Article
Endocrinology & Metabolism
Shiyun Jin, Qi Cao, Fanghan Yang, Hongying Zhu, Su Xu, Qi Chen, Ziyi Wang, Yuhong Lin, Resat Cinar, Robert J. Pawlosky, Ye Zhang, Wei Xiong, Bin Gao, George F. Koob, David M. Lovinger, Li Zhang
Summary: The study demonstrates that astrocytic ALDH2 metabolizes ethanol in the brain, affecting the behavioral effects of alcohol. It shows that astrocytic ALDH2 controls the production and behavioral effects of alcohol metabolites in different brain regions.
Article
Oncology
Zeni Wu, Yongli Han, Yunhu Wan, Xing Hua, Samantha S. Chill, Kedest Teshome, Weiyin Zhou, Jia Liu, Dongjing Wu, Amy Hutchinson, Kristine Jones, Casey L. Dagnall, Belynda D. Hicks, Linda Liao, Heather Hallen-Adams, Jianxin Shi, Christian C. Abnet, Rashmi Sinha, Anil Chaturvedi, Emily Vogtmann
Summary: This study found a relationship between oral microbiome and head and neck cancer. The presence of multiple microbial species, including periodontal pathogens, as well as higher microbial alpha-diversity and the presence of oral fungi, were associated with reduced risk of HNC. Larger studies are needed to further evaluate these associations.
Article
Medicine, General & Internal
Pia Lopez-Jornet, Carmen Zamora Lavella, Eduardo Pons-Fuster Lopez, Asta Tvarijonaviciute
Summary: Dementia patients have poorer oral health, are more likely to have fewer teeth, oral issues, and a higher risk of cognitive decline.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ciaran Moore, Michael Donnelly, Cherith Semple, Ciaran O'Neill, Gerald Mckenna
Summary: This study investigated the views of head and neck cancer (HANC) patients on their oral health and potential issues regarding compliance with clinical oral hygiene and dietary advice for the prevention of post-radiotherapy dental disease. The results showed that oral health was crucial for the overall physical and mental well-being of post-treatment HANC patients. Non-compliance with clinical advice was related to oral mucositis, high fluoride toothpaste, forgotten or inconsistent clinical advice, and inadequate supply of preventive oral hygiene products. Furthermore, patients were not informed about the high cariogenic nature of prescribed nutritional supplements.
JOURNAL OF DENTISTRY
(2023)
Article
Cell Biology
Nargess Farhangdoost, Cynthia Horth, Bo Hu, Eric Bareke, Xiao Chen, Yinglu Li, Mariel Coradin, Benjamin A. Garcia, Chao Lu, Jacek Majewski
Summary: Chromatin dysregulation plays a key role in oncogenesis, and mutations in the histone methyltransferase gene NSD1 have been identified in head and neck squamous cell carcinomas. Loss of NSD1 leads to alterations in chromatin modifications, affecting gene expression. This study sheds light on the downstream effects of NSD1 loss and provides insights into the role of chromatin modifications in cancer.
Review
Oncology
Jinfeng Liang, Lin Li, Limei Li, Xiaoying Zhou, Zhe Zhang, Yi Huang, Xue Xiao
Summary: Lipid metabolism reprogramming is a significant metabolic anomaly in cancer, including head and neck cancer. This review examines the dysregulated molecules and pathways of lipid metabolism in head and neck cancer, and discusses their associations with cancer development, treatment, and prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huiwen Xiao, Yao Fan, Yuan Li, Jiali Dong, Shuqin Zhang, Bin Wang, Jia Liu, Xingzhong Liu, Saijun Fan, Jian Guan, Ming Cui
Summary: Oral mucositis is a common complication in NOALC patients undergoing radiotherapy, and oral microbiota transplantation can alleviate the symptoms. The gut microbiota also plays a role in oral mucositis progression. Additionally, specific oral microorganisms like Lactobacillaceae could potentially serve as biomarkers for predicting NOALC prognosis after radiotherapy.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Plant Sciences
Moola M. Nyambe, Ezekeil G. Kwembeya, Kamuhelo Lisao, Renate Hans
Summary: This study provides an overview of plants used as chewing sticks in Namibia, highlighting pharmacological and phytochemical studies conducted on them. It identified a significant relationship between plant family and scientific validation, with emphasis on the need for further investigations on the therapeutic methods, mechanisms of action, efficacy, toxicity, and clinical relevance of these species.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhengrui Li, Rao Fu, Xufeng Huang, Xutao Wen, Ling Zhang
Summary: This study aimed to assess the correlation between oral microbiota and the extent of bone resorption in ORN patients. The results showed that the ORN group had higher microbial abundance and species diversity, and specific microbial communities were potentially associated with ORN. In addition, an imbalance in the oral microbiota may disrupt bone regeneration by regulating specific metabolic pathways that increase osteoclastic activity. Therefore, radiation-induced ORN is associated with significant changes in the oral microbiota.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Qi-Chao Yang, Shuo Wang, Yuan-Tong Liu, An Song, Zhi-Zhong Wu, Shu-Cheng Wan, Hui-Min Li, Zhi-Jun Sun
Summary: PCSK9 expression is upregulated in HNSCC tissues and higher expression is associated with poorer prognosis. Inhibition of PCSK9 suppresses cancer cell stemness via LDLR-dependent mechanism. PCSK9 inhibition enhances CD8(+) T cell infiltration, reduces MDSCs, and improves the efficacy of anti-PD-1 ICB therapy in HNSCC.
Article
Oncology
William J. Benjamin, Kai Wang, Katherine Zarins, Emily Bellile, Freida Blostein, Ilona Argirion, Jeremy M. G. Taylor, Nisha J. D'Silva, Steven B. Chinn, Samara Rifkin, Maureen A. Sartor, Laura S. Rozek
Summary: Further research is needed to determine the impact of the oral microbiome on head and neck cancer, including its pathogenesis and outcomes. This study used 16s rRNA sequencing to analyze oral wash samples from 52 cases and 102 controls. Significant differences were found in the diversity and composition of the oral microbiome between the cases and controls. The presence of specific bacteria associated with periodontitis was more common in the cases, particularly among older patients and smokers.
Article
Medicine, Research & Experimental
Vaishali Chandel, Saurabh Maru, Arun Kumar, Ashok Kumar, Ashok Sharma, Brijesh Rathi, Dhruv Kumar
Summary: Head and Neck tumors exhibit highly altered metabolism, with cancer cells utilizing different pathways for energy production. Monocarboxylate transporters play a crucial role in regulating lactate and maintaining pH balance, essential for cancer cell survival and growth control.
Review
Medicine, Research & Experimental
David Aaron Haynes, Christopher C. Vanison, M. Boyd Gillespie
Summary: Patients with head and neck cancer who receive recommended dental care have significantly higher survival rates compared to those who do not receive recommended dental care.
Review
Oncology
Ye Zheng, Chen Lin, Yidian Chu, Shanshan Gu, Hongxia Deng, Zhisen Shen
Summary: The joint analysis of multiple omics techniques is revolutionizing our understanding of metabolic reprogramming in tumor cells. However, the study of metabolic mechanisms in head and neck tumors is still underdeveloped. This review provides a comprehensive comparison of traditional metabolomics and spatial metabolomics, discusses the recent progress and challenges of applying spatial metabolomics in tumor research, and highlights its advances in understanding the metabolic mechanisms of head and neck tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Austin J. Iovoli, Lauren Turecki, Michelle L. Qiu, Michael Khan, Kelsey Smith, Han Yu, Sung Jun Ma, Mark K. Farrugia, Anurag K. Singh
Summary: Oral mucositis is a common adverse effect in head and neck cancer patients receiving radiation therapy. This study aimed to investigate the associations between the severity of oral mucositis and clinical outcomes and quality of life. The results showed that severe oral mucositis was associated with feeding tube placement, hospitalization, opiate use, and weight loss.
Article
Oncology
Wei-Ting Lee, Jenn-Ren Hsiao, Chun-Yen Ou, Cheng-Chih Huang, Chan-Chi Chang, Sen-Tien Tsai, Ken-Chung Chen, Jehn-Shyun Huang, Tung-Yiu Wong, Yu-Hsuan Lai, Yuan-Hua Wu, Wei-Ting Hsueh, Shang-Yin Wu, Chia-Jui Yen, Jang-Yang Chang, Chen-Lin Lin, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S. Chang
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2019)
Article
Otorhinolaryngology
Hung-Ju Lin, Jenn-Ren Hsiao, Jeffrey S. Chang, Chi-Lun Hu, Ting-Rong Chen, Wei-Ting Lee, Cheng-Chih Huang, Chun-Yen Ou, Shu-Wei Tsai, Yu-Cheng Lu, Sen-Tien Tsai, Wen-Yuan Chao, Chan-Chi Chang
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Oncology
Chan-Chi Chang, Wei-Ting Lee, Jenn-Ren Hsiao, Chun-Yen Ou, Cheng-Chih Huang, Sen-Tien Tsai, Ken-Chung Chen, Jehn-Shyun Huang, Tung-Yiu Wong, Yu-Hsuan Lai, Yuan-Hua Wu, Wei-Ting Hsueh, Shang-Yin Wu, Chia-Jul Yen, Jong-Yang Chang, Chen-Lin Lin, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S. Chang
Article
Substance Abuse
Jenn-Ren Hsiao, Wei-Ting Lee, Chun-Yen Ou, Cheng-Chih Huang, Chan-Chi Chang, Sen-Tien Tsai, Ken-Chung Chen, Jehn-Shyun Huang, Tung-Yiu Wong, Yu-Hsuan Lai, Yuan-Hua Wu, Wei-Ting Hsueh, Shang-Yin Wu, Chia-Jui Yen, Jang-Yang Chang, Chen-Lin Lin, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S. Chang
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Review
Medicine, General & Internal
Hui-Jen Tsai, Jeffrey S. Chang
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Medicine, General & Internal
Chen-Yuan Lin, Jeffrey S. Chang, Shih-Ming Huang, Chung-Jye Hung, Chien-Ling Hung, Chwen-Tzuei Chang, Horng-Ren Yang, Te-Chun Hsieh, Yu-Hui Huang, Hui-Jen Tsai
Summary: In this study, we investigated the real-world experience of sorafenib in treating advanced DTC patients in Taiwan. Most patients started with a dose of 200 mg twice daily and had a mean daily maintenance dose of 433 mg. The most common toxicity of sorafenib was hand foot skin reaction (69%), followed by diarrhea (42%), and skin rash (33%).
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Oncology
Jenn-Ren Hsiao, Cheng-Chih Huang, Chun-Yen Ou, Chan-Chi Chang, Wei-Ting Lee, Sen-Tien Tsai, Jehn-Shyun Huang, Ken-Chung Chen, Yu-Hsuan Lai, Yuan-Hua Wu, Wei-Ting Hsueh, Shang-Yin Wu, Chia-Jui Yen, Jang-Yang Chang, Chen-Lin Lin, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S. Chang
Article
Oncology
Tzu-Hui Pao, Wei-Lun Chang, Nai-Jung Chiang, Jeffrey Shu-Ming Chang, Chia-Ying Lin, Wu-Wei Lai, Yau-Lin Tseng, Yi-Ting Yen, Ta-Jung Chung, Forn-Chia Lin
RADIATION ONCOLOGY
(2020)
Article
Oncology
Tsung-Ming Chang, Pei-Yi Chu, Wen-Chun Hung, Yan-Shen Shan, Hui-You Lin, Kuo-Wei Huang, Jeffrey S. Chang, Li-Tzong Chen, Hui-Jen Tsai
Summary: Pancreatic neuroendocrine tumor (pNET) is a type of pancreatic tumor with neuroendocrine differentiation. Early stage pNET can be treated with surgical resection for long-term survival, while pNET with metastasis has a poor prognosis. In this study, it was found that c-Myc overexpression is associated with lymph node metastasis in pNET xenograft mice. Combination therapy using an mTOR inhibitor and c-Myc inhibitor or VEGFC-neutralizing protein reduced lymph node metastasis in mice with c-Myc overexpression, indicating potential therapeutic targets for pNET.
Article
Multidisciplinary Sciences
Jeffrey S. Chang, Li-Tzong Chen, Yan-Shen Shan, Pei-Yi Chu, Chia-Rong Tsai, Hui-Jen Tsai
Summary: The incidence of NETs in Taiwan has been on the rise in recent decades, with a notable improvement in the survival rate of pancreatic NETs. Female and younger patients tend to have better survival rates, and those diagnosed between 2010 and 2015 show improved survival compared to earlier years.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Cheng-Chih Huang, Yu-Chu Su, Chan-Chi Chang, Wei-Ting Lee, Chun-Yen Ou, Yuan-Hua Wu, Shang-Yin Wu, Yu-Hsuan Lai, Jehn-Shyun Huang, Ken-Chung Chen, Wei-Ting Hsueh, Sen-Tien Tsai, Chia-Jui Yen, Jang-Yang Chang, Mei-Ling Tsai, Chen-Lin Lin, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jenn-Ren Hsiao, Jeffrey S. Chang
Summary: This study found a positive association between seropositivity to HPV16 E7 and oropharyngeal cancer (OPC) risk, particularly among nonbetel quid or noncigarette users. Seropositivity to HPV16 E7 also showed moderate agreement with P16 expression in OPC, suggesting that HPV may be an important risk factor for OPC in Taiwan.
Article
Multidisciplinary Sciences
Yan-Shen Shan, Li-Tzong Chen, Chih-Hsing Wu, Yin-Fan Chang, Chih-Ting Lee, Nai-Jung Chiang, Ying-Jui Chao, Chia-Jui Yen, Hui-Jen Tsai, Hsin-En Huang, Chia-Rung Tsai, Ya-Ling Weng, Han-Chien Yang, Hui-Chin Liu, Jeffrey S. Chang
Summary: The study in Taiwan found no significant association between alcohol consumption and pancreatic cancer risk, even at high levels of drinking. There was also no significant association between alcohol use and pancreatic cancer among individuals genetically susceptible to the carcinogenic effect of alcohol. Overall, alcohol drinking was not a significant contributor to the occurrence of pancreatic cancer in Taiwan.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yen-Ting Lin, Chi-Lu Chiang, Jen-Yu Hung, Mei-Hsuan Lee, Wu-Chou Su, Shang-Yin Wu, Yu-Feng Wei, Kang-Yun Lee, Yen-Han Tseng, Jian Su, Hsin-Pei Chung, Chih-Bin Lin, Wen-Hui Ku, Tsai-Shin Chiang, Chao-Hua Chiu, Jin-Yuan Shih
Summary: The study found that the mechanisms of ALK TKI resistance were heterogeneous, with ALK mutations being found in less than one-third of patients. In patients with simultaneous paired tissue and cfDNA samples, mutations were identified in 45% and 30% of cases, respectively, with a concordance rate of 45%.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Hui-Jen Tsai, Chin-Fu Hsiao, Jeffrey S. Chang, Li-Tzong Chen, Ying-Jui Chao, Chia-Ju Yen, Yan-Shen Shan
Summary: The study revealed an association between CgA levels and tumor burden, overall survival, and tumor progression in GEP-NET patients. Higher baseline CgA levels were linked to worse overall survival, and the rate of change in CgA levels could predict tumor progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yan-Shen Shan, Li-Tzong Chen, Jin-Shang Wu, Yin-Fan Chang, Chih-Ting Lee, Chih-Hsing Wu, Nai-Jung Chiang, Hsin-En Huang, Chia-Jui Yen, Ying-Jui Chao, Hui-Jen Tsai, Chiung-Yu Chen, Jui-Wen Kang, Chin-Fu Kuo, Chia-Rung Tsai, Ya-Ling Weng, Han-Chien Yang, Hui-Chin Liu, Jeffrey S. Chang
JOURNAL OF BIOMEDICAL SCIENCE
(2020)