Article
Oncology
Min-Young Park, In-Ja Park, Hyo-Seon Ryu, Jay Jung, Min-Sung Kim, Seok-Byung Lim, Chang-Sik Yu, Jin-Cheon Kim
Summary: This study found that frequent postoperative surveillance did not improve overall survival or recurrence-free survival in patients with colorectal cancer, but it did improve post-recurrence survival. Intensive surveillance was associated with improved post-recurrence survival and overall survival in high-risk patients.
Article
Engineering, Biomedical
Feng Liu, Zheng Dai, Qian Cheng, Luming Xu, Lei Huang, Zhibo Liu, Xiaoqiong Li, Ning Wang, Guobin Wang, Lin Wang, Zheng Wang
Summary: This study develops a novel bio-scaffold for mediating postoperative colorectal cancer (CRC) recurrence by targeting long noncoding RNAs (lncRNAs). The bio-scaffold, which encapsulates lncRNA-targeting biomimetic nanosystems and chemotherapy drug Oxaliplatin (Oxa), effectively suppresses CRC local recurrence and distant metastasis, while generating robust immune memory responses.
Article
Immunology
Guozeng Xu, Lei Jiang, Cheng Ye, Guizhen Qin, Zhanxiong Luo, Yuzhen Mo, Jian Chen
Summary: The ratio of stromal CD86+TAM/CD163+TAM (CD86/CD163) was investigated as a prognostic biomarker for colorectal cancer, with results showing its effectiveness in predicting recurrence-free survival and overall survival. The ratio was found to be an independent predictor in different cohorts and showed better predictive values than tumor stage. The stromal CD86/CD163 ratio could be useful for individual risk assessment and personalized treatment in stage II-III colorectal cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Zhi-Zhong Xiong, Ming-Hao Xie, Xian-Zhe Li, Long-Yang Jin, Feng-Xiang Zhang, Shi Yin, Hua-Xian Chen, Lei Lian
Summary: This study aimed to analyze the risk factors associated with postoperative recurrence in patients with stage II CRC. It was found that tumor diameter, preoperative CA125 level, preoperative CA199 level, and ulcerative tumor were associated with postoperative recurrence. Postoperative chemotherapy could reduce the cumulative recurrence rate in patients with these high-risk factors.
Article
Surgery
Mitsuko Fukunaga, Koshi Mimori, Takaaki Masuda, Qingjiang Hu, Kazutaka Yamada, Masaki Mori
Summary: Plasma CCL2 is identified as a predictive biomarker for postoperative CRC recurrence, and is associated with the immune response of tumors.
Article
Immunology
Shan Chen, Jie Zhang, Chengjia Qian, Xiaowei Qi, Yong Mao, Tingxun Lu
Summary: This study investigated the clinical significance of dynamic changes in the lymphocyte-to-monocyte ratio (LMR) and neutrophil-lymphocyte ratio (NLR) in the prediction of postoperative recurrence in patients with colorectal cancer (CRC). The findings suggest that dynamic changes in LMR can be used as a biomarker for predicting CRC recurrence and, when combined with CEA, can improve the predictive performance for detecting CRC recurrence.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Min Young Park, In Ja Park, Hyo Seon Ryu, Jay Jung, Minsung Kim, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Summary: Frequent surveillance with CT scan does not improve overall survival (OS) in stage III colorectal cancer patients. Evaluation of other surveillance methods besides frequent CT scans is needed to detect recurrence for which curative treatment is possible, as curative resection is crucial for improving post-recurrence survival.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Mizuki Tamai, Jun Kiuchi, Yoshiaki Kuriu, Tomohiro Arita, Hiroki Shimizu, Takuma Ohashi, Hirotaka Konishi, Yusuke Yamamoto, Ryo Morimura, Atsushi Shiozaki, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
Summary: Preoperative Prognostic Nutritional Index (PNI) is crucial for the prognosis of colorectal cancer (CRC). Postoperative PNI value can serve as a prognostic biomarker for CRC patients undergoing adjuvant chemotherapy (AC). Patients with low PNI value can improve prognosis by recovering PNI value through the introduction of AC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Yuki Horio, Motoi Uchino, Masataka Igeta, Kentaro Nagano, Kurando Kusunoki, Ryuichi Kuwahara, Kei Kimura, Kozo Kataoka, Naohito Beppu, Masataka Ikeda, Hiroki Ikeuchi
Summary: This study investigated the risk factors for recurrent ulcerative colitis-associated colorectal cancer (UC-CRC). The significant risk factors for recurrence were age at surgery, undifferentiated carcinoma, lymph node metastasis, and vascular invasion. Young adult patients with stage III CRC had a worse prognosis.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Review
Medicine, General & Internal
Tomonari Kinoshita, Taichiro Goto
Summary: Despite complete resection, cancer recurrence is common, indicating possible metastasis of cancer cells. Tumor microenvironment plays a crucial role in cancer development and metastasis, with cancer-associated inflammation possibly contributing to these processes. Although the relationship between inflammation and cancer recurrence has been extensively studied, it remains challenging to identify the status of cancer-associated inflammation in clinical settings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Yuan-Tzu Lan, Shih-Ching Chang, Pei-Ching Lin, Chun-Chi Lin, Hung-Hsin Lin, Sheng-Chieh Huang, Chien-Hsing Lin, Wen-Yi Liang, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Jen-Kou Lin
Summary: Colorectal cancer patients with early recurrence display advanced pathological characteristics, worse survival rates, more APC mutations. Right-sided colon cancer patients are more likely to experience early recurrence. However, postrecurrence survival rates are not significantly different between early and late recurrence patients. Multivariate analysis identified early recurrence, old age, multiple-site recurrence, BRAF and NRAS mutations as independent prognostic factors.
Article
Surgery
Zechuan Jin, Qingbin Wu, Xiangbing Deng, Ziqiang Wang
Summary: This study investigated the survival and recurrence of stage I colorectal cancer (CRC) patients. The analysis of preoperative serological values revealed that age, white blood cell count, and the systemic inflammation index (SII) were associated with overall survival (OS), while elevated carcinoembryonic antigen (CEA) levels were related to disease-free survival (DFS). These findings suggest that stage I CRC patients still carry a clinically significant risk of recurrence, and further validation is needed to identify high-risk patients with less severe disease.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Shangjun Tang, Yongjun Chen, Shan Tian, Yumei Wang
Summary: The study found that certain clinical indicators were significantly higher in the early recurrence group compared to the late recurrence group, and TNM stage, CA-199, CA125, SII, and TBA were strong predictors for early recurrence in CRC patients. The recurrent nomogram exhibited good predictive performance and clinical utility in identifying CRC patients with early recurrence.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Yosuke Tarumi, Taisuke Mori, Koki Shimura, Yuko Izumi, Hiroyuki Okimura, Hisashi Kataoka, Tetsuya Kokabu, Fumitake Ito, Akemi Koshiba, Khaleque N. Khan, Izumi Kusuki, Jo Kitawaki
Summary: This study investigates the association between progesterone receptor (PR) expression levels in ovarian endometrioma and the recurrence of endometriosis. The results suggest that low PR expression levels in ovarian endometrioma epithelial cells may predict the recurrence of endometriosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Surgery
Kosuke Hiramatsu, Junichi Shindoh, Yutaka Hanaoka, Shigeo Toda, Masashi Ueno, Shuichiro Matoba, Hiroya Kuroyanagi
Summary: Preoperative undernutrition is associated with poorer overall survival in patients with colorectal cancer, but postoperative nutritional status changes also play a crucial role in predicting the survival outcomes. Patients with sustained or worsening undernutrition after surgery may have worse overall survival and recurrence-free survival rates.
WORLD JOURNAL OF SURGERY
(2021)