Review
Cell Biology
Rosa Molfetta, Rossella Paolini
Summary: Mast cells are tissue-resident sentinels involved in various physiological and pathological processes. They are frequently observed in tumor microenvironments, but their role in tumor initiation and growth is still controversial.
Article
Surgery
Bryan P. Kline, Gregory S. Yochum, David L. Brinton, Kathleen M. Schieffer, Taelor Weaver, Leonard Harris, Sue Deiling, Arthur S. Berg, Walter A. Koltun
Summary: This study confirmed a significant association of ARHGAP15 and COLQ SNPs with diverticular disease, while no association was found with FAM155A. The SNPs did not appear to be associated with more severe disease, but genotype at the ARHGAP15 SNP impacted expression of ARHGAP15 in the colon. Additionally, this study was the first to localize COLQ in the colon, suggesting its impact on diverticular disease through altering motility.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Surgery
Alexander T. Hawkins, Lauren R. Samuels, Russell L. Rothman, Timothy M. Geiger, David F. Penson, Matthew J. Resnick
Summary: This study identifies significant geographic variation in elective sigmoid resection for diverticulitis and suggests that factors such as surgeon density and hospital characteristics play a major role in this variation. Further research and stronger national guidelines are needed to improve patient selection for surgery.
Review
Gastroenterology & Hepatology
Aikaterini Mastoraki, Dimitrios Schizas, Athina Tousia, George Chatzopoulos, Anastasia Gkiala, Athanasios Syllaios, Maximos Frountzas, Pantelis Vassiliu, Georgios E. Theodoropoulos, Evangelos Felekouras
Summary: The review summarizes the role of molecular and genetic factors in the development of diverticular disease, and their possible contribution towards new prognostic indicators, diagnostic algorithms, and therapeutic approaches. In addition to common predisposing factors, genetic mutations, immune factors, neurotransmitters, hormones, and protein dysfunctions have been associated with early onset of symptoms, pathogenesis and prognosis of the disease. Specific structural changes in the colonic wall, altered matrix composition, and compromised motility have been identified as possible pathogenic factors for the development of diverticular disease.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Neurosciences
Nicholas Baidoo, Gareth J. Sanger, Abi Belai
Summary: Old age is associated with a higher incidence of lower bowel conditions such as constipation. This study assessed and compared the pattern of distribution of enteric glial cells (EGCs) in adult and elderly human colon. The results showed that aging does not result in a loss of Sox-10-IR EGCs in the myenteric plexus (MP) and submucosal plexus (SMP), but reduces S100-IR EGCs density within the musculature, which may contribute to colonic dysfunction.
Article
Neurosciences
Alexandra Palmer, Sarah Epton, Ellie Crawley, Marilisa Straface, Luke Gammon, Meghan M. Edgar, Yichen Xu, Shezan Elahi, Joanne Chin-Aleong, Joanne E. Martin, Cleo L. Bishop, Charles H. Knowles, Gareth J. Sanger
Summary: The study investigated the decline of human colonic neuromuscular functions among the elderly and found increased staining of p16 within the cytoplasm of myenteric nerve cell bodies in the ascending colon, suggesting a post-mitotic cellular senescence-like activity related to aging of enteric neurons within the colon.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Surgery
Cory Lee, Russyan Mark Mabeza, Arjun Verma, Sara Sakowitz, Zachary Tran, Joseph Hadaya, Hanjoo Lee, Peyman Benharash
Summary: Frailty, as assessed by the mFI-5, was found to be associated with increased perioperative morbidity and hospital resource use in patients undergoing elective colon resection for diverticular disease. Frail patients had higher odds of major adverse events, surgical site infection, postoperative ileus, prolonged length of stay, nonhome discharge, and unplanned readmission compared to non-frail patients. Deployment of frailty instruments may help improve patient selection for elective colectomy.
Article
Gastroenterology & Hepatology
Cameron W. Hunt, Ruchir Chaturvedi, Lev Brown, Caitlin Stafford, Christy E. Cauley, Robert N. Goldstone, Todd D. Francone, Hiroko Kunitake, Liliana Bordeianou, Rocco Ricciardi
Summary: The study revealed significant variability in diverticular disease mortality rates across the globe, with developing nations experiencing increasing mortality rates and expanding percentages of overweight adults. Public health interventions are needed in developing nations to alter mortality rates from diverticular disease.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Gastroenterology & Hepatology
Adam Humenick, Bao Nan Chen, David A. Wattchow, Vladimir P. Zagorodnyuk, Phil G. Dinning, Nick J. Spencer, Marcello Costa, Simon J. H. Brookes
Summary: In this study, different types of enteric neurons in the human colon were characterized immunohistochemically using a combination of retrograde tracing and multiple labeling immunohistochemistry. Long ascending neurons and descending neurons in the colon were found to have distinct types, providing insights into their functions and connectivity within the colonic enteric nervous system. This research lays the foundation for understanding the roles of these neurons and building a comprehensive account of human colonic enteric neurons.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Cell Biology
Kwang-Hyeok Kim, Jin-Ock Kim, Sang Gyu Park
Summary: In this study, a novel therapeutic agent for mast cell diseases was developed - 2G4 antibody, which was shown to effectively inhibit mast cell proliferation, migration, degranulation, and secretion of pro-inflammatory cytokines in LAD2 cells. These findings suggest that 2G4 antibody has potential as a promising treatment option for mast cell diseases.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Letter
Microbiology
Antonio Tursi, Paola Mastromarino, Daniela Capobianco, Walter Elisei, Giuseppe Campagna, Marcello Picchio, GianMarco Giorgetti, Federica Fabiocchi, Giovanni Brandimarte
Summary: This study assessed the amount of Faecalibacterium prausnitzii in fecal samples of patients with symptomatic uncomplicated diverticular disease (SUDD). The results showed that there was no significant difference in the fecal amount of Faecalibacterium prausnitzii between healthy controls (HC), asymptomatic diverticulosis (AD) patients, and SUDD patients. However, the count of Faecalibacterium prausnitzii in the microbiota of HC was lower than that in AD and SUDD subjects. This behavior is different from inflammatory bowel disease (IBD) but similar to other mucin-degrading species in the SUDD setting.
BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Ewelina Wozniak, Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Summary: Psoriasis vulgaris is a common inflammatory skin disease with complex pathogenesis involving genetic, environmental factors, and mental health. Chronic stress may influence hormonal changes, promoting autoimmunity. Mast cells play an important role in the pathophysiology of psoriasis by responding to environmental stimuli and emotional stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
David Saavedra-Perez, Yuhamy Curbelo-Pena, Jaime Sampson-Davila, Sonia Albertos, Alejandro Serrano, Luis Ibanez, Xavier Errando, Xavier Perez
Summary: The aim of this systematic review is to clarify the scientific evidence and analyze the diagnostic and therapeutic options for Symptomatic Uncomplicated Diverticular Colon Disease (SUDCD), comparing their advantages and disadvantages and proposing a diagnostic-therapeutic algorithm along with new research questions.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2021)
Review
Biochemistry & Molecular Biology
Antonio Tursi, Valerio Papa, Loris Riccardo Lopetuso, Carlo Romano Settanni, Antonio Gasbarrini, Alfredo Papa
Summary: This review summarizes the important role of gut microbiota in diverticulosis and diverticular disease (DD), highlighting the association between GM imbalance and the clinical manifestations of DD. The available data is compared with that of inflammatory bowel disease (IBD), and the rationale for using probiotics to rebalance dysbiosis in DD is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Bruno Cesar de Vasconcelos Gurgel, Patricia Guerra Peixe, Salomao Israel Monteiro Lourenco Queiroz, Roseana de Almeida Freitas, Ana Rafaela Luz de Aquino Martins, Poliana Mendes Duarte
Summary: In gingival tissues of adults and elderly individuals, there are differences in the immune expression of immature dendritic cells and degranulated mast cells. Gingivitis in the elderly is also associated with decreased microvessel growth.
CLINICAL ORAL INVESTIGATIONS
(2023)
Letter
Dermatology
Mariachiara Arisi, Alessandra Gelmetti, Marta Fusano, Luisa Lorenzi, Giulia Petrilli, Giorgio Pasolini, Annalisa Vascellaro, Marina Venturini, Piergiacomo Calzavara-Pinton
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2020)
Review
Gastroenterology & Hepatology
G. Bassotti, E. Antonelli, V. Villanacci, R. Nascimbeni, M. P. Dore, G. M. Pes, G. Maconi
TECHNIQUES IN COLOPROCTOLOGY
(2020)
Article
Oncology
Silvia Lonardi, Sara Scutera, Sara Licini, Luisa Lorenzi, Anna Maria Cesinaro, Luisa Benerini Gatta, Carlotta Castagnoli, Daniele Bollero, Rosaria Sparti, Michela Tomaselli, Daniela Medicina, Federica Calzetti, Marco Antonio Cassatella, Fabio Facchetti, Tiziana Musso, William Vermi
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Dermatology
Mariachiara Arisi, Alessandra Gelmetti, Arianna Zanca, Mariateresa Rossi, Luisa Lorenzi, Paolo Incardona, Piergiacomo Calzavara-Pinton, Marina Venturini
DERMATOLOGY AND THERAPY
(2020)
Review
Medicine, General & Internal
Elisabetta Antonelli, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, Giovanni Maconi
Summary: This review summarizes the dermatologic manifestations occurring in patients with inflammatory bowel diseases, including specific manifestations, cutaneous disorders associated with IBDs, reactive mucocutaneous manifestations of IBDs, mucocutaneous conditions secondary to treatment, and manifestations due to nutritional malabsorption. An accurate dermatological examination is crucial in all IBD patients, especially in candidates to biologic therapies where drug-induced cutaneous reactions may be clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Anna Russignan, Giada Dal Collo, Anna Bagnato, Nicola Tamassia, Mattia Bugatti, Mirella Belleri, Luisa Lorenzi, Enrica Borsi, Riccardo Bazzoni, Michele Gottardi, Carolina Terragna, William Vermi, Arianna Giacomini, Marco Presta, Marco Antonio Cassatella, Mauro Krampera, Cristina Tecchio
Summary: Macitentan effectively targets ET-1 receptors to inhibit MM cell survival and reduce pro-angiogenic cytokine release by modulating MAPK/ERK and HIF-1 alpha pathways, suggesting its potential as an anti-proliferative and anti-angiogenic therapy in MM preclinical models.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dermatology
Mariachiara Arisi, Simone Soglia, Edoardo Guasco Pisani, Anna Venturuzzo, Alessandra Gelmetti, Cesare Tomasi, Cristina Zane, Mariateresa Rossi, Luisa Lorenzi, Piergiacomo Calzavara-Pinton
Summary: The study demonstrated the effectiveness of cold atmospheric plasma in treating multiple AKs without causing skin atrophy. HFUS examination showed improvement in the features of chronic photodamage of the dermis of the skin underlying and surrounding the AK spots.
DERMATOLOGY AND THERAPY
(2021)
Article
Pathology
Luisa Lorenzi, Silvia Lonardi, Donatella Vairo, Andrea Bernardelli, Michela Tomaselli, Mattia Bugatti, Sara Licini, Mariachiara Arisi, Lorenzo Cerroni, Alessandra Tucci, William Vermi, Silvia Clara Giliani, Fabio Facchetti
Summary: This study identifies EC as a novel pDC marker of diagnostic relevance in BPDCN. The results suggest a scenario where malignant pDCs promote the blunting of IFN-I signaling through EC-driven signaling, leading to a poorly immunogenic tumor microenvironment.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Hematology
Marco Pizzi, Fabrizio Vianello, Luisa Lorenzi, Gianni Binotto, Marta Sbaraglia, Federico Scarmozzino, Andrea De Crescenzo, Vincenza Guzzardo, Simone Zoletto, Fabio d'Amore, Alberto Friziero, Mariella D'Adda, Fabio Facchetti, Angelo Paolo Dei Tos
Summary: Accessory spleens may have a significant role in immune thrombocytopenia and could contribute to relapse after splenectomy. The immune microenvironment of accessory spleens in ITP remains poorly understood. This study compared the histological features of accessory spleens and main spleens from adult patients with primary ITP, revealing similar immune events in both spleen types. These findings have implications for the mechanisms of accessory spleen-mediated ITP relapse and highlight the need for further research in spleen immunity.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Pathology
Lorenzi Luisa, Lonardi Silvia, Bonezzi Michela, Zini Stefania, Bugatti Mattia, Valzelli Arianna, Melotti Flavia, Facchetti Mattia, Ghini Iacopo, Villanacci Vincenzo, Balzarini Piera, Pizzi Marco, Giustini Viviana, Galvagni Anna, Chiarini Marco, Dei Tos Angelo Paolo, Vermi William, Casola Stefano, Facchetti Fabio
Summary: The study evaluated the performance of B-cell clonality detection using IgLC-RNAsc in tissue sections, showing better performance in diagnosing various B-cell lymphomas, especially in cases with limited tumor cell content. Investigation on mediastinal lymphomas revealed the ability of IgLC-RNAsc to identify monoclonal IgLC transcripts, providing insights into the regulation of Ig mechanisms across different lymphoma entities.
Meeting Abstract
Hematology
Alessandra Tucci, Alessandro Re, Chiara Pagani, Anna Guidetti, Anna Dodero, Fabrizio Marino, Ivana Casaroli, Giulia Soverini, Rosa Daffini, Monica Balzarotti, Giulia Campostrini, Luisa Lorenzi, Piera Balzarini, Fabio Facchetti, Carmelo Carlo-Stella, Paolo Corradini, Giuseppe Rossi
Meeting Abstract
Hematology
Samantha Ferrari, Chiara Pagani, Mariella D'Adda, Nicola Bianchetti, Annamaria Pelizzari, Doriana Gramegna, Chiara Bottelli, Luisa Lorenzi, Gabriella Vona, Alessandra Tucci, Giuseppe Rossi
Meeting Abstract
Gastroenterology & Hepatology
D. Castellani, M. Piciucchi, H. Bertani, Sbrozzi A. Vanni, U. Germani, O. Morelli, L. Petrogiannopoulos, C. Clerici, E. Antonelli, G. Bassotti, R. L. Conigliaro, R. Manta
DIGESTIVE AND LIVER DISEASE
(2020)
Meeting Abstract
Medicine, Research & Experimental
Luisa Lorenzi, Jessica Galli, Rosalba Ferraro, Donatella Vairo, Paolo Incardona, Mattia Bugatti, Debora Bresciani, Andrea Bernardelli, Simona Orcesi, Giulio Gualdi, Elisa Fazzi, Silvia Giliani, Facchetti Fabio
LABORATORY INVESTIGATION
(2020)
Meeting Abstract
Pathology
Luisa Lorenzi, Jessica Galli, Rosalba Ferraro, Donatella Vairo, Paolo Incardona, Mattia Bugatti, Debora Bresciani, Andrea Bernardelli, Simona Orcesi, Giulio Gualdi, Elisa Fazzi, Silvia Giliani, Facchetti Fabio