Article
Biochemistry & Molecular Biology
Dalila Pinheiro Leal, Gustavo Henrique Ferreira Goncalinho, Thauany Martins Tavoni, Karen Lika Kuwabara, Ana Paula Paccanaro, Fatima Rodrigues Freitas, Celia Maria Cassaro Strunz, Luiz Antonio Machado Cesar, Raul Cavalcante Maranhao, Antonio de Padua Mansur
Summary: This study demonstrated the association between energy restriction and atorvastatin treatment with changes in lipid profile, serum Sirt-1 concentrations, and HDL function.
Article
Transplantation
Yejin Kim, Jeonggyu Kang, Yoosoo Chang, Young Youl Hyun, Kyu-Beck Lee, Hocheol Shin, Sarah H. Wild, Christopher D. Byrne, Seungho Ryu
Summary: This study evaluated the association between coronary artery calcium scores (CACSs) and the development of chronic kidney disease (CKD). The results showed that higher CACS was progressively associated with an increased risk of CKD, indicating that individuals with higher CACS have a higher risk of developing CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Simon Kraler, Florian A. Wenzl, Georgios Georgiopoulos, Slayman Obeid, Luca Liberale, Arnold von Eckardstein, Olivier Muller, Francois Mach, Lorenz Raeber, Sylvain Losdat, Martin O. Schmiady, Konstantinos Stellos, Kimon Stamatelopoulos, Giovanni G. Camici, Annie Srdic, Francesco Paneni, Alexander Akhmedov, Thomas F. Luescher
Summary: sLOX-1 is associated with fatal events and plaque progression in patients with acute coronary syndromes (ACS). Increased sLOX-1 levels predict mortality risk and coronary plaque progression beyond traditional risk factors.
EUROPEAN HEART JOURNAL
(2022)
Review
Medicine, General & Internal
Jitae A. Kim, Seulgi E. Kim, Karim El Hachem, Hafeez Ul Hassan Virk, Mahboob Alam, Salim S. Virani, Samin Sharma, Andrew House, Chayakrit Krittanawong
Summary: This review summarizes the available evidence supporting the medical therapy of coronary artery disease in chronic kidney disease and ESRD patients. It also discusses the data on new emerging therapies that show promise in reducing cardiovascular events risk in the chronic kidney disease population.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chunyan Luo, Decheng Wang, Weifeng Huang, Yinhong Song, Lisha Ge, Xinyue Zhang, Lixue Yang, Jiao Lu, Xiancong Tu, Qiuyun Chen, Jian Yang, Chengqi Xu, Qing Wang
Summary: The study indicates that ADTRP and LDL receptors LDLR/CD36/LOX-1 positively regulate each other, forming a positive regulatory loop that regulates endothelial cell functions, thereby providing a potential protective mechanism against atherosclerosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Physiology
Mark T. Fuller, Omid Dadoo, Ting Xiong, Pardh Chivukula, Melissa E. MacDonald, Samuel K. K. Lee, Richard C. Austin, Suleiman A. Igdoura, Bernardo L. Trigatti
Summary: High levels of LDL cholesterol and low levels of HDL cholesterol increase the risk of cardiovascular disease. Mice that lack certain genes involved in LDL clearance or HDL functionality are used as models for studying atherosclerosis. This study compared the development of atherosclerosis in different knockout mouse models and found that mice lacking the HDL receptor had similar plaque sizes and compositions in their aortic sinuses but more extensive atherosclerosis in their descending aortas and coronary arteries. These findings suggest that factors other than hypercholesterolemia, such as inflammation and immune system dysregulation, contribute to atherosclerosis in these mice.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Nikolay K. Sadykhov, Andrey G. Kartuesov, Evgeny E. Borisov, Vasily N. Sukhorukov, Alexander N. Orekhov
Summary: Atherosclerosis is the leading cause of cardiovascular disease worldwide, and it shares several risk factors with chronic kidney disease. Patients with chronic kidney disease are more susceptible to cardiovascular problems.
Article
Multidisciplinary Sciences
Hiroki Okabe, Yoshitaka Muraoka, Yutaro Naka, Koshi Setoyama, Konosuke Inoue, Toshiya Miura, Akiyoshi Shimizu, Reo Anai, Tetsu Miyamoto, Yuki Tsuda, Masaru Araki, Shinjo Sonoda, Masaharu Kataoka
Summary: Nutritional status has a significant effect on coronary atherosclerosis in hemodialysis patients, and malnutrition can lead to the progression of coronary artery disease. Optical coherence tomography can be used to evaluate the impact of nutritional status on coronary atherosclerosis in hemodialysis patients.
Review
Chemistry, Medicinal
Evangelos Oikonomou, Paraskevas Tsaplaris, Artemis Anastasiou, Maria Xenou, Stamatios Lampsas, Gerasimos Siasos, Panteleimon Pantelidis, Panagiotis Theofilis, Aikaterini Tsatsaragkou, Ourania Katsarou, Marios Sagris, Michael-Andrew Vavuranakis, Manolis Vavuranakis, Dimitris Tousoulis
Summary: This article discusses the crucial role of interleukin-1 in the progression of atherosclerosis, the inflammatory cascade, and the clinical application of targeted anti-inflammatory treatments.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Biology
Qingyuan Zhao, Jingshu Wang, Zhen Miao, Nancy R. Zhang, Sean Hennessy, Dylan S. Small, Daniel J. Rader
Summary: Recent genetic data has provided important insights into the roles of lipoprotein subfractions and particle sizes in preventing coronary artery disease, with medium HDL particles and small HDL particles showing potential protective effects against CAD. Further investigations are required to fully understand the role of HDL particle size in CAD prevention.
Article
Cardiac & Cardiovascular Systems
Xiadan Xiang, Ji He, Wei Zhang, Qiang He, Yueming Liu
Summary: This study found a close association between cardiovascular disease and chronic kidney disease in CKD patients, with vascular calcification as a major predictor of cardiovascular disease. Vascular calcification was found to be associated with changes in bone and mineral metabolism, and bone metabolism and inflammatory markers were positively correlated with CAC scores. Additionally, a higher risk of all-cause mortality and cardiovascular hospitalization was observed when the CAC score exceeded 400.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Clinical Neurology
Sofia F. Furlan, Viktor Sinkunas, Lucas P. Damiani, Ronaldo B. Santos, Matheus Peres, Pedro A. Lemos, Chi-Hang Lee, Geraldo Lorenzi-Filho, Luciano F. Drager
Summary: This study aimed to explore the associations of obstructive sleep apnea (OSA) and sleep duration (SD) with renal function in subjects with coronary artery disease (CAD). The results showed that OSA severity and SD were not independently associated with chronic kidney disease (CKD) in CAD patients.
Review
Urology & Nephrology
Keyvan Karimi Galougahi, Steven Chadban, Roxana Mehran, Sripal Bangalore, Glenn M. Chertow, Ziad A. Ali
Summary: Chronic kidney disease significantly impacts the development and management of coronary artery disease, posing challenges for cardiovascular disease screening and treatment. The lack of randomized controlled trial data on kidney disease patients highlights the need for future research in this population.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Medicine, General & Internal
Daniel B. C. Dos Santos, Luis Henrique W. Gowdak, Elias David-Neto, Felizardo A. Nataniel, Jose J. G. De Lima, Luiz A. Bortolotto
Summary: There is a need for a simple, inexpensive, and reliable noninvasive testing method to predict coronary artery disease in patients with chronic kidney disease. Peripheral artery disease (PAD) can be diagnosed using both palpation and ultrasound (USD). Palpation-diagnosed PAD is a better predictor of combined cardiovascular events and death, as well as being associated with CAD severity and likelihood of intervention.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Food Science & Technology
Mamali Das, Kasi Pandima Devi, Tarun Belwal, Hari Prasad Devkota, Devesh Tewari, Adeleh Sahebnasagh, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, Mahsa Rasekhian, Suowen Xu, Mehran Amirizadeh, Kiumarth Amini, Maciej Banach, Jianbo Xiao, Safieh Aghaabdollahian, Seyed Mohammad Nabavi
Summary: Vascular diseases are caused by abnormal endothelial response, resulting in atherosclerosis, hypercholesterolemia, etc. Polyphenols have antioxidative, anti-inflammatory, and anti-hypertensive properties, beneficial for preventing endothelial dysfunction.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Pharmacology & Pharmacy
Iqra Ilyas, Peter J. Little, Zhiping Liu, Yanyong Xu, Danielle Kamato, Bradford C. Berk, Jianping Weng, Suowen Xu
Summary: This article reviews the current use and translational potential of mouse models in atherosclerosis research and drug discovery. Atherosclerotic cardiovascular disease is a chronic and progressive metabolic and inflammatory disease that causes premature human mortality. Despite promising preclinical studies, many drug candidates have not been translated to clinical use due to the complex disease mechanisms involved.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Editorial Material
Endocrinology & Metabolism
Xiumei Wu, Suowen Xu, Jianping Weng
Summary: In a recent article published in Nature, Chen et al. reported that pregestational hyperglycemia resulted in offspring's vulnerability to glucose intolerance due to insufficient TET3-mediated 5-methylcytosine oxidation and DNA demethylation, leading to hypermethylation and reduction of insulin-secreting genes.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Review
Chemistry, Multidisciplinary
Suo-wen Xu, Iqra Ilyas, Jian-ping Weng
Summary: This review examines the impact of COVID-19 on endothelial cell function and provides a comprehensive summary of biomarkers associated with endothelial cell activation in COVID-19. COVID-19 is considered a vascular and endothelial disease, and several drugs have shown potential in improving clinical manifestations of patients. Further research using cellular and animal models can accelerate the discovery of new drugs targeting endothelial dysfunction in COVID-19 patients.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Mengyun Xu, Xiumei Wu, Zhenghong Liu, Yu Ding, Weian Kong, Peter J. Little, Suowen Xu, Jianping Weng
Summary: This study successfully established a novel mouse model of diabetes, atherosclerosis, and fatty liver disease by injecting AAV8-PCSK9 vectors in db/db mice. The model exhibits characteristics of hyperlipidemia, aneurysm, and atherosclerotic plaque, making it suitable for studying the pathological mechanisms of cardiometabolic disease and its complications.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Food Science & Technology
Meijie Chen, Jianbo Xiao, Hesham R. El-Seedi, Krystyna Skalicka Wozniak, Maria Daglia, Peter J. Little, Jianping Weng, Suowen Xu
Summary: Natural product kaempferol possesses pleiotropic cardiovascular protective effects due to its anti-oxidation, anti-inflammation, and anti-thrombotic properties. This review highlights the antioxidant, anti-inflammatory, and cardio-protective activities of kaempferol, focusing on its potential as a drug candidate for preventing and treating atherosclerosis, the underlying pathology of most cardiovascular diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Peng Jiang, Zhenghong Liu, Tingyu Fang, Zhidan Zhang, Yu Zhang, Dongdong Wang, Peter J. Little, Suowen Xu, Jianping Weng
Summary: Despite an increase in Gdf15 levels after APAP overdose, this study concluded that Gdf15 is not involved in APAP-induced liver injury. The study also suggests that genomic analysis of mRNA expression after APAP overdose is of limited relevance unless followed up by a functional analysis of candidate genes in vivo.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Qian Ma, Qiuhua Yang, Jiean Xu, Hunter G. Sellers, Zach L. Brown, Zhiping Liu, Zsuzsanna Bordan, Xiaofan Shi, Dingwei Zhao, Yongfeng Cai, Vidhi Pareek, Chunxiang Zhang, Guangyu Wu, Zheng Dong, Alexander D. Verin, Lin Gan, Quansheng Du, Stephen J. Benkovic, Suowen Xu, John M. Asara, Issam Ben-Sahra, Scott Barman, Yunchao Su, David J. R. Fulton, Yuqing Huo
Summary: This study found that the enzyme ATIC, which mediates de novo purine synthesis, plays a critical role in the proliferation of pulmonary artery smooth muscle cells (PASMCs) and the development of pulmonary hypertension (PH). Targeting ATIC-mediated DNPS reduces the availability of purine nucleotides, leading to decreased PASMC proliferation and amelioration of PH development and progression.
EUROPEAN HEART JOURNAL
(2023)
Article
Cell Biology
Yong Liao, Zhiping Liu, Weile Ye, Zunnan Huang, Jiaojiao Wang
Summary: Monkeypox, a member of the Poxviridae family, poses a great threat to humans. This study comprehensively analyzed monkeypox-related genes (MRGs) in tumor samples from 33 types of cancer using genomic and transcriptomic approaches. The results showed that MRGs are highly correlated with immune infiltration and can predict survival in cancer patients. Genomic alterations of MRGs were associated with tumorigenesis and patient survival. Pathway analysis revealed the involvement of MRGs in various cellular processes. The study also identified potential drugs targeting MRGs.
Article
Pharmacology & Pharmacy
Jiaojiao Wang, Zhiping Liu, Jing Lu, Jiami Zou, Weile Ye, Hong Li, Si Gao, Peiqing Liu
Summary: This study found that SIRT6 regulates endothelial function by modulating the activity of NOS3. SIRT6 activates NOS3 through deacetylation and facilitates its interaction with calmodulin, leading to increased nitric oxide generation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Immunology
Yong Liao, Jiaojiao Wang, Jiami Zou, Yong Liu, Zhiping Liu, Zunnan Huang
Summary: In this study, genomic and transcriptomic techniques were used to evaluate multi-omics data from the Cancer Genome Atlas (TCGA) database to identify the SARS-CoV-2 target genes (STGs) in tumor samples from 33 types of cancers. The expression of STGs was closely linked with immune infiltration and could be used to predict survival in cancer patients. STGs were also associated with immunological infiltration, immune cells, and immune pathways. Additionally, pathway analysis revealed the involvement of STGs in signaling pathways associated with cancer. The study also developed prognostic features and a nomogram of clinical factors for STGs in cancers and compiled a list of potential STG-targeting medicines from the cancer drug sensitivity genomics database.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Lianru Ji, Lang Zhang, Zhi Liang, Xiamin Liu, Zhiping Liu, Wai Sang Poon, Yonggui Song, Baodong Chen, Rikang Wang
Summary: The newly discovered adipocytokine, omentin-1, has anti-inflammatory effects and is involved in the regulation of depressive behaviors. Its deficiency increases susceptibility to anxiety and depressive-like behaviors, impairs cerebral blood flow and blood-brain barrier permeability.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Qiuping Wang, Kui Chen, Hui Jiang, Cai Chen, Can Xiong, Min Chen, Jie Xu, Xiaoping Gao, Suowen Xu, Huang Zhou, Yuen Wu
Summary: This study presents a design of biomimetic cascade catalysis system, where metal sites are immobilized on the inner and outer layers of nanocapsules to enable efficient enzymatic cascade reactions. The biomimetic catalysis system exhibits higher activity enhancement compared to conventional systems and is successfully applied in glucose detection.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Lijing Kang, Juanjuan Yi, Chi-Wai Lau, Lei He, Qinghua Chen, Suowen Xu, Jun Li, Yin Xia, Yuanting Zhang, Yu Huang, Li Wang
Summary: Hyperglycemia activates Yes-associated protein 1 (YAP) by suppressing AMPK activity, leading to obesity-associated endothelial dysfunction and inflammation. Metformin improves vascular dysfunction by activating AMPK and promoting YAP phosphorylation.
Review
Biochemistry & Molecular Biology
Xiumei Wu, Mengyun Xu, Mengya Geng, Shuo Chen, Peter J. Little, Suowen Xu, Jianping Weng
Summary: The increasing prevalence of noncommunicable diseases (NCDs) has become a significant global public health burden. Metabolic diseases, the most common form of NCDs, have life-threatening cardiovascular complications and affect people of all ages. Protein posttranslational modification (PTM) greatly enhances the functional diversity of proteins and plays a crucial role in common metabolic diseases such as diabetes, obesity, and fatty liver diseases. Understanding the mechanisms of PTMs in metabolic diseases will provide new insights for therapeutic intervention and improvement of therapies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)