Review
Biochemistry & Molecular Biology
Lucy Lu, Adam Cole, Dan Huang, Qiang Wang, Zhongming Guo, Wancai Yang, Jim Lu
Summary: The hepsin gene is associated with prostate cancer, and its overexpression promotes cancer cell proliferation, migration, and metastasis. Increased expression of hepsin is correlated with poor prognosis for prostate cancer patients. Hepsin interacts with other oncogenic proteins, and its proteolytic activities are involved in the development of prostate cancer. Genomic amplifications of hepsin are significantly associated with prostate cancer metastasis.
Review
Cell & Tissue Engineering
Kai Song, Maryam Farzaneh
Summary: Breast cancer stem cells play a critical role in the metastasis and aggressiveness of breast cancer, making them a suitable target for treatment. Signaling pathways such as Wnt, NF kappa B, and miRNAs are key players in regulating BCSC self-renewal and metastasis. Targeting these pathways may offer a novel therapeutic approach for breast cancer diagnosis and therapy.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Oncology
Yi Li, Changyuan Wang, Ting Huang, Xijie Yu, Bole Tian
Summary: Breast cancer deaths are primarily caused by metastasis. There are several treatment options, but limited options for preventing or inhibiting breast tumor metastases. Studies have focused on the importance of the tumor microenvironment (TME) in metastasis of breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ryan D. Gillis, Edoardo Botteri, Aeson Chang, Alexandra Ziegler, Ni-Chun Chung, Cindy K. Pon, David M. Shackleford, Bettina K. Andreassen, Michelle L. Halls, Jillian G. Baker, Erica K. Sloan
Summary: The study suggests that carvedilol, a beta-blocker, may be a novel strategy to slow cancer progression. Patients using carvedilol at breast cancer diagnosis showed significantly reduced breast cancer-specific mortality.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Joel S. Parker, Michael Mullins, Maggie C. U. Cheang, Samuel Leung, David Voduc, Tammi Vickery, Sherri Davies, Christiane Fauron, Xiaping He, Zhiyuan Hu, John F. Quackenbush, Inge J. Stijleman, Juan Palazzo, J. S. Marron, Andrew B. Nobel, Elaine Mardis, Torsten O. Nielsen, Matthew J. Ellis, Charles M. Perou, Philip S. Bernard
Summary: This study developed a risk model that incorporates gene expression-based intrinsic subtypes for breast cancer prognosis and prediction of chemotherapy benefit. The intrinsic subtypes showed significant prognostic significance and remained significant even when standard parameters were incorporated. The model can be used to predict prognosis for node-negative breast cancer and assess the likelihood of efficacy from neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Xuelian Song, Changran Wei, Xiangqi Li
Summary: Breast cancer bone metastasis is a complex process involving multiple signaling pathways. This review explores the interactions between these pathways and the role of surface markers and receptors in breast tumors and bone microenvironment, providing a theoretical foundation for understanding the mechanism of BC bone metastasis and developing targeted therapies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yongchen Guo, Chunna Ren, Wentao Huang, Wancai Yang, Yonghua Bao
Summary: ACSM1 is specifically elevated in prostate cancer and associated with poor prognosis and shorter survival time. Copy number alterations of ACSM1 are frequently observed in prostate cancer, but not correlated with gene expression levels. The oncogenic role of ACSM1 in prostate cancer is mainly through metabolic and ECM-receptor interaction signaling pathways, and not related to immune cell infiltration or immune subtypes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Anita Rogic, Ila Pant, Luca Grumolato, Ruben Fernandez-Rodriguez, Andrew Edwards, Suvendu Das, Aaron Sun, Shen Yao, Rui Qiao, Shabnam Jaffer, Ravi Sachidanandam, Guray Akturk, Rosa Karlic, Mihaela Skobe, Stuart A. Aaronson
Summary: Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. The characterization of a human IBC cell line in this study suggests that the high level of CCL2 is implicated in macrophage infiltration and tumor progression.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Giovanna Rigillo, Silvia Belluti, Virginia Campani, Gregorio Ragazzini, Mirko Ronzio, Giacomo Miserocchi, Beatrice Bighi, Laura Cuoghi, Valentina Mularoni, Vincenzo Zappavigna, Diletta Dolfini, Laura Mercatali, Andrea Alessandrini, Carol Imbriano
Summary: Aberrant splicing of NF-YAl transcript is associated with aggressive mesenchymal CRC and predicts shorter survival. CRC cells overexpressing NF-YAl exhibit altered cell behavior and transcription of genes involved in cell adhesion and epithelial-mesenchymal transition. These findings suggest that NF-YAl may serve as a prognostic factor for CRC and splice-switching strategies could be used to reduce metastatic progression.
Article
Oncology
Frantisek Zitricky, Asta Foersti, Akseli Hemminki, Kari Hemminki
Summary: This study modeled survival data from the NORDCAN database and analyzed survival rates of breast cancer patients in Denmark, Finland, Norway, and Sweden from 1971 to 2020. The results showed that Sweden had the highest survival rates, but all countries showed improvements over time and approached the levels of Sweden. The risk of recurrence was higher in the 2-5 year period, which resulted in higher 10/5-year survival rates compared to 5/1-year survival rates. The study suggests that late mortality is a critical factor limiting survival in breast cancer.
Article
Biochemistry & Molecular Biology
Miranda E. Clements, Lauren Holtslander, Courtney Edwards, Vera Todd, Samuel D. R. Dooyema, Kennady Bullock, Kensey Bergdorf, Cynthia A. Zahnow, Roisin M. Connolly, Rachelle W. Johnson
Summary: Histone deacetylase inhibitors (HDACi) have been shown to induce the expression of LIFR and activate a pro-dormancy program in breast cancer cells, slowing cell proliferation and reducing tumor growth. Clinical trial data suggests that HDACi treatment in breast cancer patients leads to increased LIFR levels and decreased proliferation rates in primary tumors, which is associated with prolonged patient survival.
Article
Oncology
Angelina Regua, Csaba Papp, Andre Grageda, Baylee A. Porter, Tiffany Caza, Isabelle Bichindaritz, Mira Krendel, Abirami Sivapiragasam, Gennady Bratslavsky, Vladimir A. Kuznetsov, Leszek Kotula
Summary: Breast cancer remains one of the leading causes of mortality in women worldwide, and there is a need for better predictive and therapeutic targets. This study identifies ABI1 as a prognostic biomarker for breast cancer metastasis and demonstrates that genetic disruption of the ABI1 gene reduces lung metastases in mice. The study also shows that aberrations in ABI1 gene expression are associated with lung metastasis in primary breast cancer tumors. Targeting ABI1 may provide a therapeutic advantage for breast cancer patients.
MOLECULAR ONCOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Celestin Bigarre, Francois Bertucci, Pascal Finetti, Gaetan Macgrogan, Xavier Muracciole, Sebastien Benzekry
Summary: This study proposes a novel mathematical model to predict the risk of metastatic relapse in early-stage breast cancer patients. By using mixed-effects modeling, the researchers identified two mathematical parameters representing growth and dissemination abilities. They found that Ki67 and Thymidine Kinase-1 were associated with growth, while nodal status and Plasminogen Activator Inhibitor-1 were associated with dissemination.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Laijian Sui, Andrew Sanders, Wen G. Jiang, Lin Ye
Summary: This study identified key biomarkers, such as GDF11, CD151, PAFAH1B2, YTHDF2, as well as DPP9, FAS, ZNF519, RPP14, FAU, that play important roles in breast cancer bone metastasis, providing potential targets for therapeutic intervention.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Gulcan Bulut, Hasan Ikbal Atilgan, Gokalp Cinarer, Kazim Kilic, Deniz Yikar, Tuba Parlar
Summary: The aim of this study is to use deep learning methods to predict pathological complete response (pCR) after Neoadjuvant chemotherapy (NAC) in locally advanced breast cancer (LABC) using 18F-FDG PET/CT imaging.
Article
Respiratory System
David Shitrit, Yochai Adir, Avital Avriel, Daniel King, Gali Epstein Shochet, Alexander Guber, Sonia Schnaer, Michael Kassirer, Paul D. Blanc, Amir Abramovich
Article
Respiratory System
Gali Epstein Shochet, Lutz Wollin, David Shitrit
Meeting Abstract
Critical Care Medicine
David Shitrit, Matthew Koslow, Lilach Israeli-Shani, Gali Epstein Shochet
Meeting Abstract
Critical Care Medicine
David Shitrit, Gali Epstein Shochet, Elizabetha Brook, Omer Eyal, Evgeny Edelstein
Article
Physiology
Gali Epstein Shochet, Elizabetha Brook, Omer Eyal, Evgeny Edelstein, David Shitrit
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Oncology
Matthew Koslow, David Shitrit, Lilach Israeli-Shani, Orit Uziel, Einat Beery, Alexandra Osadchy, Yael Refaely, Gali Epstein Shochet, Aliza Amiel
Letter
Critical Care Medicine
Ori Wand, Elad Guber, Alexander Guber, Gali Epstein Shochet, Lilach Israeli-Shani, David Shitrit
Letter
Critical Care Medicine
Ori Wand, Elad Guber, Alexander Guber, Gali Epstein Shochet, Lilach Israeli-Shani, David Shitrit
Article
Health Care Sciences & Services
Alexander Guber, Gali Epstein Shochet, Sarah Kohn, David Shitrit
JOURNAL OF MEDICAL SYSTEMS
(2019)
Letter
Critical Care Medicine
Ori Wand, Avraham Unterman, Gali Epstein Shochet, David Shitrit
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Respiratory System
Gali Epstein Shochet, Elizabetha Brook, Becky Bardenstein-Wald, David Shitrit
RESPIRATORY RESEARCH
(2020)
Meeting Abstract
Critical Care Medicine
G. Epstein Shochet, E. Brook, E. Edelstein, O. Wand, D. A. King, D. Shitrit
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Meeting Abstract
Critical Care Medicine
G. Epstein Shochet, E. Abd El Qader, L. Israeli-Shani, Z. Dovrish, O. Wand, D. A. King, D. Shitrit
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Article
Medicine, General & Internal
Daniel Erez, Matthew Koslow, Gali Epstein Shochet, Zamir Dovrish, Lilach Lsraeli-Shani, David Dahan, Daniel King, David Shitrit
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2019)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)