Article
Medicine, General & Internal
Malcolm R. Battin, Sian A. Williams, Anna Mackey, Woroud Alzaher, Alexandra Sorhage, N. Susan Stott
Summary: Cerebral palsy is a common physical disability, and early diagnosis has been a focus internationally. New Zealand is developing guidelines for high-risk neonatal intensive care (NICU) graduates based on imaging data from the New Zealand Cerebral Palsy Register (NZCPR). The study reviewed imaging data from a retrospective NICU cohort and found variations in imaging frequency and modality among different gestational subgroups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Victor Daniel Vasquez Matsuda, Martin Bustelo Tejada, Livia Clemente Motta-Teixeira, Juliane Midori Ikebara, Debora Sterzeck Cardoso, Aline Vilar Machado-Nils, Vitor Yonamine Lee, Isabelle Diccini, Bruna Petrucelli Arruda, Pamela Pinheiro Martins, Natalia Myuki Morales Dias, Rafaella Pinto Tessarotto, Reza Raeisossadati, Martin Bruno, Luiz Fernando Takase, Alexandre Hiroaki Kihara, Maria Ines Nogueira, Gilberto Fernando Xavier, Silvia Honda Takada
Summary: Therapeutic hypothermia in a rodent model of preterm neonatal anoxia mainly reduces hippocampal neurodegeneration and improves performance of behavioral tasks, but does not appear to affect developmental alterations and hippocampal neurogenesis.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Pediatrics
John D. E. Barks, Yiqing Liu, Ian A. Dopp, Faye S. Silverstein
Summary: The study showed that AZ improves sensorimotor function, survival, brain tissue preservation, and composite scores in two neonatal rat models of inflammation-amplified HI brain injury. The benefits of AZ treatment increased with higher doses and decreased with longer initiation delays. The findings support further evaluation of AZ as a candidate treatment for neonatal neuroprotection, even with a 2-hour delay in initiation.
PEDIATRIC RESEARCH
(2022)
Review
Pediatrics
Rebecca Jackson, Kathryn Woodward, Meg Ireland, Conor Larkin, Jennifer J. Kurinczuk, Marian Knight, Chris Gale, Samantha Johnson, Rosie Cornish, Ela Chakkarapani
Summary: The evidence regarding the impact of antenatal and neonatal exposure to SARS-CoV-2 on developmental outcomes in infants is limited and inconsistent. Larger cohorts with outcomes assessed beyond the first year of life are needed to determine the potential longer-term impact of SARS-CoV-2 infection exposure on child development.
PEDIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Julie M. Werner, Jamie Berggren, Jennifer Loiselle, Gina Kim Lee
Summary: The study found that constraint-induced movement therapy (CIMT) is more effective than standard care in improving upper-limb activity outcomes in children with neonatal brachial plexus palsy. Future research should consider longer follow-up periods, additional comparator interventions, and analyze differences based on participant characteristics.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Review
Neurosciences
Eric M. Chin, Nicole Gorny, Maya Logan, Alexander H. Hoon
Summary: Accumulating evidence has revealed that various seemingly unrelated factors are associated with the susceptibility to cerebral palsy, including prenatal and perinatal environmental factors and fetal health. These factors accumulate and increase the risk of cerebral palsy during different developmental stages.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
A. V. Yakovlev, E. Kurmashova, E. Gataulina, E. Gerasimova, I. Khalilov, G. F. Sitdikova
Summary: In this study, we induced prenatal hyperhomocysteinemia (hHCy) in rats by feeding females with a high-methionine diet and evaluated the susceptibility to seizures in neonatal rats. The results showed that rats with hHCy exhibited more severe stages of behavior and shorter latency during flurothyl-induced epilepsy, and had higher neuronal activity. These findings suggest that the increased risk of epilepsy associated with hHCy may be due to a shift in the balance of excitation/inhibition towards excitation.
Article
Developmental Biology
Amrita Jha Kumar, Ammir Yacoub Helou, Bruna Arruda Petrucelli, Gilberto Fernando Xavier, Daniel Oliveira Martins, Marucia Chacur, Maria Ines Nogueira
Summary: Neonatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of morbidity and mortality in term-born infants, impacting early somatic, neurological, and motor development, as well as social abilities. This study evaluated sex differences in Wistar rats and observed short- and long-term impairments associated with HIE. The results indicate that anoxic males are more affected than anoxic females, with long-lasting effects predominantly affecting males, and a decrease in the number of substantia nigra cells in both sexes.
DEVELOPMENTAL PSYCHOBIOLOGY
(2022)
Article
Immunology
Mouly F. Rahman, Ceren B. Yuksel, Patrick O. McGowan
Summary: Both neonatal infections and exposure to maternal obesity are inflammatory stressors in early life that can affect offspring's physiology and behavior. This study investigated the effects of neonatal lipopolysaccharide (nLPS) administration in rat offspring born to dams consuming a high-fat diet (HFD). The study found that dual exposure to maternal HFD and nLPS can disrupt neural stress regulation but normalize spatial memory processes.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Pediatrics
Kathryn A. Martinello, Christopher Meehan, Adnan Avdic-Belltheus, Ingran Lingam, Tatenda Mutshiya, Qin Yang, Mustafa Ali Akin, David Price, Magdalena Sokolska, Alan Bainbridge, Mariya Hristova, Ilias Tachtsidis, Cally J. Tann, Donald Peebles, Henrik Hagberg, Tim G. A. M. Wolfs, Nigel Klein, Boris W. Kramer, Bobbi Fleiss, Pierre Gressens, Xavier Golay, Nicola J. Robertson
Summary: Therapeutic hypothermia did not show protection in a piglet model of inflammation-sensitized hypoxia-ischemia, as evidenced by aEEG, MRS, and immunohistochemistry. The immunosuppressive effects of hypothermia and the counteracting neuroinflammation by LPS may have led to the lack of efficacy of hypothermia in this context. Other immunomodulatory strategies may be more effective in treating inflammation-sensitized hypoxia-ischemia injuries.
PEDIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Iveta Vojtechova, Kristyna Maleninska, Viera Kutna, Ondrej Klovrza, Klara Tuckova, Tomas Petrasek, Ales Stuchlik
Summary: Maternal immune activation during pregnancy can lead to social and communication impairments in adult offspring, along with changes in various behaviors, including deficits in prepulse inhibition in females and increased startle reaction in males. Brain changes are evident in both sexes, while the sex of the offspring plays a crucial role in the development of MIA-induced behavioral alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lee Reicher, Hanin Dabaja, Yuval Ginsberg, Nizar Khatib, Yuval Fouks, Emmanuel Attali, Michael G. Ross, Zeev Weiner, Ron Beloosesky
Summary: This study found that maternal inflammation may lead to fetal brain injury by affecting the production of specific proteins, while Mg supplementation may achieve neuroprotective effects by modulating these proteins.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Tao Wang, Yusheng Zhang, Weiwu Chen, Jin Tao, Qiao Xue, Wei Ge, Wanchen Dou, Chao Ma
Summary: This study utilized a high throughput quantitative proteomic approach to evaluate proteomic changes in the hippocampus and motor cortex in a rat model of cerebral palsy (CP) induced by lipopolysaccharide (LPS) combined with hypoxia/ischemia (H/I). The research revealed that neuroinflammatory responses in the brain induced by the CP model could be reversed by the topical application of Baimai ointment. Furthermore, the application of Baimai ointment not only alleviated motor deficits in CP model rats, but also restored the proteomes in the brain cortex.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Diego Bulcao Visco, Raul Manhaes-de-Castro, Marcia Maria da Silva, Barbara J. R. Costa-de-Santana, Joaci Pereira dos Santos Junior, Luis Miguel Saavedra, Maria Daniele Teixeira Beltrao de Lemos, Juan Jose Valdez-Alarcon, Claudia Jacques Lagranha, Omar Guzman-Quevedo, Luz Torner, Ana Elisa Toscano
Summary: The study aimed to assess the effects of neonatal treatment with kaempferol on neuromotor development, neural precursor cell proliferation, microglia profile, and antioxidant enzyme gene expression in the hippocampus. Results showed that kaempferol treatment during the neonatal period attenuated the impact of cerebral palsy on reflex ontogeny and physical feature maturation. It also prevented a decrease in neural precursor cells, activated microglia profile, and increased microglia proliferation in the hippocampus. Additionally, kaempferol treatment increased the expression of antioxidant defense genes in the hippocampus.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Alyssa M. Spomer, Benjamin C. Conner, Michael H. Schwartz, Zachary F. Lerner, Katherine M. Steele
Summary: This study showed that audiovisual biofeedback was crucial in increasing plantarflexor engagement during walking, while combining audiovisual and sensorimotor modalities further boosted the rate of gait adaptation. Understanding how individuals may prioritize different forms of sensory information can inform the design and selection of biofeedback systems for clinical care.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Behavioral Sciences
Marilia Rossato Marques, Felipe Stigger, Ethiane Segabinazi, Otavio Americo Augustin, Silvia Barbosa, Francele Valente Piazza, Matilde Achaval, Simone Marcuzzo
BEHAVIOURAL BRAIN RESEARCH
(2014)
Article
Clinical Neurology
Simone Marcuzzo, Marcio Ferreira Dutra, Felipe Stigger, Patricia Severo do Nascimento, Jocemar Ilha, Pedro Ivo Kalil-Gaspar, Matilde Achaval
BRAIN & DEVELOPMENT
(2010)
Article
Neurosciences
Simone Marcuzzo, Marcio Ferreira Dutra, Felipe Stigger, Patricia Severo do Nascimento, Jocemar Ilha, Pedro Ivo Kalil-Gaspar, Matilde Achaval
Article
Neurosciences
Felipe Stigger, Arthur L. de S. Felizzola, Glaucia A. Kronbauer, Gabriela K. Couto, Matilde Achaval, Simone Marcuzzo
EXPERIMENTAL NEUROLOGY
(2011)
Article
Developmental Biology
Felipe Stigger, Patricia S. do Nascimento, Marcio F. Dutra, Gabriela K. Couto, Jocemar Ilha, Matilde Achaval, Simone Marcuzzo
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2011)
Review
Geriatrics & Gerontology
Felipe S. Stigger, Miriam A. Zago Marcolino, Karin M. Portela, Rodrigo Della Mea Plentz
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2019)
Article
Geriatrics & Gerontology
Luiz Fernado Biazus-Sehn, Rafael Reimann Baptista, Regis Gemerasca Mestriner, Bianca Pacheco Loss, Daniela Aldabe, Felipe de Souza Stigger
Summary: This study aims to evaluate the effect of dual tasking on spatiotemporal gait parameters of older adults. It found that gait speed and cadence were strongly affected by cognitive dual tasking, while stride length remained relatively unchanged. In the curved phase, participants adopted a cautious gait where maintenance of stability took preference over efficiency.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2022)