Article
Pharmacology & Pharmacy
Zhou-Shan Tao, Wan-Shu Zhou, Hong-Guang Xu, Min Yang
Summary: The study aimed to evaluate the effects of different administration modes of sodium valproate on bone health in ovariectomized rats. Results showed that intermittent administration of sodium valproate had a protective effect on bone health and may be achieved by activating the Notch/Wnt/8-catenin/RUNX2 signal axis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Qingshan Shen, Chunhui Zhang, Xiaojie Qin, Hongru Zhang, Zhiqiang Zhang, Aurore Richel
Summary: The study showed that the dietary intervention of chondroitin sulfate calcium complex (CSCa) could improve bone mineral density and microstructure in osteoporosis rats, as well as alter the composition of gut microbiota and metabolite profiles. This suggests that CSCa may have the potential to alleviate osteoporosis and related symptoms through the modulation of gut microbiota and metabolites.
CARBOHYDRATE POLYMERS
(2021)
Article
Nutrition & Dietetics
Hongmei Mao, Wenjun Wang, Lili Shi, Chen Chen, Chao Han, Jinpeng Zhao, Qin Zhuo, Shi Shen, Yan Li, Junsheng Huo
Summary: The study demonstrated that calcium supplementation alleviated bone loss caused by calcium restriction combined with estrogen deficiency in rats. The supplementation increased estradiol levels, improved bone mineral density, and affected the glycerophospholipid metabolism pathway, resulting in a decrease in bone deterioration markers.
NUTRITION & METABOLISM
(2021)
Article
Food Science & Technology
Zhebin Chen, Dasong Liu, Xue Tang, Ying Cui, Wei Hu, Joe M. Regenstein, Peng Zhou
Summary: Sea cucumber enzymatic hydrolysates (SCEH) can inhibit osteoclast generation via the NF-kappa B pathway, reduce inflammation related to osteoporosis, and improve bone metabolism, thereby increasing bone density and relieving osteoporosis.
Article
Endocrinology & Metabolism
Julien Paccou, Sammy Badr, Daniela Lombardo, Huda Khizindar, Valerie Deken, Stefan Ruschke, Dimitrios C. Karampinos, Anne Cotten, Bernard Cortet
Summary: This study aimed to determine the association between proton density fat fraction (PDFF) and fractures. A case-control study was conducted on postmenopausal women, and it was found that MRI-based measurement of proximal femur PDFF can discriminate between postmenopausal women with and without clinical vertebral fractures, independent of age, CCI, and BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Hussein Sakr, Zenat Khired, Marzieh Moghadas
Summary: This study examined the effect of a wheat grain diet on bone turnover markers in rats. The results showed that rats fed whole or refined grains had lower bone density and mineral content compared to the control group. Additionally, levels of bone turnover indicators in the blood were altered, indicating a decrease in bone turnover and mass with a grain diet.
Article
Endocrinology & Metabolism
Jie Liu, Keiichiro Watanabe, Shareef M. Dabdoub, Beth S. Lee, Do-Gyoon Kim
Summary: One-third of postmenopausal women experience osteoporotic bone fractures, but jaw bone fractures are rare. The mechanisms behind the differences between jaw bone and limb bone during postmenopause are largely unknown. This study examined the effects of estrogen deficiency on bone quantity and quality, and found that mandibular bone marrow stem cells had greater differentiation capacity than femur bone marrow stem cells.
Review
Plant Sciences
Bin Wu, Xiu-Fang Zhu, Xiao-Qiang Yang, Wei-Yi Wang, Jian-Hua Lu
Summary: The active compound osthole derived from Cnidium monnieri Cusson has shown to be effective in treating osteoporosis in rats, promoting bone formation and inhibiting bone absorption.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tiansong Yang, Qingyong Wang, Yuanyuan Qu, Chuwen Feng, Chaoran Li, Yan Yang, Zhongren Sun, Tahani A. Alahmadi, Sulaiman A. Alharbi, Shengyong Bao
Summary: Rhaponticin has therapeutic potential for osteoporosis in OVX rats, preventing bone density loss and improving bone microarchitecture, while also positively impacting body indices, bone turnover markers, inflammatory markers, and more.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Immunology
Nannan Wang, Lichun Zheng, Jun Qian, Min Wang, Lili Li, Yuezhen Huang, Qian Zhang, Yanfen Li, Fuhua Yan
Summary: This study investigated the effects of periodontitis on osteoporosis. The results showed that the salivary microbiota of patients with periodontitis aggravated femoral bone resorption in rats with ovariectomy-induced osteoporosis. Additionally, intestinal inflammation was exacerbated after the administration of periodontitis salivary microbiota in these rats. The correlation analysis of microbiota and metabolomics revealed potential involvement of lipolysis and tryptophan metabolism in bone loss induced by periodontitis salivary microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Lu-lu Li, Yang Yang, Chun-min Ma, Xiao-mei Li, Xin Bian, Yu Fu, Li-kun Ren, Ru-meng Wang, Yan-guo Shi, Na Zhang
Summary: Postmenopausal osteoporosis is a common metabolic disease in old women. Estrogen supplementation through bioactive substances, such as soybean isoflavone aglycones, has been studied for improving menopausal syndrome. This study evaluated the effect of different doses of high-purity soybean isoflavone aglycones on a rat model of osteoporosis. The results showed that the AFDP-H group had a similar intervention effect as the EE group and showed improvement in bone microstructure and prevented weight gain and increased cholesterol levels.
FRONTIERS IN NUTRITION
(2023)
Review
Pharmacology & Pharmacy
Kudzai Nyamondo, Helen Wheadon
Summary: This review explores the interactions between micro-environment and the hematopoietic system in adults, specifically focusing on the impact of bone marrow micro-environment on aging, age-related clonal hematopoiesis, and the development of myeloid malignancies. Additionally, the possible role of age-related clonal hematopoiesis and chronic inflammatory conditions in altering the dynamics of the bone marrow micro-environment is discussed.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Xiayun Wan, Akifumi Eguchi, Yuko Fujita, Li Ma, Xingming Wang, Yong Yang, Youge Qu, Lijia Chang, Jiancheng Zhang, Chisato Mori, Kenji Hashimoto
Summary: Depression is associated with low bone mineral density (BMD) and a novel antidepressant (R)-ketamine can improve reduced BMD. This study found that gut microbiota plays a role in the beneficial effects of (R)-ketamine on reducing BMD. Therefore, (R)-ketamine could be a therapeutic drug for depressed patients or patients with osteoporosis.
Article
Medicine, Research & Experimental
Anirban Sardar, Shalini Gautam, Shradha Sinha, Divya Rai, Ashish Kumar Tripathi, Geeta Dhaniya, Prabhat Ranjan Mishra, Ritu Trivedi
Summary: In this study, nanoparticles of betulinic acid (BA/NPs) were synthesized and tested in altered bone metabolisms developed after ovariectomy. The results showed that BA/NPs exert potential osteogenic efficacy by modulating key osteogenic markers and the Wnt/β-catenin signaling pathway, and can reduce bone marrow adiposity and pathological bone loss.
Article
Biotechnology & Applied Microbiology
Zhidong Lu, Peng Li, Zhirong Chen, Liang Zhang
Summary: A novel nanocombination of flavonoids encapsulated in PLGA nanoparticles showed promising results for anti-osteoporotic therapeutics, demonstrating inhibitory effects on trabecular bone loss and significant improvements in bone mineral density and microarchitecture. The cytocompatibility of the nanoparticles was also confirmed in vitro. Further research may lead to novel therapeutic management of osteoporosis.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)