Article
Microbiology
Zuhua Yu, Yingying Zhao, Ke Ding, Lei He, Chengshui Liao, Jing Li, Songbiao Chen, Ke Shang, Jian Chen, Chuan Yu, Chunjie Zhang, Yinju Li, Shaohui Wang, Yanyan Jia
Summary: This study demonstrated that Listeria monocytogenes (LM) exhibits antitumor effects by inducing autophagy, and the combination of LM and the autophagy inhibitor chloroquine (CQ) enhances the antitumor activity of LM both in vitro and in vivo.
Review
Food Science & Technology
Yujie Sun, Qingwei Zheng, Juan Sun, Li Wang, Yan Li
Summary: Autophagy dysfunction is found to be an essential mechanism in the pathogenesis of sarcopenia, and phytonutrients consumption is positively correlated with the maintenance of skeletal muscle mass and strength, involving the regulation of the autophagy pathway. However, the treatment of sarcopenia by targeting autophagy with phytonutrients is sometimes considered controversial due to the opposite effect of autophagy in sarcopenia.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Oncology
Simone Degan, Brian L. May, Yingai J. Jin, Manel Ben Hammoda, Huiying Sun, Guoqiang Zhang, Yan Wang, Detlev Erdmann, Warren Warren, Jennifer Y. Zhang
Summary: In preclinical experiments on melanoma, combination therapy with chloroquine (CQ) and MEK inhibitor trametinib (TRA) slowed down the growth of melanoma. This combination treatment decreased cancer cell proliferation and also reduced immune cell infiltration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuning He, Mark W. Zimmerman, Hillary M. Layden, Alla Berezovskaya, Julia Etchin, Megan W. Martel, Grace Thurston, Chang-Bin Jing, Ellen van Rooijen, Charles K. Kaufman, Scott J. Rodig, Leonard I. Zon, E. Elizabeth Patton, Marc R. Mansour, A. Thomas Look
Summary: Loss of the NF1 tumor suppressor gene can lead to aggressive melanomas with a high risk of treatment failure. This study established a zebrafish model of NF1-mutant melanomas harboring PTEN loss and demonstrated that mTOR inhibitors and a three-drug combination can potently induce apoptosis in NF1/PTEN-deficient melanoma cells, supporting the need for early-stage clinical trials in patients.
Review
Biochemistry & Molecular Biology
Ryan C. Russell, Kun-Liang Guan
Summary: Autophagy is a cellular degradation pathway that plays a crucial role in maintaining cellular homeostasis. It can both suppress tumorigenesis and promote cancer development. This article summarizes the effects of autophagy on cancer initiation, progression, immune infiltration, and metabolism, as well as discussing the efforts to target autophagy pharmacologically and future research directions.
Article
Environmental Sciences
Simeng Wang, Yilong Yang, Dan Luo, Lingling Zhai, Yinglong Bai, Wei Wei, Qi Sun, Lihong Jia
Summary: The study found that BPA can induce inflammatory response in the lungs, possibly through the TLR4/NF-kappa B signaling pathway and mTOR-mediated autophagy. Inhibition of autophagy can weaken the inflammatory response.
Review
Biochemistry & Molecular Biology
Jingwen Xu, David A. Gewirtz
Summary: Cisplatin, a first-line chemotherapy drug for cancer, has been found to induce autophagy in response to cancer treatments. Autophagy has been increasingly recognized as a critical factor in tumor cell death and chemoresistance. This review discusses the mechanisms of resistance to cisplatin and explores the role of autophagy in both cisplatin-sensitive and resistant cells, as well as the potential dual outcomes of combining autophagy inhibitors with cisplatin. The goal is to analyze the possible clinical application of combining cisplatin and autophagy inhibitors.
Article
Immunology
Genshen Zhong, Jiaojiao Zhang, Ying Guo, Yichun Wang, Minna Wu, Jie Ren, Yuan Li, Xiaoying Zhang, Beiyan Zhou, Weidong Zhao, Yunwei Lou, Hui Wang, Jianping Ye
Summary: The study demonstrates that IF1 gene knockout protects mice from IBD, showing reduced inflammation, preserved intestinal barrier integrity, and decreased neutrophil number and activity. IF1 may contribute to IBD pathogenesis by promoting neutrophil autophagy, and its attenuation leads to resistance to IBD in knockout mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nienke Visser, Harm Jan Lourens, Gerwin Huls, Edwin Bremer, Valerie R. Wiersma
Summary: The study found that the activity of the autophagy pathway did not differ between AraC-Res AML cells and parental AraC-sensitive AML cells, and treatment with autophagy inhibitors did not re-sensitize AraC-Res AML cells to AraC. However, in parental AraC-sensitive AML cells, treatment with AraC activated autophagy and a combination with autophagy inhibitors significantly reduced cell viability. Additionally, the combination of these drugs resulted in the highest level of cell death in patient-derived AML samples, although not additive.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Juan Wang, Liyan Qiu
Summary: In this study, a pH-responsive drug-induced self-assembled nanovesicle was developed based on an amphiphilic copolymer for the simultaneous delivery of doxorubicin hydrochloride (DOX·HCl) and chloroquine (CQ). The nanovesicle exhibited excellent delivery performance both in vitro and in vivo, and CQ enhanced the efficacy of DOX·HCl by inhibiting autophagy. Therefore, this study provides a promising strategy for precise combination therapy.
Review
Cell Biology
Tomohiko Fukuda, Osamu Wada-Hiraike
Summary: Autophagy plays a dual role in the prevention and treatment of endometrial cancer. Negative regulation of autophagy makes it a target for chemoprevention, while enhanced autophagy in established cancer is associated with further development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaofan Wei, Yunash Maharjan, Debra Dorotea, Raghbendra-Kumar Dutta, Donghyun Kim, Hyunsoo Kim, Yizhu Mu, Channy Park, Raekil Park
Summary: PEX16 regulates peroxisome abundance and function through pexophagic degradation, which is indispensable for maintaining peroxisome homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Britney Niemann, Amanda Puleo, Conley Stout, Justin Markel, Brian A. Boone
Summary: This review provides a comprehensive analysis of the detailed mechanisms of action of chloroquine/hydroxychloroquine and their clinical applications in various disease areas. Previous research has focused on specific pathways without considering the overall context, while this review offers a broader perspective and identifies common themes in the literature.
Article
Chemistry, Medicinal
Hafiz Muhammad Ahmad Javaid, Hwayeon Lim, Sooim Shin, Joo Young Huh
Summary: Chloroquine inhibits autophagy and affects mitochondrial quality and respiratory function. Additionally, chloroquine treatment induces oxidative stress, apoptosis, and metabolic dysregulation.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Minji Choi, Nagyeong Byun, Jae Ryoung Hwang, Yun-Sun Choi, Ji-Hee Sung, Suk-Joo Choi, Jung-Sun Kim, Soo-Young Oh, Cheong-Rae Roh
Summary: This study evaluated the effect of chloroquine compounds on syncytial differentiation and autophagy in primary human trophoblasts. The results showed that chloroquine compounds could mitigate biochemical and morphological syncytial trophoblast differentiation through the JAK signaling pathway rather than the inhibition of autophagic activity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ji-Hong Song, Cheol-Jung Lee, Hyun-Jung An, Sun-Mi Yoo, Han C. Kang, Joo Y. Lee, Kwang D. Kim, Dae J. Kim, Hye S. Lee, Yong-Yeon Cho
MOLECULAR CARCINOGENESIS
(2019)
Article
Biochemistry & Molecular Biology
Anna M. Mancha-Ramirez, Xiaoyu Yang, Huiyun Liang, Jacob Junco, Kevin P. Lee, Sarah F. Bovio, Maricruz Espinoza, Julia Wool, Andrew Slaga, Daniel C. Glade, Martha Hanes, Gunjan Malik, Dae Joon Kim, John DiGiovanni, Thomas J. Slaga
MOLECULAR CARCINOGENESIS
(2019)
Article
Biochemistry & Molecular Biology
Ismail S. Mohiuddin, Sung-Jen Wei, Min H. Kang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Sun-Mi Yoo, Cheol-Jung Lee, Han Chang Kang, Hye Suk Lee, Joo Young Lee, Kwang Dong Kim, Dae Joon Kim, Hyun-Jung An, Yong-Yeon Cho
MOLECULAR CARCINOGENESIS
(2019)
Article
Biochemistry & Molecular Biology
Sun-Mi Yoo, Cheol-Jung Lee, Hyun-Jung An, Joo Young Lee, Hye Suk Lee, Han Chang Kang, Sung-Jun Cho, Seung-Min Kim, Juhee Park, Dae Joon Kim, Yong-Yeon Cho
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Liza D. Morales, Anna K. Archbold, Serena Olivarez, Thomas J. Slaga, John DiGiovanni, Dae Joon Kim
MOLECULAR CARCINOGENESIS
(2019)
Article
Multidisciplinary Sciences
Cheol-Jung Lee, Hyun-Jung An, Seung-Min Kim, Sun-Mi Yoo, Juhee Park, Ga-Eun Lee, Woo-Young Kim, Dae Joon Kim, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Sung-Jun Cho, Yong-Yeon Cho
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Mihwa Kim, Liza D. Morales, Cheol Jung Lee, Serena A. Olivarez, Woo Jin Kim, Joselin Hernandez, Srinivas Mummidi, Christopher Jenkinson, Andrew T. Tsin, Ik-Soon Jang, Thomas J. Slaga, Dae Joon Kim
Article
Cell Biology
Sung-Jen Wei, Thinh H. Nguyen, In-Hyoung Yang, Dustin G. Mook, Monish Ram Makena, Dattesh Verlekar, Ashly Hindle, Gloria M. Martinez, Shengping Yang, Hiroyuki Shimada, C. Patrick Reynolds, Min H. Kang
CELL DEATH & DISEASE
(2020)
Article
Oncology
Jacob J. Junco, Taylor Chen, Raushan Rashid, Maci Terrell, Vincent U. Gant, Matthew Miller, Rachel Rau, H. Daniel Lacorazza, Karen R. Rabin
Article
Multidisciplinary Sciences
Vincent U. Gant, Jacob J. Junco, Maci Terrell, Raushan Rashid, Karen R. Rabin
Summary: Children with Down syndrome have a higher risk of developing acute lymphoblastic leukemia, with IKZF1 gene being identified as a susceptibility locus. Inherited genetic variations can impact IKZF1 expression levels, potentially increasing leukemia susceptibility both in individuals with and without Down syndrome.
Article
Biochemistry & Molecular Biology
Ga-Eun Lee, Cheol-Jung Lee, Hyun-Jung An, Han Chang Kang, Hye Suk Lee, Joo Young Lee, Sei-Ryang Oh, Sung-Jun Cho, Dae Joon Kim, Yong-Yeon Cho
Summary: Fargesin inhibits cancer cell growth by suppressing cell cycle transition and EGF-induced cell transformation through multiple signaling pathways, including CDK/cyclin and Rb-E2F pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Monika W. Perez, Oscar Sias-Garcia, Alfred Daramola, Helen Wei, Maci Terrell, Raushan Rashid, Woojun D. Park, Kevin Duong, Terzah M. Horton, Feng Li, Nikitha Cherayil, Jost Vrabic Koren, Vincent U. Gant, Jacob J. Junco, Choladda Curry, Alexandra M. Stevens, Charles Y. Lin, Joanna S. Yi
Summary: Somatic mutations are rare in pediatric acute myeloid leukemia (pAML), but studying chromatin regulation can identify new, druggable dependencies in pAML. The study found that the RARA gene was differentially regulated in pAML samples, with a RARA-associated SE detected in 64% of the cases. Additionally, RARA SE+ pAML cell lines and samples were specifically sensitive to the synthetic RARA agonist tamibarotene, showing promising results for potential treatment strategies.
Article
Hematology
Jacob J. Junco, Barry Zorman, Vincent U. Gant Jr, Jaime Mun, H. Daniel Lacorazza, Pavel Sumazin, Karen R. Rabin
Summary: Children with Down syndrome are more likely to develop B-cell acute lymphoblastic leukemia, and CRLF2 overexpression plays a crucial role in this process. CRLF2 overexpression reduces B-cell differentiation and enhances E2F signaling, potentially providing a target for therapy.
EXPERIMENTAL HEMATOLOGY
(2022)
Article
Hematology
Zhenhua Li, Ti-Cheng Chang, Jacob J. Junco, Meenakshi Devidas, Yizhen Li, Wenjian Yang, Xin Huang, Dale J. Hedges, Zhongshan Cheng, Mary Shago, Andrew J. Carroll, Nyla A. Heerema, Julie Gastier-Foster, Brent L. Wood, Michael J. Borowitz, Lauren Sanclemente, Elizabeth A. Raetz, Stephen P. Hunger, Eleanor Feingold, Tracie C. Rosser, Stephanie L. Sherman, Mignon L. Loh, Charles G. Mullighan, Jiyang Yu, Gang Wu, Philip J. Lupo, Karen R. Rabin, Jun J. Yang
Summary: This study investigates the genomics of Down syndrome-related acute lymphoblastic leukemia (DS-ALL) and identifies 15 molecular subtypes, as well as abnormal activation of key genes. It also reveals the common occurrence of somatic genomic abnormalities mediated by gene rearrangements in DS-ALL and the association between subtype heterogeneity and prognosis. These findings provide important insights into the biology of DS-ALL and offer opportunities for individualized treatment.