Article
Oncology
Honghua Peng, Guifeng Liu, Ying Bao, Xi Zhang, Lehong Zhou, Chenghui Huang, Zewen Song, Sudan Cao, Shiying Dang, Jing Zhang, Tanxiao Huang, Yuling Wu, Mingyan Xu, Lele Song, Peiguo Cao
Summary: The mutational landscape of CRC tissue was largely similar between patients with or without liver metastasis, with higher frequencies of TRIM77 and TCF7L2 mutations in patients with liver metastasis. TRIM77 mutations were identified as the independent risk factor for CRC patients with liver metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Marinde J. G. Bond, Babette I. Kuiper, Karen Bolhuis, Aysun Komurcu, Martinus J. van Amerongen, Thiery Chapelle, Cornelis H. C. Dejong, Marc R. W. Engelbrecht, Michael F. Gerhards, Dirk J. Grunhagen, Thomas van Gulik, John J. Hermans, Koert P. de Jong, Joost M. Klaase, Niels F. M. Kok, Wouter K. G. Leclercq, Mike S. L. Liem, Krijn P. van Lienden, I. Quintus Molenaar, Ulf P. Neumann, Gijs A. Patijn, Arjen M. Rijken, Theo M. Ruers, Cornelis Verhoef, Johannes H. W. de Wilt, Geert Kazemier, Anne M. May, Cornelis J. A. Punt, Rutger-Jan Swijnenburg
Summary: This study evaluated the variability in assessing resectability and local treatment planning for patients with initially unresectable colorectal cancer liver metastases. The results showed differences and disagreements in the evaluations, highlighting the need for consensus guidelines to prevent unwarranted variability in clinical practice.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Matas Jakubauskas, Lina Jakubauskiene, Bettina Leber, Angela Horvath, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: The use of chemotherapeutic agents is vital in treating colorectal cancer, but it often leads to intestinal mucositis (IM) with various clinical symptoms. This study aimed to assess the effects of probiotic supplementation on CTx-induced IM in a rat model. The results showed that probiotics alleviated the severity and duration of CTx-induced diarrhea, reduced weight and blood albumin loss, and promoted intestinal cell regeneration.
Article
Oncology
Rohin Gawdi, Cristian D. Valenzuela, Omeed Moaven, John A. Stauffer, Nico R. Del Piccolo, Tanto Cheung, Carlos U. Corvera, Andrew D. Wisneski, Charles Cha, Perry Shen, Greg Russell, Nima Zarandi, Justin Dourado
Summary: This study examined the impact of neoadjuvant, adjuvant, and perioperative chemotherapy on the outcomes of patients with resectable colorectal-liver metastases (CLM). The results showed that adjuvant and perioperative chemotherapy were independently associated with improved overall survival (OS) compared to surgery alone.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Yukihide Kanemitsu, Yasuhiro Shimizu, Junki Mizusawa, Yoshitaka Inaba, Tetsuya Hamaguchi, Dai Shida, Masayuki Ohue, Koji Komori, Akio Shiomi, Manabu Shiozawa, Jun Watanabe, Takeshi Suto, Yusuke Kinugasa, Yasumasa Takii, Hiroyuki Bando, Takaya Kobatake, Masafumi Inomata, Yasuhiro Shimada, Hiroshi Katayama, Haruhiko Fukuda
Summary: Adjuvant mFOLFOX6 chemotherapy after hepatectomy significantly improves disease-free survival (DFS) in liver-only metastatic colorectal cancer patients compared to hepatectomy alone. However, the impact of chemotherapy on overall survival (OS) remains unclear.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Sternschuss Michal, Goshen-Lago Tal, Perl Gali, Goldenfeld Miki, Brook Elana, Brenner Baroch, Kashtan Hanoch, Ben Aharon Irit, Haddad Riad
Summary: Proteomic analysis revealed a distinct protein signature in patients who benefited from colorectal cancer liver metastases resection, which was correlated with extracellular matrix pathways. Further research is needed to define the role of extracellular matrix pathways in prognostics and patient selection for colorectal cancer liver metastases surgical procedures.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Yingcheng Wu, Shuaixi Yang, Jiaqiang Ma, Zechuan Chen, Guohe Song, Dongning Rao, Yifei Cheng, Siyuan Huang, Yifei Liu, Shan Jiang, Jinxia Liu, Xiaowu Huang, Xiaoying Wang, Shuangjian Qiu, Jianmin Xu, Ruibin Xi, Fan Bai, Jian Zhou, Jia Fan, Xiaoming Zhang, Qiang Gao
Summary: This study presents a single-cell and spatial atlas of colorectal liver metastasis, revealing highly metabolically activated MRCP+ CCL18(+) M2-like macrophages at the metastatic sites. Effective neoadjuvant chemotherapy can slow down this metabolic activation, raising the possibility of targeting metabolic pathways in metastasis.
Review
Biochemistry & Molecular Biology
Daniel-Clement Osei-Bordom, Sivesh Kamarajah, Niki Christou
Summary: In the clinical management of liver metastasis of colorectal cancer, surgeons and oncologists categorize the metastasis into resectable and non-resectable groups to initiate tailored therapeutics. The combination of targeted therapies and biotherapies around these two entities is being actively explored to determine the ideal conditions for their application to improve patient survival and quality of life.
Article
Oncology
Hidemasa Kubo, Hisashi Ikoma, Yusuke Yamamoto, Ryo Morimura, Jun Kiuchi, Hiroki Shimizu, Tomohiro Arita, Yoshiaki Kuriu, Kazuma Okamoto, Eigo Otsuji
Summary: The study successfully stratified CRLM patients using a modified nomogram, recommending surgery first strategy in the low-risk group.
ANTICANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Juan Carlos Celis-Pinto, Adela Alonso Fernandez-Velasco, Maria Daniela Corte-Torres, Jorge Santos-Juanes, Noelia Blanco-Agudin, Kelvin Manuel Pina Batista, Jesus Merayo-Lloves, Luis M. Quiros, Ivan Fernandez-Vega
Summary: The study investigated the expression of PTEN-induced kinase-1 (PINK1) in surgical specimens from ninety patients with metastatic colorectal adenocarcinoma (CRC) to the liver. The results showed that positive PINK1 expression was observed in all tumoral tissues, and there were no differences between different CRCs. However, a significant under-expression of PINK1 was found in CRLMs derived from the rectum compared to other sites. Altered PINK1 expression in CRCs was associated with worse overall survival due to abnormal mitophagy function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Matthias Kelm, Julia Schollbach, Friedrich Anger, Armin Wiegering, Ingo Klein, Christoph-Thomas Germer, Nicolas Schlegel, Volker Kunzmann, Stefan Loeb
Summary: This study found that additive chemotherapy significantly prolonged overall survival and improved 10-year survival rates in patients after curative resection of metachronous colorectal liver metastases. Additive chemotherapy, more than five CRLM, and disease recurrence were identified as independent risk factors for overall survival. Randomized clinical trials are needed to determine optimal chemotherapy regimens for these patients in the future.
Article
Oncology
Preeti Kanikarla Marie, Cara Haymaker, Edwin Roger Parra, Young Uk Kim, Rossana Lazcano, Swati Gite, Daniele Lorenzini, Ignacio I. Wistuba, Rebecca S. Slack Tidwell, Xiaofei Song, Wai Chin Foo, Dipen M. Maru, Yun Shin Chun, Andy Futreal, Bryan Kee, David Menter, Luisa Solis, Ching-Wei Tzeng, Christine Parseghian, Kanwal Raghav, Van Morris, Chia-Chi Chang, Robert Jenq, Alda Tam, Chantale Bernatchez, Scott Kopetz, Jean-Nicolas Vauthey, Michael J. Overman
Summary: This study investigates the feasibility and safety of combining anti-CTLA-4 and anti-PD-L1 therapy in the preoperative management of resectable colorectal cancer liver metastases. Following treatment, evidence of T- and B-cell activation was seen in some patients, possibly contributing to prolonged relapse-free survival.
CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Hee Yeon Lee, In Sook Woo
Summary: The development of cytotoxic chemotherapy, targeted agents, and immune checkpoint inhibitors has significantly improved survival outcomes and quality of life in patients with metastatic colorectal cancer. Complete resection of resectable liver metastases can lead to long-term survival and cure, while the benefits of adjuvant chemotherapy after resection are still uncertain. Preoperative systemic treatment can potentially convert unresectable liver metastases to resectable tumors, but the optimal treatment strategy is yet to be established.
Article
Oncology
Sahir Javed, Stephane Benoist, Patrick Devos, Stephanie Truant, Rosine Guimbaud, Astrid Lievre, David Sefrioui, Romain Cohen, Pascal Artru, Aurelien Dupre, Jean-Baptiste Bachet, Christelle de la Fouchardiere, Anne Ploquin, Anthony Turpin
Summary: This study aimed to investigate the impact of surgery on the overall survival of patients with BRAFV600E-mutant colorectal liver metastases (CRLM). The results showed that CRLM resection was associated with better overall survival in these patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Ambre Giguelay, Evgenia Turtoi, Lakhdar Khelaf, Guillaume Tosato, Ikrame Dadi, Tommy Chastel, Marie-Alix Poul, Marine Pratlong, Stefan Nicolescu, Dany Severac, Antoine Adenis, Olivia Sgarbura-Popescu, Sebastien Carrere, Philippe Rouanet, Marc Ychou, Francois Quenet, Didier Pourqier, Pierre-Emmanuel Colombo, Andrei Turtoi, Jacques Colinge
Summary: This study confirms the heterogeneity of CRC-LM CAFs through single-cell transcriptomic analysis and proposes a model for recruiting different origins of CAFs to the liver in different liver malignancies. Additionally, the study finds that targeting LTBP2 with antibodies may help deplete ECM-remodeling CAFs in CRC-LMs.
Article
Gastroenterology & Hepatology
Frank Makowiec, Peter Bronsert, Andrea Klock, Ulrich T. Hopt, Hannes P. Neeff
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2018)
Article
Hematology
Jan Huelsduenker, Katja J. Ottmueller, Hannes P. Neeff, Motoko Koyama, Zhan Gao, Oliver S. Thomas, Marie Follo, Ali Al-Ahmad, Gabriele Prinz, Sandra Duquesne, Heide Dierbach, Susanne Kirschnek, Tim Laemmermann, Martin J. Blaser, Brian T. Fife, Bruce R. Blazar, Andreas Beilhack, Geoffrey R. Hill, Georg Haecker, Robert Zeiser
Article
Surgery
H. P. Neeff, P. A. Holzner, M. Menzel, P. Bronsert, A. Klock, S. A. Lang, S. Fichtner-Feigl, U. T. Hopt, F. Makowiec
Article
Gastroenterology & Hepatology
Frank Makowiec, Magdalena Menzel, Peter Bronsert, Philipp A. Holzner, Andrea Klock, Sven A. Lang, Stefan Fichtner-Feigl, Hannes P. Neeff
DIGESTIVE AND LIVER DISEASE
(2018)
Meeting Abstract
Oncology
E. Gkika, I. Strouthos, S. Adebahr, S. Kirste, D. Bettinger, R. Fritsch, V. Brass, L. Maruschke, H. P. Neeff, S. A. Lang, U. Nestle, A. L. Grosu, T. Brunner
RADIOTHERAPY AND ONCOLOGY
(2018)
Article
Oncology
Eleni Gkika, Dominik Bettinger, Leo Krafft, Michael Schultheiss, Hannes Philipp Neeff, Lars Maruschke, Michaela Schulenburg, Sonja Adebahr, Simon Kirste, Ursula Nestle, Robert Thimme, Anca-Ligia Grosu, Thomas Baptist Brunner
STRAHLENTHERAPIE UND ONKOLOGIE
(2018)
Article
Gastroenterology & Hepatology
G. Koulaxouzidis, V. Penna, H. Bannasch, H. P. Neeff, P. Manegold, F. Aigner, C. Witzel, M. E. Kreis, J. Pratschke, G. B. Stark, F. M. Lampert
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2019)
Article
Oncology
Eleni Gkika, Iosif Strouthos, Simon Kirste, Sonja Adebahr, Michael Schultheiss, Dominik Bettinger, Ralph Fritsch, Volker Brass, Lars Maruschke, Hannes Philipp Neeff, Sven Arke Lang, Ursula Nestle, Anca-Ligia Grosu, Thomas Baptist Brunner
STRAHLENTHERAPIE UND ONKOLOGIE
(2019)
Article
Surgery
Philipp Anton Holzner, Frank Makowiec, Andrea Klock, Torben Glatz, Stefan Fichtner-Feigl, Sven Arke Lang, Hannes Philipp Neeff
Article
Pharmacology & Pharmacy
Sebastian G. Wicha, Ralf G. Mundkowski, Andrea Klock, Ulrich T. Hopt, Bernd Drewelow, Charlotte Kloft, Ulrich F. Wellner, Tobias Keck, Uwe A. Wittel
JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Article
Surgery
Torben Glatz, Hannes Neeff, Philipp Holzner, Stefan Fichtner-Feigl, Oliver Thomusch
SURGICAL CASE REPORTS
(2018)
Meeting Abstract
Oncology
E. Gkika, L. Hallauer, S. Kirste, S. Adebahr, N. Bartl, H. P. Neeff, R. Fritsch, V. Brass, U. Nestle, A. L. Grosu, T. Brunner
ONCOLOGY RESEARCH AND TREATMENT
(2018)