Article
Surgery
Yujin Kato, Kohei Shigeta, Koji Okabayashi, Masashi Tsuruta, Ryo Seishima, Shimpei Matsui, Taketo Sasaki, Yuka Koseki, Yuko Kitagawa
Summary: The severity of lymph node involvement in colorectal cancer patients showed a strong correlation with lung metastases, while no significant correlation was found with other recurrence sites.
Article
Oncology
Laura Noteware, Gloria Broadwater, Nicole Dalal, Laura Alder, James E. Herndon, Scott Floyd, William Giles, Amanda E. D. Van Swearingen, Carey K. Anders, Sarah Sammons
Summary: This study investigates the impact of extracranial disease on the survival outcomes of patients with HER2 + breast cancer brain metastases. The results show that patients with isolated intracranial relapse have shorter overall survival compared to those with concurrent progressive or stable/responding extracranial disease. Additionally, receiving systemic therapy can significantly improve intracranial progression-free survival and overall survival.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Mimi Ton, Nathaniel F. Watson, Arthur Sillah, Rachel C. Malen, Julia D. Labadie, Adriana M. Reedy, Stacey A. Cohen, Andrea N. Burnett-Hartman, Polly A. Newcomb, Amanda I. Phipps
Summary: The study found that colorectal cancer patients, especially those with rectal cancer, are more likely to experience sleep issues, such as changes in sleep patterns after diagnosis. This suggests that sleep-focused survivorship care may need to be adapted based on colorectal cancer site to provide appropriate support for patients.
Article
Medicine, General & Internal
Bahar Saberzadeh-Ardestani, Jeremy C. Jones, Joleen M. Hubbard, Robert R. McWilliams, Thorvardur R. Halfdanarson, Qian Shi, Mohamad Bassam Sonbol, Jonathan Ticku, Zhaohui Jin, Frank A. Sinicrope
Summary: This cohort study found clinically significant prolongation of survival in older patients with dMMR mCRC who received first-line pembrolizumab monotherapy in routine clinical practice. Liver metastasis was associated with poorer survival compared to nonliver metastasis, indicating the importance of metastatic site in survival outcome.
Article
Oncology
Alice Bertocchi, Sara Carloni, Paola Simona Ravenda, Giovanni Bertalot, Ilaria Spadoni, Antonino Lo Cascio, Sara Gandini, Michela Lizier, Daniele Braga, Francesco Asnicar, Nicola Segata, Chris Klaver, Paola Brescia, Elio Rossi, Achille Anselmo, Silvia Guglietta, Annalisa Maroli, Paola Spaggiari, Noelia Tarazona, Andres Cervantes, Silvia Marsoni, Luca Lazzari, Maria Giovanna Jodice, Chiara Luise, Marco Erreni, Salvatore Pece, Pier Paolo Di Fiore, Giuseppe Viale, Antonino Spinelli, Chiara Pozzi, Giuseppe Penna, Maria Rescigno
Summary: Bacteria from primary tumors can lead to bacterial dissemination from the intestine to the liver, disrupting the gut vascular barrier, boosting the formation of a premetastatic niche, and enhancing the recruitment of metastatic cells. High levels of PV-1, a marker of impaired gut vascular barrier, are associated with liver bacteria dissemination and metachronous distant metastases in colorectal cancer patients, making it a prognostic marker for distant recurrence and vascular impairment.
Article
Biochemistry & Molecular Biology
Jiande Wu, Lu Zhang, Aditi Kuchi, David Otohinoyi, Chindo Hicks
Summary: This study investigated the use of DNA methylation for predicting survival in colorectal cancer (CRC). The researchers discovered signatures of CpG sites and genes associated with CRC and predictive of survival. Functional analysis revealed molecular networks and signaling pathways driving clinical outcomes.
Article
Neurosciences
Rhian Evans, Lewis M. M. Watkins, Kristen Hawkins, Gabriella Santiago, Constantinos Demetriou, Michelle Naughton, Marie Dittmer, Mark I. I. Rees, Denise Fitzgerald, B. Paul Morgan, James W. W. Neal, Owain W. W. Howell
Summary: A neuropathological study reveals the presence of complement activation products at the brain surfaces, which are associated with underlying pathology and increased complement receptor-positive microglia/macrophages in expanding cortical grey matter lesions, suggesting a potential target for modifying compartmentalized inflammation and cortical demyelination.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Oncology
Sara Cherri, Ester Oneda, Laura Zanotti, Alberto Zaniboni
Summary: Colorectal cancer is a significant health problem due to its incidence and biological complexity. Distinguishing different types of colorectal cancer based on specific characteristics is crucial for better therapeutic outcomes. The future challenge lies in studying effective combination treatments to overcome resistance mechanisms and achieve long-term treatment success. It is also important to prioritize the best therapies for first-line treatment and refine patient selection.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Simona Serrati, Letizia Porcelli, Francesco Fragassi, Marianna Garofoli, Roberta Di Fonte, Livia Fucci, Rosa Maria Iacobazzi, Antonio Palazzo, Francesca Margheri, Grazia Cristiani, Anna Albano, Raffaele De Luca, Donato Francesco Altomare, Michele Simone, Amalia Azzariti
Summary: Evolving evidence suggests that cancer-derived extracellular vesicles (EVs) play a crucial role in facilitating directional metastasis in colorectal cancer to the peritoneal surface. These EVs can induce cell apoptosis, reduce invasiveness, and promote tumor invasion. Additionally, mesothelial cells release EVs that contribute to tumor invasion and trigger pro-invasive systems in tumor cells.
Article
Oncology
Sadayuki Kawai, Nozomi Takeshima, Yu Hayasaka, Akifumi Notsu, Mutsumi Yamazaki, Takanori Kawabata, Kentaro Yamazaki, Keita Mori, Hirofumi Yasui
Summary: The study compared the efficacy and toxicity profiles of IRI- and Ox-based regimens as first-line treatments for mCRC, finding no significant difference in terms of overall survival, progression-free survival, and objective response rate between the two groups. However, there were differences in toxicity profile, with IRI-based regimens associated with higher incidence of certain adverse events, while Ox-based regimens had different toxicities such as thrombocytopenia and peripheral sensory neuropathy.
Article
Oncology
Romain Cohen, Vincent Jonchere, Christelle De La Fouchardiere, Toky Ratovomanana, Quentin Letourneur, Mira Ayadi, Lucile Armenoult, Adrien Buisson, Matthieu Sarabi, Anna Pellat, Raphael Colle, Francois Paye, Pierre Meeus, Magali Svrcek, Alex Duval, Thierry Andre
Summary: This case series describes five patients with ICI-treated MSI mCRC with disease progression limited to the adrenal glands. The treatment methods included adrenalectomy and stereotactic body radiation therapy, suggesting that the adrenal glands may be the sanctuary sites for ICI-treated MSI mCRC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell Biology
Hao Wang, Wei Wei, Zhong-Yuan Zhang, Yao Liu, Bin Shi, Wen Zhong, Hou-Shun Zhang, Xin Fang, Chun-Lei Sun, Jia-Bei Wang, Lian-Xin Liu
Summary: Metastasis in colorectal cancer (CRC) remains a major challenge, and dysregulation of N6-methyladenosine (m6A) is associated with this process. This study reveals that METTL14, a key component of m6A methylation, plays a role in inhibiting CRC metastasis by regulating the ARRDC4/ZEB1 signaling pathway. METTL14 regulates ARRDC4 mRNA stability through YHTDF2, and its protein expression is controlled by TCF4 and HuR. Clinical studies show that decreased METTL14 is associated with poor prognosis in CRC patients.
CELL DEATH & DISEASE
(2022)
Article
Nursing
Linda Larkey, Laura A. Szalacha, Julie Bucho-Gonzalez, Usha Menon
Summary: This study aims to navigate underserved and underscreened populations to clinics for colorectal cancer screening through tailored messaging. Changes in medical reimbursement and immigration policies affected healthcare delivery systems, leading to lower participation rates than anticipated. Creative strategies and community partnerships were developed to overcome these challenges.
Review
Endocrinology & Metabolism
Sabrina J. Ritch, Carlos M. Telleria
Summary: Epithelial ovarian cancer is the deadliest gynecological disease, commonly diagnosed at late stages with metastasis. Understanding the unique microenvironments that promote EOC dissemination is crucial in improving patient outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Faris Soliman, Lin Ye, Wenguo Jiang, Rachel Hargest
Summary: Peritoneal metastasis from colorectal cancer is a challenging issue with poor overall survival rates. Targeting the interaction of cancer cells with hyaluronic acid, an important molecule in peritoneal dissemination, may prevent the adhesion and colonization of tumor cells in the peritoneum.
CLINICAL COLORECTAL CANCER
(2022)