Article
Obstetrics & Gynecology
Lea L. H. Lunddorf, Andreas Ernst, Nis Brix, Linn H. Arendt, Stine L. Andersen, Jorn Olsen, Cecilia H. Ramlau-Hansen
Summary: This study found indications of earlier pubertal development in sons of mothers with hyperthyroidism. Further research is needed to investigate the observed sex-specific association.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Jakob Skov, Jan Calissendorff, Daniel Eriksson, Patrik Magnusson, Olle Kampe, Sophie Bensing, Ralf Kuja-Halkola
Summary: Hashimoto's thyroiditis (HT) and Graves' disease (GD) have a modest genetic relationship, with genetic factors playing a more significant role in men's susceptibility to HT compared to women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Kosuke Inoue, Rong Guo, Martin L. L. Lee, Ramin Ebrahimi, Natalia V. V. Neverova, Jesse W. W. Currier, Muhammad T. T. Bashir, Angela M. M. Leung
Summary: This retrospective cohort study using the U.S. Veterans Health Administration database found an association between iodine exposure and increased risk of thyroid dysfunction, particularly in men.
Review
Medicine, General & Internal
Federica Gagliardi, Enke Baldini, Eleonora Lori, Silvia Cardarelli, Daniele Pironi, Augusto Lauro, Domenico Tripodi, Piergaspare Palumbo, Eleonora D'Armiento, Giuseppe Cavallaro, Andrea Polistena, Valerio D'Orazi, Simone Sibio, Poupak Fallahi, Alessandro Antonelli, Vito D'Andrea, Salvatore Ulisse, Salvatore Sorrenti
Summary: Benign and malignant thyroid diseases are linked to the occurrence of extrathyroidal malignancies, including colorectal cancers. Understanding the relationship between these diseases can provide insights into their etiology and/or progression, as well as potential shared genetic and environmental factors. Exploring the underlying molecular mechanisms can lead to improved clinical management and increased surveillance for patients with thyroid diseases at a higher risk of developing extrathyroidal malignancies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Hossein Khaleghzadeh-Ahangar, Anis Talebi, Parvaneh Mohseni-Moghaddam
Summary: This article investigates the association between thyroid disturbances and cognitive dysfunction, particularly in relation to dementia. It summarizes the reported mechanisms by which hypothyroidism and hyperthyroidism contribute to the pathogenesis of dementia.
NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Gloria Tena Vivo, Neus Parellada Esquius, Oriol Cunillera Puertolas, Merce Albareda Riera, Monica Isidro Albaladejo, Lluis Vila Ballester
Summary: This study examined the prevalence of known thyroid disorders and hypothyroidism before pregnancy in Catalonia, Spain between 2014 and 2016. The findings showed that a significant number of women with thyroid disorders were not properly monitored during the year before pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Sewon Bann, Anne Nguyen, Sabrina Gill, Julia Raudzus, Daniel T. Holmes, Sam M. Wiseman
Summary: This study aimed to estimate the prevalence of lithium-associated thyroid and parathyroid disorders in British Columbia, Canada, and determine physician approaches to screening and management. Retrospective data collection and surveys were conducted on patients with lithium levels measured at seven hospitals. Results showed a lower usage of biochemical screening for parathyroid disorders compared to thyroid disorders, highlighting the need for updated clinical guidelines.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Laura Endres, Delia Mirela Tit, Simona Bungau, Nicoleta Anamaria Pascalau, Laura Maghiar Todan, Erika Bimbo-Szuhai, Gabriela Mariana Iancu, Nicoleta Negrut
Summary: The study revealed a positive correlation between autoimmune thyroiditis and the incidence of acne, with patients with AIT more likely to have severe acne. Elevated levels of anti-TPO and anti-TG antibodies increased the risk of developing severe acne in patients with AIT.
Review
Endocrinology & Metabolism
Vicente A. Benites-Zapata, Felipe L. Ignacio-Cconchoy, Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Ali Al-kassab-Cordova, Percy Herrera-Anazco
Summary: This study reviewed existing studies to assess differences in serum vitamin B12 levels among patients with and without thyroid disorders (TD), frequency of vitamin B12 deficiency, and presence of anti-parietal cell antibodies in TD patients. Results showed that patients with hypothyroidism had lower vitamin B12 levels compared to healthy participants, while no significant differences were observed in patients with hyperthyroidism, autoimmune thyroid disease (AITD), or subclinical hypothyroidism (SH). The frequencies of vitamin B12 deficiency were 27%, 6%, 27%, and 18% for hypothyroidism, hyperthyroidism, SH, and AITD respectively.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sam Aiyad Ali, Mads Ersboll, Naja Emborg Vinding, Jawad Haider Butt, Rasmus Rorth, Christian Selmer, Lucas Malta Westergaard, Ulrik Madvig Mogensen, Peter E. Weeke, Christian Jons, Finn Gustafsson, Emil Fosbol, Lars Kober, Soren Lund Kristensen
Summary: The incidence of thyroid dysfunction is around 5% in patients initiating amiodarone treatment, with a slightly higher incidence in those with heart failure. There is a dose-response relationship between the accumulated dose of amiodarone and the cumulative incidence of thyroid dysfunction.
Review
Medicine, General & Internal
Aina Torrejon-Moya, Keila Izquierdo-Gomez, Mario Perez-Sayans, Enric Jane-Salas, Antonio Mari Roig, Jose Lopez-Lopez
Summary: This systematic review evaluates the relationship between thyroid disorders and dental implant rehabilitation, and concludes that patients with thyroid disorders can undergo dental implant rehabilitation with similar survival rates as patients without thyroid disorders. Further studies with higher scientific evidence and larger sample sizes are needed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Lin Zhou, Kang Song, Wei Luo
Summary: This study aimed to evaluate the association between resistin levels and thyroid dysfunction and explore the variations in resistin levels before and after treatment. The results confirmed that resistin levels were significantly higher in patients with thyroid dysfunction compared to euthyroid controls. After treatment, resistin levels decreased significantly in patients with thyroid dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Linghuan Wang, Binqi Li, He Zhao, Peixin Wu, Qingzhen Wu, Kang Chen, Yiming Mu
Summary: This systematic review and meta-analysis evaluated the incidence, evaluation, and management of interferon and endocrine side effects. The study found a higher incidence of hypothyroidism and hyperthyroidism in patients treated with interferon, particularly in combination with ribavirin.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ewa Szczepanska, Piotr Glinicki, Wojciech Zgliczynski, Jadwiga Slowinska-Srzednicka, Helena Jastrzebska, Malgorzata Gietka-Czernel
Summary: This study aimed to investigate the influence of thyroid hormones and metabolic changes secondary to thyroid dysfunction on FGF21 secretion. The results showed a transient increase in FGF21 serum level during rapid-onset hypothyroidism following radioiodine treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Juliane Leger, Clemence Delcour, Jean-Claude Carel
Summary: This article discusses the diagnosis and management of fetal and neonatal thyroid dysfunctions, including congenital hypothyroidism, autoimmune hyperthyroidism, and other rare disorders. Early diagnosis and treatment are crucial in preventing irreversible neurodevelopmental delay.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Chemistry, Multidisciplinary
Osama M. Ahmed, Adel A. Ahmed, Hanaa Fahim, Mohamed Y. Zaky
Summary: This study demonstrates that quercetin and naringenin may alleviate hepatocarcinogenesis through enhancement of anti-inflammatory, antioxidant, and apoptotic actions.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gaber Ali, Hany Omar, Fatema Hersi, Amira Abo-Youssef, Osama Ahmed, Wafaa Mohamed
Summary: This study aimed to investigate the chemopreventive effect of etoricoxib on DENA/2AAF-induced HCC in male Wistar rats. The results demonstrated that etoricoxib possesses an anticancer effect through its antioxidant, anti-inflammatory, and modulation of NF-KB/COX-2/PGE2 signaling.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Nour Y. S. Yassin, Sameh F. AbouZid, Asmaa M. El-Kalaawy, Tarek M. Ali, Mazen M. Almehmadi, Osama M. Ahmed
Summary: The study evaluated the anticancer efficacy of Silybum marianum extract, silymarin, and silibinin against experimentally-induced hepatocellular carcinoma in rats, showing inhibition of cancerous lesions and improvement in liver function biomarkers. The treatment also inhibited Ki-67 expression and suppressed multiple signaling pathways while enhancing antioxidant defense mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Osama M. Ahmed, Hanaa I. Fahim, Eman E. Mohamed, Adel Abdel-Moneim
Summary: This study demonstrates that avocado extracts can attenuate hepatocarcinogenesis in rats administered DEN/2AAF through the activation of antioxidant, anti-inflammatory, and apoptotic properties.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cell Biology
Osama M. Ahmed, Sanaa R. Galaly, Mennah-Allah M. A. Mostafa, Emad M. Eed, Tarek M. Ali, Alzhraa M. Fahmy, Mohamed Y. Zaky
Summary: Thyme oil and thymol successfully counteracted doxorubicin-induced hepatotoxicity through their antiinflammatory, antioxidant, and antiapoptotic properties.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Asmaa S. Zaky, Mohamed Kandeil, Mohamed Abdel-Gabbar, Eman M. Fahmy, Mazen M. Almehmadi, Tarek M. Ali, Osama M. Ahmed
Summary: This study aimed to assess the effect and mechanism of action of aqueous extracts of Balanites aegyptiaca fruits and seeds on anti-hyperglycemic and anti-hyperlipidemic effects in nicotinamide/streptozotocin-induced diabetic rats. The extracts showed potential anti-hyperglycemic and anti-hyperlipidemic effects by increasing serum insulin levels, reducing insulin resistance, and enhancing the antioxidant defense system.
Article
Environmental Sciences
Manal N. Abdel Azeem, Osama M. Ahmed, Mohamed Shaban, Khaled N. M. Elsayed
Summary: This study aims to develop seaweed-based silver nanoparticles as therapeutic agents, and the results show their remarkable potential in free radical scavenging, anticancer, and anti-inflammatory activities. The synthesized Ag-NPs exhibited unique mechanical and physicochemical properties, and demonstrated significant inhibitory effects on human liver carcinoma cells, indicating their promising biomedical applications.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Nagwa G. Tawfik, Wafaa R. Mohamed, Hanan S. Mahmoud, Mohammed A. Alqarni, Ibrahim A. Naguib, Alzhraa M. Fahmy, Osama M. Ahmed
Summary: Isatin has shown potential in preventing liver tumor formation in experimental rats by enhancing cellular antioxidant, anti-inflammatory, and detoxification mechanisms, partly through upregulation of the Nrf2 signaling pathway.
Article
Health Care Sciences & Services
Salma A. El Kazafy, Yasser M. Fouad, Azza F. Said, Hebatallah H. Assal, Amr E. Ahmed, Ahmad El Askary, Tarek M. Ali, Osama M. Ahmed
Summary: The aim of this study was to assess the relationship between serum cytokine levels and pulmonary dysfunctions in individuals with COVID-19. The results showed that COVID-19 patients had increased levels of white blood cells (WBCs) and cytokines compared to healthy controls. Severe COVID-19 patients had lower lymphocyte counts and higher levels of IL-6, which was the most potent predictor of COVID-19 progress and severity.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Chemistry, Medicinal
Hesham M. Sayed, Ashraf S. Awaad, Fatma El-Zahraa S. Abdel Rahman, M. Al-Dossari, N. S. Abd El-Gawaad, Osama M. Ahmed
Summary: The purpose of this study was to investigate the effects of chrysin and/or bone marrow-derived mesenchymal stem cells (BM-MSCs) on streptozotocin (STZ)/nicotinamide (NA)-induced diabetic rats. The results showed that the combination of chrysin and BM-MSCs significantly improved the previously deteriorated alterations in diabetic rats, with the best therapeutic effect observed when they were used together.
Article
Chemistry, Medicinal
Eman E. Mohamed, Osama M. Ahmed, Adel Abdel-Moneim, Khairy M. A. Zoheir, Basem H. Elesawy, Ahmad Al Askary, Ahmed Hassaballa, Ahmed A. G. El-Shahawy
Summary: This study found that naringin-dextrin nanoparticles (NDNPs) have antioxidant and anti-inflammatory effects against hepatocellular carcinoma (HCC) and can inhibit tumor cell growth. Compared to pure naringin, NDNP showed better anti-tumor efficacy.
Article
Chemistry, Medicinal
Osama M. Ahmed, Ablaa S. Saleh, Eman A. Ahmed, Mohammed M. Ghoneim, Hasnaa Ali Ebrahim, Mohamed A. Abdelgawad, Mohammed Abdel-Gabbar
Summary: This study aimed to evaluate the effectiveness of bone marrow-derived mesenchymal stem cells (BM-MSCs) and hesperetin in treating a rat model of Type 1 diabetes mellitus (T1DM). The results showed that the use of hesperetin and BM-MSCs significantly improved glycemic control, insulin secretion, and pancreatic islet architecture, as well as decreased hepatic glucose output in diabetic rats. These effects may be mediated through their antioxidant, anti-inflammatory, and antiapoptotic actions.
Article
Biology
Asmaa K. Hassan, Asmaa M. El-Kalaawy, Sanaa M. Abd El-Twab, Mohamed A. Alblihed, Osama M. Ahmed
Summary: The study evaluates the anti-carcinogenic effects of hesperetin (HES) alone and in combination with capecitabine (CAP) on DMH-induced colon carcinogenesis in rats. The results show that treatment with HES and/or CAP prevents colon cancer development, reduces cell proliferation, and enhances apoptosis. Additionally, the treatments decrease oxidative stress and inflammation in the colon tissue. Therefore, HES and CAP have potential chemopreventive effects against colon cancer.
Article
Oncology
Eman E. Mohamed, Osama M. Ahmed, Khairy M. A. Zoheir, Ahmed A. G. El-Shahawy, Shadi Tamur, Anwar Shams, Jack T. Burcher, Anupam Bishayee, Adel Abdel-Moneim
Summary: Despite advancements in the field, lung malignancies are still the primary cause of cancer-attributable morbidity and mortality globally. This study found that naringin-dextrin nanocomposites (Nar-Dx-NCs) improved the preventive action of naringin against lung cancer by suppressing oxidative stress, inflammation, and cell proliferation, and activating apoptosis.
Article
Medicine, General & Internal
Raoni Conceicao Dos-Santos, Claudio da Silva-Almeida, Bruno Guimaraes Marinho, Rodrigo Rodrigues da Conceicao, Wellington da Silva Cortes, Ragab Gaber Ahmed, Roberto Laureano-Melo
Summary: Perinatal manipulation of the nitrergic system may affect adult animal behaviors. Blocking perinatal nitric oxide production decreases anxiety- and depression-like behaviors in adult mice, without significant effects on locomotor activity and pain perception.
EINSTEIN-SAO PAULO
(2023)