Article
Oncology
Nikhil Lal, Dedrick Kok Hong Chan, Minn E. Ng, Louis Vermeulen, Simon James Alexander Buczacki
Summary: High lymph node (LN) yield is predictive of overall and disease-free survival in non-metastatic colon cancer. There is no association between higher LN yield and increasing nodal positivity, but it is strongly linked with gene expression changes associated with the adaptive and dendritic cell immune response, especially in node-negative cancers. These findings were validated in an independent dataset.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Arash Azin, Dhruvin H. Hirpara, Arman Draginov, Mohammadali Khorasani, Sunil V. Patel, Catherine O'Brien, Fayez A. Quereshy, Sami A. Chadi
Summary: The study showed that resection for obstructed colon cancer is associated with higher odds of inadequate lymph node harvest compared to non-obstructed colon cancer. Factors such as age, presence of preoperative sepsis, tumor location, and surgical approach were also found to be associated with inadequate lymph node retrieval.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Jun-Peng Pei, Rui Zhang, Nan-Nan Zhang, Yong-Ji Zeng, Zhe Sun, Si-Ping Ma, Jian-Guo Zhou, Xin-Xiang Li, Jin Fan, Ji Zhu, Masanobu Abe, Zu-Bing Mei, Gang Shi, Chun-Dong Zhang
Summary: The novel TLNR classification for colon cancer, which combines LNR and T stage, showed better prognostic discrimination, model-fitting ability, and net benefits compared to the AJCC 8th TNM classification in patients with operable stage I-III colon cancer. Further studies are needed to validate the novel TLNR classification.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Huolun Feng, Zejian Lyu, Weijun Liang, Guanfu Cai, Zhenru Deng, Meiyu Jiang, Deqing Wu, Yong Li
Summary: Through rigorous statistical methods and a large sample size, the study suggests that the optimal number of ELNs for prognostic stratification in node-negative colon cancer is 15. This finding highlights the importance of ELNs as a prognostic factor in cancer patients.
Article
Gastroenterology & Hepatology
Sunseok Yoon, Woong Bae Ji, Jung Sik Kim, Kwang Dae Hong, Jun Won Um, Byung-Wook Min, Sun-Il Lee, Sanghee Kang, Yeonuk Ju, Jin Kim, Jung Myun Kwak, Se Jin Baek
Summary: This study compared the oncologic outcomes of D3 and D2 lymphadenectomy in patients with clinical stage 2/3 right colon cancer, including overall survival and disease-free survival. The results showed that D3 lymphadenectomy was associated with a significantly higher 5-year disease-free survival rate compared to D2 lymphadenectomy, while there was no significant difference in overall survival between the two groups. Therefore, D3 lymphadenectomy may improve oncologic outcomes for patients with right colon cancer.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Oncology
Yansong Xu, Yi Chen, Chenyan Long, Huage Zhong, Fangfang Liang, Ling-xu Huang, Chuanyi Wei, Shaolong Lu, Weizhong Tang
Summary: Preoperative CEA level, grading, and PNI were identified as independent risk factors for LNM in colon cancer. The nomogram constructed in this study demonstrated good consistency and calibration capabilities for predicting LNM risk in both the training and validation sets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Yi-Kai Kao, Hsin-Pao Chen, Kuang-Wen Liu, Ling-Chiao Song, Yi-Chieh Chen, Yu-Chun Lin, Chih- Chen
Summary: This study aimed to investigate the impact of insufficient lymph node harvest on survival in T4N0 colorectal cancer patients, but no significant differences were found in disease-free survival and overall survival between patients with adequate (>= 12) and inadequate (< 12) lymph node harvest.
Article
Medicine, General & Internal
Xiang Zhang, Nan Feng, Bo Wu, Yiping Wei, Wenxiong Zhang
Summary: Lymph node ratio (LNR) is an important prognostic indicator in non-small-cell lung cancer (NSCLC), with higher LNR indicating worse prognosis. This study found that LNR and positive node category have predictive value for prognosis in stage III NSCLC patients.
Article
Oncology
Wangxin Yan, Huizhen Zhou, Si Shi, Jixu Lin, Qiangkang Lin
Summary: Younger age, female gender, more lymph nodes harvested, Black race, and higher tumor grade were more prone to be diagnosed with lymph node involvement. The receipt of adjuvant chemotherapy following radical surgery significantly decreased the risk of colon cancer-specific mortality by 33.9% in T1 colon cancer with lymph node involvement.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Inge van den Berg, Marcel Smid, Robert R. J. Coebergh van den Braak, Carolien H. M. van Deurzen, Vanja de Weerd, John A. Foekens, Jan N. M. IJzermans, John W. M. Martens, Saskia M. Wilting
Summary: Circular RNAs (circRNAs) play an important role in tumor progression of colon cancer (CC) and have potential clinical value as biomarkers for diagnosis, prognosis, and treatment. A large cohort study identified a diverse catalog of circRNAs in stage I/II colon tumors and found that high circRNA diversity was associated with favorable disease-free survival (DFS). Specific circRNAs were also associated with MSI and CMS, highlighting their potential utility for prognostic stratification in patients with early-stage colon cancer.
Article
Surgery
Kiyoaki Sugiura, Yuki Seo, Yuki Tajima, Hiroto Kikuchi, Akira Hirata, Jumpei Nakadai, Hideo Baba, Takayuki Kondo, Akitsugu Makino, Yujin Kato, Shimpei Matsui, Ryo Seishima, Kohei Shigeta, Koji Okabayashi, Yuko Kitagawa
Summary: This study investigates the necessity of lymph node dissection during colon cancer surgery and finds that main lymph node metastasis (MLNM) has a significant impact on the prognosis of colon cancer patients. Adding the MLNM status to the TNM staging system can enhance prognostic evaluation and the clinical efficacy of adjuvant therapy.
WORLD JOURNAL OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Kenichi Ishii, Jun Watanabe, Kouki Goto, Yusuke Suwa, Kazuya Nakagawa, Hirokazu Suwa, Mayumi Ozawa, Atsushi Ishibe, Chikara Kunisaki, Itaru Endo
Summary: The study investigated the impact of APN metastasis on the prognosis of patients with high-risk stage III colon cancer, revealing that APN metastasis is an independent risk factor for 5-year overall survival and relapse-free survival.
SCIENTIFIC REPORTS
(2022)
Article
Otorhinolaryngology
Andreas Machens, Kerstin Lorenz, Frank Weber, Henning Dralle
Summary: In medullary thyroid cancer, the metastatic lymph node ratio (MLNR) predicts cancer-specific survival better than the number of node metastases or TNM/AJCC N classification.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
John M. Masterson, Michael Luu, Aurash Naser-Tavakolian, Stephen J. Freedland, Howard Sandler, Zachary S. Zumsteg, Timothy J. Daskivich
Summary: The number and density of metastatic lymph nodes on lymphadenectomy predict mortality in prostate cancer. The study found that the impact of lymph node density on overall mortality is negligible in patients with 3 or fewer metastatic lymph nodes, who make up the majority of patients with metastatic lymph nodes. Pathological nodal staging should primarily focus on the count of lymph nodes rather than density.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Feng Pi, Gang Tang, Chaozheng Xie, Yukun Cao, Shilai Yang, Zhengqiang Wei
Summary: This study found that lymph node ratio is a strong predictor of stage III rectal cancer recurrence and suggests that Carbon Nanoparticles use significantly affects lymph node ratio and tumor recurrence.
FRONTIERS IN ONCOLOGY
(2023)