Article
Cardiac & Cardiovascular Systems
Procolo Di Bonito, Giuliana Valerio, Maria R. Licenziati, Giuseppina Campana, Emanuele M. del Giudice, Anna Di Sessa, Anita Morandi, Claudio Maffeis, Claudio Chiesa, Lucia Pacifico, Marco G. Baroni, Melania Manco
Summary: The study revealed a significant association between uric acid levels and markers of prediabetes, insulin resistance, and insulin sensitivity in overweight/obese youth. Higher uric acid levels were correlated with elevated markers of impaired glucose metabolism, particularly post-challenge conditions.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Domenico Corica, Giorgia Pepe, Tommaso Aversa, Monica Curro, Selenia Curatola, Alessandra Li Pomi, Angela Alibrandi, Riccardo Ientile, Malgorzata Wasniewska
Summary: The study found that postprandial asprosin levels significantly change in non-diabetic children and adolescents with obesity, and are associated with metabolic variables related to diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Cherlyn Ding, Leonie Egli, Nabil Bosco, Lijuan Sun, Hui Jen Goh, Khung Keong Yeo, Jonathan Jiunn Liang Yap, Lucas Actis-Goretta, Melvin Khee-Shing Leow, Faidon Magkos
Summary: The study found that plasma BCAA levels were associated with increased insulin secretion and decreased insulin clearance in healthy Chinese subjects. This suggests that BCAA may play an important role in the regulation of glucose homeostasis.
FRONTIERS IN NUTRITION
(2021)
Article
Endocrinology & Metabolism
Elena Succurro, Maria Adelaide Marini, Alessia Riccio, Teresa Vanessa Fiorentino, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti
Summary: This study found that deteriorated glucose homeostasis in women is associated with greater fat accumulation and worsening insulin sensitivity compared to men.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Jacob D. Kohlenberg, Marcello C. Laurenti, Aoife M. Egan, Daniel Schembri Wismayer, Kent R. Bailey, Claudio Cobelli, Chiara Dalla Man, Adrian Vella
Summary: People with isolated impaired fasting glucose (IFG) have normal beta cell function. It is found that alpha cell dysfunction in IFG contributes to the pathogenesis of the disease independently of defects in insulin secretion.
Article
Hematology
Fahim Abbasi, Cindy Lamendola, Chelsea S. Harris, Vander Harris, Ming-Shian Tsai, Pragya Tripathi, Fakhar Abbas, Gerald M. Reaven, Peter D. Reaven, Michael P. Snyder, Sun H. Kim, Joshua W. Knowles
Summary: The study showed that high-intensity atorvastatin for 10 weeks increased insulin resistance and insulin secretion in individuals without type 2 diabetes, potentially leading to an increased risk of developing diabetes over time.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Medicine, Research & Experimental
Xiaorong Fu, Justin A. Fletcher, Stanislaw Deja, Melissa Inigo-Vollmer, Shawn C. Burgess, Jeffrey D. Browning
Summary: This study found that aberrant oxidative metabolism in fasting NAFL subjects is related to the inability to halt fasting de novo lipogenesis (DNL). Fasting DNL negatively correlated with hepatic beta-oxidation and ketogenesis, and positively correlated with citrate synthesis. Subjects with the highest fasting DNL were intransigent to the effects of fasting on insulin, non-esterified fatty acid, and ketone concentrations, and sustained glycogenolysis and citrate synthesis.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Yun Gi Kim, Seung-Young Roh, Joo Hee Jeong, Hyoung Seok Lee, Kyongjin Min, Yun Young Choi, Kyung-Do Han, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Summary: Long-term increase in fasting blood glucose (FBG) is associated with higher risk of sudden cardiac arrest (SCA) in individuals with diabetes mellitus (DM), while a long-term decrease in FBG is not associated with reduced SCA risk. Preventing increase in FBG can have significant impacts on public health in terms of SCA prevention.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Food Science & Technology
Masanobu Hibi, Yuji Matsui, Sachiko Niwa, Sachiko Oishi, Aya Yanagimoto, Takahiro Ono, Tohru Yamaguchi
Summary: Corosolic acid has been found to improve glucose tolerance in both healthy individuals and prediabetic subjects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Food Science & Technology
Somaye Fatahi, Ali Nazary-Vannani, Mohammad Hassan Sohouli, Zeinab Mokhtari, Hamed Kord-Varkaneh, Vihan Moodi, Shing Cheng Tan, Teck Yew Low, Fernando Zanghelini, Farzad Shidfar
Summary: The study revealed that fasting or energy-restricting diets significantly decrease fasting blood sugars, insulin, and insulin resistance levels, with modest effects on HbA1c levels. Overweight or obese individuals on energy-restricting diets for more than 8 weeks showed greater reductions in FBS, insulin, and HOMA-IR levels compared to other subgroups.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Ebru S. Selen, Susana Rodriguez, Kyle S. Cavagnini, Han-Byeol Kim, Chan Hyun Na, Michael J. Wolfgang
Summary: In this study, liver-specific Pcx knockout mice (PcxL-/-) were generated to investigate the role of Pcx in hepatic mitochondrial metabolism under different physiological states. The results showed that hepatic Pcx is important for maintaining long-term glycemia under carbohydrate-limited diets, and loss of Pcx is associated with changes in the abundance of acetylated proteins.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Medical Laboratory Technology
Jong Weon Choi, Moon Hee Lee, Tatsuyoshi Fujii
Summary: Patients with impaired fasting glucose (IFG) may be at a greater risk of insulin resistance and possible progression to diabetic nephropathy than patients with hemoglobin A1c (HbA1c)-defined prediabetes (A1c-PDM). The prevalence of microalbuminuria (MAU) was higher in IFG patients and significantly correlated with fasting plasma glucose (FPG) levels, but not with HbA1c levels.
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2022)
Article
Nutrition & Dietetics
Barbara R. Cardoso, Sabine Braat, Ross M. Graham
Summary: The study investigated the association between blood selenium concentration and glucose markers in the representative sample of the US population, finding a positive correlation between selenium and insulin, as well as HOMA-IR. While the associations with insulin and HOMA-IR remained after further adjustments, the correlation with glucose was no longer significant.
FRONTIERS IN NUTRITION
(2021)
Article
Multidisciplinary Sciences
Min Jin Lee, Ah Reum Khang, Dongwon Yi, Yang Ho Kang
Summary: This study investigated the association between relative hand grip strength and glycemic status. The results showed that individuals with lower relative hand grip strength had a higher risk of both diabetes and impaired fasting glucose. This association was stronger in younger adults compared to older adults.
Review
Endocrinology & Metabolism
P. P. Manolopoulos, G. Lavranos, I. Mamais, A. Angouridis, K. Giannakou, E. O. Johnson
Summary: Vitamin D deficiency is common in patients with thalassemia, but the prevalence and severity vary. Existing evidence is insufficient to conclude whether vitamin D supplementation is associated with bone mineral density improvement in this specific population.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Gastroenterology & Hepatology
Ismini Tzanaki, Aris P. Agouridis, Michael S. Kostapanos
Summary: Atherogenic dyslipidemia is highly prevalent in non-alcoholic fatty liver disease (NAFLD) and contributes to the increased cardiovascular risk associated with this condition. Alongside insulin resistance, it plays an important role in the development and progression of NAFLD/non-alcoholic steatohepatitis (NASH). Statins have shown potential benefits in reducing hepatic steatosis, inflammation, and fibrosis in NAFLD/NASH patients, but data for other lipid-lowering therapies are limited and conflicting.
WORLD JOURNAL OF HEPATOLOGY
(2022)
Review
Microbiology
Afroditi Konsoula, Constantinos Tsioutis, Ioulia Markaki, Michail Papadakis, Aris P. Agouridis, Nikolaos Spernovasilis
Summary: Lomentospora prolificans is an emerging opportunistic pathogen that affects both immunocompromised individuals and healthy populations. Intrinsic resistance to antifungals makes successful recovery difficult. Rapid diagnosis, surgical debridement, and timely antifungal treatment are key for successful management. Further research is needed to understand the environmental niche, pathophysiology, and species-specific therapeutic targets of this fungus.
Article
Cardiac & Cardiovascular Systems
Filippos Anastasiadis, Dimitrios Antoniadis, Dimitrios Chountis, Ioannis Mantas, Ioannis Lekakis, Moses Elisaf, Charalampos Karvounis, Athanasios Manolis, Georgios Hahalis, Ioannis Kogias, Theodora Tourtoglou, Dimitrios Gourlis, Dimitrios Tsounis
Summary: Based on the TIGREECE study in Greece, the long-term outcomes of high-risk myocardial infarction patients managed in hospitals and private clinics show that approximately 10% of patients experience recurrent cardiovascular events or death within 1-3 years, mainly of ischemic origin.
HELLENIC JOURNAL OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Anastasios Makris, Fotios Barkas, Petros P. Sfikakis, Evangelos Liberopoulos, Aris P. Agouridis
Summary: This study systematically investigated the effect of upadacitinib on lipid profile and cardiovascular disease risk. The results showed that upadacitinib treatment increased both LDL-C and HDL-C levels, but had no significant effect on MACE risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Medicinal
Charoula Lymperopoulou, Stylianos A. Kandarakis, Ismini Tzanaki, Ioanna Mylona, Theodoros Xanthos, Aris P. Agouridis
Summary: Through a systematic review, we found that statin therapy may have a protective effect on ocular diseases, including cataract formation, age-related macular degeneration, diabetic retinopathy, and non-infectious uveitis. However, the current evidence is insufficient for robust conclusions, and more large-scale randomized control trials are recommended to provide more reliable evidence.
Editorial Material
Pharmacology & Pharmacy
Aris P. Agouridis, Theodosios D. Filippatos
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Pediatrics
Aris P. Agouridis, Nikoletta Palli, Vasiliki-Eirini Karagiorga, Afroditi Konsoula, Lamprini Markaki, Nikolaos Spernovasilis, Constantinos Tsioutis
Summary: Statins have no positive effect on cognitive function and behavioral problems in children with neurofibromatosis type 1 (NF1).
Review
Oncology
Panagiotis Symvoulidis, Constantinos Tsioutis, Constantinos Zamboglou, Aris P. P. Agouridis
Summary: Through the analysis of 32 relevant studies, the results showed that statins have no impact on local control, recurrence, survival and mortality of bladder cancer, as well as BCG immunotherapy. The use of statins has no significant effect on the incidence and overall prognosis of bladder cancer.
Article
Critical Care Medicine
Frances C. Hall, Joseph Cheriyan, Andrew P. Cope, James Galloway, Ian Wilkinson, Simon Bond, Sam Norton, Edward Banham-Hall, Hannah Bayes, Michalis Kostapanos, Marianna Nodale, William G. Petchey, Thomas Sheeran, Jonathan Underwood, David R. Jayne
Summary: This study evaluated the efficacy and safety of baricitinib and ravulizumab as adjunctive treatments for COVID-19. The findings showed that neither baricitinib nor ravulizumab were effective in reducing disease severity in hospitalized adult patients with severe COVID-19. The short duration of baricitinib dosing may explain the discrepancy between this study and others. Further evaluation of targeting complement C5 activation product C5a is warranted.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Peripheral Vascular Disease
Anastasios Makris, Fotios Barkas, Petros P. Sfikakis, Evangelos Liberopoulos, Theodosios D. Filippatos, Kausik K. Ray, Aris P. Agouridis
Summary: This study investigated the association between lipoprotein(a) [Lp(a)] and interleukin-6 (IL-6) and their potential clinical implications in preventing atherosclerotic cardiovascular disease (ASCVD). The findings suggest that elevated Lp(a) levels are associated with ASCVD and IL-6(R)i can lower Lp(a) levels and potentially have anti-atherosclerotic effects.
ATHEROSCLEROSIS PLUS
(2023)
Article
Cardiac & Cardiovascular Systems
Ioannis Parthymos, Michael S. Kostapanos, George Liamis, Matilda Florentin
Summary: Hypertriglyceridemia is a risk factor for cardiovascular disease and acute pancreatitis. The current drug classes targeting triglyceride levels are insufficient, leading to the development of novel therapies.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Review
Oncology
Antonia Pagkali, Ioannis Mamais, Adamantios Michalinos, Aris P. Agouridis
Summary: The safety profile of niraparib as maintenance therapy for platinum-sensitive epithelial ovarian cancer patients was evaluated. The study found that patients treated with niraparib had a higher risk of adverse effects such as nausea, fatigue, anemia, and thrombocytopenia compared to those on placebo. However, personalized dosing of niraparib was associated with lower rates of adverse effects and discontinuation, without compromising efficacy.
Article
Peripheral Vascular Disease
Aris P. Agouridis, Antonia Pagkali, Elias Zintzaras, Evangelos C. Rizos, Evangelia E. Ntzani
Summary: The study systematically reviewed the evidence of the association between high-density lipoprotein cholesterol (HDL-C) levels and COVID-19 infection severity. Results showed that COVID-19 patients had lower HDL-C levels on admission compared to healthy controls, and low HDL-C levels were correlated with disease severity.
ATHEROSCLEROSIS PLUS
(2021)
Article
Pharmacology & Pharmacy
Debra J. Tompson, Carwyn Davies, Nicola E. Scott, Edward P. Cannons, Michalis Kostapanos, Annette S. Gross, Marcy Powell, Hiroko Ino, Ryutaro Shimamura, Hirofumi Ogura, Takashi Nagakubo, Harue Igarashi, Atsushi Nakano
Summary: By comparing the pharmacokinetics of GSK2982772 between Western and Japanese subjects, it was found that the drug was well-tolerated and exhibited similar characteristics in both populations. This suggests that Japanese subjects can be included in future global clinical studies to assess the therapeutic potential of RIPK1 inhibition for IMIDs treatment.
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2021)