Review
Oncology
Jing Gao, Song Li, Qian Xu, Xue Zhang, Miao Huang, Xin Dai, Lian Liu
Summary: Exosomes play a crucial role in the formation of pre-metastatic niches in gastric cancer, facilitating tumor metastasis by establishing a supportive environment remotely. The cell components in pre-metastatic niches secrete exosomes that interact with each other, providing signals that promote tumor growth.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yongchao Chu, Tao Sun, Chen Jiang
Summary: The emergence of disseminated metastasis is the leading cause of mortality in patients with malignant tumors. Targeting the pre-metastatic microenvironment may be a promising strategy for preventing metastasis. Nanosystems have shown strong potential in anti-metastatic therapy by selectively targeting pre-metastatic microenvironments.
CHINESE CHEMICAL LETTERS
(2022)
Review
Pharmacology & Pharmacy
Chiwei Chen, Renlun Huang, Jianfu Zhou, Lang Guo, Songtao Xiang
Summary: This article discusses the mechanism of bone metastasis in prostate cancer, focusing on the effects of pre-metastatic niche and tumor microenvironment. Furthermore, a new concept of pre-metastatic bone niche is introduced to explain bone metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yi Wang, Yuqiu Li, Junpei Zhong, Miao Li, Youjia Zhou, Qing Lin, Siwen Zong, Wenting Luo, Jiayang Wang, Keqin Wang, Jie Wang, Lixia Xiong
Summary: Cav-1 in exosomes derived from breast cancer cells promotes lung metastasis by regulating intercellular communication and PMN formation.
Article
Biochemistry & Molecular Biology
Katsuaki Ieguchi, Masabumi Funakoshi, Taishi Mishima, Kohtaro Takizawa, Tsutomu Omori, Fumio Nakamura, Makoto Watanabe, Mayumi Tsuji, Yuji Kiuchi, Shinichi Kobayashi, Takuya Tsunoda, Yoshiro Maru, Satoshi Wada
Summary: Emerging evidence suggests that neural activity contributes to tumor initiation and metastasis. Specifically, the sympathetic nervous system has been found to regulate tumor angiogenesis, growth, and metastasis. By performing chemical sympathectomy, researchers observed a decrease in lung metastasis and identified neuro-immune cell interactions in tumor-bearing mouse lungs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Rushikesh S. Joshi, Samanvi S. Kanugula, Sweta Sudhir, Matheus P. Pereira, Saket Jain, Manish K. Aghi
Summary: The review discusses the importance of cancer-associated fibroblasts (CAFs) in various cancer contexts as potential therapeutic targets. Identification of CAFs and understanding their role in promoting tumor progression may lead to the development of novel cancer therapies.
Review
Biochemistry & Molecular Biology
Huogang Wang, Mingo M. H. Yung, Hextan Y. S. Ngan, Karen K. L. Chan, David W. Chan
Summary: Metastasis, driven by tumor-associated macrophages (TAMs), is a key factor in most cancer deaths, with TAMs playing a crucial role in influencing tumor metastasis and treatment outcomes by polarizing metabolism patterns. Tumor cell-driven TAMs in the tumor microenvironment promote tumor metastasis and are associated with poor prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Kellen Wright, Thuc Ly, Matthew Kriet, Andras Czirok, Sufi Mary Thomas
Summary: Cancer cells rely on the tumor microenvironment (TME) for growth and metastasis. Among the components of TME, cancer-associated fibroblasts (CAFs) play a crucial role. CAFs are heterogeneous and can remodel the microenvironment, as well as communicate with immune cells to aid in immune evasion. This review focuses on the factors and signaling pathways of CAFs.
Review
Oncology
Pablo Hernandez-Camarero, Elena Lopez-Ruiz, Juan Antonio Marchal, Macarena Peran
Summary: The tumor microenvironment plays a crucial role in promoting drug resistance, tumor progression, metastasis, and maintaining a cancer stem-like phenotype. Different groups of stromal cells in the TME have specific spatial distributions that evolve as the tumor progresses. Understanding the interaction between TME and metastasis is essential for improving cancer clinical management.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Mahboubeh Tajaldini, Mohsen Saeedi, Taghi Amiriani, Amir Hossein Amiriani, Sima Sedighi, Fatemeh Mohammad Zadeh, Mohammad Dehghan, Mehrdad Jahanshahi, Maziar Zanjan Ghandian, Pedram Khalili, Amir Houshang Poorkhani, Ali Mohammad Alizadeh, Vahid Khori
Summary: The tumor microenvironment (TME) plays a crucial role in cancer metastasis and drug resistance. Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) regulate angiogenesis, tumor metastasis, and drug resistance by manipulating the composition and organization of extracellular matrix (ECM). Targeting TAMs and CAFs is essential for enhancing the effectiveness of anti-cancer agents.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Cell Biology
Martina Bedeschi, Noemi Marino, Elena Cavassi, Filippo Piccinini, Anna Tesei
Summary: Prostate cancer is a common cancer in European males and androgen deprivation therapy is the standard treatment. However, resistance to this therapy has led to cancer progression and long-term side effects. Studies have shown that cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment (TME) and targeting them could be a potential therapeutic approach to overcome therapy resistance in prostate cancer.
Review
Physiology
Giulia Biffi, David A. Tuveson
Summary: Efforts to develop anti-cancer therapies have mainly targeted the epithelial compartment, but recent studies have shown the significant influence of cancer-associated fibroblasts (CAFs) in tumor progression. CAFs not only promote cancer cell proliferation, therapy resistance, and immune exclusion, but may also restrain tumor progression in certain contexts. Research on CAFs has focused on their heterogeneity, plasticity, and functions across different cancer types and states, as well as advancements in therapeutic strategies targeting CAFs currently undergoing preclinical and clinical evaluation.
PHYSIOLOGICAL REVIEWS
(2021)
Review
Cell Biology
Chuwen Jiang, Zhengting Jiang, Gengyu Sha, Daorong Wang, Dong Tang
Summary: Metastasis is a multi-step process in cancer progression that leads to various obstacles in cancer treatment and high mortality rates. Metabolic reprogramming, occurring in both cancer cells and stromal cells, plays a critical role in enhancing their survival and metastatic potential. Small extracellular vesicles (sEVs) mediate metabolic reprogramming by transferring bioactive substances, such as proteins, mRNAs, and miRNAs, to reshape the tumor microenvironment and facilitate the formation of pre-metastatic niches (PMNs). Understanding the functions of sEVs in cancer cells and the TME, as well as their potential applications in tumor diagnosis and treatment, could provide valuable insights for improved outcomes.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Pharmacology & Pharmacy
Claire L. Ihle, Sabrina J. Wright-Hobart, Philip Owens
Summary: The survival rate of breast cancer patients has improved, but metastatic breast cancer still causes high mortality. Metastasis mainly occurs in the bone, and current treatment methods focus on palliative care and slowing down the progression. Recent advances in molecularly targeted agents have made breakthroughs in the treatment of metastatic breast cancer, but immunotherapies have not been fully applied in estrogen receptor-positive tumors. Therapeutic approaches targeting the bone microenvironment of metastatic breast cancer have potential applications in other bone-resident cancers.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Nadiah Abu, Nurul Ainaa Adilah Rus Bakarurraini
Summary: The interdependency between cancer cells and immune cells is crucial to understanding cancer pathogenesis. Extracellular vesicles (EVs) released by both cancer and immune cells act as messengers in this process. Tumor-derived EVs have been found to interact with immune cells, especially T cells, while T cell-derived EVs also play immunomodulatory roles. This mini-review aims to explore the impact of tumor-derived EVs and T cell-derived EVs on cancer immunosuppression, highlighting the interplay between different types of EVs and their effects on tumor immunity. The role of EVs in various types of T cells, including CD8(+), CD4(+) Th17, and Treg cells, is also discussed. Furthermore, limitations and future directions regarding this research are addressed, contributing to a better understanding of the functions of these tiny mediators.
Review
Oncology
Keyu Li, Yaliang Lan, Jiabei Wang, Lianxin Liu
Article
Cell Biology
Yaliang Lan, Jihua Han, Yan Wang, Jiabei Wang, Guangchao Yang, Keyu Li, Ruipeng Song, Tongsen Zheng, Yingjian Liang, Shangha Pan, Xirui Liu, Mingxi Zhu, Yao Liu, Fanzheng Meng, Manzoor Mohsin, Yifeng Cui, Bo Zhang, Sharma Subash, Lianxin Liu
CELL DEATH & DISEASE
(2018)
Article
Oncology
Kenji Fujiwara, May Tun Saung, Hao Jing, Brian Herbst, MacKenzie Zarecki, Stephen Muth, Annie Wu, Elaine Bigelow, Linda Chen, Keyu Li, Neolle Jurcak, Alex B. Blair, Ding Ding, Michael Wichroski, Jordan Blum, Nathan Cheadle, Jennifer Koenitzer, Lei Zheng
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Review
Medicine, General & Internal
Ke-Yu Li, Ai-Lin Wei, Ang Li
WORLD JOURNAL OF CLINICAL CASES
(2020)
Article
Oncology
Keyu Li, Jialong Yuan, Yichen Li, Hao Zhang, Xubao Liu, Nengwen Ke
Summary: This study reports a rare case of pancreatic neuroendocrine carcinoma patient who achieved radical surgery after receiving neoadjuvant therapy, providing a new treatment option for similar patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Jianxin Wang, May Tun Saung, Keyu Li, Juan Fu, Kenji Fujiwara, Nan Niu, Stephen Muth, Junke Wang, Yao Xu, Noah Rozich, Haley Zlomke, Sophia Chen, Birginia Espinoza, MacKenzie Henderson, Vanessa Funes, Brian Herbst, Ding Ding, Christina Twyman-Saint Victor, Qihong Zhao, Amol Narang, Jin He, Lei Zheng
Summary: This preclinical study demonstrates the potential of CCR2/CCR5 dual-antagonist in counteracting radiation-induced suppressive signals and enhancing the effector T cell pathway. It supports the ongoing clinical trial of combining this therapy with radiation and anti-PD-1 antibody for locally advanced pancreatic cancer.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Tao Xia, Keyu Li, Nan Niu, Yingkuan Shao, Ding Ding, Dwayne L. Thomas, Hao Jing, Kenji Fujiwara, Haijie Hu, Arsen Osipov, Chunhui Yuan, Christopher L. Wolfgang, Elizabeth D. Thompson, Robert A. Anders, Jin He, Yiping Mou, Adrian G. Murphy, Lei Zheng
Summary: This study reveals that the densities of Granzyme-B(+)CD8(+) effector T cells, non-exhausted PD-1(-)EOMES(-)CD8(+) T cells, and the PD-L1 status in tumor-associated macrophages are prognostic markers in cholangiocarcinoma. Targeting PD-L1(+) tumor-associated macrophages may be an effective immunotherapy for cholangiocarcinoma.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Pan Li, Noah Rozich, Jianxin Wang, Junke Wang, Yao Xu, Brian Herbst, Raymond Yu, Stephen Muth, Nan Niu, Keyu Li, Vanessa Funes, Jessica Gai, Arsen Osipov, Barish H. Edil, Christopher L. Wolfgang, Ming Lei, Tingbo Liang, Lei Zheng
Summary: This study investigates the potential of a combination therapy involving an anti-IL-8 antibody and an anti-PD-1 antibody for treating pancreatic ductal adenocarcinoma (PDAC). The results show that the combination treatment enhances the antitumor activity and activates the innate immune response in the tumor microenvironment. CD16+ myeloid cells, particularly granulocytes, are identified as the main target of IL-8. These findings provide a basis for further clinical testing of this combination therapy in PDAC treatment and highlight the role of peripherally derived myeloid cells in promoting the antitumor response of T cells.
Article
Gastroenterology & Hepatology
Alex B. Blair, Jianxin Wang, John Davelaar, Andrew Baker, Keyu Li, Nan Niu, Junke Wang, Yingkuan Shao, Vanessa Funes, Pan Li, Jonathan A. Pachter, Daniel C. Maneval, Felipe Dezem, Jasmine Plummer, Keith Syson Chan, Jun Gong, Andrew E. Hendifar, Stephen J. Pandol, Richard Burkhart, Yuqing Zhang, Lei Zheng, Arsen Osipov
Summary: This study identifies the synergistic effects of targeting both intracellular and extracellular components within the PDAC stroma, and supports the potential of testing anti-CXCR4 antibody in combination with FAKi as a PDAC treatment strategy.
Article
Oncology
Keyu Li, Joseph A. Tandurella, Jessica Gai, Qingfeng Zhu, Su Jin Lim, Dwayne L. Thomas II, Tao Xia, Guanglan Mo, Jacob T. Mitchell, Janelle Montagne, Melissa Lyman, Ludmila Danilova, Jacquelyn W. Zimmerman, Benedict Kinny-Koster, Tengyi Zhang, Linda Chen, Alex B. Blair, Thatcher Heumann, Rose Parkinson, Jennifer N. Durham, Amol K. Narang, Robert A. Anders, Christopher L. Wolfgang, Daniel A. Laheru, Jin He, Arsen Osipov, Elizabeth D. Thompson, Hao Wang, Elana J. Fertig, Elizabeth M. Jaffee, Lei Zheng
Summary: Successful immunotherapy for pancreatic ductal adenocarcinoma (PDAC) requires optimization and maintenance of activated effector T cells (Teff). In this study, multi-omic analyses were performed on paired pre- and post-treatment PDAC specimens collected in a neoadjuvant study to uncover sensitivity and resistance mechanisms of a PDAC vaccine (GVAX) combined with nivolumab (anti-PD-1). The results showed that immune-regulatory sites were formed in response to the combination of GVAX and nivolumab. Higher density of tumor-associated neutrophils (TANs) following the combination therapy was associated with poorer overall survival (OS), while increased expression of CD137 on T cells correlated with cytotoxic Teff signatures and increased OS. RNA sequencing analysis revealed that nivolumab altered chemotaxis signaling in CD4+ T cells and CD11b+ neutrophil degranulation, and optimal T cell activation required CD8+ T cell expression of CD137. These findings provide insights into immune pathways regulated by PD-1 in PDAC and could guide the development of more effective therapeutic combinations.
Article
Oncology
Ning Xie, Haoyu Zhou, Li Yu, Shaobing Huang, Can Tian, Keyu Li, Yi Jiang, Zhe-Yu Hu, Quchang Ouyang
Summary: In this study, an AI-based computer-aided system for Ki-67 calculation in breast cancer was developed using the SIFT algorithm. The system improved the accuracy of Ki-67 index calculation and ensured data repeatability among different hospitals and centers.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Thatcher Heumann, Carol Judkins, Keyu Li, Su Jin Lim, Jessica Hoare, Rose Parkinson, Haihui Cao, Tengyi Zhang, Jessica Gai, Betul Celiker, Qingfeng Zhu, Thomas McPhaul, Jennifer Durham, Katrina Purtell, Rachel Klein, Daniel Laheru, Ana De Jesus-Acosta, Dung T. Le, Amol Narang, Robert Anders, Richard Burkhart, William Burns, Kevin Soares, Christopher Wolfgang, Elizabeth Thompson, Elizabeth Jaffee, Hao Wang, Jin He, Lei Zheng
Summary: A neoadjuvant immunotherapy platform trial using GVAX vaccine with low-dose cyclophosphamide alone, or in combination with nivolumab and urelumab, showed increased intratumoral CD8+ CD137+ cells and potentially improved disease-free and overall survivals in patients with resectable pancreatic adenocarcinoma. This combination therapy demonstrates a promising efficacy signal and warrants further investigation.
NATURE COMMUNICATIONS
(2023)
Proceedings Paper
Health Care Sciences & Services
Keyu Li, Dongsheng Wu, Lanlan Ping
Summary: An eight-unit MIMO array antenna composed of four ring-slots is proposed for metal-framed mobile terminals in the 5G era. The antenna achieves high isolation and good radiation performance in the LTE band 42 (3.4-3.6 GHz) of 5G communication.
2022 PROGNOSTICS AND HEALTH MANAGEMENT CONFERENCE, PHM-LONDON 2022
(2022)
Article
Oncology
Arsen Osipov, Alex B. Blair, Juliane Liberto, Jianxin Wang, Keyu Li, Brian Herbst, Shiqi Li, Nan Niu, Rufiaat Rashid, Ding Ding, Yanan Liu, Zaiqi Wang, Christopher L. Wolfgang, Richard A. Burkhart, Daniel Laheru, Lei Zheng
Summary: The study demonstrated that FAK inhibition can enhance the antitumor response to radiotherapy in PDAC, with the combination therapy being T cell dependent. FAK inhibition in combination with radiotherapy increased CD8+ T cell infiltration significantly, while inhibiting granulocyte infiltration. This suggests the potential of using FAK inhibitors as radiosensitizers for PDAC and priming the tumor microenvironment for immunotherapy.
CANCER BIOLOGY & MEDICINE
(2021)