Article
Chemistry, Multidisciplinary
Shanshan Qin, Gaozhi Ou, Biao Wang, Zheyu Li, Rui Hu, Ying Li, Yunhuang Yang
Summary: This study reports a photolithography-free method for rapid fabrication of PDMS devices. By using a laser cutter to ablate a tape, a male photoresist mold can be obtained within 5 minutes by a simple heating-step. The method offers advantages of low input, simple operation procedure, and short fabrication time.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biotechnology & Applied Microbiology
Darius Leon Zibulski, Niels Schlichting, Johannes Kabisch
Summary: The rapid prototyping of biological functions aims to generate, screen, and select variant libraries as quickly as possible. This study introduces a new workflow called HyperXpress, which combines ligase cycling reaction, multiply-primed rolling circle amplification, and cell-free protein synthesis into a single vessel reaction. By expanding, reducing, and replacing beta-strands of three different green fluorescent proteins, the authors demonstrate the high flexibility of HyperXpress for semi-rational protein engineering, resulting in six functional, new-to-nature GFP prototypes in single-day experiments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Computer Science, Information Systems
Teng-Wen Chang, Chun-Yen Chen, Hsin-Yi Huang, Tsai-Ling Hsieh, Weixin Huang, Sambit Datta
Summary: Designs involving multiple disciplinary teams require a dynamic process of design-fabrication-assembly (DFA) for effective collaboration and understanding. The proposed visualization system (ViDA) has been evaluated through experiments and projects, demonstrating its effectiveness in short-term prototyping time cost and interdisciplinary team collaboration.
MULTIMEDIA TOOLS AND APPLICATIONS
(2022)
Article
Chemistry, Applied
Nico Nys, Michael Koenig, Peter Neugebauer, Matthew J. Jones, Heidrun Gruber-Woelfler
Summary: Traditional fabrication technologies limit lab-scale crystallizer design, but additive manufacturing provides an opportunity to overcome these challenges by using traditional materials such as glass or metal alloys. However, despite its potential, this technology has not yet found widespread use in crystallizer design.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Biochemical Research Methods
Yesman Akuoko, Robert L. Hanson, David H. Harris, Jacob B. Nielsen, Elaine Lazalde, Adam T. Woolley
Summary: The study demonstrates the fabrication of microfluidic devices for DNA capture and fluorescence detection of antibiotic resistance gene sequences, showing simplicity, robustness, and affordability. Results indicate that relative fluorescence increases with target DNA concentration, with synthetic target DNA exhibiting higher fluorescence signal and percent recovery compared to plasmid DNA.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yizhou Zhang, Ruiqi Dong, Uri R. Gabinet, Ryan Poling-Skutvik, Na Kyung Kim, Changyeon Lee, Omar Q. Imran, Xunda Feng, Chinedum O. Osuji
Summary: A lyotropic liquid crystal mesophase has been developed to fabricate submicron films with 1-nm-scale pores, which exhibit excellent molecular weight cutoffs and water permeabilities, making them promising for nanofiltration applications.
Article
Optics
Larry O'Connell, Brice Poirier, Oleksii Bratash, Charlene Pleniere, Loic Leroy, Yoann Roupioz, Pierre R. Marcoux
Summary: This study demonstrates the feasibility of using commercial laser direct writing equipment for rapid electrode patterning on glass substrates, particularly for electrokinetically active plasmonic sensors. The results show that using a commercial printed circuit board prototyper, interdigitated electrode arrays can be patterned on gold-coated glass slides and surface plasmon resonance prisms. These patterned surfaces can be used for trapping and electrokinetic manipulation of bacteria, as well as for sensing bacterial interactions using surface plasmon resonance imaging.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Carlie Rein, Mehmet Toner, Derin Sevenler
Summary: Soft lithography allows rapid prototyping of precise microfluidic features using a deformable elastomer like polydimethylsiloxane (PDMS). However, for applications where flexibility of PDMS is a drawback, more rigid materials like epoxy and glass have been proposed. Devices fabricated from epoxy and glass offer superior mechanical performance, feature resolution, and solvent compatibility compared to alternatives. This article presents a detailed step-by-step method for fabricating rigid microfluidic devices from soft lithography patterned epoxy and glass, demonstrating their use in high throughput cell focusing with rigid high aspect ratio spiral microchannels.
SCIENTIFIC REPORTS
(2023)
Review
Engineering, Manufacturing
Kirsten Lussenburg, Aimee Sakes, Paul Breedveld
Summary: This article systematically reviews and analyzes the current state-of-the-art of non-assembly mechanisms, discussing the challenges encountered in their design and production.
ADDITIVE MANUFACTURING
(2021)
Article
Computer Science, Software Engineering
Yue Li, Lihong Qiao, Zhicheng Huang, Nabil Anwer
Summary: The paper proposes a novel method for evaluating the assemblability of cylindrical parts assembly considering surface deviations, by simulating the assembly process and defining posture space to achieve quantitative evaluation of assembly posture.
COMPUTER-AIDED DESIGN
(2021)
Article
Engineering, Electrical & Electronic
Zhaoping Tang, Jun Peng, Jianping Sun, Xin Meng
Summary: This study focuses on the development of industrial robots in high-precision fields, specifically addressing the issue of motion reliability. By considering the influence of joint clearance on motion reliability, a kinematic model of the industrial robot is established, and a kinematic equation is derived. A non-probability positioning accuracy reliability measure is proposed based on non-probability theory and method, allowing for the assessment of different states of reliability. The study also explores the impact of joint clearances on robot end-effector displacement error and analyzes the motion reliability in different working regions. Additionally, the research direction of space division and partition parameter calibration is proposed to further study the non-probabilistic calibration of robot workspace partitions.
Article
Engineering, Mechanical
Yufan Cheng, Xinchen Zhuang, Tianxiang Yu
Summary: This paper proposes a time-dependent kinematic reliability analysis method that takes into account the truncated random variables and joint clearances, effectively addressing the issues of dimension variables and correlation between joint clearance variables. The proposed method transforms time-dependent reliability into time-independent reliability, greatly reducing computational complexity and obtaining upper and lower bounds of failure probability.
PROBABILISTIC ENGINEERING MECHANICS
(2024)
Article
Engineering, Manufacturing
Saja Aabith, Richard Caulfield, Omid Akhlaghi, Anastasia Papadopoulou, Shervanthi Homer-Vanniasinkam, Manish K. Tiwari
Summary: Direct-write printing has been instrumental in additive manufacturing, especially in extrusion-based printing, expanding the range of materials and applications. However, the synthesis and preparation of printing inks for direct-write printing can be complex. This study develops a precise 3D printable polymer that allows for the easy prototyping of micrometre-scale silicone structures without the need for cleanroom facilities.
ADDITIVE MANUFACTURING
(2022)
Article
Engineering, Mechanical
Xinchen Zhuang, Tianxiang Yu, Jingyi Liu, Bifeng Song
Summary: This study conducts kinematic reliability analysis of high-precision planar mechanisms experiencing non-uniform wear. A wear prediction method based on Archard's wear model is presented, and the maximum entropy model and numerical integration are used to calculate kinematic reliability. A Monte Carlo simulation based method is developed for reference solution calculation.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2022)
Article
Chemistry, Multidisciplinary
Yawei Sun, Jiaqi Zhang, Feng Liu, Qilu Zhang
Summary: Rapid and scalable self-assembly of an amphiphilic 21-arm star copolymer, (polystyrene-block-polyethylene glycol)(21), in aqueous solution has been achieved using reverse solvent exchange procedure. The resulting nanoparticles show narrow size distribution, which is confirmed by transmission electron microscope (TEM) and nanoparticle tracking analysis (NTA). The kinetic-controlled self-assembly mechanism of the copolymers involves the star topology of the amphiphilic copolymer and deep quenching condition during phase separation.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)