Article
Cell & Tissue Engineering
Benjamin K. Schilling, Jocelyn S. Baker, Chiaki Komatsu, Kacey G. Marra
Summary: Peripheral nerve injury and muscle atrophy have a significant healthcare burden in the United States, partly due to the lack of specific preventative therapies. Injecting skeletal muscle-derived ECM directly into denervated muscle can promote muscle regeneration and improve muscle function.
JOURNAL OF TISSUE ENGINEERING
(2021)
Article
Engineering, Biomedical
Binghui Jin, Yunru Yu, Xiangxiang Chen, Yanhong Yang, Yushan Xiong, Young Jun Im, Yuanjin Zhao, Jian Xiao
Summary: The study proposes a novel microtube for sciatic nerve regeneration using gradient decellularized porcine sciatic nerve extracellular matrix hydrogel (pDScNM-gel). The pDScNM is shown to enhance cell proliferation and migration, improve axon growth, and these effects can also be achieved through coculture in a gradient pDScNM microtube. In vivo sciatic nerve regeneration and functional recovery are demonstrated by assembling the gradient pDScNM microtubes with a medical silicon tube.
BIOACTIVE MATERIALS
(2023)
Article
Medicine, General & Internal
Mete Zeynal, Hakan Hadi Kadioglu
Summary: This study evaluates sciatic nerve injuries due to intramuscular injections, which is a common issue in medical practice. The results show that certain pharmaceutical agents can cause nerve damage, with endoneurial and intrafascicular injections potentially causing more harm than epineurial injections.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Shuai Wei, Qian Hu, Jianxiong Ma, Xiu Dai, Yu Sun, Gonghai Han, Haoye Meng, Wenjing Xu, Lei Zhang, Xinlong Ma, Jiang Peng, Yu Wang
Summary: Compared to conventional artificial nerve guide conduits, acellular nerve grafts derived from natural nerves have natural advantages. In this study, a composite technology based on supercritical carbon dioxide was used to process the peripheral nerve of a large mammal and obtain acellular nerve xenografts. The extracted grafts showed improved cell adhesion and proliferation, reduced inflammatory response, and promoted nerve regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Environmental
Lisa Melymuk, Jonathan Blumenthal, Ondrej Sanka, Adriana Shu-Yin, Veena Singla, Katerina Sebkova, Kristi Pullen Fedinick, Miriam L. Diamond
Summary: The environmentally sound management (ESM) of polychlorinated biphenyls (PCBs) is a major challenge globally, with only 30% of countries on track to achieve the 2028 goal. While countries like Canada and Czechia are close to reaching the goal, the USA still faces significant inventory and reduction challenges. The failure to manage global PCB stocks after more than 30 years highlights the need to prioritize reducing production and use of other persistent organic pollutants (POPs).
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Surgery
Benjamin K. Schilling, Jocelyn S. Baker, Chiaki Komatsu, David M. Turer, Fuat Baris Bengur, W. Vincent Nerone, Feng Qin, Adam R. Cottrill, Lauren E. Kokai, J. Peter Rubin, Kacey G. Marra
Summary: The therapeutic properties of nanofat injected into denervated gastrocnemius after sciatic nerve injury were investigated. The results showed that nanofat injection significantly increased muscle strength and promoted muscle repair-associated inflammatory gene expressions. The increased therapeutic breadth of nanofat could potentially include muscular recovery after nerve injury.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Surgery
Mehmet Selim Comez, Yakup Borazan, Tumay Ozgur, Cafer Tayer Isler, Mustafa Cellat, Mehmet Guvenc, Muhammed Enes Altug
Summary: The study demonstrated that perineural dexamethasone has protective effects against sciatic nerve damage induced by intraneural bupivacaine, reducing the severity of nerve damage.
JOURNAL OF INVESTIGATIVE SURGERY
(2021)
Article
Food Science & Technology
Minsu Seo, Dongin Lim, Shengshu Kim, Taeyeon Kim, Bum Sun Kwon, Kiyeun Nam
Summary: This study compared the effects of BoNT/A and ESWT on injured peripheral nerves, showing that both treatments could activate Schwann cells, increase expression levels of proteins related to axonal regeneration, and improve motor function in the injured nerve.
Article
Biochemistry & Molecular Biology
Liangfu Jiang, Xingyu Ouyang, Dupiao Zhang, Gang Wang, Zhe Zhang, Wei Wang, Hede Yan
Summary: This study presents a Gel-Ppy modified nerve conduit with excellent biocompatibility and conductivity, and evaluates its performance in promoting nerve regeneration in vitro and in vivo. The results demonstrate that Gel-Ppy modified nerve conduit can significantly enhance Schwann cell proliferation, contribute to Schwann cell regeneration in vivo, and improve axon diameters and myelin sheath thickness, leading to the amelioration of muscle atrophy, nerve conduction, and motor function recovery. Further investigation indicates that the Gel-Ppy conduit facilitates nerve regeneration by upregulating the Rap1 pathway to induce neurite outgrowth. Therefore, Gel-Ppy modified nerve conduit can provide a favorable microenvironment for nerve regeneration and be popularized as a novel therapeutic strategy for peripheral nerve injury.
Article
Chemistry, Medicinal
Haili Xiao, Chao Wei, Huiying Liu, Zhiqiang Li, Cihua Zheng, Jun Luo
Summary: The natural drug lentinan has been found to regulate autophagy, promoting the clearance of myelin debris and enhancing nerve regeneration. The study demonstrated that lentinan activates the AMPK/mTOR signaling pathway, accelerating autophagic flux and promoting the phagocytosis of myelin debris by Schwann cells. These findings suggest that lentinan may be a cost-effective and natural treatment for peripheral nerve injury.
PHYTOTHERAPY RESEARCH
(2023)
Article
Neurosciences
Rahul Shankar Rao Rayilla, M. U. R. Naidu, Phanithi Prakash Babu
Summary: This study presents a surgical approach to induce demyelination in the rat sciatic nerve, followed by remyelination after Teriflunomide (TF) treatment. Histology and immunostaining reveal demyelination or myelin loss after sciatic nerve injury, with no self-recovery. The rotarod test confirms the motor function loss in nerve-damaged rats. Transmission electron microscopy shows axonal atrophy and inter-axonal gaps in these rats. TF administration restores motor function, repairs axonal atrophy with inter-axonal spaces, and promotes myelin secretion or remyelination. These findings demonstrate the potential of the surgical procedure and TF treatment in inducing and repairing demyelination.
Article
Cell Biology
Bo Wang, Chang-Feng Lu, Zhong-Yang Liu, Shuai Han, Pi Wei, Dian-Ying Zhang, Yu-Hui Kou, Bao-Guo Jiang
Summary: A novel nerve graft composed of chitin scaffolds and a small autologous nerve was used to repair sciatic nerve defects in rats, and it effectively facilitated nerve regeneration and restored neurological function, suggesting its potential as a new option for tissue-engineered nerve scaffolds.
NEURAL REGENERATION RESEARCH
(2022)
Article
Orthopedics
Zhigang Liu, Fulin Tao, Weicheng Xu, Fanxiao Liu, Jinlei Dong, Lianxin Li, Zhenhai Hao, Dongsheng Zhou, Shun Lu
Summary: This study retrospectively analyzed the characteristics, clinical features, treatment, and factors affecting neurological recovery of patients diagnosed with acetabular fracture between January 2014 and June 2021. The study found that all injuries involved the posterior wall or posterior column of the acetabulum, and most patients had posterior dislocation of the hip joint. Patients with intraoperative nerve abnormalities showed better neurological recovery, and those with partial recovery took longer to recover.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Cell Biology
Su-Long Wang, Xi-Lin Liu, Zhi-Chen Kang, Yue-Shu Wang
Summary: The effect of platelet-rich plasma on nerve regeneration in a rabbit model of sciatic nerve small-gap defects with preserved epineurium was investigated. Results showed that platelet-rich plasma with specific concentrations of whole blood platelets promoted repair of sciatic nerve injury. Proteomics analysis revealed that platelet-rich plasma affects angiogenesis and intracellular ubiquitin levels in the regeneration process.
NEURAL REGENERATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Waleed M. Renno, Mohammad Afzal, Bincy Paul, Divya Nair, Jijin Kumar, Jassim M. Al-Hassan
Summary: Preparations from the epidermal gel secretion of Arabian Gulf catfish showed potent anti-inflammatory and healing properties in clinical trials for diabetic foot ulcers and other disorders. A unique protein and lipid preparation from the catfish secretion accelerated the healing of nerve injuries in rats, enhancing neurobehavioral performance and histomorphological regeneration. SPF-FB treatment decreased neurobehavioral deficits, promoted axonal regeneration, and protected spinal neurons by modulating astrocytic activity and GAP-43 expression.
FRONTIERS IN PHARMACOLOGY
(2021)
