Article
Biochemistry & Molecular Biology
Paramjit S. Tappia, Anureet K. Shah, Bram Ramjiawan, Naranjan S. Dhalla
Summary: Ischemia/reperfusion injury can compromise cardiac function recovery, but ischemic preconditioning (IP) can reduce oxidative stress and intracellular Ca2+ overload, improving cardiac function and providing cardioprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Eliana P. Bin, Tamara Zaobornyj, Mariana Garces, Veronica D'Annunzio, Bruno Buchholz, Timoteo Marchini, Pablo Evelson, Ricardo J. Gelpi, Martin Donato
Summary: The rupture of the plasma membrane is the key point in cell death, which can be prevented by remote ischemic preconditioning through inhibiting MMP-2 activity. Besides, remote ischemic preconditioning also improves mitochondrial function, increasing membrane potential, ATP production and respiratory control.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Katharina Feige, Sebastian Roth, Rene M'Pembele, Anna Galow, Sarah Koenig, Martin Stroethoff, Annika Raupach, Giovanna Lurati Buse, Alexander M. Mathes, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza
Summary: The adverse impact of common diseases like diabetes mellitus and acute hyperglycemia on morbidity and mortality from myocardial infarction (MI) has been well documented. The relationship between blood glucose and mortality appears linear, and this seems to be independent of a diagnosis of diabetes. This study investigates the influence of acute and prolonged hyperglycemia on the protective effect of transferred human RIPC-plasma and suggests that hyperglycemia might obstruct translation into the clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Christopher Lotz, Johannes Herrmann, Quirin Notz, Patrick Meybohm, Franz Kehl
Summary: Mitochondria play a crucial role in myocardial ischemia/reperfusion injury and pharmacological cardiac conditioning, including maintaining cellular function, regulating calcium balance and cell death, participating in aging and mitochondrial regeneration, etc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Fengxiang Lv, Yingfan Wang, Dan Shan, Sile Guo, Gengjia Chen, Li Jin, Wen Zheng, Han Feng, Xiaohu Zeng, Shuo Zhang, Yan Zhang, Xinli Hu, Rui-Ping Xiao
Summary: S255 phosphorylation of MG53 plays a crucial role in regulating insulin signaling and E3 ligase activity, with the S255A mutant showing potential for treating cardiac ischemia/reperfusion injury, especially in patients with metabolic disorders.
CIRCULATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Xinhao Liu, Hui Chen, Zhibing Yan, Lei Du, Dou Huang, Wei Dong Gao, Zhaoyang Hu
Summary: This study evaluated the protective effects of liver ischemic preconditioning (RLIPC) on I/R injury in streptozotocin-induced type 1 diabetic rats. RLIPC significantly reduced infarct size and cardiac tissue damage, inhibited apoptosis, improved cardiac functions, and preserved cardiac morphology in diabetic hearts post I/R. Western blotting showed that RLIPC stimulated phosphorylation of ventricular GSK-3 beta and STAT-5, indicating its strong cardioprotective properties against myocardial I/R injury in diabetic hearts.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Wei Xiong, Rui Zhou, Yan Qu, Yuqiao Yang, Zhuoran Wang, Ning Song, Rongbi Liang, Jinqiao Qian
Summary: The study demonstrated that dexmedetomidine preconditioning can alleviate degranulation of mast cells and apoptosis of cardiomyocytes caused by I/R injury, and inhibit the activation of inflammatory related factors HMGB1, TLR4, and NF-KB p65.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Clinical Neurology
Yi-Na Zhang, Qiong Wu, Nan-Nan Zhang, Hui-Sheng Chen
Summary: Ischemic preconditioning (IPC) can protect the blood-brain barrier (BBB) by interfering with glycocalyx, improving neurological pathology in rat models of cerebral ischemia-reperfusion injury (IRI).
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Medicine, Research & Experimental
Annika Raupach, Katharina Feige, Christian Reiter, Timo Brandenburger, Nicole Heinen, Andre Heinen, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza
Summary: The study found that RIPC did not induce the phosphorylation of AKT or STAT5 in a rat model, nor did it modulate the activation of AKT and STAT5 following I/R, suggesting that RIPC-induced cardioprotection may not be mediated by the activation of AKT or STAT5 at the investigated time points.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Maria Tsoumani, Anastasios Georgoulis, Panagiota-Efstathia Nikolaou, Ioannis V. Kostopoulos, Theano Dermintzoglou, Ioanna Papatheodorou, Anastasia Zoga, Panagiotis Efentakis, Maria Konstantinou, Evangelos Gikas, Nikolaos Kostomitsopoulos, Andreas Papapetropoulos, Antigone Lazou, Alexios- Leandros Skaltsounis, Derek J. Hausenloy, Ourania Tsitsilonis, Ioulia Tseti, Fabio Di Lisa, Efstathios K. Iliodromitis, Ioanna Andreadou
Summary: Oleuropein demonstrates cardioprotective effects against ischemia reperfusion injury by reducing infarct size, possibly through activating antioxidant defense genes via the Nrf-2 axis. Additionally, oleuropein enhances the cardioprotective manifestation of ischemic postconditioning, showing a synergistic effect in experimental models of IRI.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, General & Internal
Katharina Feige, Carolin Torregroza, Milena Gude, Patrick Maddison, Martin Stroethoff, Sebastian Roth, Giovanna Lurati Buse, Markus W. Hollmann, Ragnar Huhn
Summary: The cardioprotective effect of remote ischemic preconditioning (RIPC) has been observed in experimental studies but not in clinical trials. Propofol is believed to have a negative impact on the release of humoral factors after RIPC. Furthermore, comorbidities may interact with the cardioprotective properties of RIPC. This study found that propofol-free RIPC did not lead to the release of cardioprotective humoral factors in male patients undergoing CABG surgery, regardless of the presence of diabetes mellitus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Leonardo Jorge Cordeiro de Paula, Augusto Hiroshi Uchida, Paulo Cury Rezende, Paulo Soares, Thiago Luis Scudeler
Summary: Ischemic preconditioning is a phenomenon that increases tissue or organ's tolerance to ischemia by applying brief cycles of ischemia/reperfusion. This review discusses the effects of various medications on myocardial ischemic preconditioning, which has potential therapeutic implications.
CURRENT VASCULAR PHARMACOLOGY
(2022)
Article
Physiology
Badr Khbouz, Francois Lallemand, Arianna Cirillo, Pascal Rowart, David Legouis, Nor Eddine Sounni, Agnes Noel, Pascal De Tullio, Sophie de Seigneux, Francois Jouret
Summary: This study investigates the protective effects and mechanisms of kidney-centered irradiation against renal ischemia-reperfusion injury (I/R). Kidney irradiation increased vascular surface in the renal parenchyma and conferred resistance against renal I/R damage. These findings suggest potential strategies for the treatment of ischemic acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ludmila Filaretova, Olga Komkova, Maria Sudalina, Natalia Yarushkina
Summary: Remote ischemic preconditioning (RIPC) has been shown to protect various organs from ischemia-reperfusion injury, with glucocorticoids potentially playing a role in this protective effect. Studies demonstrated that RIPC reduced gastric erosion area in rats, and the involvement of glucocorticoids was confirmed through experiments with glucocorticoid inhibitors and receptor antagonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Christine Gyldenkerne, Michael Maeng, Lars Kjoller-Hansen, Akiko Maehara, Zhipeng Zhou, Ori Ben-Yehuda, Hans Erik Botker, Thomas Engstrom, Mitsuaki Matsumura, Gary S. Mintz, Ole Froebert, Jonas Persson, Rune Wiseth, Alf I. Larsen, Lisette O. Jensen, Jan E. Nordrehaug, Oyvind Bleie, Elmir Omerovic, Claes Held, Stefan K. James, Ziad A. Ali, Hans C. Rosen, Gregg W. Stone, David Erlinge
Summary: Patients with diabetes have a higher risk of major adverse cardiac events due to both treated culprit lesions and untreated nonculprit lesions. However, this study did not identify diabetes-related high-risk plaque characteristics using multimodality imaging.
Article
Cardiac & Cardiovascular Systems
Martin Bodtker Mortensen, Omar Dzaye, Hans Erik Botker, Jesper Moller Jensen, Michael Maeng, Jacob Fog Bentzon, Helle Kanstrup, Henrik Toft Sorensen, Jonathon Leipsic, Ron Blankstein, Khurram Nasir, Michael J. Blaha, Bjarne Linde Norgaard
Summary: Low-density lipoprotein cholesterol (LDL-C) is associated with atherosclerotic cardiovascular disease (ASCVD), but its association with ASCVD risk is modified by the presence of coronary artery calcification (CAC). This study found that LDL-C is only associated with ASCVD events in patients with CAC, and not in those without CAC. This information is valuable for individualized risk assessment among middle-aged people with or without coronary atherosclerosis.
Article
Clinical Neurology
Jane Agergaard, Benjamin Yamin Ali Khan, Thomas Engell-Sorensen, Berit Schiottz-Christensen, Lars ostergaard, Eva K. Hejbol, Henrik D. Schroder, Henning Andersen, Jakob Udby Blicher, Thomas Holm Pedersen, Thomas Harbo, Hatice Tankisi, M. U. L. T. I. C. O. V. Consortium MULTICOV Consortium
Summary: This study examined 84 patients with long COVID using qEMG and sfEMG, and performed muscle biopsies in a subset of patients. The results showed that the mean MUP duration was decreased in >= 1 muscles in 52% of the patients, and the mean jitter was increased in 17% of the patients in the tibialis anterior and 25% in the extensor digitorum communis. Muscle biopsies revealed damage of terminal nerves and motor endplate with abundant basal lamina material. These findings suggest a muscle pathophysiology behind fatigue in long COVID.
CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Peter Ferdinandy, Ioanna Andreadou, Gary F. Baxter, Hans Erik Botker, Sean M. Davidson, Dobromir Dobrev, Bernard J. Gersh, Gerd Heusch, Sandrine Lecour, Marisol Ruiz-Meana, Coert J. Zuurbier, Derek J. Hausenloy, Rainer Schulz
Summary: Preconditioning, postconditioning, and remote conditioning of the myocardium have the potential to provide novel therapeutic paradigms for cardioprotection. However, the lack of rigorous preclinical evaluation and consideration of cardiovascular risk factors and comorbidities may be a major reason for the failure to develop cardioprotective drugs.
PHARMACOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Rajkumar Rajanathan, Tina Myhre Pedersen, Halvor Osterby Guldbrandsen, Lenette Foldager Olesen, Morten B. Thomsen, Hans Erik Botker, Vladimir V. Matchkov
Summary: Heterozygous mice for the migraine-associated mutation (G301R) in the Na+,K+-ATPase alpha(2)-isoform have decreased expression of cardiovascular alpha(2)-isoform and exhibit a pro-contractile vascular phenotype associated with reduced cardiac efficiency. This study aims to assess the functional contribution of the alpha(2)-isoform to in vivo cardiovascular function and showed that the ouabain-induced vascular response was augmented in alpha(+/G301R)(2) mice, leading to suppressed cardiac function.
Article
Cardiac & Cardiovascular Systems
Gregory Wood, Pia Hedegaard Johnsen, Anders Lehmann Dahl Pedersen, Christian Alcaraz Frederiksen, Steen Hvitfeldt Poulsen, Hans Erik Botker, Won Yong Kim
Summary: Remote ischaemic conditioning (RIC) applied before primary percutaneous coronary intervention (PPCI) in patients with ST-elevation myocardial infarction does not improve left ventricular function 3 months after infarction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Susanne Bendesgaard Pedersen, Jens Cosedis Nielsen, Hans Erik Botker, Aparna Udupi, Jeffrey J. Goldberger
Summary: This study aimed to investigate the association between beta-blocker dose and mortality following acute myocardial infarction. A nationwide cohort study in Denmark was conducted, and the results showed that any dose of beta-blocker was associated with a significant reduction in mortality compared to no treatment. The largest reduction in mortality was observed within the first year after acute myocardial infarction for doses >25%-50% of the recommended target dose, suggesting that higher doses are unnecessary.
AMERICAN JOURNAL OF MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gerd Heusch, Hans Erik Botker, Peter Ferdinandy, Rainer Schulz
EUROPEAN HEART JOURNAL
(2023)
Article
Physiology
Jakob Wang, Anna-Maria Godsk Mogensen, Frederik Thybo, Magnus Brandbyge, Jonas Brorson, Gerrit van Hall, Jakob Agergaard, Frank Vincenzo de Paoli, Benjamin F. Miller, Hans Erik Botker, Jean Farup, Kristian Vissing
Summary: This study found that low-load blood flow-restricted resistance exercise (BFRRE) is effective in promoting muscle hypertrophy and improving muscle function in older individuals. However, its impact on age-related skeletal muscle decay at a cellular level is still unclear. BFRRE resulted in significant increases in muscle fiber morphology, integrated muscle protein synthesis, and muscle functional capacity without changes in muscle stem cells (MuSCs) and myonuclear content.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Cecilia Hvitfeldt Fuglsang, Lars Pedersen, Morten Schmidt, Jan Vandenbroucke, Hans Erik Botker, Henrik Toft Sorensen
Summary: This study used Danish national registries to examine the impact of migraine on the risk of premature myocardial infarction (MI) and ischemic/hemorrhagic stroke among men and women. They found that migraine was associated with similarly increased risk of premature ischemic stroke among both men and women, but there may be an increased risk of MI and hemorrhagic stroke only among women.
Article
Cardiac & Cardiovascular Systems
Roni Nielsen, Kristian Hylleberg Christensen, Nigopan Gopalasingam, Kristoffer Berg-Hansen, Jacob Seefeldt, Casper Homilius, Ebbe Boedtkjer, Mads Jonsson Andersen, Henrik Wiggers, Niels Moller, Hans Erik Botker, Soren Mellemkjaer
Summary: The study demonstrates that 3-hydroxybutyrate (3-OHB) infusion in patients with PAH or CTEPH can decrease pulmonary vascular resistance, improve cardiac output, and enhance right ventricular function. Experimental rat studies also support the relaxing effect of ketone bodies on pulmonary arteries.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cell Biology
Rajkumar Rajanathan, Claudia Vilaseca i Riera, Tina Myhre Pedersen, Christian Staehr, Elena V. Bouzinova, Jens Randel Nyengaard, Morten B. Thomsen, Hans Erik Botker, Vladimir V. Matchkov
Summary: This study investigated the expression of two isoforms (alpha(1) and alpha(2)) of the Na+,K+-ATPase in the cardiovascular system, and the contribution of the alpha(2)-isoform to cardiac contractility. The study found that hearts with the alpha(+/G301R)(2) mutation exhibited greater contractility and a stronger response to ouabain, which was associated with increased systolic work.
Article
Biochemistry & Molecular Biology
Gerd Heusch, Ioanna Andreadou, Robert Bell, Edoardo Bertero, Hans-Erik Botker, Sean M. Davidson, James Downey, Philip Eaton, Peter Ferdinandy, Bernard J. Gersh, Mauro Giacca, Derek J. Hausenloy, Borja Ibanez, Thomas Krieg, Christoph Maack, Rainer Schulz, Frank Sellke, Ajay M. Shah, Holger Thiele, Derek M. Yellon, Fabio Di Lisa
Summary: This review summarizes the roles of reactive oxygen species (ROS) in myocardial ischemia/reperfusion injury and cardioprotection. It emphasizes the need for cardioprotection beyond rapid reperfusion in acute myocardial infarction and discusses the pathomechanisms of myocardial ischemia/reperfusion, different modes of cell death in myocardial infarction, and interventions to protect the ischemic/reperfused myocardium. The second part focuses on ROS, providing an overview of molecular and cellular mechanisms involved in ischemia/reperfusion injury.
Letter
Rheumatology
Brian Bridal Logstrup, Kevin Kris Warnakula Olesen, Dzenan Masic, Christine Gyldenkerne, Pernille Gro Thrane, Torkell Ellingsen, Hans Erik Botker, Michael Maeng
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Casper Homilius, Jacob Marthinsen Seefeldt, Julie Sorensen Axelsen, Tina Myhre Pedersen, Trine Monberg Sorensen, Roni Nielsen, Henrik Wiggers, Jakob Hansen, Vladimir V. Matchkov, Hans Erik Botker, Ebbe Boedtkjer
Summary: The ketone body 3-hydroxybutyrate (3-OHB) directly acts on the heart to increase cardiac contractility and directly acts on blood vessels to lower systemic vascular resistance, leading to increased cardiac output and improved coronary perfusion. This finding strengthens the therapeutic rationale for 3-OHB in heart failure management.
BASIC RESEARCH IN CARDIOLOGY
(2023)
