期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 167, 期 6, 页码 2734-2738出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2012.06.104
关键词
Arterial stiffness; Exercise; Cardiac rehabilitation
资金
- Robert S. Flinn Endowment for Cardiovascular Medicine (University of New Mexico School of Medicine)
Background: Exercise has been shown to beneficially alter arterial stiffness in selected clinical settings. However, the effects of a standardized exercise protocol - cardiac rehabilitation (CR) - on measures of arterial stiffness in patients with established coronary heart disease (CHD) has not been well studied. Methods: Using applanation tonometry, we studied arterial vascular properties in 26 men and 22 women (mean age 60.5 +/- 10.8 years) with established CHD over a 20 week CR program. All patients continued to receive their anti-anginal and vasoactive medications. In addition to standard hemodynamics we estimated central aortic pressure, central arterial pulsatility, augmentation index and arterial pulse wave velocity (PWV). Results: After 20 weeks of CR, there were no significant changes in resting heart rate or peripheral blood pressure. In 33 patients with at least two follow-up visits, central aortic systolic pressure was consistently lower than peripheral arterial blood pressure and decreased over the CR program time (baseline, 109 +/- 16 mm Hg; final, 105 +/- 14 mm Hg. p=0.01). Both carotid-radial (n=12) and carotid-femoral (n=21) - derived PWV decreased over the CR program (carotid-radial: baseline, 7.3 +/- 1.2 m/s; final, 6.6 +/- 1.2 m/s, p=0.028. carotid-femoral: baseline, 7.2 +/- 1.4 m/s; final, 6.5 +/- 1.3 m/s, p=0.02). Conclusions: In this group of patients with established CHD, arterial PWV was noted to significantly decrease over a 20 week CR program. This change occurred in the absence of detectable changes in peripheral blood pressure or heart rate. Decreases in PWV may serve as a sensitive indicator of improved arterial stiffness in patients with atherosclerotic arterial disease notwithstanding ongoing medical therapy. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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