Article
Chemistry, Medicinal
Javier R. Balboa, Dominik J. Essig, Sana Ma, Nichlas Karer, Louise S. Clemmensen, Soren W. Pedersen, Andreas C. Joerger, Stefan Knapp, Soren Ostergaard, Kristian Stromgaard
Summary: The complex of NMDAR, nNOS, and PSD-95 is an important therapeutic target for acute ischemic stroke. By designing a cyclic nNOS β-hairpin mimetic peptide and generating peptide arrays, a potent inhibitor of the nNOS/PSD-95 interaction was identified.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Neurosciences
Kara A. Lau, Xin Yang, Mengia S. Rioult-Pedotti, Stephen Tang, Mark Appleman, Jianan Zhang, Yuyang Tian, Caitlin Marino, Mudi Yao, Qin Jiang, Ayumi C. Tsuda, Yu-Wen Alvin Huang, Cong Cao, John Marshall
Summary: Angelman Syndrome (AS) is a severe cognitive disorder caused by loss of neuronal expression of the E3 ubiquitin ligase UBE3A. Researchers have found that a peptidomimetic compound called CN2097, which binds to the TrkB-associated scaffolding protein PSD-95, can restore synaptic plasticity and learning deficits in AS mice. CN2097 normalizes autophagy and restores synaptic protein levels, leading to improvements in cognitive and motor function.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Neurosciences
Anna Caly, Malgorzata A. Sliwinska, Magdalena Ziolkowska, Kacper Lukasiewicz, Roberto Pagano, Jakub M. Dzik, Katarzyna Kalita, Tytus Bernas, Michael G. Stewart, K. Peter Giese, Kasia Radwanska
Summary: A study using IntelliCage examined the behavioral processes supporting spatial choices of aged female mice living in a group, finding that old animals use behavioral strategies characterized by an increased tendency for perseverative visits and social interactions, resulting in a robust preference for the reward corner during the spatial choice task.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Shan Liu, Jiang Wang, Shanshan Li, Lihui Cai
Summary: This paper explores the significance of periodic and aperiodic components in the power spectrum of EEG signals for epilepsy detection and prediction. It concludes that aperiodic neural activity plays a decisive role in classification.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Behavioral Sciences
Wen-Jun Gao, Nancy R. Mack
Summary: PSD-95 knockout mice exhibit hyposociability during adolescence but hypersociability in adulthood, with the adolescent deficiency accompanied by NMDAR hyperfunction in the mPFC and delayed mPFC maturation until adulthood.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yonghong Zhang, Xiaoqian Fang, Luis Ascota, Libo Li, Lili Guerra, Audrey Vega, Amanda Salinas, Andrea Gonzalez, Claudia Garza, Andrew Tsin, Johannes W. Hell, James B. Ames
Summary: Chemical synaptic transmission is a highly regulated process and imbalanced neurotransmitters can lead to impairments. PSD-95 plays a crucial role in synaptic development and maturation, and its interaction with zinc may influence its postsynaptic membrane association and palmitoylation.
Article
Biochemistry & Molecular Biology
Nicole Zarate, Taylor A. Intihar, Dahyun Yu, Jacob Sawyer, Wei Tsai, Maha Syed, Luke Carlson, Rocio Gomez-Pastor
Summary: PSD-95 levels are reduced in aging and neurodegenerative diseases like Huntington's disease, along with depletion of Heat Shock transcription Factor 1 (HSF1). HSF1 directly regulates PSD-95 expression, playing a crucial role in synaptic gene regulation with implications in synapse maintenance under both basal and pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Euan Parnell, Roos A. A. Voorn, M. Dolores Martin-de-Saavedra, Daniel D. D. Loizzo, Marc Dos Santos, Peter Penzes
Summary: In this study, a Kalirin-7 missense mutation associated with severe developmental delay was identified. The mutation resulted in reduced Kalirin-7 function, leading to impaired neuroarchitecture and connectivity, which may contribute to developmental delay in the patient.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Sara Ayuso-Dolado, Gema M. Esteban-Ortega, Oscar G. Vidaurre, Margarita Diaz-Guerra
Summary: Postsynaptic density protein-95 (PSD-95) is critical for signaling complex assembly at excitatory synapses and interference of its processing by excitotoxicity could be a promising therapeutic target for stroke and other excitotoxicity-associated pathologies.
Article
Multidisciplinary Sciences
Louise Laursen, Raviteja Inturi, Soren Ostergaard, Per Jemth
Summary: This study investigated the interaction between the PSG supramodule and other proteins in the post-synaptic density using bioinformatics and biophysical methods. The results showed that the PDZ3 domain had specific binding with peptides, and mutations in PDZ3 could affect the affinity and specificity of the interaction. Additionally, the study found that the ADGRB1 protein formed liquid droplets with the PSG supramodule, providing new insights into PSD formation.
Article
Cell Biology
Yuanyuan Zhu, Rui Wang, Ze Fan, Danlei Luo, Guohong Cai, Xinyang Li, Jiao Han, Lixia Zhuo, Li Zhang, Haifeng Zhang, Yan Li, Shengxi Wu
Summary: Abnormal amino acid metabolism in neural cells is associated with major depressive disorder. Taurine levels were significantly reduced in the extracellular fluid of the cerebral medial prefrontal cortex in mice with chronic social defeat stress-induced depression. Taurine supplementation can serve as an intervention for depression by protecting cortical neurons from synaptic protein deficits and dendritic spine loss.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Emran Hossen, Yasuhiro Funahashi, Md. Omar Faruk, Rijwan Uddin Ahammad, Mutsuki Amano, Kiyofumi Yamada, Kozo Kaibuchi
Summary: Rho-kinase phosphorylates PSD-93 downstream of NMDARs, increasing its association with PSD-95 and NMDARs to regulate structural synaptic plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Stachowicz
Summary: PSD-95 is a crucial component of excitatory synapses and plays a role in synaptic plasticity. Its involvement in the side effects of antidepressants related to cognitive function and psychosis is being explored. Understanding the mechanisms of action of compounds with antidepressant potential, such as PSD-95, can aid in the development of safer drugs.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Immunology
Lian Liu, Luqi Dai, Dan Xu, Yinchan Wang, Lin Bai, Xiaoting Chen, Mengzhou Li, Shuai Yang, Yuying Tang
Summary: The dysfunction of glutamatergic synaptic plasticity in the basolateral amygdala is a critical mechanism underlying depression-like behaviors induced by chronic pain. Peripheral spared nerve injury (SNI) activated astrocytes to release IL-6 in the BLA, promoting PSD-95 palmitoylation and enhancing the synaptic trafficking of GluR1 and NR2B, which subsequently mediated the depression-like behaviors induced by nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Cell Biology
Anagh Sinha Ravi, Menglong Zeng, Xudong Chen, Gerardo Sandoval, Javier Diaz-Alonso, Mingjie Zhang, Roger A. Nicoll
Summary: Recent research suggests that the TARP/PSD-95 complex is an essential interaction underlying AMPAR trafficking and LTP. The interaction between PSD-95 and AMPAR auxiliary subunits TARPs can capture AMPARs and enhance synaptic transmission and LTP.
Article
Genetics & Heredity
Qian Jiang, Fang Liu, Chunyue Miao, Qi Li, Zhen Zhang, Ping Xiao, Lin Su, Kaihui Yu, Xiaoli Chen, Feng Zhang, Aravinda Chakravarti, Long Li
GENETICS IN MEDICINE
(2018)
Article
Genetics & Heredity
Zhijie Gao, Hua Xie, Qian Jiang, Nan Wu, Xiaoli Chen, Qian Chen
BMC MEDICAL GENETICS
(2018)
Article
Neurosciences
Xiao-Zhen Liu, Qin Zhang, Qian Jiang, Bao-Ling Bai, Xiao-Juan Du, Fang Wang, Li-Hua Wu, Xiao-Lin Lu, Yi-Hua Bao, Hui-Li Li, Ting Zhang
CNS NEUROSCIENCE & THERAPEUTICS
(2018)
Letter
Genetics & Heredity
Qian Jiang, Xiaoli Chen, Feng Zhang, Aravinda Chakravarti, Long Li
GENETICS IN MEDICINE
(2018)
Editorial Material
Gastroenterology & Hepatology
Ya Ma, Qian Jiang, Zhengrong Wang
Article
Genetics & Heredity
Qian Jiang, Yang Wang, Qi Li, Zhen Zhang, Ping Xiao, Hui Wang, Na Liu, Jian Wu, Feng Zhang, Aravinda Chakravarti, Wei Cai, Long Li
ORPHANET JOURNAL OF RARE DISEASES
(2019)
Article
Genetics & Heredity
Hui Wang, Qi Li, Zhen Zhang, Ping Xiao, Long Li, Qian Jiang
FRONTIERS IN GENETICS
(2019)
Article
Cell Biology
Yang Wang, Qian Jiang, Hao Cai, Ze Xu, Wenjie Wu, Beilin Gu, Long Li, Wei Cai
Article
Genetics & Heredity
Yang Wang, Qian Jiang, Aravinda Chakravarti, Hao Cai, Ze Xu, Wenjie Wu, Beilin Gu, Long Li, Wei Cai
JOURNAL OF MEDICAL GENETICS
(2020)
Article
Surgery
Qi Li, Zhen Zhang, Qian Jiang, Yuchun Yan, Ping Xiao, Ya Ma, Long Li
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2020)
Article
Pediatrics
Lihua Wu, Ping Xiao, Qi Li, Zhen Zhang, Hui Wang, Qian Jiang, Long Li
PEDIATRIC SURGERY INTERNATIONAL
(2020)
Article
Genetics & Heredity
Lu Han, Zhen Zhang, Hui Wang, Hui Song, Qing Gao, Yuchun Yan, Ran Tao, Ping Xiao, Long Li, Qian Jiang, Qi Li
ORPHANET JOURNAL OF RARE DISEASES
(2020)
Article
Genetics & Heredity
Qian Jiang, Yang Wang, Yang Gao, Hui Wang, Zhen Zhang, Qi Li, Shuhua Xu, Wei Cai, Long Li
Summary: Hirschsprung disease is a neurocristopathy caused by genetic defects, with research showing that in Chinese population, a significant portion of HSCR families exhibit compound inheritance of rare and common variants at the RET locus. Common RET variants may modify the penetrance of rare null RET mutations in HSCR.
Review
Pediatrics
Zhen Zhang, Bo Li, Qian Jiang, Qi Li, Agostino Pierro, Long Li
Summary: Hirschsprung disease (HSCR) is a congenital intestinal disorder characterized by a lack of ganglion cells in the colon. Hirschsprung-associated enterocolitis (HAEC) is a serious complication of HSCR, but its causes and mechanisms are still not well understood. Various factors, including the mucus barrier, microbiota, immune function, colon obstruction, and genetic variations, have been associated with HAEC. Current research on HAEC largely focuses on mouse models and offers potential insights for future treatments.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Genetics & Heredity
Lihua Wu, Jianhong Wang, Lei Wang, Qi Xu, Bo Zhou, Zhen Zhang, Qi Li, Hui Wang, Lu Han, Qian Jiang, Lin Wang
Summary: This study provides detailed knowledge about the clinical manifestations, genetic spectrum, and physical, language, neurodevelopment features and genotype-phenotype correlations of Chinese patients with Mowat-Wilson syndrome (MWS). The study found that all patients had lower height and weight, and some had microcephaly. Patients performed better in cognitive play and social communication than in receptive and expressive language.
FRONTIERS IN GENETICS
(2022)
