Article
Cardiac & Cardiovascular Systems
Ovidiu Chioncel, Lina Benson, Maria G. Crespo-Leiro, Stefan D. Anker, Andrew J. S. Coats, Gerasimos Filippatos, Theresa McDonagh, Cornelia Margineanu, Alexandre Mebazaa, Marco Metra, Massimo F. Piepoli, Marianna Adamo, Giuseppe M. C. Rosano, Frank Ruschitzka, Gianluigi Savarese, Petar Seferovic, Maurizio Volterrani, Roberto Ferrari, Aldo P. Maggioni, Lars H. Lund
Summary: This study investigates the prevalence and associations of non-cardiac comorbidities (NCCs) with in-hospital and post-discharge outcomes in acute heart failure (AHF) patients with different ejection fraction (EF) categories. Multiple NCCs are associated with poor outcomes, and the association between individual comorbidities and post-discharge outcomes varies among different EF categories, suggesting the need for specific multidisciplinary management programs for different comorbidities in post-discharge phase.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Valentin Mertz, Yves Cottin, Sid Ahmed Bentounes, Julie Pastier-Debeaumarche, Romain Didier, Julien Herbert, Marianne Zeller, Gregory Y. H. Lip, Laurent Fauchier
Summary: The study aims to assess the prognosis of AF patients and found that patients with cardiac or extra-cardiac concomitant conditions have worse outcomes compared to patients with Lone AF.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Sabina Medrek, Sebastian Szmit
Summary: Mortality in lung cancer is influenced by various factors, including concomitant cardiovascular disease. Comorbidities and cardiotoxicity can affect the prognosis of early-stage lung cancer. The cardiotoxic effects of radiotherapy and chemoradiotherapy have been shown to impact overall survival. Acute arterial and venous thromboembolic events appear to be related to histological malignancy, clinical advancement, and optimal cardiac treatment, potentially influencing survival time. Prognosis in advanced and unresectable lung cancer primarily depends on histopathological and molecular factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Nhat Quang Tran, Gautam Goel, Nirmala Pudota, Michael Suesserman, John Helms, Daniel Lasaga, Dan Olson, Edward Bowen, Sanmitra Bhattacharya
Summary: Hospital readmissions rate is a significant issue in healthcare systems, causing financial burden. This study uses machine learning-based survival analysis to evaluate the quality of care risk. Different survival models are applied to explore the risk of readmissions considering patient demographics and hospital discharges. Deep-learning models show effectiveness in estimating the quality of care risk.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Xiaoyan Cai, Xiong Liu, Lichang Sun, Yiting He, Sulin Zheng, Yang Zhang, Yuli Huang
Summary: This study found that prediabetes is associated with an increased risk of heart failure, with different definitions of prediabetes having slightly different impacts on the risk of heart failure. Further research is needed to evaluate effective treatments for prediabetes in order to prevent the development and progression of heart failure.
DIABETES OBESITY & METABOLISM
(2021)
Review
Cardiac & Cardiovascular Systems
Amr Abdin, Stefan D. Anker, Javed Butler, Andrew J. Stewart Coats, Ingrid Kindermann, Mitja Lainscak, Lars H. Lund, Marco Metra, Wilfried Mullens, Giuseppe Rosano, Jonathan Slawik, Jan Wintrich, Michael Boehm
Summary: Timely diagnosis and treatment are crucial for the prognosis of patients with acute HF, and early and intensive treatment in the post-worsening HF period may reduce rates of early readmission and mortality.
Review
Cardiac & Cardiovascular Systems
Amr Abdin, Stefan D. Anker, Javed Butler, Andrew J. Stewart Coats, Ingrid Kindermann, Mitja Lainscak, Lars H. Lund, Marco Metra, Wilfried Mullens, Giuseppe Rosano, Jonathan Slawik, Jan Wintrich, Michael Boehm
Summary: In patients with heart failure, acute decompensation can occur rapidly and has a poor prognosis comparable to acute myocardial infarction. Therefore, timely diagnosis and immediate treatment are crucial for improving outcomes.
Article
Cardiac & Cardiovascular Systems
Daichi Maeda, Yuya Matsue, Nobuyuki Kagiyama, Kentaro Jujo, Kazuya Saito, Kentaro Kamiya, Hiroshi Saito, Yuki Ogasahara, Emi Maekawa, Masaaki Konishi, Takeshi Kitai, Kentaro Iwata, Hiroshi Wada, Masaru Hiki, Taishi Dotare, Tsutomu Sunayama, Takatoshi Kasai, Hirofumi Nagamatsu, Tetsuya Ozawa, Katsuya Izawa, Shuhei Yamamoto, Naoki Aizawa, Ryusuke Yonezawa, Kazuhiro Oka, Shin-Ichi Momomura, Tohru Minamino
Summary: The ability of heart failure patients to recognize their own comorbidities is low. Patients with less accurate recognition of their comorbidities may be at higher risk for all-cause mortality or heart failure rehospitalization.
Article
Cardiac & Cardiovascular Systems
Pau Codina, Elisabet Zamora, Wayne C. Levy, Elena Revuelta-Lopez, Andrea Borrellas, Giosafat Spitaleri, German Cediel, Maria Ruiz-Cueto, Elena Canedo, Evelyn Santiago-Vacas, Mar Domingo, David Buchaca, Isaac Subirana, Javier Santesmases, Rafael de la Espriella, Julio Nunez, Josep Lupon, Antoni Bayes-Genis
Summary: This study assessed the changes in predicted mortality risk after 12 months of management in a multidisciplinary HF clinic. The results showed a significant decline in mortality risk and improvement in cardiac function after 12 months, indicating the importance of repeated risk assessment after optimizing HF treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Lorenzo Falsetti, Vincenzo Zaccone, Emanuele Guerrieri, Giulio Perrotta, Ilaria Diblasi, Luca Giuliani, Linda Elena Gialluca Palma, Giovanna Viticchi, Agnese Fioranelli, Gianluca Moroncini, Adolfo Pansoni, Marinella Luccarini, Marianna Martino, Caterina Scalpelli, Maurizio Burattini, Nicola Tarquinio
Summary: This study aimed to evaluate the accuracy of EHMRG score in predicting in-hospital death among elderly AHF patients. The results showed that EHMRG score was fairly accurate in the whole cohort, with better performance observed in the first seven days of hospitalization.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Michael Drozd, Samuel D. Relton, Andrew M. N. Walker, Thomas A. Slater, John Gierula, Maria F. Paton, Judith Lowry, Sam Straw, Aaron Koshy, Melanie McGinlay, Alexander D. Simms, V. Kate Gatenby, Robert J. Sapsford, Klaus K. Witte, Mark T. Kearney, Richard M. Cubbon
Summary: Comorbidities have a significant impact on the life expectancy of patients with heart failure, with men experiencing greater excess loss of life compared to women.
Article
Cardiac & Cardiovascular Systems
Zekun Feng, Olumuyiwa P. Akinrimisi, Jeffrey A. Gornbein, Quynh A. Truong, Saumya Das, Jagmeet P. Singh, Olujimi Ajijola
Summary: In stable HFrEF patients, both single and combined biomarkers can better predict cardiovascular outcomes compared to the currently recommended biomarker, N-terminal pro B-type natriuretic peptide, according to an observational cohort study. Larger studies are needed to validate these findings.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Medicine, General & Internal
Francesca Coccina, Anna M. Pierdomenico, Chiara Cuccurullo, Jacopo Pizzicannella, Oriana Trubiani, Sante D. Pierdomenico
Summary: The study aimed to assess the risk of heart failure in elderly treated hypertensive patients with different types of hypertension. The results showed that patients with uncontrolled hypertension, nonresistant hypertension, and resistant hypertension had a significantly higher risk of developing heart failure compared to those with controlled hypertension.
Article
Cardiac & Cardiovascular Systems
Michiel T. H. M. Henkens, Jerremy Weerts, Job A. J. Verdonschot, Anne G. Raafs, Sophia Stroeks, Maurits A. Sikking, Hesam Amin, Sanne G. J. Mourmans, Chrit B. G. Geraeds, Sandra Sanders-van Wijk, Arantxa Barandiaran Aizpurua, Nicole H. M. K. Uszko-Lencer, Ingrid P. C. Krapels, Petra F. G. Wolffs, Han G. Brunner, Rick E. W. Leeuwen, Wouter Verhesen, Simon M. Schalla, Antonius W. M. Stipdonk, Christian Knackstedt, Xiaofei Li, Myrurgia A. Abdul Hamid, Pieter Paassen, Mark R. Hazebroek, Kevin Vernooy, Hans-Peter Brunner-La Rocca, Vanessa P. M. Empel, Stephane R. B. Heymans
Summary: The Maastricht Cardiomyopathy registry aims to improve diagnosis, risk stratification, and management of cardiomyopathy phenotypes beyond the limits of left ventricular ejection fraction. The registry collects patient characteristics, diagnostic measurements, treatment information, biobanking, quality of life assessment, and regular follow-up. It uses a data-driven approach and a hypothesis-driven approach to answer research questions.
Article
Cardiac & Cardiovascular Systems
Dong Hu, Lei Xiao, Shiyang Li, Senlin Hu, Yang Sun, Yan Wang, Dao Wen Wang
Summary: Through analyzing the transcriptomic and whole exome sequencing data of heart failure patients, a 31-SNP genetic risk score (GRS) was constructed, which, when combined with traditional risk factors (TRFs), showed promise in predicting mortality risk associated with heart failure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Javed Butler, Gerasimos Filippatos, Tariq Jamal Siddiqi, Martina Brueckmann, Michael Bohm, Vijay K. Chopra, Joao Pedro Ferreira, James L. Januzzi, Sanjay Kaul, Ileana L. Pina, Piotr Ponikowski, Sanjiv J. Shah, Michele Senni, Ola Vedin, Subodh Verma, Barbara Peil, Stuart J. Pocock, Faiez Zannad, Milton Packer, Stefan D. Anker
Summary: This study evaluated the impact of Empagliflozin on health-related quality of life in patients with heart failure and preserved ejection fraction. The results showed that Empagliflozin reduced the risk of major heart failure outcomes and improved health-related quality of life. The effects were consistent across different levels of baseline health status.
Article
Cardiac & Cardiovascular Systems
Savina Nodari, Francesco Fioretti, Francesco Barilla
Summary: Early epidemiologic studies suggested that increasing glucose concentrations lead to higher risks of complications in diabetes. However, recent evidence has shown that aggressive efforts to achieve low HbA1c levels can result in worse clinical outcomes and greater risk of hypoglycaemia. This has led to a paradigm shift in the treatment of diabetes.
HEART FAILURE REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, Modele O. Ogunniyi, Inder S. Anand, Akshay S. Desai, Mirta Diez, Jonathan G. Howlett, Jose C. Nicolau, Eileen O'Meara, Subodh Verma, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Daniel Lindholm, Felipe A. Martinez, Olof Bengtsson, Piotr Ponikowski, Marc S. Sabatine, Mikaela Sjostrand, Scott D. Solomon, Anna Maria Langkilde, Pardeep S. Jhund, John J. McMurray
Summary: The study investigated the efficacy and safety of dapagliflozin in Black and White patients with heart failure and found that it had similar benefits in reducing worsening heart failure and cardiovascular death in both racial groups.
JACC-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, Joanne Simpson, Pardeep S. Jhund, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, Olof Bengtsson, Mikaela Sjostrand, Daniel Lindholm, Anna Maria Langkilde, Scott D. Solomon, John J. McMurray
Summary: The MAGGIC score is positively associated with the relative risk of the primary endpoint. Dapagliflozin treatment provides similar benefits for the primary endpoint across the spectrum of MAGGIC risk score.
JACC-HEART FAILURE
(2022)
Article
Medicine, General & Internal
Piotr Gajewski, Marat Fudim, Veraprapas Kittipibul, Zoar J. Engelman, Jan Biegus, Robert Zymlinski, Piotr Ponikowski
Summary: In patients with heart failure, permanent ablation of the right greater splanchnic nerve leads to a significant reduction in intracardiac filling pressures during exercise within 24 hours following the procedure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Su Ern Yeoh, Kieran F. Docherty, Pardeep S. Jhund, Mark C. Petrie, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, Olof Bengtsson, David W. Boulton, Peter J. Greasley, Anna Maria Langkilde, Mikaela Sjostrand, Scott D. Solomon, John J. V. McMurray
Summary: Hyponatremia is prognostically important in heart failure patients, but does not modify the benefits of dapagliflozin on heart failure exacerbation and mortality.
JACC-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Carly Adamson, Lorna M. Cowan, Rudolf A. de Boer, Mirta Diez, Jaroslaw Drozdz, Andre Dukat, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Charlotta E. A. Ljungman, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, Daniel Lindholm, Olof Bengtsson, David W. Boulton, Peter J. Greasley, Anna Maria Langkilde, Mikaela Sjostrand, Scott D. Solomon, John J. McMurray, Pardeep S. Jhund
Summary: Abnormal liver tests are common in patients with severe heart failure and are associated with adverse clinical outcomes. This study aimed to investigate the prognostic significance of abnormal liver tests in ambulatory patients with heart failure with reduced ejection fraction (HFrEF), explore any treatment interaction between bilirubin and sodium-glucose cotransporter 2 (SGLT2) inhibitors, and examine change in liver tests with SGLT2 inhibitor treatment.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Review
Physiology
Anna Langner-Hetmanczuk, Stanislaw Tubek, Piotr Niewinski, Piotr Ponikowski
Summary: Peripheral chemoreceptors play a crucial role in sensing hypoxia in mammals and adapting to oxygen-deficient conditions. However, chronic overstimulation of these receptors can lead to the progression of sympathetically-mediated diseases. Therefore, deactivating peripheral chemoreceptors has been proposed as a treatment method for these disorders. This review article provides an overview of the physiological background and current understanding of the effects of commonly prescribed medications on the acute and tonic activities of peripheral chemoreceptors.
FRONTIERS IN PHYSIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. H. Butt, P. Dewan, K. Docherty, S. Inzucchi, P. Ponikowski, F. Martinez, O. Bengtsson, M. Sjostrand, S. D. Solomon, M. Sabatine, M. Kosiborod, A. M. Langkilde, P. S. Jhund, L. Kober, J. J. V. Mcmurray
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Medicine, General & Internal
Jose M. Castellano, Stuart J. Pocock, Deepak L. Bhatt, Antonio J. Quesada, Ruth Owen, Antonio Fernandez-Ortiz, Pedro L. Sanchez, Francisco Marin Ortuno, Jose M. Vazquez Rodriguez, Alexandra Domingo-Fernandez, Inigo Lozano, Maria C. Roncaglioni, Marta Baviera, Andreana Foresta, Luisa Ojeda-Fernandez, Furio Colivicchi, Stefania A. Di Fusco, Wolfram Doehner, Antje Meyer, Francois Schiele, Fiona Ecarnot, Ales Linhart, Jean-Claude Lubanda, Gregory Barczi, Bela Merkely, Piotr Ponikowski, Marta Kasprzak, Juan M. Fernandez Alvira, Vicente Andres, Hector Bueno, Timothy Collier, Frans Van de Werf, Pablo Perel, Moises Rodriguez-Manero, Angeles Alonso Garcia, Marco Proietti, Mikkel M. Schoos, Tabassome Simon, Jose Fernandez Ferro, Nicolas Lopez, Ettore Beghi, Yannick Bejot, David Vivas, Alberto Cordero, Borja Ibanez, Valentin Fuster
Summary: The study showed that taking a polypill containing aspirin, ramipril, and atorvastatin within 6 months after myocardial infarction significantly reduced the risk of major adverse cardiovascular events compared to usual care.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
S. E. Yeoh, P. Jhund, K. Docherty, M. C. Petrie, S. E. Inzucchi, L. Kober, M. N. Kosiborod, F. A. Martinez, P. Ponikowski, M. S. Sabatine, O. Bengtsson, A. M. Langkilde, M. Sjostrand, S. D. Solomon, J. J. V. Mcmurray
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Correction
Cardiac & Cardiovascular Systems
John R. Teerlink, Rafael Diaz, G. Michael Felker, John J. V. McMurray, Marco Metra, Scott D. Solomon, Kirkwood F. Adams, Inder Anand, Alexandra Arias-Mendoza, Tor Biering-Sorensen, Michael Bohm, Diana Bonderman, John G. F. Cleland, Ramon Corbalan, Maria G. Crespo-Leiro, Ulf Dahlstrom, Luis E. Echeverria Correa, James C. Fang, Gerasimos Filippatos, Candida Fonseca, Eva Goncalvesova, Assen R. Goudev, Jonathan G. Howlett, David E. Lanfear, Mayanna Lund, Peter Macdonald, Vyacheslav Mareev, Shin-ichi Momomura, Eileen O'Meara, Alexander Parkhomenko, Piotr Ponikowski, Felix J. A. Ramires, Pranas Serpytis, Karen Sliwa, Jindrich Spinar, Thomas M. Suter, Janos Tomcsanyi, Hans Vandekerckhove, Dragos Vinereanu, Adriaan A. Voors, Mehmet B. Yilmaz, Faiez Zannad, Lucie Sharpsten, Jason C. Legg, Siddique A. Abbasi, Claire Varin, Fady I. Malik, Christopher E. Kurtz
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Correction
Cardiac & Cardiovascular Systems
Radoslaw Sierpinski, Krystian Josiak, Tomasz Suchocki, Katarzyna Wojtas-Polc, Grzegorz Mazur, Aleksandra Butrym, Piotr Rozentryt, Peter Van der Meer, Josep Comin-Colet, Stephan Von Haehling, Wojciech Kosmala, Monika Przewlocka-Kosmala, Waldemar Banasiak, Jolanta Nowak, Adriaan A. Voors, Stefan D. Anker, John G. F. Cleland, Piotr Ponikowski, Ewa A. Jankowska
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Davor Milicic, Binyamin Ben Avraham, Ovidiu Chioncel, Yaron D. Barac, Eva Goncalvesova, Avishai Grupper, Johann Altenberger, Maria Frigeiro, Arsen Ristic, Nicolaas De Jonge, Steven Tsui, Jacob Lavee, Giuseppe Rosano, Marisa Generosa Crespo-Leiro, Andrew J. S. Coats, Petar Seferovic, Frank Ruschitzka, Marco Metra, Stefan Anker, Gerasimos Filippatos, Stamatis Adamopoulos, Miriam Abuhazira, Jeremy Elliston, Israel Gotsman, Righab Hamdan, Yoav Hammer, Tal Hasin, Lorrena Hill, Osnat Itzhaki Ben Zadok, Wilfried Mullens, Sanemn Nalbantgil, Massimo Francesco Piepoli, Piotr Ponikowski, Luciano Potena, Arjang Ruhparwar, Aviv Shaul, Laurens F. Tops, Stephan Winnik, Tiny Jaarsma, Finn Gustafsson, Tuvia Ben Gal
Summary: The advancements in LVAD technology and the shortage of donor hearts have led to an increase in LVAD-supported patients, especially older patients undergoing destination therapy, who are at higher risk for other comorbidities. This article provides definitions and a structured approach for managing LVAD-supported patients presenting with various complications in the emergency department, as well as discussing the challenging issue of declaring death in these patients.
Article
Cardiac & Cardiovascular Systems
Mateusz Sokolski, Sander Trenson, Justyna M. Sokolska, Domenico D'Amario, Philippe Meyer, Nana K. Poku, Tor Biering-Sorensen, Mats C. Hojbjerg Lassen, Kristoffer G. Skaarup, Eduardo Barge-Caballero, Anne-Catherine Pouleur, Davide Stolfo, Gianfranco Sinagra, Klemens Ablasser, Viktoria Muster, Peter P. Rainer, Markus Wallner, Alessandra Chiodini, Pascal S. Heiniger, Fran Mikulicic, Judith Schwaiger, Stephan Winnik, Huseyin A. Cakmak, Margherita Gaudenzi, Massimo Mapelli, Irene Mattavelli, Matthias Paul, Irina Cabac-Pogorevici, Claire Bouleti, Marzia Lilliu, Chiara Minoia, Jeroen Dauw, Jerome Costa, Ahmet Celik, Nathan Mewton, Carlos E. L. Montenegro, Yuya Matsue, Goran Loncar, Michal Marchel, Aris Bechlioulis, Lampros Michalis, Marcus Dorr, Edgard Prihadi, Felix Schoenrath, Daniel R. Messroghli, Wilfried Mullens, Lars H. Lund, Giuseppe M. C. Rosano, Piotr Ponikowski, Frank Ruschitzka, Andreas J. Flammer
Summary: The study assessed the outcome of hospitalized COVID-19 patients with heart failure (HF) compared to those with other cardiovascular diseases and risk factors. It found that patients with HF had a higher in-hospital mortality rate, and acute HF events during hospitalization were associated with further increased mortality.