Review
Biochemistry & Molecular Biology
Karolina Wolodko, Juan Castillo-Fernandez, Gavin Kelsey, Antonio Galvao
Summary: Maternal obesity can lead to impaired leptin signaling, resulting in high levels of estrogen and leptin in the bloodstream, which adversely affects ovarian function. This review highlights the potential impact of impaired leptin signaling on folliculogenesis and oocyte developmental competence in both mice and women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mengchi Chen, Haotian Jiang, Chunping Zhang
Summary: Primary ovarian insufficiency (POI) is a heterogeneous disease characterized by non-functional ovaries in women under 40. Genetic factors play a crucial role in POI cases, accounting for around 20% to 25%. This paper reviews various genetic causes of POI, including chromosomal abnormalities, single gene mutations, defects in mitochondrial functions, and non-coding RNA abnormalities, providing valuable insights for diagnosing and predicting POI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Leonie Dopavogui, Florence Cadoret, Gaspard Loison, Sara El Fouikar, Francois-Xavier Frenois, Frank Giton, Sandrine Ellero-Simatos, Frederic Lasserre, Arnaud Polizzi, Clemence Rives, Nicolas Loiseau, Roger D. Leandri, Nicolas Gatimel, Laurence Gamet-Payrastre
Summary: Female infertility has a multifactorial origin, and exposure to contaminants, including pesticides, is considered to be involved in this reproductive disorder. This study found that exposure to a common pesticide mixture can disrupt folliculogenesis in mice, leading to abnormal ovarian structure and changes in hormone levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yingjun Chen, Qinghua Liu, Ruiyan Liu, Chan Yang, Xiaodong Wang, Zaohong Ran, Shanshan Zhou, Xiang Li, Changjiu He
Summary: This study in a mouse model revealed that early folliculogenesis requires a minimum of two weeks, with different stages showing specific characteristics such as oocyte size at Type 4-5 stage and theca folliculi formation at PD10-12. The study also highlighted the importance of the PD22-23 period for studying puberty initiation, providing valuable insights into the biological events of this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Reproductive Biology
Shinichiro Shirouzu, Naohiro Sugita, Narantsog Choijookhuu, Yu Yamaguma, Kanako Takeguchi, Takumi Ishizuka, Mio Tanaka, Fidya Fidya, Kengo Kai, Etsuo Chosa, Yoshihiro Yamashita, Chihiro Koshimoto, Yoshitaka Hishikawa
Summary: This study revealed the essential role of HMGB2 in ovarian folliculogenesis and fertilization, with its depletion leading to alterations in ovarian morphology and function.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Veterinary Sciences
Renato F. Silva, Laritza F. Lima, Rebeca M. P. Rocha, Ivina R. Brito, Gerlane M. Silva, Hudson H. Correia, Giovanna Q. Rodrigues, Anna C. A. Ferreira, Diana C. S. Nunes-Pinheiro, Arlindo A. A. N. Moura, Larissa B. R. Silveira, Edson G. Lo Turco, Matthew B. Wheeler, Ana P. R. Rodrigues, Claudio C. Campello, Jose R. Figueiredo
Summary: Ethanol treatment increased degeneration rates of follicles and oocytes, but led to higher estradiol secretion and meiotic resumption. It decreased mRNA levels of certain genes but increased others. The metabolomic profiles of follicles were similar between ethanol and rbFSH treatments, different from the Control treatment.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Agriculture, Dairy & Animal Science
Amanda J. Morton, Juliana I. Candelaria, Stephanie P. McDonnell, Daniel P. Zgodzay, Anna C. Denicol
Summary: The glycoprotein FSH plays a critical role in the development of ovarian follicles, promoting growth and steroidogenesis. It has been found to have survival and growth-promoting effects in earlier-stage preantral follicles as well. Studies in rodents and domestic animals have provided evidence for the role of FSH in regulating the growth and survival of preantral follicles. Further research in this area could lead to the development of more effective fertility programs.
Article
Reproductive Biology
Robert T. Rydze, Bethany K. Patton, Shawn M. Briley, Hannia Salazar Torralba, Gregory Gipson, Rebecca James, Aleksandar Rajkovic, Thomas Thompson, Stephanie A. Pangas
Summary: The study on Grem2 (-/-) mice shows that the lack of the BMP antagonist Grem2 leads to a complex reproductive phenotype, primarily resulting from disruptions in the hypothalamic-pituitary-ovarian axis causing irregular estrous cycles.
BIOLOGY OF REPRODUCTION
(2021)
Review
Agriculture, Dairy & Animal Science
Amanda J. Morton, Juliana I. Candelaria, Stephanie P. Mcdonnell, Daniel P. Zgodzay, Anna C. Denicol
Summary: FSH plays a crucial role in the development and growth of ovarian follicles, promoting the maturation and steroidogenic activity of the enclosed oocyte. It has been shown to have survival and growth-promoting effects in earlier-stage preantral follicles. Understanding the effects of FSH beyond antral follicle growth is important for improving fertility programs.
Article
Multidisciplinary Sciences
Abdulkarem Alrezaki, Nouf Aldawood, Shamsa Alanazi, Maria Arafah, Zuzana Fabova, Yacine Badjah, Alexander Sirotkin, Saleh Alwasel, Abdel Halim Harrath
Summary: The study found that sage extract has effects on ovarian function, with high doses increasing estradiol concentration levels and promoting follicle development while reducing the number of abnormal follicles.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Review
Cell Biology
Bikem Soygur, Diana J. Laird
Summary: The ovary is essential for female reproduction and health, but studying its function in mammals faces challenges due to unique characteristics. Advances in optical tissue clearing and 3D visualization technologies have provided a platform to explore the structure of the ovary and have potential applications in treating ovarian diseases and extending female reproductive lifespan.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Malgorzata Grzesiak, Klaudia Kapusta, Kinga Kaminska, Sylwia Palka, Michal Kmiecik, Joanna Zubel-Lojek
Summary: The study investigated the effects of dietary supplementation with nettle or fenugreek on folliculogenesis and steroidogenesis in juvenile rabbit ovaries. Nettle decreased primordial and early antral follicles, while increasing primary follicles, and fenugreek increased primary and antral follicles but decreased early antral follicles. Fenugreek also targeted steroidogenic enzymes, affecting estradiol biosynthesis and plasma concentration, potentially influencing sexual maturation in rabbits.
Review
Biochemistry & Molecular Biology
Kenya Imaimatsu, Aya Uchida, Ryuji Hiramatsu, Yoshiakira Kanai
Summary: This article discusses the mechanism of gonadal sex differentiation along the cortical-medullary axis and compares the features of the cortical and medullary regions of the ovary in mammalian species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Xuejiao Bian, Qin Xie, Yuxiao Zhou, Haibo Wu, Junqi Cui, Liling Jia, Lun Suo
Summary: The study investigated transcriptome variances and pathway enrichment during mouse folliculogenesis using RNA-seq, identifying eight master transcription factors driving folliculogenesis. The research provides novel insights into controlled ovarian stimulation in future infertility treatment.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sang Mi Lee, Min Chul Choi, Jeong Won Lee, Taehoen Kim, Su Jin Jang
Summary: Peritoneal and nodal gliomatosis is a rare disease characterized by mature glial tissue growth on the peritoneum and lymph nodes. It is often associated with teratoma and does not affect prognosis. We present a case of a 22-year-old woman with ovarian immature teratoma, where PET/CT revealed FDG uptake in the peritoneal cavity and lymph nodes, which were diagnosed as peritoneal and nodal gliomatosis.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Respiratory System
Thomas Sonnweber, Sabina Sahanic, Alex Pizzini, Anna Luger, Christoph Schwabl, Bettina Sonnweber, Katharina Kurz, Sabine Koppelstatter, David Haschka, Verena Petzer, Anna Boehm, Magdalena Aichner, Piotr Tymoszuk, Daniela Lener, Markus Theurl, Almut Lorsbach-Koehler, Amra Tancevski, Anna Schapfl, Marc Schaber, Richard Hilbe, Manfred Nairz, Bernhard Puchner, Doris Huettenberger, Christoph Tschurtschenthaler, Malte Asshoff, Andreas Peer, Frank Hartig, Romuald Bellmann, Michael Joannidis, Can Gollmann-Tepekoylu, Johannes Holfeld, Gudrun Feuchtner, Alexander Egger, Gregor Hoermann, Andrea Schroll, Gernot Fritsche, Sophie Wildner, Rosa Bellmann-Weiler, Rudolf Kirchmair, Raimund Helbok, Helmut Prosch, Dietmar Rieder, Zlatko Trajanoski, Florian Kronenberg, Ewald Woell, Gunter Weiss, Gerlig Widmann, Judith Loeffler-Ragg, Ivan Tancevski
Summary: A study found that some COVID-19 patients still experienced persistent symptoms and lung function impairment 100 days after the onset of the disease, but there was significant improvement in symptoms and cardiopulmonary status over time.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Letter
Hematology
Verena Petzer, Simon Schwendinger, David Haschka, Verena Vogi, Piotr Tymoszuk, Francesco Burkert, Sabina Sahanic, Thomas Sonnweber, Rosa Bellmann-Weiler, Judith Loeffler-Ragg, Ivan Tancevski, Johannes Zschocke, Guenter Weiss, Dominik Wolf, Emina Jukic
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Medicine, General & Internal
Alexander Hoffmann, David Haschka, Lara Valente de Souza, Piotr Tymoszuk, Markus Seifert, Laura von Raffay, Richard Hilbe, Verena Petzer, Patrizia L. Moser, Manfred Nairz, Guenter Weiss
Summary: Iron supplementation worsens the clinical course of bacterial infection in anaemic mice by increasing iron delivery to bacteria and impairing the immune response. This has important implications for iron supplementation strategies in areas with high endemic burden of infections.
Article
Cell Biology
Natascha Brigo, Christa Pfeifhofer-Obermair, Piotr Tymoszuk, Egon Demetz, Sabine Engl, Marina Barros-Pinkelnig, Stefanie Dichtl, Christine Fischer, Lara Valente De Souza, Verena Petzer, Laura von Raffay, Richard Hilbe, Sylvia Berger, Markus Seifert, Ulrike Schleicher, Christian Bogdan, Gunter Weiss
Summary: Unlike its detrimental function in infections with other intraphagosomal microorganisms, ARG1 did not support bacterial survival in systemic salmonellosis, indicating differential roles of arginine metabolism for host immune response and microbe persistence depending on the type of pathogen.
Article
Medicine, Research & Experimental
David Haschka, Piotr Tymoszuk, Verena Petzer, Richard Hilbe, Simon Heeke, Stefanie Dichtl, Sergej Skvortsov, Egon Demetz, Sylvia Berger, Markus Seifert, Anna-Maria Mitterstiller, Patrizia Moser, Dirk Bumann, Manfred Nairz, Igor Theurl, Guenter Weiss
Summary: Iron is essential for both mammals and pathogens, and inflammation-induced changes in iron metabolism play a crucial role in host defense against infections. The iron storage protein FTH in myeloid cells is important for controlling bacterial spread and modulating NF-κB and inflammasome-mediated cytokine activation.
Article
Health Care Sciences & Services
Verena Rass, Bogdan-Andrei Ianosi, Laura Zamarian, Ronny Beer, Sabina Sahanic, Anna Lindner, Mario Kofler, Alois Josef Schiefecker, Philipp Mahlknecht, Beatrice Heim, Victoria Limmert, Thomas Sonnweber, Alex Pizzini, Piotr Tymoszuk, Christoph Scherfler, Atbin Djamshidian, Stefan Kiechl, Ivan Tancevski, Klaus Seppi, Bettina Pfausler, Judith Loeffler-Ragg, Raimund Helbok
Summary: The study found that about one-third of patients experienced impaired HR-QoL 3 months after COVID-19 diagnosis. Factors associated with impaired HR-QoL included younger age, longer hospitalization, impaired sleep, and anxiety symptoms.
QUALITY OF LIFE RESEARCH
(2022)
Article
Biology
Thomas Sonnweber, Piotr Tymoszuk, Sabina Sahanic, Anna Boehm, Alex Pizzini, Anna Luger, Christoph Schwabl, Manfred Nairz, Philipp Grubwieser, Katharina Kurz, Sabine Koppelstaetter, Magdalena Aichner, Bernhard Puchner, Alexander Egger, Gregor Hoermann, Ewald Woell, Guenter Weiss, Gerlig Widmann, Ivan Tancevski, Judith Loeffler-Ragg
Summary: This study observed the respiratory and symptom recovery in COVID-19 patients during the follow-up period. The results showed that 49% of patients reported persistent symptoms at the 6-month follow-up. Structural lung abnormalities and impaired lung function were more common in severe cases. The study also found that early clinical indicators could predict the risk of incomplete pulmonary recovery.
Article
Immunology
David Haschka, Verena Petzer, Francesco Robert Burkert, Gernot Fritsche, Sophie Wildner, Rosa Bellmann-Weiler, Piotr Tymoszuk, Guenter Weiss
Summary: This study characterized the features of neutrophils and monocyte subsets in COVID-19 patients within 72 hours of hospital admission, and found that inflammation-driven neutrophil expansion, depletion of CD16(+) nonclassical monocytes, and changes in surface marker expression were associated with the severity of the infection.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Manfred Nairz, Sabina Sahanic, Alex Pizzini, Anna Boehm, Piotr Tymoszuk, Anna-Maria Mitterstiller, Laura von Raffay, Philipp Grubwieser, Rosa Bellmann-Weiler, Sabine Koppelstatter, Andrea Schroll, David Haschka, Martina Zimmermann, Silvia Blunder, Kristina Trattnig, Helene Naschberger, Werner Klotz, Igor Theurl, Verena Petzer, Clemens Gehrer, John E. Mindur, Anna Luger, Christoph Schwabl, Gerlig Widmann, Guenter Weiss, Judith Loeffler-Ragg, Ivan Tancevski, Thomas Sonnweber
Summary: The CovILD study systematically followed up COVID-19 patients and found that S-specific IgG levels are correlated with immune activation, pulmonary function, and CT abnormalities. An S-specific IgG-based recovery score accurately predicted delayed pulmonary recovery after COVID-19. Therefore, S-specific IgG levels can serve as a useful immunological surrogate marker.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Christine Fischer, Lara Valente de Souza, Timea Komlodi, Luiz F. Garcia-Souza, Chiara Volani, Piotr Tymoszuk, Egon Demetz, Markus Seifert, Kristina Auer, Richard Hilbe, Natascha Brigo, Verena Petzer, Malte Asshoff, Erich Gnaiger, Gunter Weiss
Summary: Iron is essential for metabolism and its deficiency can lead to metabolic dysfunction and anemia. In a rat model of iron deficiency anemia (IDA), mitochondrial respiration was increased in peripheral blood mononuclear cells (PBMCs) but remained unaffected in the liver. This suggests that PBMC mitochondrial function cannot be a valid surrogate for liver respiration. Iron deficiency resulted in different metabolic reprogramming in blood cells and liver tissue.
Article
Medicine, General & Internal
Katharina Huefner, Piotr Tymoszuk, Dietmar Ausserhofer, Sabina Sahanic, Alex Pizzini, Verena Rass, Matyas Galffy, Anna Boehm, Katharina Kurz, Thomas Sonnweber, Ivan Tancevski, Stefan Kiechl, Andreas Huber, Barbara Plagg, Christian J. Wiedermann, Rosa Bellmann-Weiler, Herbert Bachler, Gunter Weiss, Giuliano Piccoliori, Raimund Helbok, Judith Loeffler-Ragg, Barbara Sperner-Unterweger
Summary: COVID-19 outpatients are at higher risk of mental health issues following recovery, and specific acute symptoms may lead to deterioration of mental health. Early psychological and psychiatric interventions may be beneficial for these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Biology
Natascha Brigo, Christa Pfeifhofer-Obermair, Egon Demetz, Piotr Tymoszuk, Guenter Weiss
Summary: Macrophages play a crucial role in host defense against intracellular pathogens such as Salmonella. Through phagocytosis, macrophages can eliminate bacteria. Infection with Salmonella can cause gastrointestinal disorders and systemic infection.
Article
Biology
Christa Pfeifhofer-Obermair, Natascha Brigo, Piotr Tymoszuk, Guenter Weiss
Summary: Salmonella enterica serovar Typhimurium is a bacterium that causes gastrointestinal disorders and typhoid fever-like infections. We established an experimental model to study the role of different cell types in defending against bacterial infections.
Letter
Hematology
Verena Petzer, Normann Steiner, Olga Angelova-Unterberger, Gabriele Hetzenauer, Kathrin Philipp-Abbrederis, Ella Willenbacher, Clemens Feistritzer, Wolfgang Willenbacher, Jakob Rudzki, Reinhard Stauder, Florian Kocher, Andreas Seeber, Andreas Pircher, Piotr Tymoszuk, Christian Isara, Alexander Egger, Vilmos Fux, Markus Anliker, Eberhard Gunsilius, David Nachbaur, Stefan Schmidt, Dominik Wolf
Article
Respiratory System
Thomas Sonnweber, Eva-Maria Schneider, Manfred Nairz, Igor Theurl, Guenter Weiss, Piotr Tymoszuk, Judith Loeffler-Ragg
Summary: Comparing different risk stratification tools in patients with precapillary pulmonary hypertension, the study found that non-invasive follow-up evaluations significantly improve the accuracy of risk estimation. Inaccuracies were found in certain risk classes, but additional evaluation steps could significantly improve risk prediction for these patients.
RESPIRATORY RESEARCH
(2021)