Article
Cardiac & Cardiovascular Systems
Andrew E. Arai, Jeanette Schulz-Menger, Dipan J. Shah, Yuchi Han, W. Patricia Bandettini, Arun Abraham, Pamela K. Woodard, Joseph B. Selvanayagam, Christian Hamilton-Craig, Ru-San Tan, James Carr, Lynette Teo, Christopher M. Kramer, Bernd J. Wintersperger, Mukesh G. Harisinghani, Scott D. Flamm, Matthias G. Friedrich, Igor Klem, Subha Raman, Daniel Haverstock, Zheyu Liu, Guenther Brueggenwerth, Marta Santiuste, Daniel S. Berman, Dudley J. Pennell
Summary: The study demonstrates that vasodilator stress perfusion cardiovascular magnetic resonance (CMR) performed with gadobutrol has superior diagnostic accuracy for the diagnosis and exclusion of significant coronary artery disease (CAD) compared to gated single-photon emission computed tomography (SPECT).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Anna Baritussio, Alessandra Scatteia, Santo Dellegrottaglie, Chiara Bucciarelli-Ducci
Summary: Cardiovascular magnetic resonance is a valuable imaging technique with clear applications in managing patients with coronary artery disease, from diagnosis to prognosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Silvestre R. Duran, Tyler Huffaker, Bryant Dixon, Vasu Gooty, Riad Abou Zahr, Yousef Arar, Joshua S. Greer, Ryan J. Butts, Mohammad T. Hussain
Summary: Cardiac MRI with quantitative adenosine stress perfusion testing is safe and feasible for estimating myocardial perfusion in pediatric heart transplant patients. Myocardial perfusion reserve did not significantly differ between patients with coronary allograft vasculopathy and comparison patients. This method shows potential and warrants further investigation in a larger cohort.
PEDIATRIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shi-hai Zhao, Wei-feng Guo, Zhi-feng Yao, Shan Yang, Hong Yun, Yin-yin Chen, Tong-tong Han, Xiao-yue Zhou, Cai-xia Fu, Meng-su Zeng, Chen-guang Li, Cui-zhen Pan, Hang Jin
Summary: In this study, a fully automated pixel-wise post-processing framework was used to evaluate quantitative cardiovascular magnetic resonance myocardial perfusion imaging (CMR-MPI). The study aimed to assess the additional value of coronary magnetic resonance angiography (CMRA) in the diagnostic performance of fully automated pixel-wise quantitative CMR-MPI for detecting hemodynamically significant coronary artery disease (CAD). The results showed that the fully automated pixel-wise quantitative CMR-MPI can accurately detect hemodynamically significant CAD, but the integration of CMRA did not provide significantly additive value.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ming-Yen Ng, Chi Yeung Chin, Pui Min Yap, Eric Yuk Fai Wan, JoJo Siu Han Hai, Stephen Cheung, Hung Fat Tse, Chiara Bucciarelli-Ducci, Dudley John Pennell, Kai-Hang Yiu
Summary: ATP-induced perfusion defects are predictive of MACE, primarily driven by cardiac hospitalization, late coronary revascularization, and cardiac death. Significant independent predictors of MACE include stress-induced perfusion defect, lower LVEF, and infarct detected by LGE.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Cardiac & Cardiovascular Systems
Panagiotis Antiochos, Yin Ge, Bobak Heydari, Kevin Steel, Scott Bingham, Shuaib M. Abdullah, J. Ronald Mikolich, Andrew E. Arai, Patricia Bandettini, Amit R. Patel, Afshin Farzaneh-Far, John F. Heitner, Chetan Shenoy, Steve W. Leung, Jorge A. Gonzalez, Dipan J. Shah, Subha Raman, Victor A. Ferrari, Jeanette Schulz-Menger, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
Summary: Stress CMR-assessed ischemia was strongly associated with MI/CV death and reclassified patient risk beyond CV risk factors, especially in those considered to be at intermediate risk. Absence of ischemia was associated with a <2% annual rate of MI/CV death.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Ryan A. Romans, Jimmy C. Lu, Sowmya Balasubramanian, Wendy Whiteside, Sunkyung Yu, Osamah T. Aldoss, Aimee K. Armstrong, Brian A. Boe, David T. Balzer, Jason T. Christensen, Thomas K. Jones, Britton Keeshan, Daniel McLennan, George T. Nicholson, Neil Patel, Arash Salavitabar, Shabana Shahanavaz, Patrick M. Sullivan, Mariel E. Turner, Jeffrey D. Zampi
Summary: This study evaluated the accuracy of cardiac magnetic resonance (CMR) in predicting coronary artery (CA) compression during transcatheter pulmonary valve implantation (TPVi). The results showed that CMR can help predict the risk for CA compression during TPVi, although it cannot completely exclude CA compression.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Multidisciplinary Sciences
Matthew K. Burrage, Mayooran Shanmuganathan, Qiang Zhang, Evan Hann, Iulia A. Popescu, Rajkumar Soundarajan, Kelvin Chow, Stefan Neubauer, Vanessa M. Ferreira, Stefan K. Piechnik
Summary: This study compared two commonly used T1 mapping approaches in terms of stress T1 response and ECV measurement stability. The results showed that ShMOLLI demonstrated a greater stress T1 response, strong correlation with increased MBF, and higher ECV stability compared to the MOLLI variants tested.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Elizabeth Hillier, Jason Covone, Matthias G. Friedrich
Summary: Oxygenation-sensitive cardiac magnetic resonance imaging (OS-CMR) is a diagnostic technique that uses the paramagnetic properties of deoxyhemoglobin for tissue contrast. By combining standardized breathing maneuvers, OS-CMR can monitor changes in myocardial oxygenation, providing markers for coronary vascular function without the need for exogenous contrast agents or pharmacological stress agents.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Cardiac & Cardiovascular Systems
Anda Bularga, John Hung, Marwa Daghem, Stacey Stewart, Caelan Taggart, Ryan Wereski, Trisha Singh, Mohammed N. Meah, Takeshi Fujisawa, Amy V. Ferry, Justin Chiong, William S. Jenkins, Fiona E. Strachan, Scott Semple, Edwin J. R. van Beek, Michelle Williams, Damini Dey, Chris Tuck, Andrew H. Baker, David E. Newby, Marc R. Dweck, Nicholas L. Mills, Andrew R. Chapman
Summary: Coronary and cardiac imaging of patients with type 2 myocardial infarction identified coronary artery disease in two-thirds of patients and left ventricular systolic dysfunction in one-third of patients. Unrecognized and untreated coronary or cardiac disease is seen in most patients with type 2 myocardial infarction, presenting opportunities for initiation of evidence-based treatments with major potential to improve clinical outcomes.
Review
Medicine, General & Internal
Lukas D. D. Weberling, Dirk Lossnitzer, Norbert Frey, Florian Andre
Summary: Coronary artery disease (CAD) is a global burden with increasing prevalence and recommendations for non-invasive imaging prior to invasive procedures. Both coronary computed tomography angiography (cCTA) and stress cardiac magnetic resonance imaging (CMR) are appropriate imaging modalities, offering high diagnostic accuracy and safety profiles. Advances in technology have improved the quality and functional assessment capabilities of both modalities, allowing for better risk stratification. This review compares the strengths and weaknesses of cCTA and CMR in assessing CAD, providing physicians with rationales for selecting the most appropriate modality for individual patients.
Article
Cardiac & Cardiovascular Systems
Gemma A. Figtree, Philip D. Adamson, Charalambos Antoniades, Roger S. Blumenthal, Michael Blaha, Matthew Budoff, David S. Celermajer, Mark Y. Chan, Clara K. Chow, Damini Dey, Girish Dwivedi, Nicola Giannotti, Stuart M. Grieve, Christian Hamilton-Craig, Bronwyn A. Kingwell, Jason C. Kovacic, James K. Min, David E. Newby, Sanjay Patel, Karlheinz Peter, Peter J. Psaltis, Stephen T. Vernon, Dennis T. Wong, Stephen J. Nicholls
Summary: Coronary artery disease (CAD) is the leading cause of adult mortality globally. Improvements in imaging techniques have provided a better understanding of different phenotypes of coronary atherosclerosis, which are associated with different risks for acute ischemic events. Noninvasive coronary imaging techniques have the potential to accelerate cardiovascular drug development and reduce costs and timelines.
Article
Cardiac & Cardiovascular Systems
Ailis Ceara Haney, Janek Salatzki, Hauke Hund, Matthias G. Friedrich, Evangelos Giannitsis, Norbert Frey, Henning Steen, Dirk Lossnitzer, Johannes Riffel, Florian Andre
Summary: This study evaluates the prognostic value of stress cardiac magnetic resonance (CMR) in a real-world cohort of patients with known severe coronary artery stenosis but without inducible ischemia. The results suggest that patients with severe and moderate coronary artery stenosis but without inducible ischemia have similar long-term outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Giulia Vinco, Clementina Dugo, Marzia Rigolli, Cristina Dematte, Cristiana Giovanelli, Fabio Caruso, Alessandro Marinetti, Andrea Chiampan, Carmelo Ciccio, Carlo Cosimo Quattrocchi, Giulio Molon, Maurizio Del Greco
Summary: Stress cardiovascular magnetic resonance imaging has been extensively validated for the assessment of ischemic heart disease, providing detailed information on cardiac structure and function, as well as the presence and degree of myocardial ischemia and viability. It has demonstrated excellent sensitivity and specificity in detecting coronary artery stenosis and has strong prognostic value in clinical risk stratification.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Vasken Dilsizian, Henry Gewirtz, Thomas H. Marwick, Raymond Y. Kwong, Paolo Raggi, Mouaz H. Al-Mallah, Charles A. Herzog
Summary: Patients with chronic kidney disease (CKD) have a higher risk of cardiovascular complications and mortality compared to the general population, even after kidney transplantation. The evaluation of coronary artery disease (CAD) in CKD patients, as well as the use of non-nephrotoxic contrast agents, remains a topic of debate.
JACC-CARDIOVASCULAR IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Thomas A. Kite, Sameer A. Kurmani, Vasiliki Bountziouka, Nicola J. Cooper, Selina T. Lock, Chris P. Gale, Marcus Flather, Nick Curzen, Adrian P. Banning, Gerry P. McCann, Andrew Ladwiniec
Summary: For NSTE-ACS, an early invasive strategy does not reduce all-cause mortality, myocardial infarction, admission for heart failure, repeat revascularization, or increase major bleeding or stroke risk when compared with a delayed invasive strategy. However, an early invasive strategy can significantly reduce recurrent ischemia and length of hospital stay.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Nikolaos Fragakis, Antonios P. Antoniadis, Melani Sotiriadou, Christina Virgiliou, Iris Ballauri, Helen G. Gika, Dimitrios Bougiouklis, Spyros Gerou, Charalampos Lazaridis, Stavros Vergopoulos, Constantinos Bakogiannis, Georgios Giannopoulos, Georgios A. Theodoridis, Christodoulos E. Papadopoulos, Theodoros D. Karamitsos, Vassilios Vassilikos
Summary: In syncopal patients without underlying structural disease, the levels of ADP are associated with the clinical presentation of neurally mediated syncope and the outcomes of HUTT and ADT. NPS patients with positive HUTT show excessive ADP release at the time of syncope, explaining the lack of prodromes in this form of syncope.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Panagiotis Charalampidis, Eleftherios Teperikidis, Aristi Boulmpou, Christodoulos E. Papadopoulos, Victoria Potoupni, Konstantina Tsioni, Pantelitsa Rakitzi, Theodoros Karamitsos, Vassilios Vassilikos
Summary: Research on the potential value of homocysteine (Hcy) levels in predicting atrial fibrillation (AF) revealed that Hcy levels seem to hold predictive value in paroxysmal atrial fibrillation (PAF), along with potential mechanisms of action and special considerations for clinically relevant diagnostic procedures. Gaps of evidence were identified and considerations for future clinical trial design were presented.
Article
Cardiac & Cardiovascular Systems
Sandeep Arunothayaraj, Jens Flensted Lassen, Gerald J. Clesham, Mark S. Spence, Rene Koning, Adrian P. Banning, Mitchell Lindsay, Evald H. Christiansen, Mohaned Egred, James Cockburn, Darren Mylotte, Philippe Brunel, Miroslaw Ferenc, Thomas Hovasse, Adrian Wlodarczak, Manuel Pan, Marc Silvestri, Andrejs Erglis, Evgeny Kretov, Alaide Chieffo, Thierry Lefevre, Francesco Burzotta, Olivier Darremont, Goran Stankovic, Marie-Claude Morice, Yves Louvard, David Hildick-Smith
Summary: This study aimed to analyze the impact of technical variables on procedural outcomes and periprocedural myocardial infarction following left main bifurcation intervention. The results showed that the use of jailed wires was associated with successful rewiring of jailed vessels, and the use of jailed wires was not associated with increased risk of periprocedural myocardial infarction. Side vessel preparation in provisional cases was linked to increased side vessel dissection requiring stenting. The use of noncompliant balloons for proximal optimization technique was associated with a reduction in the need for additional side vessel intervention and periprocedural myocardial infarction.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Mayooran Shanmuganathan, Ambra Masi, Matthew K. Burrage, Rafail A. Kotronias, Alessandra Borlotti, Roberto Scarsini, Abhirup Banerjee, Dimitrios Terentes-Printzios, Qiang Zhang, Evan Hann, Elizabeth Tunnicliffe, Andrew Lucking, Jeremy Langrish, Rajesh Kharbanda, Giovanni Luigi De Maria, Adrian P. Banning, Robin P. Choudhury, Keith M. Channon, Stefan K. Piechnik, Vanessa M. Ferreira
Summary: The acute responses in both infarcted and noninfarcted myocardium post-STEMI are independent incremental predictors of long-term major adverse cardiac events (MACE). These findings may have implications for treatment and risk stratification in STEMI.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Noman Ali, David Hildick-Smith, Jessica Parker, Christopher J. Malkin, Michael S. Cunnington, Shuslim Gurung, Jonathan Mailey, Philip A. MacCarthy, Apurva Bharucha, Stephen J. Brecker, Stephen P. Hoole, Stephen Dorman, Sagar N. Doshi, Andrew Wiper, Mamta H. Buch, Adrian P. Banning, Mark S. Spence, Daniel J. Blackman
Summary: This study evaluated the long-term valve function and incidence of severe structural valve deterioration (SVD) among patients >=10 years post-TAVI and with at least 5 years of echocardiographic follow-up. The study found that the incidence of severe SVD was 5.9% in patients with echocardiographic follow-up exceeding 10 years. The incidence of severe SVD was higher in patients with balloon-expandable valves compared to self-expanding valves.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Alice Moroni, Federico Marin, Gabriele Venturi, Roberto Scarsini, Flavio Ribichini, Giovanni Luigi De Maria, Adrian P. Banning
Summary: Percutaneous coronary intervention (PCI) is increasingly used to treat unprotected left main coronary artery (ULMCA) disease in patients who cannot undergo cardiac surgery. However, treating failed stents in ULMCA is complex and poses unique challenges. Intracoronary imaging has provided new insights into mechanisms of stent failure and treatment options have significantly improved. This study provides an overview of ULMCA stent failure and proposes a tailored algorithm for best management.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Pavlos Rouskas, Thomas Zegkos, Dimitris Ntelios, Thomas Gossios, Despoina Parcharidou, Christos A. Papanastasiou, Theodoros Karamitsos, Vassilis Vassilikos, Kostantinos Kouskouras, Georgios K. Efthimiadis
Summary: Apical hypertrophic cardiomyopathy (ApHCM) is a variant of hypertrophic cardiomyopathy (HCM) with distinct imaging and clinical characteristics. This study found that ApHCM has a lower rate of all-cause mortality and arrhythmic events compared to non-ApHCM. Atrial fibrillation and HCM risk-sudden cardiac death were identified as independent predictors of overall mortality and cardiovascular hospitalizations in ApHCM patients.
HELLENIC JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Georgios Sidiropoulos, Antonios Antoniadis, Athanasios Saplaouras, Georgios Bazoukis, Konstantinos P. Letsas, Theodoros D. Karamitsos, Georgios Giannopoulos, Nikolaos Fragakis
Summary: This meta-analysis examined the value of echocardiographic indices of RV function as potential predictors of CRT outcomes in patients with standard indications for CRT. The results showed that baseline tricuspid annular plane systolic excursion was consistently higher in CRT responders, suggesting its potential as an additional component in the selection process of CRT candidates.
HELLENIC JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sneha S. Jain, Ditian Li, Ovidiu Dressler, Lak Kotinkaduwa, Patrick W. Serruys, A. Pieter Kappetein, Joseph F. Sabik, Marie-Claude Morice, John Puskas, David E. Kandzari, Dimitri Karmpaliotis, Nicholas J. Lembo, W. Morris Brown, Adrian P. Banning, Gregg W. Stone
Summary: This study assessed the association between periprocedural major adverse events (MAE) and subsequent mortality after percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for left main coronary artery revascularization. The study found that nonfatal periprocedural MAE strongly predicted both early and late mortality after both PCI and CABG.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Medicine, General & Internal
Vasileios Anastasiou, Stylianos Daios, Dimitrios V. Moysidis, Maria-Anna Bazmpani, Thomas Zegkos, Theodoros Karamitsos, Kali Makedou, Christos Savopoulos, Georgios Efthimiadis, Antonios Ziakas, Vasileios Kamperidis
Summary: This study aims to investigate the role of serial echocardiographic assessment in predicting mortality and readmission rates in patients with acute heart failure. State-of-the-art echocardiographic assessments, including speckle tracking analysis and myocardial work analysis, are performed upon admission and pre-discharge. The study also includes long-term follow-up to evaluate outcomes.
Review
Medicine, General & Internal
Vasileios Anastasiou, Stylianos Daios, Maria-Anna Bazmpani, Dimitrios V. Moysidis, Thomas Zegkos, Theodoros Karamitsos, Antonios Ziakas, Vasileios Kamperidis
Summary: Intervention before irreversible myocardial damage is crucial for favorable outcomes in aortic stenosis (AS). Left ventricular ejection fraction (LVEF) is currently recommended for determining the intervention threshold, but it has limitations in detecting subtle signs of damage. Strain imaging, which describes intramyocardial contractile force, shows promise in identifying maladaptive changes in AS. This review summarizes the evidence on LVEF and strain imaging in AS prognosis, aiming to shift towards a strain-based approach for risk stratification and treatment decisions.
Article
Cardiac & Cardiovascular Systems
Maria-Anna Bazmpani, Christos A. Papanastasiou, Vasilios Giampatzis, Vasileios Kamperidis, Thomas Zegkos, Pantelis Zebekakis, Christos Savopoulos, Haralambos Karvounis, Georgios K. Efthimiadis, Antonios Ziakas, Theodoros D. Karamitsos
Summary: Heart failure (HF) is a leading cause of unplanned hospital admissions worldwide. This study compared the demographics, in-hospital management, and short-term outcomes of HF patients admitted to Internal Medicine Departments (IMD) versus cardiology departments (CD). The results showed that patients in IMD had higher in-hospital mortality and worse short-term outcomes, including a higher risk of death and rehospitalization for HF. Overall, HF patients admitted to IMD had worse short-term outcomes compared to those admitted to CD.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Sophie I. Mavrogeni, Alexandros Kallifatidis, Soultana Kourtidou, Niki Lama, Aikaterini Christidi, Efstathios Detorakis, Grigorios Chatzantonis, Thomas Vrachliotis, Theodoros Karamitsos, Konstantinos Kouskouras, Nikolaos Kelekis
Summary: Cardiovascular disease is the leading cause of morbidity/mortality worldwide. Early diagnosis is crucial, and cardiovascular imaging, especially cardiovascular magnetic resonance (CMR), plays a significant role in providing tissue characterization and functional assessment. This article provides an overview of the indications, sequences, and reporting of CMR findings in various cardiovascular diseases. The roles of CMR indices in evaluating clinical scenarios and its advantages over other imaging modalities are discussed.
HELLENIC JOURNAL OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Sandeep Arunothayaraj, Jens Lassen, Gerald Clesham, Mark Spence, Adrian Banning, Mitchell Lindsay, Evald Christiansen, Mohaned Egred, James Cockburn, Darren Mylotte, Philippe Brunel, Miroslaw Ferenc, Thomas Hovasse, Adrian Wlodarczak, Manuel Pan, Marc Silvestri, Andrejs Erglis, Evgeny Kretov, Alaide Chieffo, Thierry Lefevre, Francesco Burzotta, Olivier Darremont, Goran Stankovic, Marie-Claude Morice, Yves Louvard, David Hildick-Smith
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)