Article
Food Science & Technology
Yung-Tsung Chen, Shiou-Yun Chiou, Ai-Hua Hsu, Yu-Chun Lin, Jin-Seng Lin
Summary: The study found that LRH05 significantly reduces body weight gain and WAT weight in mice, as well as improving hepatic steatosis and glucose intolerance. LRH05 can ameliorate the pro-inflammatory process by regulating gene expression and reducing inflammatory macrophage infiltration.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Nutrition & Dietetics
Luis Fontana, Julio Plaza-Diaz, Paula Robles-Bolivar, Hector Valente-Godinez, Maria Jose Saez-Lara, Francisco Abadia-Molina, Carolina Gomez-Llorente, Angel Gil, Ana I. Alvarez-Mercado
Summary: This study found that Bifidobacterium breve, Lactobacillus paracasei, and Lactobacillus rhamnosus can modulate macrophage polarization in the liver and decrease circulating levels of inflammation-related mediators. Lactobacillus paracasei also increased the ratio of P-Akt/Akt and NF-kB protein levels.
Article
Oncology
Xiang Liu, Ge Jin, Qiang Tang, Shumin Huang, Yujie Zhang, Yue Sun, Tianyu Liu, Zixuan Guo, Cheng Yang, Bangmao Wang, Kui Jiang, Weilong Zhong, Hailong Cao
Summary: Early life colonisation with Lactobacillus rhamnosus GG (LGG) can inhibit intestinal tumour formation in offspring by influencing gut microbiota composition and regulating signaling pathways.
BRITISH JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Joshua A. Owens, Bejan J. Saeedi, Crystal R. Naudin, Sarah Hunter-Chang, Maria E. Barbian, Richard U. Eboka, Lauren Askew, Trevor M. Darby, Brian S. Robinson, Rheinallt M. Jones
Summary: The study shows that oral administration of Lactobacillus rhamnosus GG can enhance colonic CD8 T-cell responses in mice and reduce tumor burden. This suggests the potential use of LGG to augment antitumor immune responses in colorectal cancer patients and increase the efficacy of immunotherapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Food Science & Technology
Yongsong Bai, Kaidi Ma, Jibo Li, Jianping Li, Chongpeng Bi, Anshan Shan
Summary: The study showed that Deoxynivalenol (DON) has detrimental effects on the liver, while Lactobacillus rhamnosus GG (LGG) can protect the liver from DON-induced injury.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Applied
Cong Xu, Jiage Ma, Zhijing Liu, Wan Wang, Xin Liu, Shanshan Qian, Lijun Chen, Liya Gu, Chuanqiang Sun, Juncai Hou, Zhanmei Jiang
Summary: In this study, shell-core fibers were prepared using coaxial electrospinning technology and were found to have higher thermal stability and higher survival rate of probiotics.
Article
Dentistry, Oral Surgery & Medicine
Ying-Wu Chen, Ming-Lun Lee, Cheng-Yang Chiang, Earl Fu
Summary: This study examined the effects of Bifidobacterium and Lactobacillus on periodontitis using a rat model. The results showed that the combination of these probiotics enhanced IL-10 levels and ameliorated the symptoms of periodontitis. Single-use of probiotics also had some alleviating effects.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Food Science & Technology
Federico Bueno, Alexander Chouljenko, Subramaniam Sathivel
Summary: The addition of Lactobacilli to coffee kombucha shifted the proportion of microbial families and allowed them to survive in the beverage for 15 days, even after exposure to simulated gastrointestinal conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaoyang Ma, Yoon-Jung Shin, Hyo-Min Jang, Min-Kyung Joo, Jong-Wook Yoo, Dong-Hyun Kim
Summary: The study showed that human fecal Lactobacillus rhamnosus NK210 and Bifidobacterium longum NK219 have positive effects on immune homeostasis, particularly in controlling immune imbalance and gut dysbiosis.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Naiara Hennig Neuenfeldt, Carla Andressa Almeida Farias, Renius de Oliveira Mello, Silvino Sasso Robalo, Juliano Smanioto Barin, Leila Picolli da Silva, Edson Irineu Muller, Erico Marlon Moraes Flores, Milene Teixeira Barcia, Cristiano Ragagnin de Menezes
Summary: This study demonstrates that the co-microencapsulation of blueberry extract improves the survival rate of Lactobacillus rhamnosus and shows promising application in food.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Bonilla Zavaleta, L. I. Lozano Coavichi, L. C. Velasco Rodriguez, E. Flores Andrade, Hugo S. Garcia, M. P. Rascon Diaz
Summary: Co-microcapsules containing L. rhamnosus and krill oil were prepared using whey protein as wall material through spray drying. Viability of the microcapsules and co-microcapsules at different drying process temperatures was above 1 x 1010 CFU/mL. The main phospholipid detected in the co-microcapsules was phosphatidylethanolamine, and the fatty acids profile revealed a low content of SFA but high levels of MUFA and PUFA. The survivability of L. rhamnosus in the co-microcapsules was influenced by storage temperature, with higher temperatures decreasing the water activity range for stable viability.
Article
Biotechnology & Applied Microbiology
Taiyu Zhai, Wenbo Ren, Pingping Wang, Lei Zheng
Summary: Gut microbiota plays an important role in atherosclerosis, and probiotic Lactobacillus rhamnosus GG can effectively inhibit the generation of AS plaques. It participates in the antiatherosclerotic mechanism by altering the composition of gut microbiota and metabolites.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fuli Zheng, Zhi Wang, Catherine Stanton, R. Paul Ross, Jianxin Zhao, Hao Zhang, Bo Yang, Wei Chen
Summary: In this study, it was found that strains of L. reuteri and L. rhamnosus significantly slowed weight gain in mice, alleviated blood glucose and lipid disorders, tissue damage, and gut microbiota disorders, produced SCFAs to induce satiety hormones, inhibit food intake, and increase satiety, ultimately improving metabolic syndrome.
Article
Environmental Sciences
Chenyan Hu, Mengyuan Liu, Lizhu Tang, Baili Sun, Zileng Huang, Lianguo Chen
Summary: The study investigated the interactive effects between probiotic bacteria and the aquatic pollutant PFBS on zebrafish reproduction. It found that probiotic supplementation mitigated the negative impacts of PFBS on egg production by promoting oocyte growth and modulating hormonal signals. Overall, the study provided mechanistic evidence of how probiotics can influence the reproductive outcomes in the presence of environmental pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Yanxin Ren, Fangyi Pei, Xinbo Cao, Wen Zhang, Renpeng Du, Jingping Ge, Wenxiang Ping
Summary: This study found that Lonicera caerulea fruit polyphenols (LCP) have inhibitory effects on caries-causing bacteria. The research shows that LCP can change the surface morphology of bacteria and reduce the cariogenic effect. Therefore, LCP has the potential to be a potential plaque biofilm inhibitor and QS inhibitor in drugs and functional foods.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Jolanta Zalejska-Fiolka, Anna Birkova, Tomasz Wielkoszynski, Beata Hubkova, Beata Szlachta, Rafal Fiolka, Urszula Blaszczyk, Aleksandra Kuzan, Andrzej Gamian, Maria Marekova, Michal Toborek
Summary: The study evaluates the influence of hyperglycemia on weight loss in obese premenopausal women. The results indicate that patients with normoglycemia achieved successful weight loss, while patients with hyperglycemia experienced undesired outcomes. The study highlights the importance of introducing weight reduction strategies early, before the development of hyperglycemia.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Medicinal
Milena J. Szafraniec, Monika Toporkiewicz, Andrzej Gamian
Summary: The study demonstrates that zinc pheophorbide a has strong photodynamic activity against human endothelial cells, making it a promising photosensitizer for vascular-targeted photodynamic therapy for solid tumors. It also shows that endothelial cells are more susceptible to photodynamic treatment compared to tumor cells.
Article
Immunology
Bernadeta Nowak, Grzegorz Majka, Malgorzata Srottek, Anna Skalkowska, Janusz Marcinkiewicz
Summary: The purpose of the study was to establish an experimental model of CIA to test the arthritogenicity of inhaled PM. The results showed that various components of PM significantly increased the incidence and severity of CIA.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2022)
Article
Biochemistry & Molecular Biology
Przemyslaw Zdziarski, Andrzej Gamian
Summary: This study investigated the level of monocytes during CMV infection. The results showed that significant monocytosis was observed during the logarithmic phase of CMV infection. The increased count and percentage of monocytes correlated with viral replication in several clinical situations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kinga Gostomska-Pampuch, Jacek R. Wisniewski, Karol Sowinski, Wieslaw Gruszecki, Andrzej Gamian, Magdalena Staniszewska
Summary: The study found that the glycation product MAGE, generated from the reaction of melibiose with a protein, is more efficiently formed under dry conditions compared to aqueous conditions. Different structures of myoglobin with melibiose were identified, including crosslinking and non-crosslinking modifications. The results suggest that MAGE adduct is initiated by coupling melibiose to a model myoglobin protein and can further rearrange into more advanced structures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Piotr Kuropka, Anna Leskow, Katarzyna Malolepsza-Jarmolowska, Maciej Dobrzynski, Malgorzata Tarnowska, Jacek Majda, Maciej Janeczek, Katarzyna Zybura-Wszola, Andrzej Gamian
Summary: This study investigated the immunostimulating effect of levamisole on hematological parameters and its impact on the inflammatory response in the rat pleural cavity. The results showed significant modifications in hematological parameters and a reduction in leukocyte infiltrations in the lungs with single and triple doses of levamisole administration.
Article
Biochemistry & Molecular Biology
Kamil Litwinowicz, Andrzej Gamian
Summary: Microbiome alterations are important factors influencing the course of alcohol use disorder (AUD) and alcoholic liver disease (ALD). This study provides a comprehensive evaluation of microbiome alterations associated with AUD and ALD using advanced bioinformatics methods. The results show consistent changes in the abundance of certain microbial families, reduced butyrate-producing families in AUD and further reduction in ALD. There is also an increase in endotoxin-producing Proteobacteria in AUD, with the largest increase observed in the ALD group. These alterations may contribute to intestinal permeability and inflammation in AUD and ALD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bozena Futoma-Koloch, Michal Malaszczuk, Kamila Korzekwa, Malgorzata Steczkiewicz, Andrzej Gamian, Gabriela Bugla-Ploskonska
Summary: Salmonella enterica is a common pathogen that can be used as a model organism for studying bacterial biology. In this study, the researchers investigated the changes in virulence-related phenotypes of Salmonella enterica strains subjected to consecutive passages in human serum. They found that eight passages may not be enough to develop serum resistance, and observed changes in the composition of membrane proteins and binding of complement components. They also observed the development of multi-drug resistance and tolerance to disinfectants in some strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Svitlana Zubchenko, Iryna Kril, Halyna Potemkina, Anna Havrylyuk, Aleksandra Kuzan, Andrzej Gamian, Valentyna V. Chopyak
Summary: The role of AGEs in allergic inflammation needs further investigation. This study found that allergic rhinitis patients had lower levels of AGEs in their blood, which may be attributed to continuous activation of cells effectively clearing glycation products.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Microbiology
Agnieszka Razim, Sabina Gorska, Andrzej Gamian
Summary: CD is a Gram-positive, anaerobic bacterium that primarily infects hospitalized and elderly individuals who have undergone long-term antibiotic therapy. The increasing elderly population and antibiotic usage suggest that CD infections will continue to rise. Currently, there is no vaccine available for CD. Clinical trials using toxin-based antigens have shown limited efficacy in preventing colonization and transmission between patients. Therefore, a CD vaccine should include antigens from the bacterium or its spores to effectively combat toxins and inhibit patient colonization.
Article
Immunology
Bernadeta Nowak, Anna Wadolek, Olga Mazuryk, Anna Poznanska, Katarzyna Majzner, Grzegorz Majka, Maria Oszajca, Malgorzata Baranska, Grazyna Stochel, Janusz Marcinkiewicz
Summary: This study aimed to investigate whether oxidative modification of ovalbumin (OVA) by air particulate matter (PM) altered its antigenicity and/or immunogenicity. The results showed that the immunogenicity of PM-modified OVA was significantly higher than that of control OVA, possibly due to slower degradation and longer persistence in dendritic cells. Further research is needed to determine the association between this phenomenon and the increased risk of autoimmune diseases observed in areas with high PM pollution.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2023)
Article
Microbiology
Monika Kozinska, Ewa Augustynowicz-Kopec, Andrzej Gamian, Anna Chudzik, Mariola Pasciak, Przemyslaw Zdziarski
Summary: Cutaneous tuberculosis is a rare disease that accounts for a small percentage of extrapulmonary tuberculosis cases. Its clinical manifestations are diverse and may resemble other dermatoses, making diagnosis challenging. It is important to note that most extrapulmonary tuberculosis cases, including skin tuberculosis, can indicate systemic involvement. This paper presents a case of an immunocompromised patient diagnosed with cutaneous tuberculosis almost a year after the initial dermatological lesions appeared on the lower extremities. Concurrently, a diagnosis of pulmonary tuberculosis was made due to respiratory symptoms, and radiological and microbiological confirmations were obtained.
Article
Infectious Diseases
Ewa Brzozowska, Tomasz Lipinski, Agnieszka Korzeniowska-Kowal, Karolina Filik, Andrzej Gorski, Andrzej Gamian
Summary: Bacteriophages are viruses that infect bacteria and are widely present in the environment, food, and normal microflora. The human microbiome is a complex network of bacteria, bacteriophages, and human cells. This study aimed to determine the levels of naturally generated antibodies specific to a bacteriophage in human serum using an ELISA-based assay. The results showed that the average level of anti-I11mO19 phage antibodies in human serum was 190 μg/mL, but cross-reactivity with other E. coli phages was also observed.
Article
Immunology
Iwona Filipczak-Bryniarska, Katarzyna Nazimek, Bernadeta Nowak, Paulina Skalska, Martyna Cieslik, Angelika Fedor, Magdalena Gebicka, Gabriela Kruk, Joanna Pelka-Zakielarz, Michael Kozlowski, Krzysztof Bryniarski
Summary: This study investigated the immune effects induced by tramadol alone or in combination with acetaminophen or dexketoprofen in healthy mice. The results suggest that these drugs slightly reduce the inflammatory reaction of macrophages but do not impair their ability to activate adaptive immune responses. Some combinations also enhance humoral and cellular immune responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Joanna Piechowicz, Andrzej Gamian, Ositadima Chukwu, Dorota Polak-Jonkisz
Summary: This study evaluated the levels of various metabolites related to NO synthesis in the plasma of children with different stages of CKD and identified significant differences between control and CKD groups. Children with CKD showed disturbances in most metabolites of NO synthesis, with ADMA levels being a potential indicator of CKD progression, supported by a negative correlation with eGFR.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)