Article
Surgery
Byung Min Lee, Jee Suk Chang, Woong Sub Koom, Hwa Kyung Byun, Han Sang Kim, Seung-Hoon Beom, Caleb Oh, Young Joo Suh, Joong Bae Ahn, Sang Joon Shin, Byung Jo Park, Seong Yong Park
Summary: This study aimed to assess the effect of local ablative therapy (LAT) on overall survival in patients with lung metastases from colorectal cancer (CRC). The results showed that patients treated with LAT had significantly higher survival rates compared to those treated with systemic therapy alone.
Article
Oncology
Pina Ziranu, Paolo Albino Ferrari, Francesco Guerrera, Pietro Bertoglio, Alessandro Tamburrini, Andrea Pretta, Paraskevas Lyberis, Giulia Grimaldi, Eleonora Lai, Massimiliano Santoru, Fabio Bardanzellu, Laura Riva, Francesca Balconi, Eleonora Della Beffa, Marco Dubois, Matteo Pinna-Susnik, Clelia Donisi, Enrico Capozzi, Valeria Pusceddu, Alessandro Murenu, Marco Puzzoni, Federico Mathieu, Sabrina Sarais, Aiman Alzetani, Luca Luzzi, Piergiorgio Solli, Piero Paladini, Enrico Ruffini, Roberto Cherchi, Mario Scartozzi
Summary: This study analyzed the data of 260 colorectal cancer patients with lung metastases and established the Meta-Lung Score, which can provide valuable prognostic information and guide surgical selection and prognosis assessment.
Article
Oncology
Nagore Garcia-Exposito, Ricard Ramos, Valentin Navarro-Perez, Kevin Molina, Maria Dolores Arnaiz, Susana Padrones, Jose Carlos Ruffinelli, Cristina Santos, Ferran Guedea, Arturo Navarro-Martin
Summary: Colorectal cancer is a common malignancy and lung and liver are the most common sites of metastasis. Surgery has been the traditional treatment for lung metastases, but stereotactic body radiotherapy (SBRT) is becoming increasingly favored. This study aimed to compare the local control rates of SBRT and surgery in patients with colorectal cancer lung metastases.
Article
Oncology
Halla Vidarsdottir, Christina Siesing, Bjorn Nodin, Per Jonsson, Jakob Eberhard, Karin Jirstrom, Hans Brunnstrom
Summary: This study investigated prognostic factors in CRC patients treated with pulmonary metastasectomy, including the expression of RBM3. The research found that factors such as age, number of metastases, size of metastasis, disease-free interval, RBM3 score in lung metastasis, and adjuvant chemotherapy were associated with overall survival in these patients.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Martijn van Dorp, Constantia Trimbos, Wilhelmina H. Schreurs, Chris Dickhoff, David J. Heineman, Bart Torensma, Geert Kazemier, Frank J. C. van den Broek, Ben J. Slotman, Max Dahele
Summary: In this retrospective cohort study, pulmonary metastasectomy and SABR showed comparable overall survival, local recurrence-free survival, and complication rates in patients with colorectal pulmonary metastases, despite significantly lower progression-free survival and local control rates in the SABR group.
Article
Oncology
Konstantinos Grapatsas, Fabian Doerr, Hruy Menghesha, Martin Schuler, Viktor Gruenwald, Sebastian Bauer, Hartmut H. -J. Schmidt, Stephan Lang, Rainer Kimmig, Stefan Kasper, Natalie Baldes, Servet Boeluekbas
Summary: This study investigates the morbidity and mortality after pulmonary metastasectomy (PM) and develops a score to predict high-risk patients. Preoperative cardiovascular comorbidities, major lung resections, repeated pulmonary metastasectomy, and open thoracotomy are identified as independent factors for postoperative complications. The developed Essen score can accurately predict the occurrence of postoperative complications.
Article
Oncology
Pernilla Hansdotter, Peter Scherman, Maziar Nikberg, Sune H. H. Petersen, Erik Holmberg, Magnus Rizell, Peter Naredi, Ingvar Syk, COLOFOL study grp
Summary: The lungs are the second most common site for metachronous metastases in colorectal cancer, and the role of adjuvant chemotherapy is unclear. This study aimed to evaluate pulmonary recurrences in a modern multimodal treated population and their survival depending on management. The results showed that a high proportion of lung recurrences were possible to resect, with better survival rates observed in patients treated with surgery combined with chemotherapy.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yue Han, Xue Yan, Weihua Zhi, Ye Liu, Fei Xu, Dong Yan
Summary: This study retrospectively evaluated the safety and efficacy of percutaneous CT-guided microwave ablation in colorectal cancer lung metastases. The results showed that MWA therapy can be safely and effectively used for the treatment of selected CRC pulmonary metastases, and patients without liver metastases at the diagnosis of lung metastases have better prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Martijn van Dorp, Semih uenal, Simone Gooijer, Chris Dickhoff, Frank Jozef Christiaan van den Broek, Geert Kazemier, Wilhelmina Hendrika Schreurs, Famke Lorelei Schneiders, Max Dahele, David Jonathan Heineman
Summary: This study describes the experience with salvage surgery in 17 patients who had local recurrence of colorectal pulmonary metastases following stereotactic ablative radiotherapy (SABR). The results show that salvage resection is a feasible option with acceptable morbidity and good oncological outcome in a highly selected cohort.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Theresa Stork, Rebecca Boemans, Jendrik Hardes, Arne Streitburger, Uta Dirksen, Christoph Poettgen, Hans-Ulrich Schildhaus, Sebastian Bauer, Stephane Collaud, Clemens Aigner
Summary: PM is a safe procedure with encouraging long-term outcomes. Patients with more than three metastases and progression under chemotherapy had significantly worse OS.
Article
Oncology
Fumiaki Takatsu, Hiromasa Yamamoto, Yasuaki Tomioka, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Katsuhito Takahashi, Shinichi Toyooka
Summary: This study retrospectively analyzed patients with retroperitoneal sarcoma metastasized to the lungs and found that age, disease-free interval, and size of metastasis were associated with prognosis. Pulmonary metastasectomy can be an effective management strategy for these patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Mohamed Hassan, Benjamin Ehle, Bernward Passlick, Konstantinos Grapatsas
Summary: This study investigated the feasibility and survival rate of pulmonary metastasectomy (PM) in elderly patients. The results showed no significant difference in the rate of postoperative complications and length of hospital stay between the elderly group and the non-elderly group. Although the 5-year survival rate was slightly lower in the elderly group compared to the non-elderly group, the difference was not statistically significant. COPD was associated with poor survival in the elderly group.
Article
Pathology
Emanuela Pilozzi, Damiano Fedele, Andrea Montori, Laura Lorenzon, Valentina Peritore, Giorgia Mannocchi, Nikta Bagheri, Chiara Leone, Antonio Palumbo, Michela Roberto, Giulio Ranazzi, Erino Rendina, Genoveffa Balducci, Mohsen Ibrahim
Summary: This study investigated histological patterns of metastases and mutations in MAPkinase pathway genes in colorectal lung metastasis (CLM) patients, showing that C pattern metastases had significantly worse disease-free survival (DFS). KRAS mutations were observed in 39% of patients, with codon 13 mutations associated with synchronous metastasis and poor prognosis. No mutations were found in exon 2 of NRAS gene, while 1.4% harbored a mutation in BRAF, indicating a potential prognostic role of KRAS mutations and histological patterns in CLM.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Gustavo C. L. Gossling, Marcio F. Chedid, Fernando S. Pereira, Rafaela K. da Silva, Leonardo B. Andrade, Nicolas Peruzzo, Mauricio G. Saueressig, Gilberto Schwartsmann, Aparna R. Parikh
Summary: This study aimed to identify clinicopathological and molecular features associated with progression-free survival (PFS) and overall survival (OS) after pulmonary metastasectomy for metastatic colorectal cancer. The findings suggest that disease-free interval, synchronous presentation, and number and size of lesions are significant prognostic factors for OS, while presenting with more than one lesion is predictive for PFS but not for OS.
Review
Biochemistry & Molecular Biology
Carolin Czauderna, Kim Luley, Nikolas von Bubnoff, Jens U. Marquardt
Summary: Liver metastases are the most common site of metastasis in colorectal cancer. Current treatment approaches involve systemic therapies and surgical/interventional strategies, with the use of predictive and prognostic biomarkers leading to improved survival rates. Treatment selection based on patient status, tumor characteristics, and molecular/genetic status is recommended for better outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Chiara Riganti, Marcello Francesco Lingua, Iris Chiara Salaroglio, Chiara Falcomata, Luisella Righi, Deborah Morena, Francesca Picca, Daniele Oddo, Joanna Kopecka, Monica Pradotto, Roberta Libener, Sara Orecchia, Paolo Bironzo, Valentina Comunanza, Federico Bussolino, Silvia Novello, Giorgio Vittorio Scagliotti, Federica Di Nicolantonio, Riccardo Taulli
Article
Oncology
Clizia Zichi, Marco Tampellini, Marcello Tucci, Cristina Sonetto, Chiara Baratelli, Maria P. Brizzi, Giorgio V. Scagliotti
Article
Oncology
Giuseppe Pelosi, Mauro Papotti, Luisella Righi, Giulio Rossi, Stefano Ferrero, Silvano Bosari, Fiorella Calabrese, Izidor Kern, Patrick Maisonneuve, Angelica Sonzogni, Adriana Albini, Sergio Harari, Fausto Barbieri, Enrica Capelletto, Anna Maria Catino, Domenica Cavone, Angela De Palma, Nicola Fusco, Francesca Lunardi, Eugenio Maiorano, Andrea Marzullo, Silvia Novello, Nikolaos Papanikolaou, Giulia Pasello, Antonio Pennella, Federica Pezzuto, Alessandra Punzi, Elena Prisciandaro, Federico Rea, Lorenzo Rosso, Anna Scattone, Gabriella Serio
JOURNAL OF THORACIC ONCOLOGY
(2018)
Article
Oncology
Namrata S. Patil, Luisella Righi, Hartmut Koeppen, Wei Zou, Stefania Izzo, Federica Grosso, Roberta Libener, Marco Loiacono, Valentina Monica, Consuelo Buttigliero, Silvia Novello, Priti S. Hegde, Mauro Papotti, Marcin Kowanetz, Giorgio V. Scagliotti
JOURNAL OF THORACIC ONCOLOGY
(2018)
Article
Oncology
Joanna Kopecka, Iris C. Salaroglio, Luisella Righi, Roberta Libener, Sara Orecchia, Federica Grosso, Vladan Milosevic, Preeta Ananthanarayanan, Luisa Ricci, Enrica Capelletto, Monica Pradotto, Francesca Napoli, Massimo Di Maio, Silvia Novello, Menachem Rubinstein, Giorgio V. Scagliotti, Chiara Riganti
Article
Multidisciplinary Sciences
Francesca Bertolini, Giulia Casarotti, Luisella Righi, Enrico Bollito, Carlo Albera, Silvia Anna Racca, Donato Colangelo, Barbara Mognetti
Article
Oncology
Marta Betti, Anna Aspesi, Daniela Ferrante, Marika Sculco, Luisella Righi, Dario Mirabelli, Francesca Napoli, Milena Rondon-Lagos, Elisabetta Casalone, Francesca Vignolo Lutati, Paola Ogliara, Paolo Bironzo, C. Laura Gironi, Paola Savoia, Antonella Maffe, Silvana Ungari, Federica Grosso, Roberta Libener, Renzo Boldorini, Michele Valiante, Barbara Pasini, Giuseppe Matullo, Giorgio Scagliotti, Corrado Magnani, Irma Dianzani
GENES CHROMOSOMES & CANCER
(2018)
Review
Oncology
Umberto Malapelle, Sara Pilotto, Francesco Passiglia, Francesco Pepe, Pasquale Pisapia, Luisella Righi, Angela Listi, Paolo Bironzo, Lorenzo Belluomini, Fabrizio Tabbo, Maria Lucia Reale, Gianluca Russo, Caterina De Luca, Silvia Novello, Giancarlo Troncone
Summary: Efforts have been made to optimize detection and clinical management of EGFR mutations in NSCLC, with a shift towards comprehensive detection platforms and new generation tyrosine kinase inhibitors targeting both common and uncommon mutations. Implementing these advances in routine practice remains critical, as it has the potential to impact long-term survival and quality of life for patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Francesca Napoli, Angela Listi, Vanessa Zambelli, Gianluca Witel, Paolo Bironzo, Mauro Papotti, Marco Volante, Giorgio Scagliotti, Luisella Righi
Summary: The tumor immune microenvironment plays a crucial role in the growth and progression of malignant pleural mesothelioma. Understanding the pathological characteristics of this microenvironment can lead to the discovery of new biomarkers and the development of advanced therapeutic strategies for this aggressive disease.
Review
Oncology
Virginia Liberini, Annapaola Mariniello, Luisella Righi, Martina Capozza, Marco Donatello Delcuratolo, Enzo Terreno, Mohsen Farsad, Marco Volante, Silvia Novello, Desiree Deandreis
Summary: Lung cancer, especially non-small cell lung cancer, remains a primary cause of cancer-related death. New therapeutic approaches, including immunotherapy, have shown significant improvement in patient survival and quality of life. However, the identification of predictive biomarkers is crucial to determine which patients will benefit most from immunotherapy-based treatments.
Article
Oncology
Paolo Bironzo, Luca Primo, Silvia Novello, Luisella Righi, Silvana Candeloro, Lorenzo Manganaro, Federico Bussolino, Fabrizio Pirri, Giorgio V. Scagliotti
Summary: The aim of this study is to develop a technological platform for precision medicine, which includes comprehensive analysis and predictive algorithms based on the collection of lung cancer samples and patient biological information, to provide personalized diagnosis and treatment for patients.
CLINICAL LUNG CANCER
(2022)
Article
Cell Biology
Annapaola Mariniello, Fabrizio Tabbo, Davide Indellicati, Martina Tesauro, Nicole Alessia Rezmives, Maria Lucia Reale, Angela Listi, Enrica Capelletto, Simona Carnio, Valentina Bertaglia, Caterina Mecca, Lorena Consito, Marco De Filippis, Maristella Bungaro, Chiara Paratore, Massimo Di Maio, Francesco Passiglia, Luisella Righi, Dario Sangiolo, Silvia Novello, Massimo Geuna, Paolo Bironzo
Summary: This study explored and compared T cell characteristics in broncho-alveolar lavage (BAL) from tumor affected and contralateral lung, as well as matched peripheral blood (PB), in lung cancer patients. The results showed that T cells in BAL from advanced lung cancer patients presented features of exhaustion, which could be potential biomarkers for cancer immunotherapy outcome.
Review
Pathology
V Ascoli, B. Murer, A. Nottegar, C. Luchini, R. Carella, F. Calabrese, F. Lunardi, I Cozzi, L. Righi
Review
Oncology
Giuseppe Pelosi, Angelica Sonzogni, Sergio Harari, Adriana Albini, Enrica Bresaola, Caterina Marchio, Federica Massa, Luisella Righi, Gaia Gatti, Nikolaos Papanikolaou, Namrata Vijayvergia, Fiorella Calabrese, Mauro Papotti
TRANSLATIONAL LUNG CANCER RESEARCH
(2017)
Article
Oncology
P. Boffetta, L. Righi, C. Ciocan, C. Pelucchi, C. La Vecchia, C. Romano, M. Papotti, E. Pira
ANNALS OF ONCOLOGY
(2018)