期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷 56, 期 5, 页码 377-383出版社
U B C PRESS
DOI: 10.1387/ijdb.113416bu
关键词
Sox gene; lamprey; cyclostome; neural crest
资金
- NIH [DE017911]
- MRC [G0902418] Funding Source: UKRI
- Medical Research Council [G0902418] Funding Source: researchfish
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE017911] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS086907] Funding Source: NIH RePORTER
Members of the Sox (Sry-related high mobility group box) family of transcription factors play a variety of roles during development of both vertebrates and invertebrates. A marked expansion in gene number occurred during the emergence of vertebrates, apparently via gene duplication events that are thought to have facilitated new functions. By screening a macroarrayed library as well as the lamprey genome, we have isolated genes of the Sox B, D, E and F subfamilies in the basal jawless vertebrate, lamprey. The expression patterns of all identified Sox genes were examined from gastrulation through early organogenesis (embryonic day 4-14), with particular emphasis on the neural crest, a vertebrate innovation. Coupled with phylogenetic analysis of these Sox genes, the results provide insight into gene duplication and divergence in paralog deployment occurring during early vertebrate evolution.
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