Article
Immunology
Runlong Lin, Jing Yu, Aijuan Tian, Xiaomei Wang, Xin Yuan, Wengui Xu, Wenli Xie
Summary: This study examined the effects of COVID-19 on vascular inflammatory response in DLBCL patients using PET/CT imaging. It was found that vascular inflammation is elevated in the early post-COVID-19 phase in DLBCL cases, highlighting the importance of protecting vascular function and preventing complications in these patients.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Paolo Molinari, Lara Caldiroli, Elena Dozio, Roberta Rigolini, Paola Giubbilini, Massimiliano M. Corsi Romanelli, Piergiorgio Messa, Simone Vettoretti
Summary: This study quantified AGEs and sRAGE isoforms in patients with CKD and evaluated their association with eGFR changes. While sRAGE decreased and AGEs/sRAGE ratio increased at follow up, their relationship with eGFR was not significant. AGEs/sRAGE was associated with renal function, suggesting a potential role in CKD progression that requires further investigation.
Article
Cell Biology
Yanna Lei, Qingsong Cui, Guang Yang, Limei Piao, Aiko Inoue, Hongxian Wu, Xiang Li, Masafumi Kuzuya, Xian Wu Cheng
Summary: The study demonstrates that pitavastatin can prevent vascular senescence and atherogenesis induced by chronic stress and high fat diet in mice, potentially by increasing GLP-1 and APN levels and suppressing plaque inflammation and oxidative stress.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Rosaria Anna Fontanella, Lucia Scisciola, Maria Rosaria Rizzo, Surina Surina, Celestino Sardu, Raffaele Marfella, Giuseppe Paolisso, Michelangela Barbieri
Summary: The study confirmed the role of epigenetics in obesity-related cardiovascular complications, and proposed plasma miRNA-21 and IL-6 as well as NF-kB DNA methylation changes in nucleated blood cells as potential biomarkers for evaluating cardiovascular risk in obesity. It also showed the protective role of adiponectin in preventing epigenetic modifications induced by increased adipose tissue content in obese individuals. Further research is needed to explore the exact mechanisms of obesity-related epigenetic modifications in blood cells and their reflection of changes in adipose and myocardial tissues.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sing Hon Kwok, Frankie Choi
Summary: In this report, a 54-year-old woman with a 3-month history of skin rash and bilateral hearing loss is presented. Multiple investigations failed to diagnose relapsing polychondritis, until F-18-FDG PET/CT showed a characteristic FDG activity pattern-the oto-rhino-tracheobronchial triad. The patient was subsequently diagnosed and treated for relapsing polychondritis. The second FDG PET/CT revealed differential response in different disease sites, leading to an escalation of treatment.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Biology
Xia Lu, Raffaella Calabretta, Wolfgang Wadsak, Alexander R. Haug, Marius Mayerhoefer, Markus Raderer, Xiaoli Zhang, Jingle Li, Marcus Hacker, Xiang Li
Summary: This study compared the uptake of [Ga-68]PentixaFor and [F-18]FDG in arterial lesions and found that [Ga-68]PentixaFor PET/MRI identified more lesions and showed higher uptake. It also revealed an increased uptake of [Ga-68]PentixaFor in patients with high-risk cardiovascular factors and a correlation between elevated uptake in active arterial segments and the heart.
Article
Cardiac & Cardiovascular Systems
Philip M. Robson, Audrey Kaufman, Alison Pruzan, Marc R. Dweck, Maria-Giovanna Trivieri, Ronan Abgral, Nicolas A. Karakatsanis, Patrick M. Brunner, Emma Guttman, Zahi A. Fayad, Venkatesh Mani
Summary: Non-invasive positron emission tomography (PET) is a powerful tool for monitoring vascular inflammation and atherosclerotic plaque, with PET/MR offering advantages in soft tissue contrast. Research shows that the scan-rescan repeatability of F-18-FDG PET/MR in the aorta and carotid arteries is less than 5%, comparable to F-18-FDG PET/CT.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
David J. Liesker, Stijn Legtenberg, Paola A. Erba, Andor W. J. M. Glaudemans, Clark J. Zeebregts, Jean-Paul P. M. De Vries, Nabil Chakfe, Ben R. Saleem, Riemer H. J. A. Slart
Summary: This study aimed to assess the variability of [F-18]FDG-PET/LDCT reporting in suspected VGEI using a standardized reporting format. The results showed that less than half of the reports met all the pre-selected criteria, and the incompleteness of reports led to lower sensitivity and specificity.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Wolfgang Roll, Philipp Schindler, Max Masthoff, Rebecca Strotmann, Joern Albring, Christian Reicherts, Matthias Weckesser, Benjamin Noto, Matthias Stelljes, Michael Schaefers, Georg Evers
Summary: The combined use of F-18-FDG-PET-MRI was found to be highly reliable for assessing acute intestinal GvHD and providing information on clinical severity. The number of affected segments and metabolic volume in PET-MRI correlated significantly with clinical stage, indicating its potential for clinical application in managing GvHD.
Article
Cardiac & Cardiovascular Systems
Jakub Toczek, Ansel T. Hillmer, Jinah Han, Chi Liu, Dana Peters, Hamed Emami, Jing Wu, Irina Esterlis, Kelly P. Cosgrove, Mehran M. Sadeghi
Summary: This small pilot study did not find significant differences in vascular or systemic inflammation between PTSD and healthy control subjects as assessed by FDG PET imaging. While limited by the small sample size, it suggests that further research is needed to establish the potential link between CVD and PTSD.
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Sollini, Silvia Morbelli, Michele Ciccarelli, Maurizio Cecconi, Alessio Aghemo, Paola Morelli, Silvia Chiola, Fabrizia Gelardi, Arturo Chiti
Summary: The study hypothesized that whole-body [18F]FDG-PET/CT could provide insight into the pathophysiology of long COVID. Results revealed increased [18F]FDG uptake in various organs of long COVID patients, suggesting underlying systemic inflammation. Brain hypometabolism patterns were associated with persistent symptoms, indicating different temporal sequences of brain and whole-body inflammatory changes. Whole-body [18F]FDG PET was found to hold potential value in disclosing the pathophysiology of long COVID.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Tasnim Khessib, Benjamin Franc, Eric Yang, Farshad Moradi
Summary: A 68-year-old man with a history of pulmonary adenocarcinoma on maintenance pembrolizumab presented with new soft tissue stranding and inflammation on F-18-FDG PET/CT, which were confirmed as immunotherapy-related toxicity on biopsy. He discontinued pembrolizumab, which he had been taking for 3 years. Recognizing immunotherapy-related adverse effects on F-18-FDG PET/CT is crucial for timely cessation of treatment.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthieu Dietz, Gilles Chironi, Yann-Erick Claessens, Ryan Lukas Farhad, Isabelle Rouquette, Benjamin Serrano, Valerie Nataf, Florent Hugonnet, Benoit Paulmier, Frederic Berthier, Olivia Keita-Perse, Francesco Giammarile, Christophe Perrin, Marc Faraggi
Summary: The study aimed to assess the inflammatory status in COVID-19 patients at the presumed peak of the inflammatory phase using FDG PET/CT scans. The results showed heterogeneous glucose uptake typically focused on the lungs.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shih-hsin Chen, Kenneth Miles, Stuart A. Taylor, Balaji Ganeshan, Manuel Rodriquez, Francesco Fraioli, Simon Wan, Asim Afaq, Robert Shortman, Darren Walls, Luke Hoy, Raymond Endozo, Aman Bhargava, Matthew Hanson, Joseph Huang, Sherif Raouf, Daren Francis, Shahab Siddiqi, Tan Arulampalam, Bruce Sizer, Michael Machesney, Nicholas Reay-Jones, Sanjay Dindyal, Tony Ng, Ashley Groves
Summary: This study suggests that vascular-metabolic imaging with FDG-PET/CT can provide specific prognostic markers for colorectal cancer patients. Different patient groups exhibit distinct vascular-metabolic signatures, which could help predict survival outcomes.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Himanshu R. Dashora, Joel S. Rosenblum, Kaitlin A. Quinn, Hugh Alessi, Elaine Novakovich, Babak Saboury, Mark A. Ahlman, Peter C. Grayson
Summary: This study aimed to evaluate the performance of qualitative and large-vessel vasculitis. Clinical and imaging assessments were conducted on patients with giant cell arteritis or Takayasu arteritis. The results showed that the semiquantitative evaluation method had better correlation and reliability compared to the qualitative evaluation method.
JOURNAL OF NUCLEAR MEDICINE
(2022)
