Review
Oncology
Jaime Huertas, H. Thomas Lee
Summary: This review summarizes the diverse physiological effects of cathepsins, including immune responses, cell death, and intracellular protein degradation. Cathepsins play a crucial role in ischemia reperfusion injury, and modulation of cathepsins may have therapeutic potential for attenuating such injuries.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Juan A. Montero, Carlos Ignacio Lorda-Diez, Juan M. Hurle
Summary: This paper proposes a new perspective on the regulation of programmed cell death (PCD) in developing systems based on epigenetics. It challenges the traditional view that PCD is solely controlled by specific gene-encoded signals, arguing that the signals and local tissue interactions responsible for embryonic tissue growth and differentiation play a significant role in PCD. The study suggests that cells retain an epigenetic profile sensitive to DNA damage, resulting in their subsequent elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Lawrence M. Schwartz
Summary: Cell death is a normal and essential component of development and homeostasis, but dysregulation of this process underlies most human diseases. Autophagy is a process mediated by the formation of double membrane vesicles, which allows cells to survive stresses and may also mediate cell death during development and pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kewal Kumar Mahapatra, Soumya Ranjan Mishra, Bishnu Prasad Behera, Shankargouda Patil, David A. Gewirtz, Sujit Kumar Bhutia
Summary: Lysosomes are crucial organelles responsible for degrading cellular cargo and maintaining cellular homeostasis, playing a critical role in the connection between autophagy and endocytosis. Damage to the lysosomal membrane can lead to selective lysosomal degradation pathway and trigger lysophagy in severe cases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kukuh Madyaningrana, Vijith Vijayan, Christoph Nikolin, Abid Aljabri, Srinu Tumpara, Elena Korenbaum, Harshit Shah, Metodi Stankov, Heiko Fuchs, Sabina Janciauskiene, Stephan Immenschuh
Summary: The study demonstrates that human alpha1-antitrypsin (A1AT) rescues endothelial cells from free heme-mediated pro-inflammatory activation, cell death, and dysfunctional autophagy through a unique pathway. A1AT inhibits heme-mediated generation of mitochondrial reactive oxygen species and restores dysfunctional autophagy in endothelial cells. The findings suggest that A1AT therapy may be beneficial in treating hemolytic disorders such as sickle cell disease.
Article
Immunology
Silvie Kremserova, Anna Kocurkova, Michaela Chorvatova, Anna Klinke, Lukas Kubala
Summary: The study reveals that MPO plays a role in regulating PMN cell death by enhancing cell membrane permeabilization and phosphatidylserine surface exposure, thereby extending the lifespan of PMNs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiwang Yang, Ya Wen, Shaomin Liu, Liqiang Duan, Tongfeng Liu, Zhou Tong, Zhuo Wang, Yinmin Gu, Yibo Xi, Xiaodong Wang, Dingsan Luo, Ruobing Zhang, Yajuan Liu, Yang Wang, Tianyou Cheng, Siyuan Jiang, Xiaofeng Zhu, Xiaohui Yang, Yongbo Pan, Shuwen Cheng, Qinong Ye, Jinfei Chen, Xiaoding Xu, Shan Gao
Summary: The study revealed the critical role of a long noncoding RNA LCDR in regulating lysosome function, which affects lung cancer cell survival. LCDR interacts with hnRNP K to maintain lysosomal membrane integrity, leading to lysosomal cell death and apoptosis. Targeting LCDR/hnRNP K/LAPTM5 axis may provide potential therapeutic targets for cancer treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Jianan Zhao, Kai Wei, Ping Jiang, Cen Chang, Lingxia Xu, Linshuai Xu, Yiming Shi, Shicheng Guo, Yu Xue, Dongyi He
Summary: Gout is a chronic inflammatory arthritis disease characterized by hyperuricemia and triggered by interactions among various factors. Recent studies have shown that multiple programmed cell death pathways are involved in the inflammatory response, contributing to the initiation of inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
I-Tsu Chyuan, Ching-Liang Chu, Chia-Lang Hsu, Meng-Hsun Pan, Hsiu-Jung Liao, Chien-Sheng Wu, Ping-Ning Hsu
Summary: Recent evidence suggests that TRAIL can suppress T cell activation and autoimmune inflammation through an apoptosis-independent pathway. The TRAIL receptor (TRAIL-R) on T cells plays a crucial role in the suppression of inflammation and disease induction. This effect is primarily achieved by directly inhibiting T cell activation rather than inducing cell apoptosis. Additionally, TRAIL-R signaling downregulates genes involved in T cell signaling pathways, T cell differentiation, and proinflammatory cytokines. These findings highlight the importance of TRAIL-R in T cell-mediated autoimmune diseases and suggest its potential as a novel immune checkpoint receptor.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Liyan Wang, Xicheng Liu, Yuting Wu, Xian He, Xiaohui Guo, Wenshan Gao, Lin Tan, Xiang-Ai Yuan, Jinfeng Liu, Zhe Liu
Summary: This paper investigates the potential value of half-sandwich iridium(III) complexes with favorable luminescence performance in the anticancer field. Ten fluorescent complexes were prepared and showed potential antiproliferative activity, with Ir6 exhibiting the best activity and excellent fluorescence performance. Ir6 followed an energy-dependent cellular uptake mechanism, specifically accumulating in mitochondria and inducing mitochondrial-mediated apoptosis. It also arrested the cell cycle, catalyzed NADH oxidation, reduced the mitochondrial membrane potential, induced an increase in ROS level, and exhibited an oxidation mechanism. In vivo antitumor assay confirmed that Ir6 effectively inhibited tumor growth and was safer than cisplatin.
INORGANIC CHEMISTRY
(2023)
Review
Food Science & Technology
Camille Pin, Laure David, Eric Oswald
Summary: Bacteria can release extracellular vesicles, called OMVs, which have diverse functions in host-pathogen interactions during infections. These vesicles have remarkable capabilities, such as disseminating throughout the organism, transporting toxins, and being internalized by eukaryotic cells. They not only impact host cell viability but also interfere with essential cellular machinery.
Article
Cell Biology
Mateus Milani, Philippe Pihan, Claudio Hetz
Summary: Calcium is a crucial messenger in regulating cellular processes and interorganelle communication. Lysosomal function is dependent on calcium, and ion channels on the lysosomal membrane regulate lysosomal properties such as pH. Lysosome-dependent cell death (LDCD) is a specific type of cell death involving lysosomes that plays important roles in tissue homeostasis, development, and pathology. This article focuses on recent advances in understanding the role of calcium signaling in LDCD.
Article
Plant Sciences
Jinsong Su, Qiuyue Li, Jia Liu, Hongling Wang, Xuanhao Li, Dhondrup Wuentrang, Chuan Liu, Qian Zhao, Ruyu Yao, Xianli Meng, Yi Zhang
Summary: The study aimed to explore the anti-rheumatoid arthritis (RA) effect and mechanism of Rhamnella gilgitica extract on collagen-induced arthritis (CIA) in rats. Results showed that RGEA promoted apoptosis, inhibited inflammation, and regulated the JAK-STAT pathway, contributing to its anti-RA effect.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Noelia Pinal, Mireya Ruiz-Losada, Natalia Azpiazu, Gines Morata
Summary: Regeneration is a mechanism to repair damaged tissues. We studied the regenerative response in Drosophila wing discs after irradiation, and found that size compensation occurs even without the function of JNK, JAK/STAT, and Wg pathways. Additionally, generalized damage does not increase the proliferation rate of surviving cells, and irradiated discs experience a developmental delay and rejuvenation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Leonie Dejas, Karin Santoni, Etienne Meunier, Mohamed Lamkanfi
Summary: This article summarizes the importance of neutrophils in immune response and their different forms of regulated cell death, with a focus on the role of neutrophil pyroptosis in infections and autoinflammation.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aimee Parker, Oliver J. Maclaren, Alexander G. Fletcher, Daniele Muraro, Peter A. Kreuzaler, Helen M. Byrne, Philip K. Maini, Alastair J. M. Watson, Carmen Pin
Editorial Material
Biochemistry & Molecular Biology
Trevor D. Littlewood, Peter Kreuzaler, Gerard I. Evan
Article
Biochemistry & Molecular Biology
S. Pensa, K. Neoh, H. K. Resemann, P. A. Kreuzaler, K. Abell, N. J. Clarke, T. Reinheckel, C. R. Kahn, C. J. Watson
CELL DEATH AND DIFFERENTIATION
(2014)
Article
Biochemistry & Molecular Biology
Asja Guzman, Monika Zelman-Femiak, Jan H. Boergermann, Sandra Paschkowsky, Peter A. Kreuzaler, Peter Fratzl, Gregory S. Harms, Petra Knaus
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Oncology
Christine J. Watson, Peter A. Kreuzaler
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
(2009)
Article
Cell Biology
Peter A. Kreuzaler, Anna D. Staniszewska, Wenjing Li, Nader Omidvar, Blandine Kedjouar, James Turkson, Valeria Poli, Richard A. Flavell, Richard W. E. Clarkson, Christine J. Watson
NATURE CELL BIOLOGY
(2011)
Article
Multidisciplinary Sciences
Ivonne Gamper, Deborah L. Burkhart, Megan J. Bywater, Daniel Garcia, Catherine H. Wilson, Peter A. Kreuzaler, Mark J. Arends, Yao-Wu Zheng, Alessandra Perfetto, Trevor D. Littlewood, Gerard I. Evan
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Robert D. Hume, Sara Pensa, Elizabeth J. Brown, Peter A. Kreuzaler, Jessica Hitchcock, Anke Husmann, Jonathan J. Campbell, Annabel O. Lloyd-Thomas, Ruth E. Cameron, Christine J. Watson
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Peter Kreuzaler, Matthew A. Clarke, Elizabeth J. Brown, Catherine H. Wilson, Roderik M. Kortlever, Nir Piterman, Trevor Littlewood, Gerard I. Evan, Jasmin Fisher
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Review
Endocrinology & Metabolism
Peter Kreuzaler, Yulia Panina, Joanna Segal, Mariia Yuneva
MOLECULAR METABOLISM
(2020)
Article
Endocrinology & Metabolism
Peter Kreuzaler, Paolo Inglese, Avinash Ghanate, Ersa Gjelaj, Vincen Wu, Yulia Panina, Andres Mendez-Lucas, Catherine MacLachlan, Neill Patani, Catherine B. Hubert, Helen Huang, Gina Greenidge, Oscar M. Rueda, Adam J. Taylor, Evdoxia Karali, Emine Kazanc, Amy Spicer, Alex Dexter, Wei Lin, Daria Thompson, Mariana Silva Dos Santos, Enrica Calvani, Nathalie Legrave, James K. Ellis, Wendy Greenwood, Mary Green, Emma Nye, Emma Still, Simon Barry, Richard J. A. Goodwin, Alejandra Bruna, Carlos Caldas, James MacRae, Luiz Pedro Sorio de Carvalho, George Poulogiannis, Greg McMahon, Zoltan Takats, Josephine Bunch, Mariia Yuneva
Summary: Tumors are heterogeneous, hindering their classification and therapy. Spatially resolved omics-level analyses of tumor metabolism are lacking. This study shows that pantothenic acid associates with MYC-high areas in mammary tumors, fueling Krebs cycle activity. MYC upregulates the multivitamin transporter SLC5A6, and dietary restriction of pantothenic acid reverses MYC-mediated metabolic changes and hampers tumor growth.
Review
Oncology
Peter Kreuzaler, Christine J. Watson
NATURE REVIEWS CANCER
(2012)