期刊
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
卷 41, 期 6, 页码 1650-1660出版社
OXFORD UNIV PRESS
DOI: 10.1093/ije/dys171
关键词
BMI; obesity; longitudinal study; growth; FTO gene; breastfeeding; children; RAINE; Australia; linear mixed-effects model
资金
- NH
- MRC
- ALVA foundation, Toronto
- Canadian Institute of Health Research [MOP82893]
- The University of Western Australia (UWA)
- Raine Medical Research Foundation
- Telethon Institute for Child Health Research, UWA Faculty of Medicine, Dentistry and Health Sciences, Women and Infants Research Foundation
- Curtin University
Introduction For years, body mass index (BMI) has been used by scientists to track weight problems and obesity in children and adults. Recent studies have implicated the fat mass and obesity gene (FTO) in the increase of BMI in young adults. A longer duration of breastfeeding is known to reduce the risk of being overweight later in life, but its ability to modify the effect because of FTO is not known. Methods We studied 1096 children from the Western Australian Pregnancy (Raine) cohort who were followed up from birth to 14 years of age. Linear mixed-effects models were used to investigate BMI growth trajectories in boys and girls separately. Results An association was found between BMI growth and the duration of exclusive breastfeeding (EXBF) among carriers of the risk allele of the FTO SNP rs9939609. In girls, EXBF interacts with the SNP at baseline and can reverse the increase in BMI because of SNP risk allele by age 14 years after 3 months of EXBF. In boys, EXBF reduces BMI both in carriers and non-carriers of the risk allele with an association found after 10 years of age. Six months of EXBF will put the boys' BMI growth curves back to the normal range. Conclusions Our study could have major health implications by providing new perspectives for the prevention of growth problems in children carrying risk alleles in the FTO gene.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据