Article
Food Science & Technology
Lan Tang, Shengnan Li, Jie Yu, Yujie Zhang, Lilin Yang, Dayan Tong, Jie Xu
Summary: This study found that chronic exposure to nonylphenol (NP) can increase anxiety behavior in rats and reduce the expression of key proteins/genes in the BDNF/TrkB/CREB signaling network.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Reproductive Biology
Bin Liu, Yongjie Liu, Shuman Li, Pingping Chen, Jun Zhang, Liping Feng
Summary: This study investigated the reproductive outcomes of BDNF treatment and potential mechanisms in aged mice. The results showed that BDNF treatment could improve ovarian function and fertility in aged mice by promoting ovarian cell proliferation and activating the TrkB and cyclin D1-creb signaling pathways. Therefore, targeting the BDNF-TrkB signaling pathway may be a potential novel therapeutic strategy to reverse ovarian aging.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shir Shlomi, Roni Toledano, Keren Nitzan, Sigal Dror Shahaf, Emanuela P. Break, Dan Frenkel, Ravid Doron
Summary: Stressful and unpredictable life events are associated with numerous diseases, with adolescence being a sensitive period in brain development. Research shows that exposure to unpredictable chronic mild stress during adolescence can have long-term effects on cognition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Saima Khatoon, Mohammed Samim, Mansi Dahalia, Nidhi
Summary: Fisetin has been found to improve cognitive function in mice with PTZ-induced kindling through modulation of oxidative stress markers, gene expressions, and neurotransmitter levels. These findings suggest a therapeutic potential of fisetin against cognitive dysfunction associated with PTZ-induced kindling.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Samira S. Valvassori, Gustavo C. Dal-Pont, Roger B. Varela, Wilson R. Resende, Fernanda F. Gava, Franciele G. Mina, Josiane Budni, Joao Quevedo
Summary: The study demonstrated that ouabain affects the behavior and memory of rats, including increasing locomotion and exploration behavior, as well as reducing memory index and aversive memory. Moreover, ouabain induced alterations in the BDNF signaling pathway, which may be associated with memory impairment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Environmental Sciences
Yi-Zhou Li, Zi-Yao Wu, Bi-Qi Zhu, Yu-Xiao Wang, Ya-Qi Kan, Huai-Cai Zeng
Summary: In this study, the role of the BDNF-TrkB-CREB signaling pathway in bisphenol S (BPS)-induced neurotoxicity was investigated. The results showed that BPS damaged the hippocampal ultrastructure and reduced the number of synapses in male mice. Additionally, BPS increased the methylation rate of BDNF promoter IV and altered the expression of various proteins involved in the pathway. These findings suggest that the BDNF-TrkB-CREB pathway may play a role in BPS-induced neurotoxicity through methylation regulation.
Article
Biology
Guillermo Moya-Alvarado, Reynaldo Tiburcio-Felix, Maria Raquel Ibanez, Alejandro A. Aguirre-Soto, Miguel Guerra, Chengbiao Wu, William C. Mobley, Eran Perlson, Francisca C. Bronfman
Summary: Brain-derived neurotrophic factor (BDNF) and its receptors, tropomyosin kinase receptor B (TrkB) and the p75 neurotrophin receptor (p75), play a crucial role in regulating dendritic growth in the central nervous system (CNS). Through axonal signaling, BDNF enhances dendritic growth from the neuronal cell body, mediated by cAMP response element-binding protein (CREB) and axonal TrkB activity. Dynein-dependent transport of BDNF-TrkB-containing endosomes is necessary for long-distance induction of dendritic growth. These axonal signaling endosomes coordinate the transcription and translation of genes involved in learning and memory regulation.
Article
Environmental Sciences
Rundong Liu, Lin Bai, Mengchen Liu, Ruike Wang, Yingying Wu, Qiong Li, Yue Ba, Huizhen Zhang, Guoyu Zhou, Fangfang Yu, Hui Huang
Summary: Lead and high-fat diets are co-occurring risk factors for cognitive impairment. This study found that combined exposure to lead and high-fat diets exacerbates cognitive deficits and affects synaptic plasticity through multiple signaling pathways. The study highlights the importance of evaluating the effects of mixed exposures on brain function in realistic environments and the need to modulate central pathways to prevent neurological disorders.
ENVIRONMENTAL POLLUTION
(2022)
Article
Plant Sciences
Wen-Kai Wang, Yuan Zhou, Lu Fan, Yue Sun, Fan Ge, Mei Xue
Summary: The study demonstrates that the TCM formula DBD effectively improves glucose tolerance in DD rats and alleviates depression-like behavior. DBD exerts antidepressant-like effects by regulating the CREB/BDNF/TrkB pathway to protect and remodel hippocampal neurons. Additionally, the main active component, ferulic acid (FA), significantly contributes to the treatment effects of DBD.
Article
Behavioral Sciences
Tao Tong, Yiping Chen, Chonyao Hao, Junliang Shen, Wenjie Chen, Wenjing Cheng, Simin Yan, Jianguo Li, Yuhan Li, Tuergong Gulizhaerkezi, Jingyu Zeng, Xianjun Meng
Summary: This study aimed to explore the potential mechanism of the antidepressant effect of acupuncture. The results showed that acupuncture therapy can improve behavioral deficits, increase serum levels of 5-hydroxytryptamine and FNDC5/IRISIN, and reduce the impact of CUMS on pro-BDNF. Both acupuncture and fluoxetine can improve the %area of IBA-1, GFAP, BrdU, and DCX in LHb, as well as increase the expression of BDNF/TrkB/CREB. These findings suggest that acupuncture therapy may relieve depression-related manifestations through the BDNF/TrkB/CREB pathway in LHb.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Jing Wang, Yichen Cai, Jingyi Sun, Hua Feng, Xiaoyu Zhu, Qian Chen, Feng Gao, Qingbin Ni, Leilei Mao, Mingfeng Yang, Baoliang Sun
Summary: In this study, non-invasive treatment methods using AAV vectors carrying BDNF or TrkB genes were performed on stroke-injured rats. The combination therapy significantly improved upper limb motor functional recovery and neurotransmission efficiency, promoting axonal remodeling and restoration of synaptic structures.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mostafa A. Rabie, Heba I. Ibrahim, Noha N. Nassar, Reham M. Atef
Summary: Huntington's disease (HD) is a neurodegenerative disease characterized by progressive impairment in motor, behavioral, and cognitive functions. This study investigated the protective effects of the adenosine A1 receptor agonist CHA in an HD-like rat model induced by 3-nitropropionic acid (3NP). The results showed that CHA attenuated neuronal death, improved cognitive and motor deficits, and reduced inflammatory and oxidative stress markers. These effects were associated with the activation of the PI3K/Akt/CREB/BDNF pathway and a decrease in astrocyte and microglia activation. Overall, CHA may have a protective effect against HD by modulating oxidative stress, excitotoxicity, and inflammatory pathways.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Medicine, General & Internal
Teodora Yaneva-Sirakova, Latchezar Traykov, Kiril Karamfiloff, Ivo Petrov, Julieta Hristova, Dobrin Vassilev
Summary: Carotid stenting can affect the levels of neurotrophins, which are important for the survival, development, and function of neurons.
ANNALS OF MEDICINE
(2023)
Article
Neurosciences
Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu Lu
Summary: The abnormal increase of NR6A1 in the hippocampus impairs the CREB-BDNF signaling cascade, leading to the development of depression-like behaviors. Genetic knockdown of NR6A1 can prevent stress-induced depression-like behaviors.
Article
Biochemistry & Molecular Biology
Zhijian Jin, Yifan Lu, Xiongyan Wu, Tao Pan, Zhenjia Yu, Junyi Hou, Airong Wu, Jianfang Li, Zhongyin Yang, Chen Li, Min Yan, Chao Yan, Zhenggang Zhu, Bingya Liu, Weihua Qiu, Liping Su
Summary: In this study, anlotinib inhibited gastric cancer (GC) cell growth by inducing apoptosis and G2/M phase arrest in a dose- and time-dependent manner. The interaction between epithelial and stromal cells in the tumor microenvironment affects the response of GC cells to anlotinib. Secreted lactate from GC cells activates cancer-associated fibroblasts (CAFs) to produce BDNF in a NF-kappa B-dependent manner, reducing the sensitivity of GC cells to anlotinib. Targeting the BDNF-TrkB pathway increased the sensitivity of GC cells to anlotinib in a human patient-derived organoid model.
Article
Biochemistry & Molecular Biology
Mahadev Patil, Anurag Noonikara-Poyil, Shrinivas D. Joshi, Shivaputra A. Patil, Siddappa A. Patil, Abby M. Lewis, Alejandro Bugarin
Summary: In this study, two series of new piperazine and triazolo-pyrazine derivatives were synthesized in a single-step reaction and fully characterized. Testing against bacterial and fungal strains revealed strong antimicrobial activity for N-{[(3-chlorophenyl)-4-(dibenzo[b,f][1,4]thiazepin-11-yl)]}piperazine-1-carboxamide (3o). Promising results from molecular docking studies suggest potential for developing more potent antimicrobials.
MOLECULAR DIVERSITY
(2022)
Article
Chemistry, Organic
Praveen M. Parkali, A. Shyam Kumar, Pohamba K. Johanna, Shilomboleni T. Prodensia, Sruthi Turaga, Vinod Shaiva, Gurubasavaraj Pujar, Shrinivas D. Joshi, Tejraj M. Aminabhavi, Sheshagiri R. Dixit
Summary: Molecular docking and 3D-QSAR studies were conducted on a series of pyrimidine derivatives to develop inhibitors for Enoyl ACP Reductase, a key enzyme in fatty acid biosynthesis and antitubercular drug development. Results from the models and structural features analysis provided insights into predicting better inhibitory potency and the importance of specific amino acid residue interactions. This study contributes to the development of novel Enoyl ACP reductase inhibitors by understanding the specific activity of compounds.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Green & Sustainable Science & Technology
Sudhanshu Joshi, Manu Sharma, Rashmi Prava Das, Joanna Rosak-Szyrocka, Justyna Zywiolek, Kamalakanta Muduli, Mukesh Prasad
Summary: This study examines the significance of AI and its implementation barriers in healthcare systems in developing countries. It finds that there are critical implementation barriers at different levels, which provide insights for decision makers. The findings contribute to the understanding of various implementation issues related to governance, scalability, and privacy of AI in public healthcare.
Article
Green & Sustainable Science & Technology
Manu Sharma, Sunil Luthra, Sudhanshu Joshi, Anil Kumar, Akshat Jain
Summary: The study aims to investigate the impact of green logistics on the adoption of Circular Economy (CE) in the era of Industry 4.0 (I4.0). By implementing green initiatives, the logistics sector shows its strong concern for environmental issues and promotes sustainable logistics and circular practices to address critical issues such as waste generation, resource scarcity, renewable resource use, and climate change. The study examines the relationships between green logistics practices, I4.0 technologies, and CE adoption while also considering the moderating effects of institutional pressure and supply chain flexibility. The findings suggest that firms can enhance CE adoption driven by I4.0 technologies with green logistics practices as a mediator, and the moderating effect of supply chain flexibility is significant while the moderating effect of institutional pressure is insignificant. The study provides valuable insights for managers and contributes to the theoretical understanding of green logistics and CE adoption.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Management
Sudhanshu Joshi, Manu Sharma, Shalini Bartwal, Tanuja Joshi, Mukesh Prasad
Summary: This study explores the challenges of integrating lean manufacturing and Industry 4.0 in the manufacturing industry, and identifies lack of standardization, lack of vision, and lack of trained support as the major obstacles. The research provides valuable insights for managers to implement lean manufacturing and Industry 4.0 in smart manufacturing.
Article
Management
Sudhanshu Joshi, Manu Sharma, Akhilesh Barve
Summary: This study employs the Best Worst Method (BWM) to identify the most critical implementation barriers of IoT and Blockchain technology in Waste Electrical and Electronic Equipment (WEEE) management. The findings reveal that developing a legislative support system, ineffective database management, low understanding of cognitive technologies, and concerns regarding information security and privacy are the key issues in implementing these technologies in closed-loop supply chains.
SUPPLY CHAIN FORUM
(2023)
Article
Green & Sustainable Science & Technology
Manu Sharma, Sudhanshu Joshi, Mukesh Prasad, Shalini Bartwal
Summary: This study proposes a model to examine the critical barriers and suggest strategies for implementing Circular Economy (CE) in the Oil & gas (O&G) industry. The results show that 'knowledge barriers' are the most critical, and the strategies 'Developing collaborative model' and 'Internal research and development, innovation' are the most significant for reducing the barriers.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Green & Sustainable Science & Technology
Sudhanshu Joshi, Manu Sharma, Banu Y. Ekren, Yigit Kazancoglu, Sunil Luthra, Mukesh Prasad
Summary: Food waste reduction and security are major concerns in agri-food supply chains, as more than a third of global food production is wasted or lost due to mismanagement. Resilient food supply chains need to address challenges such as resource scarcity, climate change, and waste generation. This study explores supply chain innovations, using SWARA analysis, to identify the most significant innovations for developing resilient food supply chains. The results highlight the importance of business strategy and technological innovations in bringing resilience to food supply chains.
Article
Business
Manu Sharma, Deepak Kaushal, Sudhanshu Joshi
Summary: Social media has become a major source of information for young users, but it has a severe impact on mental state due to information overload, which is still a concern for researchers. The addiction of Generation Z users to mobile phones/gadgets is increasing with the rise of social media, leading to a complete transformation in their behavioral outcomes. Behavioral issues such as stress, fatigue, fear of missing out, phubbing, and anxiety are on the rise, but the relationship between these issues and information overload has not been sufficiently examined. The study finds that social media platforms need to understand users' compulsive usage, which results in fatigue and anxiety, and government information support plays a positive role in reducing fatigue and anxiety.
JOURNAL OF RETAILING AND CONSUMER SERVICES
(2023)
Review
Multidisciplinary Sciences
Sunil Luthra, Shruti Agrawal, Anil Kumar, Manu Sharma, Sudhanshu Joshi, Jatin Kumar
Summary: Psychological and mental well-being of young adults has been greatly influenced by the COVID-19 pandemic, leading to a global concern. This research study provides an overview of the international scientific studies on the effect of COVID-19 on young adults' psychological well-being. It reveals the top-cited authors, documents, journals, productive countries, keywords, and themes in this area. The United States has contributed the most publications, followed by the United Kingdom and Italy. The study highlights the importance of addressing the psychological health of young adults worldwide.
Article
Health Policy & Services
Sudhanshu Joshi, Manu Sharma
Summary: The widespread use of Blockchain technology (BT) in developing nations is still in its early stages and requires a comprehensive evaluation. The healthcare sector is increasingly in need of digitalization to improve operational efficiency. However, the limited research on BT has hindered its full utilization in the healthcare sector. This study aims to identify the main obstacles to BT adoption in developing nations' public health systems, using a multi-level analysis and hybrid approach. The findings of this study provide guidance and insight for decision-makers on implementation challenges.
Article
Management
Manu Sharma, Sudhanshu Joshi
Summary: This study aims to explore the factors that affect the selection of digital suppliers and evaluate the alternatives for identifying the best supplier that enhances the quality management systems (QMS) for digital supply chains (DSCs). The study reveals that supplier competency is the most significant factor in selecting digital suppliers, and supplier S-8 has been ranked as the best supplier.
Article
Business
Sudhanshu Joshi, Rohit Kumar Singh, Manu Sharma
Summary: This study aims to identify the factors influencing the adoption of sustainable agribusiness practices in India and examines the most pertinent issues. The findings can provide guidance for agribusiness regulators and intermediaries, while contributing to a new understanding of sustainable agribusiness-based issues in India.
GLOBAL BUSINESS REVIEW
(2023)
Article
Management
Saket Shanker, Akhilesh Barve, Kamalakanta Muduli, Anil Kumar, Jose Arturo Garza-Reyes, Sudhanshu Joshi
Summary: This study aims to analyze the factors influencing perishable food supply chains during the pandemic and improve their resiliency. The research revealed that factors like import-export restrictions and fear of violating social distancing guidelines are primary factors causing disruptions, while price fluctuations of perishable products and panic buying are crucial effects impacting perishable food supply chains.
INTERNATIONAL JOURNAL OF LOGISTICS-RESEARCH AND APPLICATIONS
(2022)
Article
Business
Rohit Kumar Singh, Sudhanshu Joshi, Manu Sharna
GLOBAL BUSINESS REVIEW
(2023)