Article
Public, Environmental & Occupational Health
Casey Crump, Jan Sundquist, Kristina Sundquist
Summary: This study aimed to examine the risks of ADHD in preterm and early term birth survivors and found that both preterm and early term birth were associated with increased risks of ADHD in males and females, independently of other covariates and shared familial factors.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Psychology, Developmental
Linn Andersson Konke, Terje Falck-Ytter, Emily J. H. Jones, Amy Goodwin, Karin Brocki
Summary: The current study used the infant sibling design to investigate whether proband traits of autism and ADHD can provide information about their infant siblings' temperament. Parent ratings of autistic traits and ADHD traits were used in older siblings diagnosed with autism, and their infant siblings' temperament traits at 9 months of age were examined. Specific associations were found across siblings, with proband autistic traits related to low levels of approach in infant siblings, and proband ADHD traits related to high levels of infant activity. These findings suggest that inherited liability may influence early emerging behaviors in infant siblings.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Environmental Sciences
Ching-chun Huang, Shih-chun Pan, Wei-shan Chin, Yu-cheng Chen, Chih-da Wu, Chin-yu Hsu, Pinpin Lin, Pau-chung Chen, Yue Leon Guo
Summary: This study aimed to evaluate the association between exposure to petrochemical facilities and emissions and the risk of ADHD development in children. The results indicated that residents of townships near petrochemical plants, highly affected by petrochemical-containing prevailing winds, and with high benzene concentrations had an increased risk of ADHD development. This study provides clear evidence that living near petrochemical plants increases the risk of ADHD in children.
ENVIRONMENTAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Silvia Alemany, Claudia Avella-Garcia, Zeyan Liew, Raquel Garcia-Esteban, Kosuke Inoue, Tim Cadman, Monica Lopez-Vicente, Llucia Gonzalez, Isolina Riano Galan, Ainara Andiarena, Maribel Casas, Katerina Margetaki, Katrine Strandberg-Larsen, Deborah A. Lawlor, Hanan El Marroun, Henning Tiemeier, Carmen Iniguez, Adonina Tardon, Loreto Santa-Marina, Jordi Julvez, Daniela Porta, Leda Chatzi, Jordi Sunyer
Summary: The study found that children prenatally exposed to acetaminophen were more likely to have borderline or clinical ASC and ADHD symptoms in the future. The association was slightly stronger among boys, but postnatal exposure to acetaminophen did not show any significant association with ASC or ADHD symptoms. The results support the need to provide clear information to pregnant women and their partners about the potential risks of acetaminophen use.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Dong Liu, Yaping Ren, Tianfeng Wu, Huiping Shen, Peijing Yan, Yu Meng, Qianlong Zhang, Jun Zhang, Pinqing Bai, Jian Zhao
Summary: The study found that paternal smoking before pregnancy and parental smoking or second-hand smoke exposure before pregnancy were all risk factors for offspring developing ADHD.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Psychology, Multidisciplinary
Morgan M. Grotewiel, Megan E. Crenshaw, Amelia Dorsey, Elizabeth Street
Summary: Hyperfocus and flow are intense concentration experiences associated with reduced perception of irrelevant stimuli and improved task performance. Hyperfocus has been historically seen as a symptom of ADHD, autism, or schizophrenia, while flow is regarded as an enjoyable experience in positive psychology. Recent studies suggest that hyperfocus and flow may be the same phenomenon viewed from different perspectives.
CURRENT PSYCHOLOGY
(2023)
Article
Pediatrics
Isabelle Le Ray, Chen Wang, Catarina Almqvist, Paul Lichtenstein, Brian M. D'Onofrio, Stefan Johansson, Henrik Larsson, Mina A. Rosenqvist
Summary: At a population level, children treated for neonatal jaundice had an increased risk of ADHD. However, in the sibling comparisons, there was no clear association between neonatal jaundice and ADHD. This suggests that the association between neonatal jaundice and ADHD is likely influenced by shared familial factors.
Article
Multidisciplinary Sciences
Hsin-Yi Fan, Cheuk-Kwan Sun, Yu-Shian Cheng, Weilun Chung, Ruu-Fen Tzang, Hsien-Jane Chiu, Chun-Ning Ho, Kuo-Chuan Hung
Summary: This study provides a systematic review and analysis of the effectiveness of electroencephalogram-based neurofeedback (EEG-NF) in treating the core symptoms of attention-deficit hyperactivity disorder (ADHD) in adolescents/adults. The results suggest that EEG-NF can effectively improve inattention symptoms, but its effectiveness in reducing hyperactivity/impulsivity remains inconclusive.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Medicinal
Toyosaku Ota, Kazuhiko Yamamuro, Kosuke Okazaki, Toshifumi Kishimoto
Summary: In summary, studies suggest that GXR is an effective monotherapy treatment option for adults with ADHD, with positive effects on attention, emotion, and behavior through its activity at post-synaptic alpha 2A receptors.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Psychiatry
Dara E. Babinski, Erika F. H. Saunders, Fan He, Duanping Liao, Amanda M. Pearl, Daniel A. Waschbusch
Summary: This study examined the diagnostic indicators, clinical characteristics, and functional impairment associated with adult ADHD using electronic medical records and self-report measures. The results showed a significant difference in prevalence of ADHD between self-report screening and medical records. ADHD was found to contribute to functional impairment even when controlling for other psychiatric comorbidities.
PSYCHIATRY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
E. M. Bruxel, C. R. Moreira-Maia, G. C. Akutagava-Martins, T. P. Quinn, M. Klein, B. Franke, M. Ribases, P. Rovira, C. Sanchez-Mora, D. B. Kappel, N. R. Mota, E. H. Grevet, C. H. D. Bau, M. Arcos-Burgos, L. A. Rohde, M. H. Hutz
Summary: This study conducted a meta-analysis to investigate the association between ADGRL3 gene variants and ADHD susceptibility in children and adults, finding significant correlation in children but not in adults. The results suggest that ADGRL3 gene is predominantly associated with childhood ADHD.
MOLECULAR PSYCHIATRY
(2021)
Review
Behavioral Sciences
Miguel Garcia-Argibay, Lin Li, Ebba Du Rietz, Le Zhang, Honghui Yao, Johan Jendle, Josep A. Ramos-Quiroga, Marta Ribases, Zheng Chang, Isabell Brikell, Samuele Cortese, Henrik Larsson
Summary: We conducted a systematic review and meta-analysis to explore the association between ADHD and T2D. Our findings suggest that individuals with ADHD have a significantly increased risk of developing T2D, and this association can be largely explained by psychiatric comorbidities. Early identification and treatment of ADHD comorbidities may be crucial in reducing the risk of T2D in individuals with ADHD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychology, Multidisciplinary
Erica D. Musser, Stephanie S. J. Morris, Kathleen Feeney, Rosario Pintos Lobo, Edward F. Ester
Summary: Inattention is a key symptom of ADHD, but the mechanisms underlying it are unclear. More specific approaches are needed to link disruptions in cognitive performance with ADHD behaviors. A pilot study found that even typically developing children did not maximally extract and combine information to maximize rewards in a cognitive task targeting attention selection mechanisms.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Medicine, General & Internal
Grace Mengqin Ge, Edmund C. L. Cheung, Kenneth K. C. Man, Patrick Ip, Wing Cheong Leung, Gloria H. Y. Li, Annie W. C. Kung, Ching-Lung Cheung, Ian C. K. Wong
Summary: The study found that maternal levothyroxine treatment during pregnancy is associated with an increased risk of preterm birth in offspring, but not significantly associated with low birth weight, ADHD, or ASD.
Article
Pediatrics
Li-Fan Pai, Der-Shiun Wang, Wan-Fu Hsu, Shao-Wei Huang, Chi-Hsiang Chung, Shyi-Jou Chen, Wu-Chien Chien, Der-Ming Chu
Summary: This study found that children with ADHD have a higher risk of central precocious puberty. Early referral to a pediatric endocrinologist for evaluation can lead to correct diagnosis. Early intervention treatment with gonadotropin-releasing hormone agonist may improve final height in children with central precocious puberty.
PEDIATRIC RESEARCH
(2022)
Article
Psychiatry
Ida Ringbom, Jaana Suvisaari, Antti Kaariala, Andre Sourander, Mika Gissler, Ian Kelleher, David Gyllenberg
Summary: This study demonstrates that individuals with psychotic disorders are more likely to be NEET, with a higher percentage of long-term NEET. Family-related risk factors have weaker predictive ability for long-term NEET in individuals with psychotic disorders. Among individuals with psychotic disorders, educational problems are associated with adverse labor market outcomes.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Clinical Neurology
Aino Korhonen, Liisa Verho, Karoliina Aarnio, Kirsi Rantanen, Anna Saaros, Hannele Laivuori, Mika Gissler, Minna Tikkanen, Petra Ijas
Summary: This nationwide population-based cohort study in Finland found that pregnancy-related subarachnoid hemorrhage (pSAH) is rare but has high mortality and morbidity. The study showed that the incidence of pSAH has not significantly changed over time, but the age of the mother has an impact on the incidence. Most pSAH cases were aneurysmal and these patients had higher mortality and morbidity rates.
Article
Medicine, General & Internal
Martta Kerkela, Mika Gissler, Tanja Nordstrom, Olavi Ukkola, Juha Veijola
Summary: This study examined the association between participation in the longitudinal follow-up study and cardiometabolic disorders. The results showed that participation in the study may have a weak positive health effect among men.
ANNALS OF MEDICINE
(2023)
Article
Respiratory System
Anna Pulakka, Kari Risnes, Johanna Metsala, Suvi Alenius, Katriina Heikkila, Sara Marie Nilsen, Pieta Nasanen-Gilmore, Peija Haaramo, Mika Gissler, Signe Opdahl, Eero Kajantie
Summary: This study investigated the association between gestational age and obstructive airway disease in adulthood. The results showed that the odds of developing obstructive airway disease were higher for individuals born preterm compared to those born full term. The association was consistent across different gestational age groups and in both Finnish and Norwegian data.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Oncology
Sarah Marie Bjornholt, Sarah Elizabeth Sponholtz, Ole Mogensen, Kirsten Bouchelouche, Erik Thorlund Parner, Gudrun Neumann, Kirsten Marie Jochumsen, Bushra Hassan Hamid, Morten Billow Davidsen, Signe Frahm Bjorn, Katja Dahl, Pernille Tine Jensen
Summary: The SENTIREC-endo study investigates the risks and benefits of a national protocolled adoption of sentinel lymph node mapping in women with early-stage low-grade endometrial cancer. The study found that this technique is safe and can provide more accurate treatment allocation for patients in both low and intermediate risk groups.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
M. Venetkoski, O. Ylikorkala, J. M. Joensuu, M. Gissler, T. S. Mikkola, H. Savolainen-Peltonen
Summary: This study compared the trends of hormone therapy (HT) use between women with and without a history of pre-eclampsia. The results showed that the use of HT increased in women with a history of pre-eclampsia during the later half of the follow-up period, possibly due to changes in international recommendations, increased awareness of pre-eclampsia-related cardiovascular risk later in life, and the aim to reduce this risk through HT.
Editorial Material
Clinical Neurology
Marte-Helene Bjork, Torbjoern Tomson, Julie Werenberg Dreier, Silje Alvestad, Nils Erik Gilhus, Mika Gissler, Jannicke Igland, Maarit K. Leinonen, Yuelian Sun, Hakon Magne Vegrim, Helga Zoega, Jakob Christensen
Summary: Women taking antiseizure medication during pregnancy are often advised to take high doses of folic acid supplements (1mg to 5mg) to minimize the risk of birth defects. However, a recent report has shown a link between high dose folic acid intake and an increased risk of childhood cancer in the offspring. This has sparked a debate regarding the recommended dose of folic acid for pregnant women on antiseizure medication. In this Commentary, the authors explain their findings, the methodology used, and address emerging questions.
Article
Clinical Neurology
Teresa Vest, Kirsi Rantanen, Liisa Verho, Karoliina Aarnio, Aino Korhonen, Anna Richardt, Daniel Strbian, Mika Gissler, Hannele Laivuori, Minna Tikkanen, Petra Ijas
Summary: Intracerebral hemorrhage during pregnancy or puerperium (pICH) is a major cause of maternal death globally, but limited epidemiological data exist on its etiology and outcomes. This study found that hypertensive disorders of pregnancy (HDPs) were the main risk factor for pICH, with high maternal mortality and a significant proportion of surviving women experiencing severe disabilities three months later. Therefore, early recognition and treatment of HDPs are crucial in preventing this serious pregnancy complication.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Zahra Roustaei, Anna Heino, Sonja Kiuru-Kuhlefelt, Joan K. Morris, Svetlana Glinianaia, Ester Garne, Maria Loane, Judith Rankin, Mika Gissler
Summary: A study in Finland found that children with major congenital anomalies are less likely to apply for further education compared to children without anomalies. However, most non-chromosomal congenital anomalies did not have a significant impact on educational achievement. Factors such as male sex, lower maternal education levels, and younger maternal age were associated with lower educational achievement in children with congenital anomalies.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Obstetrics & Gynecology
A. Tuominen, L. Saavalainen, M. Niinimaki, M. Gissler, A. But, P. Harkki, O. Heikinheimo
Summary: This study found that the incidence of first live birth was lower in women before surgical verification of endometriosis, regardless of the type of endometriosis.
HUMAN REPRODUCTION
(2023)
Article
Psychology, Clinical
Judit Ozsvar, Mika Gissler, Catharina Lavebratt, Ida A. K. Nilsson
Summary: This study identified various prenatal and at birth exposures associated with offspring eating disorders, some of which are specific to certain types of eating disorders and show sex-specific associations. Confounding by maternal BMI cannot be excluded, however, highlighting the importance of subtype- and sex-stratified analyses.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Pediatrics
Joanne Given, Joan K. Morris, Ester Garne, Elisa Ballardini, Laia Barrachina-Bonet, Clara Cavero-Carbonell, Mika Gissler, Francesca Gorini, Anna Heino, Sue Jordan, Amanda J. Neville, Anna Pierini, Ieuan Scanlon, Joachim Tan, Stine K. Urhoj, Maria Loane
Summary: This study aimed to evaluate the prescription rates of insulin/insulin analogues in children aged 0-9 years with and without major congenital anomalies. The results showed that children with chromosomal anomalies had an increased risk of developing diabetes requiring insulin therapy, while children with non-chromosomal anomalies had a similar risk to the reference group. Female children had a reduced risk, and preterm births without congenital anomalies were more likely to be prescribed insulin/insulin analogues.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
Kaukonen Sesilia, Pajula Susanna, Koljonen Virve, Gissler Mika, Ulander Veli-Matti, Kaijomaa Marja
Summary: This study evaluates the outcomes of pregnancies and deliveries after bariatric surgery (BS). It found that women who underwent BS had higher risks for pregnancy-induced hypertension, gestational diabetes, pre-term delivery, labor induction, and caesarean sections. However, BS can still be considered a safe and advisable treatment for obesity among fertile-aged women.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Endocrinology & Metabolism
Lotta S. Holopainen, Hanna H. Taehtinen, Mika Gissler, Paeivi E. Korhonen, Mikael O. Ekblad
Summary: This study found that compared to women with a higher body surface area (BSA), underweight and normal weight pregnant women with a smaller BSA may be more susceptible to gestational diabetes mellitus (GDM) and have a pathological oral glucose tolerance test (OGTT). In overweight pregnant women, a higher BSA may increase the risk of GDM and pathological OGTT. Additionally, maternal smoking may increase the risk of diabetes and pathological OGTTs in almost all body mass index groups.
ACTA DIABETOLOGICA
(2023)
Article
Obstetrics & Gynecology
Maiju Kekki, Topias Koukkula, Anne Salonen, Mika Gissler, Hannele Laivuori, Tuomas T. Huttunen, Kati Tihtonen
Summary: This study retrospectively analyzed the occurrence of birth injuries in different modes of delivery, focusing on vaginal breech deliveries. The study found that birth injuries were rare in vaginal breech deliveries, with brachial plexus palsy being the most common type of injury. The incidence of severe birth injury in vaginal breech deliveries was twice as high as in cephalic vaginal deliveries.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)