Article
Biochemistry & Molecular Biology
Louise M. Arildsen Jakobsen, Weiwei He, Nicholas Ditzel, Marianne Danielsen, Trine K. Dalsgaard, Niklas Rye Jorgensen, Peter Bollen, Hanne C. Bertram
Summary: This study investigated the effects of whey protein complexation of vitamin D-3 supplements on bone health in rats. The results showed that complexation did not improve the bioavailability of vitamin D-3 or have any significant impact on bone strength or microstructure.
Review
Biochemistry & Molecular Biology
Thayaalini Subramaniam, Mh Busra Fauzi, Yogeswaran Lokanathan, Jia Xian Law
Summary: Skin injury healing involves complex processes with various cells, extracellular matrix, and mediators. Cell differentiation, migration, and proliferation are crucial for tissue integrity restoration. Although calcium shows promise in wound healing, challenges need to be addressed before clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Vrisiis Kofina, Mutlu Demirer, Barbaros S. Erdal, Timothy D. Eubank, Vedat O. Yildiz, Dimitris N. Tatakis, Binnaz Leblebicioglu
Summary: This study found that a history of bone grafting alters the healing response of soft tissues following implant placement surgery. Soft tissue closure was slower in grafted bone (GG) areas, and blood perfusion recovery was slower in GG sites.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Multidisciplinary Sciences
Megan W. Bourassa, Steven A. Abrams, Jose M. Belizan, Erick Boy, Gabriela Cormick, Carolina Diaz Quijano, Sarah Gibson, Filomena Gomes, G. Justus Hofmeyr, Jean Humphrey, Klaus Kraemer, Keith Lividini, Lynnette M. Neufeld, Cristina Palacios, Julie Shlisky, Prashanth Thankachan, Salvador Villalpando, Connie M. Weaver
Summary: Calcium intake remains inadequate in many low- and middle-income countries, especially in Africa and South Asia. Food-based approaches, such as promoting calcium-rich animal-source and plant foods, improving food processing techniques, fortifying staple foods with calcium, and biofortification, can be effective methods to improve calcium intake and bioavailability, particularly among pregnant women and children.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Endocrinology & Metabolism
Micheal O. Breasail, Kate A. Ward, Simon M. Schoenbuchner, Mustapha Ceesay, Michael Mendy, Landing M. Jarjou, Sophie E. Moore, Ann Prentice
Summary: Bone changes were observed between the early second and third trimesters in pregnant women from rural Gambia, with an increase in bone density and content in both the radius and tibia. Despite higher resorption in late pregnancy, it remained lower compared to non-pregnant non-lactating women in the same community. This suggests a shift in the ratio of resorption to formation throughout pregnancy.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Shangyan Gu, Yu Lu, Yuji Wang, Wensheng Lu, Wei Wang
Summary: In this study, the C18ADPA hydrogel was utilized as a drug carrier for in vivo delivery of a copper salt, promoting wound healing in a mouse model. Cryo-SEM images revealed a structural transition from a layered structure to a self-assembled fibrillar network after drug loading. The hydrogel formulation exhibited clear advantages in regenerating tissue structure.
Article
Chemistry, Multidisciplinary
Min-juan Shen, Chen-yu Wang, Dong-xiao Hao, Jia-xin Hao, Yi-fei Zhu, Xiao-xiao Han, Lige Tonggu, Ji-hua Chen, Kai Jiao, Franklin R. Tay, Li-na Niu
Summary: The idea that RNA can play nonbiological roles in the nanomaterial world is revolutionary. RNA molecules can self-assemble into various nanostructures and have the potential to replicate bone healing. The development of RNA-biomineral nanomachines can mimic bone formation and create an environment conducive to rapid biomineralization and osteogenesis.
ADVANCED MATERIALS
(2022)
Review
Physiology
Olga Krizanova, Adela Penesova, Jozef Sokol, Alica Hokynkova, Amir Samadian, Petr Babula
Summary: This review outlines new possibilities for cutaneous wound healing through modulation of signaling molecules, with a specific focus on gasotransmitters and calcium. It also highlights the importance of addressing chronic wounds caused by diabetes and inflammation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
M. Asadniaye Fardjahromi, H. Nazari, S. M. Ahmadi Tafti, A. Razmjou, S. Mukhopadhyay, M. E. Warkiani
Summary: The use of nano-metal organic framework (nanoMOF) scaffolds presents a promising opportunity to enhance the properties of bone and wound tissue engineering scaffolds due to their unique characteristics such as high internal surface areas, high porosity, good mechanical stability, biocompatibility, and tunability. Incorporating nano-MOFs into scaffolds has been shown to be favorable for regenerating imperfect tissues, offering advantages such as high antibacterial activity, high drug loading capacity, and controlled drug release. However, challenges and clinical barriers need to be addressed for the implementation of these nanomaterials in orthopedic and wound clinics.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Swathi Balaji, Walker D. Short, Benjamin W. Padon, Jorge A. Belgodere, Sarah E. Jimenez, Naresh T. Deoli, Anna C. Guidry, Justin C. Green, Tanuj J. Prajapati, Fayiz Farouk, Aditya Kaul, Dongwan Son, Olivia S. Jung, Carlos E. Astete, Myungwoong Kim, Jangwook P. Jung
Summary: In this study, functionalized lignin was used to provide antioxidation to the extracellular microenvironments of wounds and deliver oxygen for enhanced vascularization and healing. Lignin composites with oxygen-generating nanoparticles were found to release a significant amount of oxygen per day for at least 7 days. The in situ formation of these composites enhanced tissue granulation, blood vessel formation, and fibroblast infiltration, and remodeled collagen architecture after 28 days.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Cell Biology
Di Li, Jin-wei Ren, Teng Xu, Lin Li, Peng Liu, Yong Li
Summary: The study showed that oral administration of bovine bone collagen oligopeptides (BCOP) significantly promoted wound healing in mice by increasing protein levels and tensile strength, reducing inflammatory markers, and enhancing the expression of vascular growth factors.
Review
Nutrition & Dietetics
Khemayanto Hidayat, Jing-Si Chen, Tian-Ci Wang, Yu-Jie Liu, Yu-Jie Shi, Hong-Wen Su, Biao Liu, Li-Qiang Qin
Summary: This meta-analysis study suggests that milk supplementation can have a positive impact on hip and lumbar spine bone density, as well as reducing bone turnover markers and parathyroid hormone concentrations, potentially preventing bone loss.
ADVANCES IN NUTRITION
(2022)
Review
Food Science & Technology
Taylor C. Wallace, Regan L. Bailey, Joan Lappe, Kimberly O. O'Brien, Ding Ding Wang, Shivani Sahni, Connie M. Weaver
Summary: The role of dairy products in long-term bone health and fracture prevention remains controversial, with some studies suggesting potential risks associated with dairy consumption. Evidence supports a moderate effect of dairy consumption on bone density in middle-aged to older adults, while insufficient evidence exists for its effects on other age groups. Further research is needed to better understand the impact of dairy consumption on bone health across different age groups and ethnicities.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Engineering, Environmental
Ki-Seok Han, Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Myeong-Hyeon Wang
Summary: The study successfully extracted high-quality bovine bone-derived hydroxyapatite (BB-HAP) through acid/alkali treatment and calcination process, demonstrating its biocompatibility for use in wound dressing and implantable materials.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Tobias Malte Ballhause, Shan Jiang, Weixin Xie, Jan Sevecke, Christine Dowling, Tobias Dust, Sabine Brandt, Peter R. Mertens, Timur Alexander Yorgan, Thorsten Schinke, Karl-Heinz Frosch, Anke Baranowsky, Johannes Keller
Summary: Notch signaling regulates cell fate in multiple tissues including the skeleton. A rare inherited disease called Hajdu-Cheney-Syndrome (HCS), caused by Notch2 gene mutations, is characterized by early-onset osteoporosis and increased risk for fractures and non-union. In this study, bone regeneration in mice with HCS mutation was examined and it was found that structural indices of bone regeneration were normal, but there were signs of increased callus turnover and impaired biomechanical stability of healed fractures.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Tabata P. Sato, Bruno V. M. Rodrigues, Daphne C. R. Mello, Eliseu A. Munchow, Juliana S. Ribeiro, Joao Paulo B. Machado, Luana M. R. Vasconcellos, Anderson O. Lobo, Marco C. Bottino, Alexandre L. S. Borges
Summary: The study found that incorporating nHAp particles into chitosan nanofibers did not compromise their overall morphology, topography, physical, and biological characteristics. Additionally, the nHAp-loaded fibers demonstrated greater antibacterial potential and antibiofilm activity compared to the control fibers.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Camilla Magnoni Moretto Nunes, Camila Lopes Ferreira, Daniella Vicensotto Bernardo, Cassia Carolina Rabelo Lopes, Luma Collino, Victoria Clara da Silva Lima, Daphne de Camargo Reis Mello, Luana Marotta Reis de Vasconcellos, Maria Aparecida Neves Jardini
Summary: The study indicated that applying PEMF for a shorter period of time and in the early stages of bone healing can effectively optimize the events in bone tissue that lead to osseointegration.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Nanoscience & Nanotechnology
Ricardo Pereira Nogueira, Jose Deuzimar Uchoa, Fanny Hilario, Gabriela de Fatima Santana-Melo, Luana Marotta Reis de Vasconcellos, Fernanda Roberta Marciano, Virginie Roche, Alberto Moreira Jorge Junior, Anderson Oliveira Lobo
Summary: The study focuses on investigating the biological and electrochemical behavior of TiO2 nanotubes-modified surfaces, revealing that the transition from amorphous to crystalline structures significantly enhances biological activity and corrosion resistance. The outstanding bioactivity of crystallized nano-structures is attributed to the increase in hydrophilicity, while enhanced electrochemical stability is due to the thickening of the ruble barrier layer beneath the nanotubes.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
G. B. Minhoto, R. D. Khoury, E. I. F. Orozco, R. F. Prado, M. C. Valera
Summary: This study aimed to establish an experimental model combining chronic stress and apical periodontitis in rats, finding that stress exacerbated the progression of periapical lesions, with significantly higher inflammatory response and bone loss observed at 21 days after initiation.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Engineering, Biomedical
Lais Morandini Rodrigues, Elis A. Lima Zutin, Elisa M. Sartori, Fabio A. P. Rizzante, Daniela B. S. Mendonca, Paul H. Krebsbach, Karl J. Jepsen, Lyndon F. Cooper, Luana M. R. Vasconcellos, Gustavo Mendonca
Summary: The study found that nanoscale surface implants promoted more bone formation associated with higher levels of Osterix gene expression. The surface characteristics of these implants can directly influence bone formation by adherent cells.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Engineering, Biomedical
Joyce Rodrigues de Souza, Elisa Camargo Kukulka, Juliani Caroline Ribeiro Araujo, Tiago Moreira Bastos Campos, Renata Falchete do Prado, Luana Marotta Reis de Vasconcellos, Gilmar Patrocinio Thin, Alexandre Luiz Souto Borges
Summary: The aim of this study was to produce and test polymeric scaffolds composed of polylactic acid (PLA) fibers associated with a 58S bioglass doped with therapeutic ions for use in tissue engineering. Scaffolds were produced through electrospinning process and characterized chemical and morphologically. In vitro tests showed that all materials had cell viability (>70%), total protein production, and alkaline phosphatase activity. The results suggest that the development of polylactic acid scaffolds associated with 58S bioglass doped with therapeutic ions is feasible for bone tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Review
Oncology
Maria Leticia de Almeida Lanca, Yasmin Rodarte Carvalho, Janete Dias Almeida, Estela Kaminagakura
Summary: This case report describes a rare case of metastatic colon adenocarcinoma to the maxilla, with only the second case reported in the palate. A literature review revealed 45 clinical cases of colon adenocarcinoma with metastasis to the oral cavity.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Engineering, Biomedical
Juliani Caroline Ribeiro de Araujo, Leonardo Alvares Sobral Silva, Vinicius Almeida de Barros Lima, Tiago Moreira Bastos Campos, Paulo Noronha Lisboa Filho, Roberta Okamoto, Luana Marotta Reis de Vasconcellos
Summary: With increasing life expectancy, the prevalence of osteoporosis has risen, leading to a search for strategies to regenerate bone tissue. The sonochemical technique was used to functionalize bioglass, resulting in modified surface characteristics. In vitro tests showed favorable cell adhesion and differentiation, with no cytotoxicity observed. Animals treated with teriparatide demonstrated new bone formation, indicating positive effects on bone tissue. Further studies are required to investigate the long-term effects of the interaction between bioglass and teriparatide.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Suelen Simoes Amaral, Beatriz Samara de Sousa Lima, Sarah Oliveira Marco Avelino, Bruno Roberto Spirandeli, Tiago Moreira Bastos Campos, Gilmar Patrocinio Thim, Eliandra de Sousa Triches, Renata Falchete do Prado, Luana Marotta Reis de Vasconcellos
Summary: The objective of this study was to investigate the osteogenic and antimicrobial effect of bioactive glass S53P4 incorporated into beta-tricalcium phosphate (beta-TCP) scaffolds in vitro and the bone neoformation in vivo. The incorporation of S53P4 bioglass promotes significant changes in the crystalline phases formed and in the morphology of the surface of the scaffolds. The beta-TCP/S53P4 scaffolds did not demonstrate an in vitro cytotoxic effect, presented similar alkaline phosphatase activity, and induced a significantly higher protein amount when compared to beta-TCP.
BIOENGINEERING-BASEL
(2023)
Article
Materials Science, Textiles
Lilian de Siqueira, Veronica Ribeiro dos Santos, Juliani Caroline Ribeiro de Araujo, Hugo Gutemberg Patino de Oliveira Filho, Luana Marotta Reis de Vasconcellos, Eliandra de Sousa Triches, Alexandre Luiz Souto Borges
Summary: This study developed a novel method to improve the properties of biomaterials by electrospinning poly (lactic acid) (PLA)/polycaprolactone (PCL) fibers and electrospraying bioactive particles from an amorphous multicomponent silica-calcium-phosphorus system (AMS). In vitro and in vivo evaluations were conducted using male rats, and the results showed promising outcomes for bone regeneration.
FIBERS AND POLYMERS
(2023)
Article
Biology
Sarah O. M. Avelino, Rafael M. Neves, Leonardo A. Sobral-Silva, Rubens N. Tango, Claudio A. Federico, Mariana R. C. Vegian, Luis Augusto de Almeida-Silva, Estela Kaminagakura, Jose Benedito O. Amorim, Luana M. R. Vasconcellos
Summary: This study assessed the impact of radiotherapy on soft tissue in surgical wounds in rats. The results showed that radiotherapy had effects on the surrounding soft tissues, regardless of the duration.
Article
Nanoscience & Nanotechnology
Mirian M. Machado-Paula, Marcus A. F. Corat, Luana M. R. de Vasconcellos, Juliani C. R. Araujo, Gujie Mi, Paria Ghannadian, Tatiane Toniato, Fernanda R. Marciano, Thomas J. Webster, Anderson O. Lobo
Summary: In this study, a next-generation bone regeneration material was developed by combining polycaprolactone fibers, carbon nanotubes, and hydroxyapatite nanoparticles. Rotary jet spinning fibers showed the best outcomes in repairing rat calvarial defects, and their rough topography allowed for better cellular growth and spreading. Incorporating nanoparticles and bone marrow mesenchymal stem cells enhanced cell performance and resulted in greater bone neoformation.
ACS APPLIED BIO MATERIALS
(2022)
Article
Engineering, Biomedical
Maria Fernanda Lima Villaca-Carvalho, Juliani Caroline Ribeiro de Araujo, Juliana Mariano Beraldo, Renata Falchete do Prado, Mari Eli Leonelli de Moraes, Luiz Roberto Coutinho Manhaes Junior, Eduardo Norberto Codaro, Heloisa Andrea Acciari, Joao Paulo Barros Machado, Natal Nerimio Regone, Anderson Oliveira Lobo, Fernanda Roberta Marciano, Luana Marotta Reis de Vasconcellos
Summary: This study aimed to optimize osseointegration in dental implants through anodization, obtaining anatase phase and controlled nanotopography. The results demonstrated that the anodized group had better performance in micro-CT and reverse torque tests compared to the other groups, showing the positive impact of anodizing technique on the chemical composition and structure of TiO2 film in enhancing biological characteristics for osseointegration.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2021)
Article
Engineering, Biomedical
Luana Marotta Reis Vasconcellos, Gabriela E. Santana-Melo, Edmundo Silva, Vanessa Fernandes Pereira, Juliani Caroline Ribeiro Araujo, Andre Diniz Rosa Silva, Andre S. A. Furtado, Conceicao de Maria Vaz Elias, Bartolomeu Cruz Viana, Fernanda Roberta Marciano, Anderson Oliveira Lobo
Summary: The study demonstrates the potential of electrospun PBAT filled with synthetic nanohydroxyapatite and graphene nanoribbons as bone grafts, showing improvements in bone regeneration in vivo in rats.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2021)
