient motion. The proposed method reduces local tissue displacements of the left ventricle and demonstrates fast processing time compared to conventional methods, making it suitable for daily clinical routine.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Physiology
Mathias Polz, Katharina Bergmoser, Martin Horn, Michael Schoerghuber, Jasmina Lozanovic, Theresa Rienmueller, Christian Baumgartner
Summary: This study presents a novel digital model for predicting cumulative fluid balance (CFB) based on system theory. The model utilizes recorded patient fluid data as the sole parameter source and applies the concept of a transfer function. The results demonstrate that a combination of 48-hour estimation time and 8-16-hour prediction time achieves high accuracy in CFB prediction. This study provides a promising proof of principle for developing computational models for fluid prediction that do not require large datasets.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Education & Educational Research
Lisa -Maria Norz, Werner O. Hackl, Nils Benning, Petra Knaup-Gregori, Elske Ammenwerth
Summary: The aim of this work was to translate and validate the original English CoI Survey to German. After a systematic translation process and validation in two higher education settings in two countries, it was confirmed that the German version of the CoI Survey is reliable and valid.
Article
Computer Science, Interdisciplinary Applications
Verena Dornauer, Michael Netzer, Eva Kaczko, Lisa-Maria Norz, Elske Ammenwerth
Summary: Cognitive presence is crucial for meaningful online learning. We developed a German-language classifier using linguistic analysis and other learning traces to monitor and support students' learning progress. The classifier showed an accuracy of up to 82%.
INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE IN EDUCATION
(2023)
Editorial Material
Health Care Sciences & Services
Kathrin Cresswell, Michael Rigby, Farah Magrabi, Philip Scott, Jytte Brender, Catherine K. Craven, Zoie Shui-Yee Wong, Polina Kukhareva, Elske Ammenwerth, Andrew Georgiou, Stephanie Medlock, Nicolette F. De Keizer, Pirkko Nykanen, Mirela Prgomet, Robin Williams
Summary: Despite the renewed interest in AI-CDS, there is a lack of empirical evidence supporting their effectiveness, highlighting the need for rigorous evaluation and monitoring of health information technology. Assessment of design, implementation, and adoption contexts, prioritizing ethics and outcomes, and incorporating these dimensions in decision-making are crucial for successful implementation and optimization of benefits.
Article
Materials Science, Multidisciplinary
Kirill Keller, Christoph Leitner, Christian Baumgartner, Luca Benini, Francesco Greco
Summary: We present the fabrication of a fully printed, lead-free, polymer piezoelectric transducer and demonstrate the characterization of its structural, dielectric, and ferroelectric properties at different processing stages. The performance of the transducer made with poly(vinylidene fluoride-trifluoroethylene) is evaluated through resonance frequency analyses, acoustic power measurements, and pulse-echo experiments. Importantly, we demonstrate an optimal performance in the medical ultrasound range (<15 MHz) with acoustic power >1 W cm(-2) for the first time in a fully printed transducer, which shows promise for applications in epidermal and wearable electronics. Overall, these findings lay a strong foundation for future research in the field of flexible ultrasound transducers.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Editorial Material
Oncology
Christian Baumgartner, Daniela Baumgartner
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Stefan Richter, Elske Ammenwerth
Summary: This study aims to develop and evaluate a catalogue of measures and indicators to assist hospitals in implementing and evaluating risk management for medical devices according to IEC 80001-1. Through a Delphi study, a catalogue consisting of 49 measures and 18 indicators was developed and its practicability was verified through a case study. This catalogue will help hospitals overcome difficulties in implementing and evaluating IT risk management for medical devices according to IEC 80001-1.
BMJ HEALTH & CARE INFORMATICS
(2023)
Article
Computer Science, Information Systems
Eveline Prochaska, Elske Ammenwerth
Summary: The digital version of the Nine-Hole Peg Test (dNHPT) was validated in this study, showing good test-retest and interrater reliability, as well as moderate concurrent validity.
