Article
Environmental Sciences
Yu Wei, Wenfeng Geng, Taifa Zhang, Huan He, Jinxia Zhai
Summary: This study aimed to evaluate the protective effects of N-acetylcysteine (NAC) on meiotic arrest in spermatocytes and decreased sperm quality in BDE-209-exposed mice. The results showed that pretreatment with NAC attenuated the oxidative stress status induced by BDE-209, improved testicular histology and sperm quality, and enhanced DNA damage repair. Therefore, NAC may have a protective effect against the spermatogenesis dysfunction caused by BDE-209.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Shiyao Sun, Yuhong Jin, Junhua Yang, Zhihui Zhao, Qinxiong Rao
Summary: The study showed that exposure to BDE-209 can cause nephrotoxicity in broilers through oxidative stress and inflammation, which activate the phosphorylation of key proteins of the MAPK signaling pathways, and subsequently induce mitochondria-mediated kidney apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Yin Shi, Shengfeng Xu, Natalie Y. L. Ngoi, Qi Zeng, Zu Ye
Summary: Hypoxia in the tumor microenvironment, causing excessive ROS and genomic instability, is a hallmark of cancer contributing to self-renewal, metastasis, and therapy resistance. PRL-3, an oncoprotein, has been found to regulate apoptosis resistance by negatively affecting p38 MAPK activity in response to hypoxia stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Toxicology
Yanan Li, Huiming Yang, Huiming Nong, Fan Wang, Yajie Wang, Yue Xu, Junhong Zhang, Hao Zhao, Zhixin Cao, Qianqian Yang, Jianfeng Li
Summary: The expression of HMGCR in cochlear hair cells and HEI-OC1 cells and its role in cisplatin-induced ototoxicity were studied. HMGCR was found to be widely expressed in auditory cells and exerted a protective effect against cisplatin-induced ROS injury, regulating p38 MAPK-dependent apoptosis and autophagy.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Weike Shaoyong, Wanrong Zhang, Chenyang Wang, Zhongyun Kou, Wenlong Yong, Junheng Jiao, Wenyong Yan, Weijun Pang
Summary: The study found that exposure to BDE-209 resulted in reduced body weight, intestinal oxidative stress, apoptosis, autophagy, and inflammation in mice, as well as decreased intestinal mucus barrier and increased gut permeability. Furthermore, BDE-209 lowered levels of intestinal short-chain fatty acids. NAC attenuated the effects of BDE-209 on gut toxicity through the oxidative stress pathway.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Ming-Fang Wu, Yen-Hsiang Huang, Ling-Yen Chiu, Shur-Hueih Cherng, Gwo-Tarng Sheu, Tsung-Ying Yang
Summary: Curcumin induces apoptosis in chemoresistant lung cancer cells through generation of ROS, and p38 MAPK is identified as a crucial signaling pathway for this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Pinaki Chaudhuri, Priya Putta, Michael A. Rosenbaum, Linda M. Graham
Summary: Endothelial cell migration is crucial for repairing monolayer disruption after angioplasties, but it is inhibited by lipid oxidation products like lysophosphatidylcholine (lysoPC). LysoPC activates phospholipase A2 to release arachidonic acid (ArA), which then activates arachidonic acid-regulated calcium (ARC) channels formed by STIM1, Orai1, and Orai3 proteins.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Zhu Zhang, Wen-qing Chen, Shi-qing Zhang, Jing-xuan Bai, Bin Liu, Ken Kin-Lam Yung, Joshua Ka-Shun Ko
Summary: The study revealed that isoliquiritigenin (ISL) inhibited the progression of pancreatic cancer by blocking autophagy through the p38 MAPK signaling pathway.
Article
Environmental Sciences
Weijue Liu, Sihao Li, Qing Zhou, Zhushan Fu, Pinya Liu, Xiyue Cao, Shuhua Xi
Summary: BDE-47 impairs placental angiogenesis by inhibiting cell migration and invasion, and induces placental toxicity by inhibiting proliferation, increasing apoptosis and autophagy. In vitro, activation of the p38 MAPK signaling pathway is involved in the processes of placental injury caused by BDE-47.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell Biology
Fabrizio Fontana, Monica Marzagalli, Michela Raimondi, Valentina Zuco, Nadia Zaffaroni, Patrizia Limonta
Summary: The study found that Vitamin E-derived delta-tocotrienol can induce G1 phase cell cycle arrest and mitochondrial apoptosis in ovarian cancer cells. Additionally, the proapoptotic activity of delta-TT was found to be correlated with mitochondrial ROS production and subsequent activation of JNK and p38. Furthermore, it was observed that delta-TT can synergize with cisplatin, enhancing its cytotoxicity and re-sensitizing ovarian cancer cells to its anti-tumor effects.
CELL PROLIFERATION
(2021)
Article
Environmental Sciences
Xiangyang Li, Jianhui Liu, Guiqing Zhou, Yujian Sang, Yue Zhang, Li Jing, Zhixiong Shi, Xianqing Zhou, Zhiwei Sun
Summary: This study found that both BDE-209 and DBDPE can cause testicular damage, decrease sperm quantity and motility, increase sperm malformation rates, and induce cell senescence and apoptosis in rat testis by shortening telomere length and reducing telomerase activity. BDE-209 had more severe effects on male reproduction compared to DBDPE.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Takuya Nagai, Tomohisa Sekimoto, Syuji Kurogi, Tomomi Ohta, Shihoko Miyazaki, Yoichiro Yamaguchi, Takuya Tajima, Etsuo Chosa, Mai Imasaka, Kumiko Yoshinobu, Kimi Araki, Masatake Araki, Narantsog Choijookhuu, Katsuaki Sato, Yoshitaka Hishikawa, Taro Funamoto
Summary: This study reveals that Tmem161a is a crucial regulator in bone structure and function. Depletion of Tmem161a leads to thicker and stronger bones in mice.
SCIENTIFIC REPORTS
(2023)
Review
Multidisciplinary Sciences
El-Shaimaa A. Arafa, Mohamed S. Refaey, Omnia A. M. Abd El-Ghafar, Emad H. M. Hassanein, Ahmed M. Sayed
Summary: Research has shown that certain ginsenosides have therapeutic potential in downregulating p38 MAPK signaling, leading to their pharmacological benefits in various ailments. Studies on individual ginsenosides have focused on their specific molecular mechanisms of action, rather than the effects of whole-plant extracts.
Article
Biochemistry & Molecular Biology
Lanlan Zhu, Fei Xu, Xiuhua Kang, Jing Zhou, Qinqin Yao, Yang Lin, Wei Zhang
Summary: This study demonstrates that NAC inhibits pulmonary fibrosis in COPD by suppressing the VWF/p38 MAPK axis, promoting immune response, and inhibiting epithelial-mesenchymal transformation (EMT).
MOLECULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Hyun-Soo Park, Joo-Hui Han, Jeong Won Park, Do-Hyung Lee, Keun-Woo Jang, Miji Lee, Kyung-Sun Heo, Chang-Seon Myung
Summary: The study found that sodium propionate (SP) inhibits proliferation and induces apoptosis in breast cancer cells by inhibiting JAK2/STAT3 signaling, increasing ROS levels, and activating p38 MAPK.
ACTA PHARMACOLOGICA SINICA
(2021)