Article
Veterinary Sciences
Lucy A. Parker, Lucrecia Acosta, Mariana Noel Gutierrez, Israel Cruz, Javier Nieto, Enrique Jorge Deschutter, Fernando Jorge Bornay-Llinares
Summary: The study utilized city land registry for random selection of domestic dog samples and compared with shelter dogs, showing a higher prevalence among shelter dogs. The seroprevalence among domestic dogs was significantly lower than among the abandoned dogs and the spatial distribution of infected dogs was fairly homogenous throughout the city.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Ali Taghipour, Amir Abdoli, Afifeh Ramezani, Ahmad Abolghazi, Mirza Ali Mofazzal Jahromi, Salar Maani, Seyede Manizhe Heidar Nejadi, Sima Rasti, Morteza Shams, Ezatollah Ghasemi
Summary: Leishmaniasis is a prevalent parasitic infection caused by different species of Leishmania, with alterations in trace elements impacting disease prognosis and potentially serving as adjunct therapies.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Fausto Quintavalla, Giuseppina Basini, Simona Bussolati, Gennaro Giuseppe Carrozzo, Antonio Inglese, Roberto Ramoni
Summary: Leishmaniasis, a disease under strict observation by World Health Organization, has unclear pathogenesis. The study aimed to compare oxidative stress parameters in healthy and affected dogs, revealing modifications in several parameters in canine Leishmaniasis. Further research is needed to shed light on the disease's pathogenesis.
Article
Biochemistry & Molecular Biology
Mehdi Sagha Kahvaz, Shahrzad Soltani, Sheyda Soltani, Manuela Colla Carvalheiro, Masoud Foroutan
Summary: The study measured serum levels of trace metals in 80 CL patients and 80 healthy volunteers, finding significantly lower zinc, iron, and selenium levels, and higher copper levels, in CL patients. Additionally, CL patients had a significantly lower zinc/copper ratio compared to controls. These alterations in trace element levels may be part of the organism's defense strategy in response to CL infection. Serum levels of these trace elements could serve as a useful marker for estimating the prognosis of CL infection.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Chemistry, Analytical
Tiago S. Ferreira, Ewaldo E. C. Santana, Antonio F. L. Jacob Junior, Paulo F. Silva Junior, Luciana S. Bastos, Ana L. A. Silva, Solange A. Melo, Carlos A. M. Cruz, Vivianne S. Aquino, Luis S. O. Castro, Guilherme O. Lima, Raimundo C. S. Freire
Summary: This research uses machine learning techniques to classify cases of canine visceral leishmaniasis, with logistic regression achieving the best metrics.
Article
Microbiology
Daniel Silva Dias, Juliana Martins Machado, Patricia Aparecida Fernandes Ribeiro, Amanda Sanchez Machado, Fernanda Fonseca Ramos, Lais Moreira Nogueira, Ana Alice Maia Goncalves, Luana de Sousa Ramos, Isadora Braga Gandra, Flaviane Silva Coutinho, Michelli dos Santos, Jonatas Oliveira da Silva, Miguel Angel Chavez-Fumagalli, Rafael Goncalves Teixeira-Neto, Ana Thereza Chaves, Mariana Campos-da-Paz, Amanda A. Souza, Rodolfo Cordeiro Giunchetti, Sonia Maria Freitas, Sandra Lyon, Danielle Ferreira de Magalhaes-Soares, Julia Angelica Goncalves Silveira, Eduardo Sergio Silva, Eduardo Antonio Ferraz Coelho, Alexsandro Sobreira Galdino
Summary: Background: Visceral leishmaniasis (VL) is a critical public health problem in over ninety countries, and control measures in Brazil have been insufficient. A chimeric protein called rMELEISH was developed for the accurate diagnosis of VL in dogs and humans. In trials, rMELEISH showed 100% sensitivity and specificity in distinguishing VL cases from other diseases and healthy samples. These preliminary results suggest that rMELEISH has potential for future diagnostic studies in the field.
Article
Immunology
Romulo Pessoa-e-Silva, Lays Adrianne Mendonca Trajano-Silva, Victor Vaitkevicius-Antao, Wagner Jose Tenorio dos Santos, Franklin Barbalho Magalhaes, Danielle Maria Nascimento Moura, Eiji Kevin Nakasone Nakasone, Virginia Maria Barros de Lorena, Milena de Paiva-Cavalcanti
Summary: The study evaluated the in vitro cellular immune response of dogs elicited by new recombinant proteins of Leishmania infantum. Results showed that Lci13 significantly increased IFN-gamma expression in uninfected animals, suggesting its potential for immunoprophylaxis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Larissa Ferreira de Araujo Paz, Adalucia da Silva, Hemilly Rayanne Ferreira da Silva, Milena Paiva Cavalcanti, Valeria Marcal Felix de Lima, Maria Rosario Oliveira da Cunha Beltrao, Maria Beatriz Araujo Silva, Osvaldo Pompilio de Melo Neto, Zulma Maria Medeiros, Wagner Jose Tenorio dos Santos
Summary: Dogs are the main reservoir for human visceral leishmaniasis and the diagnosis of canine visceral leishmaniasis (CVL) is crucial for disease control. The current serological tests for CVL have variable sensitivity and specificity. Research on novel recombinant proteins, such as Q5, may improve the diagnosis of CVL. This study aimed to evaluate the diagnostic potential of Q5 in an ELISA assay using a large number of CVL-suspected sera.
VETERINARY SCIENCES
(2023)
Article
Microbiology
Jonathan L. M. Fontes, Bianca R. Mesquita, Reginaldo Brito, Juliana C. S. Gomes, Caroline V. B. de Melo, Washington L. C. dos Santos
Summary: The spleen plays a crucial role in the immunopathogenesis of visceral leishmaniasis, with alterations in white-pulp microenvironments increasing susceptibility to coinfections and mortality in patients. Using modified immunohistochemistry with biotinylated soluble L. infantum membrane antigens, researchers detected the presence of anti-L. infantum antibody-secreting cells in spleen sections from CanL-affected dogs. CanL dogs displayed hyperglobulinemia and more plasma cells in their RP compared to healthier controls, with a lower proportion of Anti-Leish-PC in RP than in PALS. Dysproteinemia was associated with plasmacytosis in both RP and PALS, correlating with a more severe clinical presentation.
Article
Parasitology
Alexandre Redson S. Silva, Hugo S. Oliveira, Ana Amelia D. Gomes, Hugo Enrique O. Beserra, Jeana P. Silva, Thais R. Santos-Doni, Miriam H. Tsunemi, Mary Marcondes, Sheila C. Rahal, Maria J. Mamprim
Summary: This study evaluated joint involvement in dogs with visceral leishmaniasis, finding that over 91% of dogs had joint abnormalities, with most abnormalities observable through radiographic and CT imaging. The most severely affected joints were the tarsal, followed by the stifle, carpal, and elbows, with most dogs presenting bilateral joint abnormalities.
VETERINARY PARASITOLOGY
(2021)
Article
Biochemical Research Methods
Gustavo Larios, Matheus Ribeiro, Carla Arruda, Samuel L. Oliveira, Thalita Canassa, Matthew J. Baker, Bruno Marangoni, Carlos Ramos, Cicero Cena
Summary: The study investigates the use of mid-infrared spectroscopy and multivariate analysis for fast, accurate, and easy diagnosis of canine visceral leishmaniasis, demonstrating an overall accuracy above 85% with principal component analysis and machine learning algorithms.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Public, Environmental & Occupational Health
Claudia Abeijon, Stefano Pizzirani, Antonio Campos-Neto
Summary: Canine visceral leishmaniasis is a serious zoonotic disease caused by Leishmania infantum, with diagnosis primarily reliant on observing parasites in bone marrow or lymph node aspirates. Serological tests currently available are unable to differentiate active disease from exposure to parasite antigens.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Multidisciplinary Sciences
Renata Rocha da Silva, Fernanda de Santana Fontes Vasconcelos, Debora dos Santos Tavares, Priscila Lima dos Santos
Summary: This study conducted a systematic review and meta-analysis to investigate the association between IL-10 single nucleotide polymorphisms (SNPs) and the progression of leishmaniasis. The results showed that IL-10 SNPs were not significantly associated with leishmaniasis progression and were not considered a risk factor.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Patricia Sampaio Tavares Veras, Maria Borges Rabelo de Santana, Claudia Ida Brodskyn, Deborah Bittencourt Mothe Fraga, Manuela Silva Solca, Juliana Perrone Bezerra De Menezes, Bruna Martins Macedo Leite, Helena Mariana Pitangueira Teixeira
Summary: Leishmaniasis is a widespread group of infectious diseases that significantly impact global health. The causative agents are protozoan parasites that give rise to various clinical manifestations. Visceral leishmaniasis is the most severe form and can be life-threatening if left untreated.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Parasitology
Raissa Barbosa de Castro, Joao Victor Badaro de Moraes, Gustavo Costa Bressan, Raphael de Souza Vasconcellos, Abelardo Silva-Junior, Juliana Lopes Rangel Fietto
Summary: This review explores studies on new antigens for canine visceral leishmaniasis (CVL) serodiagnosis, evaluating their potential for accurate diagnostic tools. The results indicate that there are several promising antigens, but further testing is needed. The analysis also highlights the use of control substances and alternative assay platforms.
VETERINARY PARASITOLOGY
(2022)
Article
Physiology
Matheus Rocha Almeida, Jacques Gabriel Alvares Horta, Natalia Alves de Matos, Ana Beatriz Farias de Souza, Thalles de Freitas Castro, Leandro da Silva Candido, Monica Campos Andrade, Silvia Dantas Cangussu, Guilherme de Paula Costa, Andre Talvani, Frank Silva Bezerra
Summary: Pressure-controlled ventilation mode in healthy adult female rats resulted in changes in lung structure, redox imbalance, and increased inflammation.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Cell Biology
Emilia M. Soares, Juliana F. Ferraz, Rodrigo S. Oliveira, Luiza I. S. Dias, Cornelio S. Santiago, Andrea A. Pletsch, Eliana Morielle-Versute, Sebastiao R. Taboga, Carolina C. Souza, Mateus R. Beguelini
Summary: The study aimed to analyze the epididymis of the bat Molossus molossus, evaluating its morphological and morphometric variations, as well as aspects of its hormonal control during the annual reproductive cycle. The results showed that the epididymal physiology of M. molossus is impacted by total testicular regression and posterior recrudescence, with a delay in response due to sperm storage. The seasonal variations in epididymal physiology seem to be correlated to rainfall and photoperiod, regulated in part by the expression of the androgen receptor in epithelial cells.
Article
Anatomy & Morphology
Edna S. S. Albernaz, Cornelio S. Santiago, Luiz H. A. Guerra, Fernanda C. A. Santos, Rejane M. Goes, Eliana Morielle-Versute, Sebastiao R. Taboga, Carolina C. Souza, Mateus R. Beguelini
Summary: The study found that the ventral and dorsal regions of the male prostate in Artibeus lituratus exhibit differences in morphology, physiology, and regulation, being influenced differently by testicular and abiotic factors. Despite these differences, both prostatic regions remain highly synchronized during the main reproductive peak in September.
JOURNAL OF MORPHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ana Beatriz Farias de Souza, Natalia Alves de Matos, Thalles de Freitas Castro, Guilherme de Paula Costa, Laser Antonio Machado Oliveira, Katiane de Oliveira Pinto Coelho Nogueira, Iara Mariana Lellis Ribeiro, Andre Talvani, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Hesperidin can protect the lungs of mice submitted to mechanical ventilation by reducing the inflammatory response and oxidative damage, and may act to prevent mechanical ventilation-induced injuries.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Daniela Fonseca Abdo Rocha, Pedro Alves Machado-Junior, Ana Beatriz Farias Souza, Thalles de Freitas Castro, Guilherme de Paula Costa, Andre Talvani, Frank Silva Bezerra, Silvia Dantas Cangussu
Summary: The study demonstrates that lycopene can protect mouse liver from damage caused by long-term cigarette smoke exposure, improving pathological changes, inflammatory responses, and antioxidant profiles. This is the first study to suggest lycopene as a potential pharmacological tool for treating hepatic damage caused by long-term cigarette smoke exposure.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Natalia Pereira da Silva Araujo, Natalia Alves de Matos, Michel Oliveira, Ana Beatriz Farias de Souza, Thalles de Freitas Castro, Pedro Alves Machado-Junior, Debora Maria Soares de Souza, Andre Talvani, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and mortality worldwide, with cigarette smoke playing a key role in its development. Quercetin may have potential as a preventive agent for smoke-induced pulmonary emphysema.
Article
Immunology
Gregorio Grama Cavalcante, Anna Gabriella Guimaraes, Camila Pereira Queiroz-Glauss, Marcela Helena Goncalves Pereira, Angelica Samer Lallo Dias, Laila Sampaio Horta, Jamil Silvano de Oliveira, Silvia Dantas Cangussu, Paula Prazeres Magalhaes, Remo Castro Russo, H. C. Santiago
Summary: Animals treated with amoxicillin and trimethoprim/sulfamethoxazole displayed more severe allergic airway inflammation, while mice treated with metronidazole showed better lung function and lower lung inflammation. Additionally, the composition of gut microbiota may also impact the development of airway inflammation.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Pathology
Wagner Luiz Tafuri, Thaise Yumie Tomokane, Ana Maria Goncalves Silva, Luciane Kanashiro-Galo, David Miichael Mosser, Juarez Antonio Simoes Quaresma, Carla Pagliari, Mirian N. Sotto
Summary: This study found that fibrosis is a common process in keloid, lacaziosis, and localized scleroderma. Vimentin may be the main myofibroblast general marker in these diseases.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2022)
Article
Nutrition & Dietetics
Thalles de Freitas Castro, Natalia Alves de Matos, Ana Beatriz Farias de Souza, Guilherme de Paula Costa, Luiza Oliveira Perucci, Andre Talvani, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Maternal protein restriction during pregnancy has adverse effects on the lungs of offspring, including decreased body weight, inflammation and oxidative stress, and simplification of lung structure.
Article
Biotechnology & Applied Microbiology
Pamela Felix da Silva, Natalia Alves de Matos, Camila de Oliveira Ramos, Thalles de Freitas Castro, Natalia Pereira da Silva Araujo, Ana Beatriz Farias de Souza, Guilherme de Paula Costa, Silvia Dantas Cangussu, Andre Talvani, Akinori Cardozo Nagato, Frank Silva Bezerra
Summary: Short-term exposure to e-cigarettes leads to more severe respiratory inflammation and lung damage compared to cigarette smoke.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Anatomy & Morphology
Pollyana B. Pimentel, Juliana Filgueira Ferraz, Cornelio Souza Santigo, Emilia Miguel Soares, Eliana Morielle-Versute, Sebastiao R. Taboga, Carolina C. Souza, Mateus R. Beguelini
Summary: Despite being highly diverse and widely distributed, the reproductive accessory glands (RAGs) of bats have received limited attention in research. This study aimed to analyze and compare the composition, anatomy, and histology of male RAGs in three cosmopolitan bat families (Vespertilionidae, Molossidae, and Emballonuridae). The results revealed that the RAGs of these bat species consist of an intra-abdominal prostatic complex, urethral glands, and inguinal bulbourethral glands, but lack ampullary glands or seminal vesicles. The prostatic complex varies in the number of regions and lobed structure among the species.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Anatomy & Morphology
Pollyana B. Pimentel, Cornelio S. Santigo, Juliana F. Ferraz, Eliana Morielle-Versute, Sebastiao R. Taboga, Carolina C. Souza, Mateus R. Beguelini
Summary: This study aims to characterize the male reproductive accessory glands (RAGs) of Pteronotus gymnonotus (Mormoopidae: Chiroptera). The results demonstrate that the RAGs of P. gymnonotus are composed of a prostatic complex, urethral glands, bulbourethral glands, and ampullary glands. It is proposed that the RAGs of P. gymnonotus possibly evolved from a common ancestor shared with the families Phyllostomidae and Nocti-lionidae, with the development of an exclusive feature - ampullary glands.
Article
Medicine, Research & Experimental
Ana Beatriz Farias Souza, Yannick Diedrich, Pedro Alves Machado-Junior, Thalles de Freitas Castro, Leonardo Spinelli Estevao Lopes, Jamille Mirelle de Oliveira Cardoso, Bruno Mendes Roatt, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Mechanical ventilation is a lifesaving therapy for respiratory failure patients, but it can also cause lung injury. The prone position and exogenous surfactant have protective effects on the lungs, but their association has been rarely studied in individuals without previous lung injury. This study found that combining the prone position with surfactant pre-treatment could have a cumulative protective effect against ventilator-induced lung injury. The surfactant pre-treatment was more efficient in promoting lung protection and reducing oxidative damage than the prone position alone.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sttefany Viana Gomes, Bruna Vidal Dias, Pedro Alves Machado Junior, Renata Rebeca Pereira, Debora Maria Soares de Souza, Gustavo Silveira Breguez, Wanderson Geraldo de Lima, Cintia Lopes de Brito Magalhaes, Silvia Dantas Cangussu, Andre Talvani, Karina Barbosa Queiroz, Allan Jefferson Cruz Calsavara, Daniela Caldeira Costa
Summary: High-fat diet intake can worsen metabolic adaptation and protection against pathogens in sepsis by causing immunometabolic changes in the liver and white adipose tissue. A study on female mice found that chronic high-fat diet decreased survival rate, increased serum cytokine storm, exacerbated white adipose tissue inflammation, and caused hepatocellular injury in septic mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Public, Environmental & Occupational Health
Alexandre Faria Alvares Lacerda, Denise Santana Oliveria, Juliane Vilela Fereira Salomao, Luiz Gustavo Rodrigues Oliveira, Adriano Monte-Alegre, Jose Yure Gomes dos Santos, Carolina Carvalho de Souza, Jairo Torres Magalhaes-Junior, E. Theo Araujo-Santos
Summary: This study conducted a retrospective cohort study of leishmaniasis cases reported in Barreiras city between 2007 and 2016, finding that the disease in the city had similar epidemiological characteristics to other regions of Brazil. Visceral leishmaniasis was most prevalent in children, while cutaneous leishmaniasis was primarily found in adults. The disease showed an urban configuration and had a wide distribution in Barreiras city, with vectors of different clinical forms occurring in the urban area.
SPATIAL AND SPATIO-TEMPORAL EPIDEMIOLOGY
(2021)