Review
Biochemistry & Molecular Biology
Sung-Min Hwang, Youn-Yi Jo, Cinder Faith Cohen, Yong-Ho Kim, Temugin Berta, Chul-Kyu Park
Summary: This review focuses on the mechanisms by which venom-derived peptides interact with the outer pore region of TRPV1 to control receptor functions and how these mechanisms can drive the development of new types of analgesics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dubravka Vukovic, Marin Ogorevc, Ivo Tripkovic, Neira Puizina-Ivic, Mirna Saraga-Babic, Snjezana Mardesic
Summary: LS patients show abnormal distribution and density of nerve fibers, increased density of macrophages and mast cells in the skin. Genital and extragenital LS have different pathological characteristics. These findings provide insights into the pathogenesis of LS and suggest potential therapeutic targets.
Review
Neurosciences
Rodrigo C. Meza, Carlos Ancaten-Gonzalez, Chiayu Q. Chiu, Andres E. Chavez
Summary: This article discusses the roles of TRPV1 in both central and peripheral systems, exploring its regulation of synaptic function and potential therapeutic applications.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Hideki Sakatani, Masamitsu Kono, Tatsuya Shiga, Hiroki Kuwazoe, Denisa Nanushaj, Ibu Matsuzaki, Shin-Ichi Murata, Masayasu Miyajima, Yuka Okada, Shizuya Saika, Muneki Hotomi
Summary: Olfactory disorders, closely related to cognitive deterioration, can be caused by infections, aging, and environmental chemicals. This study focused on the involvement of TRPV1 and TRPV4 channels in olfactory receptor neuron (ORN) regeneration, demonstrating that TRPV1 stimulates progenitor cell proliferation while TRPV4 regulates proliferation and maturation, suggesting their essential roles in ORN regeneration.
LABORATORY INVESTIGATION
(2023)
Article
Medicine, Legal
Antonio Guzam, Araceli Tortajada, Ana-Paz Marin, Cristina Vila, Gregorio Encina
Summary: Cizolirtine, a substance used for pain and urinary incontinence, showed an increased incidence of tumors in mice and rats. In mice, it was associated with an increase in skin fibrosarcomas and sarcomas, while in rats, it was associated with liver adenomas and carcinomas, possibly due to increased liver metabolism and related changes. However, the relevance of these findings to humans remains uncertain.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jiaqi Bao, Zhicheng Gao, Yilan Hu, Lifang Ye, Lihong Wang
Summary: The activation of TRPV1 channels plays a protective role in the prevention and treatment of cardiovascular complications induced by diabetes, specifically diabetic cardiomyopathy. It helps inhibit the occurrence and progression of DCM, improving cardiac structure and function.
Article
Multidisciplinary Sciences
Dongni Xie, Yamei Xu, Yao Yang, Ziyi Hua, Jiao Li, Gang Fu, Qingqing Wu
Summary: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious side effect of systematic administration of bisphosphonates (BPs). Sensory denervation facilitates the occurrence of BRONJ, but therapeutic use of CGRP can effectively prevent the progression of BRONJ.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Neurosciences
Mamoru Shibata, Chunhua Tang
Summary: Migraine is a common and debilitating headache disorder with elusive pathogenesis, likely involving abnormal trigeminal and central nervous system activity. TRP channels, which transduce noxious stimuli into pain signals, play important roles in migraine pathophysiology by co-localizing with calcitonin gene-related peptide in the trigeminal ganglion and regulating its release. Effective anti-migraine therapies, such as botulinum neurotoxin type A, also impact TRP cation channel functions.
NEUROSCIENCE BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Jing Hu, Mengkang Gao, Yang Zhang, Yusui Wang, Zhenrui Qiao, Weiya Zhang, Qiang Wang, Lin Yan, Hai Qian
Summary: In this study, three series of new piperazine urea TRPV1 antagonists were designed, synthesized, and evaluated, among which compound 5ac showed excellent TRPV1 antagonistic activity, good bioavailability, and no hyperthermia side effects. The molecular docking study revealed that compound 5ac interacted well with the amino acid residues on rTRPV1 through hydrophobic interaction, making it an efficient TRPV1 antagonist and a potential candidate for analgesic drug development.
BIOORGANIC CHEMISTRY
(2021)
Review
Physiology
Guangxin Peng, Xiaoling Tang, Yang Gui, Jing Yang, Lifang Ye, Liuyang Wu, Ya Hui Ding, Lihong Wang
Summary: TRPV1 plays a significant role in fibrotic diseases, regulating the fibrotic processes and potentially serving as a therapeutic target.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Immunology
Lin Shang, Siqi Zhao, Huijuan Shi, Xinzhu Xing, Jingya Zhang, Yanling He
Summary: Pruritus is a common and painful symptom in psoriasis that greatly affects quality of life. Neurogenic inflammation induced pruritus is the predominant mechanism in psoriasis, with the nerve growth factor (NGF)-mediated TRPV1 pathway playing a crucial role. However, the development of systemic TRPV1 antagonists has been hindered by elevated core temperature. Therefore, topical application of TRPV1 antagonists and interference with TRPV1 activation pathway mediators could be promising therapeutic options. This review focuses on recent advances in understanding the complex regulation of the NGF-mediated TRPV1 pathway in psoriatic pruritus and the potential therapeutic approaches derived from this knowledge.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qiqi Yan, Jun Tang, Xin Zhang, Liuyang Wu, Yunyi Xu, Lihong Wang
Summary: TRPV1 channel plays a beneficial role in heart diseases, but the specific mechanism in pathological myocardial hypertrophy remains unclear, posing a research gap. The study aims to provide new treatment targets for pathological myocardial hypertrophy by summarizing the role and mechanism of TRPV1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Tao Zhang, Yuan Tian, Xiaoqing Zheng, Ruomeng Li, Li Hu, Xindong Shui, Yingxue Mei, Quling Wang, Mi Zhang, Xiuzhi Zheng, Long Wang, Dongmei Chen, Wucheng Tao, Tae Ho Lee
Summary: This study found that capsaicin can promote autophagy and reduce the abnormal accumulation of tau protein by activating the TRPV1 channel, thereby improving synaptic damage and cognitive impairment. Experimental validation showed that this effect is mediated by the AMPK/mTOR signaling pathway. The results of this study reveal the role of capsaicin in restoring tau protein homeostasis through modulating cellular autophagy and support the potential of TRPV1 as a therapeutic target for tauopathies.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Lingfeng Zhang, Yantao Xu, Yingxu Ma, Tianjian Xie, Chan Liu, Qiming Liu
Summary: This article provides a bibliometric analysis of the relationship between transient receptor potential vanilloid (TRPV) and cardiovascular system disease. The findings show significant growth in the field since 2008, with the United States and China in dominant positions. The study suggests the need for intercontinental cooperation and future research on pharmacological mechanisms and new clinical disease application areas.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Hideaki Yamada, Naoaki Sakata, Tomoko Tanaka, Hideaki Tagashira, Gumpei Yoshimatsu, Ryo Kawakami, Hideichi Wada, Takahiro Iwamoto, Shohta Kodama
Summary: This study showed that activating TRPV4 can improve blood flow in the ischemic hindlimb animal model by promoting both angiogenesis and lymphangiogenesis. It suggests that upregulating both lymphatic and blood vessels through TRPV4 activation could be a promising therapeutic strategy for peripheral artery disease.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
