期刊
METALLOMICS
卷 7, 期 5, 页码 786-794出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5mt00011d
关键词
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资金
- NIH [NIH K22AI104805-01]
- NIAID [R01AI110618]
- American Lebanese Syrian Associated Charities (ALSAC)
Copper is universally toxic in excess, a feature exploited by the human immune system to facilitate bacterial clearance. The mechanism of copper intoxication remains unknown for many bacterial species. Here, we demonstrate that copper toxicity in Streptococcus pneumoniae is independent from oxidative stress but, rather, is the result of copper inhibiting the aerobic dNTP biosynthetic pathway. Furthermore, we show that copper-intoxicated S. pneumoniae is rescued by manganese, which is an essential metal in the aerobic nucleotide synthesis pathway. These data provide insight into new targets to enhance copper-mediated toxicity during bacterial clearance.
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