期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 127, 期 2, 页码 290-291出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2007.04.048
关键词
contrast nephropathy; NGAL; cystatin C; coronary artery disease; PCI
The aim of the study was to assess whether NGAL and cystatin C could predict contrast-induced nephropathy in non-diabetic patients (n = 60, mean age 60 +/- 11 years) with normal serum creatinine undergoing elective PCI. We found a significant rise in serum NGAL after 2, 4 and 8 h, and in urinary NGAL after 4, 8 and 24 h after PCI. Cystatin C rose significantly 8 and 24 h after the procedure. Prevalence of CIN was 10%. We found 90% sensitivity and 74% specificity of serum and 76% sensitivity and 80% specificity of urinary NGAL increase. NGAL may represent a sensitive early biomarkers of renal impairment after PCI. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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