期刊
INTERNATIONAL JOURNAL OF CANCER
卷 145, 期 1, 页码 10-19出版社
WILEY
DOI: 10.1002/ijc.31867
关键词
curcumin; analogs; growth; metastasis; pancreatic cancer
类别
Curcumin is a polyphenolic constituent of turmeric that is known to have various molecular effects in preclinical models, leading to prevention and anticancer properties. In clinical trials, curcumin has failed to demonstrate activity against pancreatic cancer possibly due to its low bioavailability and potency. Using the curcumin molecular model, our group and others have synthesized several analogs with better bioavailability and higher potency in pancreatic cancer in vitro and xenograft models. This mini review summarizes some of the known molecular effects of curcumin analogs and their potential role as novel therapeutics for pancreatic cancer.
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