Understanding variation in disease risk: the elusive concept of frailty

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

A Hierarchical Frailty Model for Familial Testicular Germ-Cell Tumors

(2013) Morten Valberg et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

(2013) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

Benefits of Statins in Elderly Subjects Without Established Cardiovascular Disease

(2013) Gianluigi Savarese et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Similarities in the Age-Specific Incidence of Colon and Testicular Cancers

(2013) Luis Soto-Ortiz et al.   PLoS One

Schizophrenia susceptibility and age of diagnosis — A frailty approach

(2013) Elisabeth Svensson et al.   SCHIZOPHRENIA RESEARCH

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Risk Prediction Models for Colorectal Cancer: A Review

(2012) A. K. Win et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Inference about Causation from Examination of Familial Confounding: Application to Longitudinal Twin Data on Mammographic Density Measures that Predict Breast Cancer Risk

(2012) J. Stone et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Cancer Risks forMLH1andMSH2Mutation Carriers

(2012) James G. Dowty et al.   HUMAN MUTATION

Epigenesis for epidemiologists: does evo-devo have implications for population health research and practice?

(2012) George Davey Smith   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Commentary: Ageing--what's all the noise about? Developments after Gartner

(2012) T. B. Kirkwood   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Commentary: A gerontological perspective on Klaus Gartner's discovery that phenotypic variability of mammals is driven by stochastic events

(2012) G. M. Martin   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals?1,2

(2012) Klaus Gärtner   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Commentary: The presence of bifurcations as a ‘third component of individual differences’: implications for quantitative (behaviour) genetics

(2012) Kees-Jan Kan et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Commentary: Why are there difficulties in controlling genetic variability?

(2012) A. Ruvinsky   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Commentary: Gartner's 'third component': still an open question

(2012) H. Oey et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Commentary: Random variability of quantitative characteristics, an intangible epigenomic product, supporting adaptation

(2012) K. Gartner   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Rare and common variants: twenty arguments

(2012) Greg Gibson   NATURE REVIEWS GENETICS

Frailty modeling of age-incidence curves of osteosarcoma and Ewing sarcoma among individuals younger than 40 years

(2012) Morten Valberg et al.   STATISTICS IN MEDICINE

Second events following ductal carcinoma in situ of the breast: a register-based cohort study

(2011) Ragnhild Sørum Falk et al.   BREAST CANCER RESEARCH AND TREATMENT

Ageing, physical activity and mortality—a 42-year follow-up study

(2011) Anne K Gulsvik et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Epidemiology, epigenetics and the ‘Gloomy Prospect’: embracing randomness in population health research and practice

(2011) George Davey Smith   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Epidemiology: Study of a lifetime

(2011) Helen Pearson   NATURE

Racial/ethnic differences in colorectal cancer risk: The multiethnic cohort study

(2010) Nicholas J. Ollberding et al.   INTERNATIONAL JOURNAL OF CANCER

Epigenetic Basis for Fetal Origins of Age-Related Disease

(2010) Reid F. Thompson et al.   JOURNAL OF WOMENS HEALTH

A hierarchical frailty model applied to two-generation melanoma data

(2010) Tron Anders Moger et al.   LIFETIME DATA ANALYSIS

Epigenetics as a unifying principle in the aetiology of complex traits and diseases

(2010) Arturas Petronis   NATURE

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Uncovering the roles of rare variants in common disease through whole-genome sequencing

(2010) Elizabeth T. Cirulli et al.   NATURE REVIEWS GENETICS

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

Boys live dangerously in the womb

(2009) Johan G. Eriksson et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Frailty modeling of bimodal age-incidence curves of nasopharyngeal carcinoma in low-risk populations

(2009) M. Haugen et al.   BIOSTATISTICS

Etiologic factors in testicular germ-cell tumors

(2009) Katherine A McGlynn et al.   Future Oncology

Familial risks in nervous-system tumours: a histology-specific analysis from Sweden and Norway

(2009) Kari Hemminki et al.   LANCET ONCOLOGY

Single-Cell Profiling Reveals the Origin of Phenotypic Variability in Adipogenesis

(2009) Thuc T. Le et al.   PLoS One

Somatic evolutionary genomics: Mutations during development cause highly variable genetic mosaicism with risk of cancer and neurodegeneration

(2009) S. A. Frank   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

(2008) RC Painter et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Evaluation of screening strategies for pre-malignant lesions using a biomathematical approach

(2008) Jihyoun Jeon et al.   MATHEMATICAL BIOSCIENCES

Age-specific incidence of cancer: Phases, transitions, and biological implications

(2008) R. Meza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA