Article
Immunology
Mariska T. Meijer, Alex F. de Vos, Brendon P. Scicluna, Joris J. Roelofs, Cherine Abou Faycal, Gertraud Orend, Fabrice Uhel, Tom van der Poll
Summary: While TNC plays a role in shaping the immune response during lipopolysaccharide-induced inflammation, its role may be superseded by other factors during pneumosepsis caused by a common gram-negative pathogen.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Flavia Rayssa Braga Martins, Maycon Douglas de Oliveira, Jessica Amanda Marques Souza, Celso Martins Queiroz-Junior, Francisco Pereira Lobo, Mauro Martins Teixeira, Nathalia Luisa Malacco, Frederico Marianetti Soriani
Summary: This study aimed to investigate the inflammatory mechanisms involved in pneumococcal pneumonia associated with chronic ethanol exposure. The results showed that alcohol-fed mice produced higher levels of nitric oxide and CXCL1 during pneumonia, exhibited reduced leukocyte infiltration and less severe lung inflammation, but no changes in survival after infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Tomohiro Hosoda, Sohei Harada, Koh Okamoto, Sumire Ishino, Makoto Kaneko, Masahiro Suzuki, Ryota Ito, Miyuki Mizoguchi
Summary: In patients with coronavirus disease who deteriorate rapidly, co-infections by bacterial and fungal pathogens, including hypervirulent Klebsiella pneumoniae in eastern Asia, should be considered in the differential diagnosis.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
I-Ren Chen, Shih-Neng Lin, Xin-Ni Wu, Sheng-Hua Chou, Fu-Der Wang, Yi-Tsung Lin
Summary: Klebsiella pneumoniae is a common pathogen causing nosocomial pneumonia and community-acquired pneumonia in Asia. This study found that K. pneumoniae bacteremic pneumonia has a high mortality rate, with nosocomial pneumonia having a higher mortality rate compared to community-acquired pneumonia. Factors such as not receiving appropriate definitive therapy, disease severity, and host factors contribute to the 28-day mortality.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Lin Gan, Hanyu Fu, Ziyan Tian, Jinghua Cui, Chao Yan, Guanhua Xue, Zheng Fan, Bing Du, Junxia Feng, Hanqing Zhao, Yanling Feng, Ziying Xu, Tongtong Fu, Xiaohu Cui, Rui Zhang, Shuheng Du, Shiyu Liu, Yao Zhou, Qun Zhang, Ling Cao, Jing Yuan
Summary: This study screened two phages, pKp11 and pKp383, that could effectively treat ST11 and ST383 multidrug-resistant Klebsiella pneumoniae infections. These phages showed a broad host range, high lytic activity, and high environmental adaptability. They were able to reduce bacterial loads, inflammation, and pathogenic injuries in a mouse infection model. These findings highlight the potential of phage therapy as a new approach for treating multidrug-resistant K. pneumoniae infections.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Jonathan Z. Lau, Shanny Hsuan Kuo, Yael Belo, Einav Malach, Bar Maron, Hannah E. Caraway, Myung Whan Oh, Yi Zhang, Nahed Ismail, Gee W. Lau, Zvi Hayouka
Summary: The indiscriminate use of antibiotics has led to an urgent need for novel therapeutics to manage bacterial infectious diseases and counteract bacterial resistance. This study evaluates the effectiveness of the peptide mixture FK5P against carbapenem-resistant Klebsiella pneumoniae and Klebsiella oxytoca. FK5P rapidly kills the bacteria, inhibits biofilm formation, and disrupts mature biofilms. In mouse models, FK5P reduces bacterial burden and increases survival rates. These results demonstrate that FK5P is a safe and promising therapy for Klebsiella species and other bacterial pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Immunology
Dakang Hu, Wenjie Chen, Qi Zhang, Meng Li, Zehua Yang, Yong Wang, Yunkun Huang, Gang Li, Dongxing Tian, Pan Fu, Weiwen Wang, Ping Ren, Qing Mu, Lianhua Yu, Xiaofei Jiang
Summary: This study investigated the epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP) and hypervirulent carbapenem-resistant Klebsiella pneumoniae (Hv-CRKP) in mainland China. Molecular determination of CR-HvKP and Hv-CRKP showed biases compared to mouse lethality test, with the exact prevalence of CR-HvKP being less than 1.0% and that of Hv-CRKP even lower.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daiane Boff, Remo Castro Russo, Helena Crijns, Vivian Louise Soares de Oliveira, Matheus Silverio Mattos, Pedro Elias Marques, Gustavo Batista Menezes, Angelica Thomaz Vieira, Mauro Martins Teixeira, Paul Proost, Flavio Almeida Amaral
Summary: This study tested the anti-inflammatory effect of CXCL9(74-103) in Klebsiella pneumoniae-induced pneumonia. The treatment with CXCL9(74-103) reduced neutrophil migration, decreased the production of IL-1 beta, and improved lung function in infected mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Fatemeh Asgari, Domenico Supino, Raffaella Parente, Nadia Polentarutti, Matteo Stravalaci, Remi Porte, Fabio Pasqualini, Marialuisa Barbagallo, Chiara Perucchini, Camilla Recordati, Elena Magrini, Andrea Mariancini, Federica Riva, Alessia Giordano, Sadaf Davoudian, Thierry Roger, Cornelis van't Veer, Sebastien Jaillon, Alberto Mantovani, Andrea Doni, Cecilia Garlanda
Summary: The study highlights the important role of PTX3 in controlling Klebsiella pneumoniae infection by modulating inflammatory responses and tissue damage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Sharmi Naha, Kirsty Sands, Suchandra Mukherjee, Shanta Dutta, Sulagna Basu
Summary: This study aimed to understand the susceptibility trend and molecular mechanisms of colistin resistance in neonatal isolates over a 12 year period. The results showed that colistin-resistant Klebsiella pneumoniae had multiple mechanisms of resistance, including overexpression of two-component systems and AcrAB-TolC pump and its regulators. The presence of strains with dual carbapenemases causing sepsis in neonates is alarming.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
Suejung Jo, Hyun Mi Kang, Seong Koo Kim, Jae Wook Lee, Nack-Gyun Chung, Bin Cho, Dae Chul Jeong, Yeon-Joon Park
Summary: A 12-year-old male adolescent with acute lymphoblastic leukemia undergoing HSCT experienced six episodes of recurrent K. pneumoniae sepsis, despite treatment with susceptible antibiotics. Extensive diagnostic evaluations failed to discover the primary source, leading to multiple recurrences. Through enterobacterial repetitive intergenic consensus (ERIC)-PCR, the relationship between the episodes was identified, and the source of bacteremia was recognized.
Article
Horticulture
Xiangli Sun, Zebin Yuan, Bo Wang, Liping Zheng, Jianzhong Tan
Summary: The study found that exogenous putrescine (Put) has positive effects on the chilling tolerance of Anthurium andraeanum. Pretreatment of anthurium seedlings with Put resulted in the accumulation of endogenous NO, with the NOS-dependent pathway playing a vital role in its generation. The NOS-dependent pathway was identified as the primary source of endogenous NO in Put-pretreated anthurium.
SCIENTIA HORTICULTURAE
(2023)
Article
Biochemistry & Molecular Biology
Sumeet Manandhar, Amy Scott-Thomas, Michael Harrington, Priyanka Sinha, Anna Pilbrow, Arthur Mark Richards, Vicky Cameron, Madhav Bhatia, Stephen T. Chambers
Summary: This study measured the concentrations of hydrogen sulfide (H2S) and substance P (SP) in the peripheral blood of patients with Escherichia coli or Klebsiella pneumoniae bacteraemia. The study found that the concentrations of H2S and SP varied with the site of infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wanhai Qin, Xanthe Brands, Cornelis van 't Veer, Alex F. de Vos, Brendon P. Scicluna, Tom van der Poll
Summary: This study demonstrates that myeloid cell Tet2 does not play a role in the host response during gram-negative bacterial pneumonia and pneumosepsis.
Review
Biochemistry & Molecular Biology
Ana C. Palei, Joey P. Granger, Frank T. Spradley
Summary: This review provides an overview of NOS isoforms and biochemistry, as well as the role of NO in blood pressure control during normal pregnancy, with a focus on the impact of placental malperfusion on NO bioavailability and the development of PE. The article also discusses strategies for targeting the NOS system therapeutically in treating PE. Throughout, the importance of experimental animal studies in understanding NOS biology and finding ways to prevent or alleviate PE is emphasized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Veronica Vargas Horewicz, Sandra Crestani, Regina de Sordi, Edir Rezende, Jamil Assreuy
EUROPEAN JOURNAL OF PHARMACOLOGY
(2015)
Article
Cell Biology
K. C. Camargo, J. R. Gomes, M. M. Loddi, R. de Sordi, C. L. S. Costa-Ayub, M. A. de M. Soares
Article
Critical Care Medicine
Regina Sordi, Fausto Chiazza, Massimo Collino, Jamil Assreuy, Christoph Thiemermann
Article
Pharmacology & Pharmacy
Vanessa Kovalski, Ana P. Prestes, Junior G. Oliveira, Gustavo F. Alves, Daiandra F. R. Colarites, Jheniffer E. L. Mattos, Regina Sordi, Jose C. R. Vellosa, Daniel Fernandes
EUROPEAN JOURNAL OF PHARMACOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Florence L. Johnson, Nimesh S. A. Patel, Gareth S. D. Purvis, Fausto Chiazza, Jianmin Chen, Regina Sordi, Guillaume Hache, Viktoria V. Merezhko, Massimo Collino, Muhammed M. Yaqoob, Christoph Thiemermann
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2017)
Article
Medicine, Research & Experimental
Ana Paula Prestes, Willian Moreira Machado, Junior Garcia Oliveira, Luiz Renato Olchanheski, Fabio Andre Santos, Gustavo Ferreira Alves, Arthur Silveira Prudente, Michel Fleith Otuki, Katia Sabrina Paludo, Regina Sordi, Daniel Fernandes
Article
Dentistry, Oral Surgery & Medicine
Luiz Renato Olchanheski, Regina Sordi, Junior Garcia Oliveira, Gustavo Ferreira Alves, Reila Taina Mendes, Fabio Andre Santos, Daniel Fernandes
JOURNAL OF APPLIED ORAL SCIENCE
(2018)
Article
Surgery
Regina Sordi, Fausto Chiazza, Debora Collotta, Giuseppe Migliaretti, Romain A. Colas, Paul Vulliamy, Karim Brohi, Jesmond Dalli, Massimo Collino, Christoph Thiemermann
Summary: The study found that trauma results in a significant reduction in plasma levels of resolvin D1 in patients. In rat experiments, RvD1 has a protective effect on organ damage and dysfunction caused by hemorrhagic shock.
Article
Pharmacology & Pharmacy
Regina Sordi, Angela Cristina Bet, Ana Maria Della Justina, Gustavo Campos Ramos, Jamil Assreuy
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Daniel Fernandes, Leticia Kramer Pacheco, Regina Sordi, Karin Scheschowitsch, Gustavo Campos Ramos, Jamil Assreuy
Summary: A study found that early and partial blockade of the AT 1 receptor with a low dose of losartan can counteract sepsis-induced refractoriness to vasoconstrictors, providing an opportunity to improve the outcome of this condition.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Filipe Rodolfo Moreira Borges Oliveira, Jamil Assreuy, Regina Sordi
Summary: Sepsis is a major cause of acute kidney injury (AKI), involving mechanisms such as oxidative stress and endothelial dysfunction. Nitric oxide (NO) is an important element in these mechanisms. The different isoforms of nitric oxide synthase (NOS) contribute differently to nitrergic signaling in the kidneys. While endothelial and neuronal isoforms are important under basal conditions, the inducible isoform (iNOS) is significantly increased during sepsis. Inhibiting iNOS selectively without affecting other isoforms is ideal, but iNOS also plays a role in immune defense, so targeting NO effectors may be a more interesting approach.
BIOSCIENCE REPORTS
(2022)
Article
Biology
Lucas Braga Albino, Regina Sordi, Junior Garcia de Oliveira, Daniel Fernandes
Summary: Adenosine is a vital regulator in the cardiovascular system that affects various processes through G protein-coupled receptors. Caffeine, a widely used pharmacological tool, blocks adenosine receptors and can reverse its cardiovascular effects. This study evaluated the dose and duration of caffeine needed to block adenosine-induced cardiovascular changes in rats. The results showed that a dose of 30 mg/kg of caffeine effectively blocked adenosine-induced events for up to 4 hours, providing valuable information for future studies.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2023)
Article
Surgery
Regina Sordi, Kiran K. Nandra, Fausto Chiazza, Florence L. Johnson, Claudia P. Cabrera, Hew D. Torrance, Noriaki Yamada, Nimesh S. A. Patel, Michael R. Barnes, Karim Brohi, Massimo Collino, Christoph Thiemermann
Meeting Abstract
Critical Care Medicine
Noriaki Yamada, Lukas Martin, Regina Sordi, Klaus Brandenburg, Tobias Schuerholz, Christoph Thiemermann
Meeting Abstract
Biochemistry & Molecular Biology
Thiago Correa, Regina Sordi, Jose Eduardo da Silva-Santos