期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷 55, 期 4-5, 页码 505-509出版社
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.103238ct
关键词
zebrafish; angiogenesis; xenotransplantation; tumor; VEGF
资金
- Ministero dell'Istruzione
- Universita e Ricerca
- Associazione Italiana per la Ricerca sul Cancro
- Cariplo Foundation
Zebrafish (Danio rerio) represents a powerful model system in cancer research. Recent observations have shown the possibility to exploit zebrafish to investigate tumor angiogenesis, a pivotal step in cancer progression and target for anti-tumor therapies. Experimental models have been established in zebrafish adults, juveniles, and embryos, each one with its own advantages and disadvantages. Novel genetic tools and high resolution in vivo imaging techniques are also becoming available in zebrafish. It is anticipated that zebrafish will represent an important tool for chemical discovery and gene targeting in tumor angiogenesis. This review focuses on the recently developed tumor angiogenesis models in zebrafish, with particular emphasis to tumor engrafting in zebrafish embryos.
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