Article
Oncology
Haihua Huang, Zhentian Kai, Yuchen Wang, Xiaomiao Zhang, Jin Wang, Wei Zhang, Qian Xue, Hang Zhang, Hansong Jin, Peize Meng, Shuilong Zhang, Yueyue Yang, Honghua Yang, Wanning Liang, Guangbing Zha, Peng Luo, Yan Xu, Weiwei Shi, Zheng Ruan
Summary: In this study, we evaluated factors influencing the detection sensitivity of circulating tumor DNA (ctDNA) and found that histological subtypes and disease stages played significant roles in ctDNA detection rate. Additionally, we discovered that DNA extracted from bronchoalveolar lavage fluid had higher levels of ctDNA compared to plasma, suggesting its potential as a valuable sample source for tumor detection. Furthermore, tumor cellularity was shown to have a significant impact on the design of personalized ctDNA panels and the overall detection sensitivity.
Review
Pharmacology & Pharmacy
M. S. Sarvan, Lakshmi Prasanthi Nori
Summary: This article provides a framework for understanding personalized and precision medicine, emphasizing tailored patient identification, diagnosis, and treatment. Investigating predictive variables for diseases within communities and customization of healthcare will lead to more individualized care for patients.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Oncology
Miao Su, Zhe Zhang, Li Zhou, Chao Han, Canhua Huang, Edouard C. Nice
Summary: Cancer is a major global public health issue and personalized/precision medicine plays a crucial role in its diagnosis and treatment. Research focuses on cancer biomarkers, the impact of the microbiome, the application of emerging omics technologies, and future prospects.
Article
Computer Science, Artificial Intelligence
Animesh Ray
Summary: Machine learning is revolutionizing biology by enabling the analysis of massive biological datasets and solving biological problems. It is distinct from classical statistical methods and has the potential to transform medicine, public health, and agricultural technology while providing valuable gene-based guidance for complex environmental management.
WILEY INTERDISCIPLINARY REVIEWS-DATA MINING AND KNOWLEDGE DISCOVERY
(2022)
Article
Clinical Neurology
Cecilia Samieri, Hussein N. Yassine, Debora Melo van Lent, Sophie Lefevre-Arbogast, Ondine van de Rest, Gene L. Bowman, Nikolaos Scarmeas
Summary: Personalized nutrition may offer advantages in preventing dementia by incorporating individuals' dietary exposure history and biological characteristics to shape health more effectively. Further research from observational epidemiology to basic science is needed to achieve better prevention outcomes.
ALZHEIMERS & DEMENTIA
(2022)
Article
Medicine, General & Internal
Si Chen, Nan Wang, Siqi Xiong, Xiaobo Xia
Summary: This bioinformatic study identifies NFKB1, IL18, KITLG, TLR9, FKBP2, and HDAC4 as key genes for POAG and GM regulation. Immune response modulated by macrophages plays an important role in POAG and may be potential targets for future predictive, preventive, and personalized diagnosis and treatment.
Review
Health Care Sciences & Services
Roberta Pastorino, Claudia Loreti, Silvia Giovannini, Walter Ricciardi, Luca Padua, Stefania Boccia
Summary: The current development of personalized medicine in disease prevention is still in its infancy, with a focus on identifying informative markers for disease risk before manifestation or early detection. Implementation of personalized medicine could lead to new preventive measures or early treatments targeted to high-risk individuals, enabling personalized prevention and rehabilitation. Integration of personalized medicine into prevention aims to benefit citizens, patients, healthcare professionals, healthcare authorities, and industry, ultimately contributing to better health and quality of life.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Health Care Sciences & Services
Valentyn Fournier, Thomas Prebet, Alexandra Dormal, Maite Brunel, Robin Cremer, Loris Schiaratura
Summary: This study found that students unfamiliar with the medical field tended to view personalized medicine more positively compared to targeted therapies, while familiar students showed no significant difference in their perceptions. Only students familiar with the medical field defined personalized medicine and targeted therapies with technical aspects such as genetics or immunology. Further research is needed to explore other factors influencing the definitions of personalized medicine and targeted therapies and their potential impact in clinical settings.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Manish Pratap Singh, Sandhya Rai, Ashutosh Pandey, Nand K. Singh, Sameer Srivastava
Summary: Molecular subtypes-based therapies provide a new potential framework for precise outcomes in clinical settings, as colorectal cancer is a highly heterogeneous malignancy with different pathological and genetic signatures in each subtype. Designing therapeutic stratification based on these features may lead to improved treatment outcomes.
Review
Medicine, General & Internal
Neha Jain, Upendra Nagaich, Manisha Pandey, Dinesh Kumar Chellappan, Kamal Dua
Summary: In the era of medical revolution, genomic testing plays a crucial role in the development of predictive, preventive, and personalized medicine. Techniques such as predictive screening and facial analysis can enhance diagnostic accuracy and treatment effectiveness. The application of genomic technologies, artificial intelligence, and machine learning is essential for the advancement of preventive and personalized medicine. Biomarkers are important for diagnosis, prognosis, and selection of personalized medicine. This review highlights the applicability and challenges of predictive diagnostics in the development of personalized medicine.
Review
Biochemistry & Molecular Biology
Sarisha Jagasia, Erdal Tasci, Zhuge Ying, Kevin Camphausen, Andra Valentina Krauze
Summary: This article reviews the clinically relevant molecular features and current cost of care for glioma patients, highlighting the promising direction of precision medicine using artificial intelligence approaches in glioma treatment.
Review
Biochemistry & Molecular Biology
Mubashir Hassan, Faryal Mehwish Awan, Anam Naz, Enrique J. deAndres-Galiana, Oscar Alvarez, Ana Cernea, Lucas Fernandez-Brillet, Juan Luis Fernandez-Martinez, Andrzej Kloczkowski
Summary: Big data has great potential in healthcare for personalized medicine and health care. The large volumes of biomedical and clinical data present opportunities and challenges for analysis and interpretation, and the development of new algorithms has enabled personalized precision medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Fangyoumin Feng, Bihan Shen, Xiaoqin Mou, Yixue Li, Hong Li
Summary: The response rate of most anti-cancer drugs is limited due to cancer heterogeneity and complex drug mechanisms. Personalized treatment using molecular biomarkers shows promise. Advances in pharmacogenomics, especially computational methods in drug response prediction, have been successful and increasingly utilized in personalized cancer medicine.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Cardiac & Cardiovascular Systems
Changwei Li, Yang Pan, Ruiyuan Zhang, Zhijie Huang, Davey Li, Yunan Han, Claire Larkin, Varun Rao, Xiao Sun, Tanika N. Kelly
Summary: Cardiovascular disease (CVD) is a major cause of disability and death worldwide, developing gradually throughout the life-course and influenced by genomic background. Advances in genomics, including gene-editing techniques and whole-genome sequencing, provide opportunities for discovering genomic mechanisms underlying CVD and using this knowledge for prevention and treatment.
CIRCULATION RESEARCH
(2023)
Article
Biology
Ramon Cacabelos, Vinogran Naidoo, Olaia Martinez-Iglesias, Lola Corzo, Natalia Cacabelos, Rocio Pego, Juan C. Carril
Summary: Alzheimer's disease is a significant health problem with high societal cost and resource consumption. Managing patients with AD is complex and requires multidisciplinary approach. Personalized therapeutic regimens are necessary due to concomitant diseases and the need to reduce adverse drug reactions, drug-drug interactions, and unnecessary costs. Predictive and differential diagnosis can be aided by genomic, epigenetic, neuroimaging, and biochemical biomarkers.
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)