Article
Biochemistry & Molecular Biology
Lei Zhang, Yidong Li, Chaohua Hu, Yangmin Chen, Zhuo Chen, Zhe-Sheng Chen, Jian-Ye Zhang, Shuo Fang
Summary: This study reveals CDK6-PI3K as a novel target signaling axis to reverse ABCB1-mediated multidrug resistance for the first time in cancers. Deficiency of CDK6 leads to downregulation of ABCB1 expression and reversal of multidrug resistance.
Article
Biochemistry & Molecular Biology
Wen-Wei Chang, Bing-Yen Wang, Shih-Hong Chen, Peng-Ju Chien, Gwo-Tarng Sheu, Ching-Hsiung Lin
Summary: This study found that in pemetrexed-resistant NSCLC cells, overexpression of BMI1 leads to downregulation of miR-145-5p, resulting in increased expression of Sp1 and induction of the EMT process. Increasing miR-145-5p expression could serve as a sensitizing agent for pemetrexed-resistant NSCLC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Ignacio Fernando Hall, Montserrat Climent, Chiara Viviani Anselmi, Laura Papa, Vinicius Tragante, Luca Lambroia, Floriana Maria Farina, Marcus E. Kleber, Winfried Maerz, Carlo Biguori, Gianluigi Condorelli, Leonardo Elia
Summary: The study identifies a SNP, rs41291957 (A), near the miR-143/145 cluster that upregulates miR-143 and miR-145, modulating vascular smooth cell phenotype and acting as a protective factor against coronary artery disease.
EMBO MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Shu-Li Liu, Mao-Hua Chen, Xiao-Bo Wang, Rong-Kai You, Xue-Wei An, Qiu Zhao, Ren-Shu Wang
Summary: The study revealed that upregulation of PCGEM1 in glioma tissues and cell lines was associated with poor prognosis. Knockdown of PCGEM1 suppressed cell proliferation, migration, invasion, and tumor growth in vivo by acting as a ceRNA for miR-539-5p to regulate CDK6 expression. This suggests that PCGEM1 may serve as a potential therapeutic target for glioma.
Article
Biochemistry & Molecular Biology
Eduarda O. Z. Minin, Layde R. Paim, Elisangela C. P. Lopes, Larissa C. M. Bueno, Luis F. R. S. Carvalho-Romano, Edmilson R. Marques, Camila F. L. Vegian, Jose A. Pio-Magalhaes, Otavio R. Coelho-Filho, Andrei C. Sposito, Jose R. Matos-Souza, Wilson Nadruz, Roberto Schreiber
Summary: In this study, hypertensive patients with carotid plaques were found to have increased expression of miR-145-5p and miR-let7c, suggesting a potential role of these miRNAs as biomarkers for subclinical atherosclerosis in hypertensive individuals.
Article
Biotechnology & Applied Microbiology
Peilin Zhong, Aihua Guo, Linhua Wang, Xiurong Lin, Mei Feng
Summary: This study aimed to investigate the effect of circRNA CDK6 (circCDK6) on the development and biological behavior of cervical cancer. The results showed that circCDK6 expression level significantly increased in various cervical cancer cells. MiR-449a was identified as a potential target of circCDK6, and silencing circCDK6 led to increased expression of miR-449a. CircCDK6 participated in tumorigenesis and cancer progression and potentially functioned as a tumor suppressor in cervical cell progression through the Epithelial-Mesenchymal Transition (EMT) process by regulating miR-449a.
Article
Oncology
Bing Li, Zhi Wang, Fan Yang, Jing Huang, Xingwei Hu, Shiyan Deng, Maobo Tian, Xiaoyun Si
Summary: miR-449a-5p inhibits CM proliferation by targeting CDK6, which provides a potential molecular target for preventing myocardial injury.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Jessica Gambardella, Urna Kansakar, Celestino Sardu, Vincenzo Messina, Stanislovas S. Jankauskas, Raffaele Marfella, Paolo Maggi, Xujun Wang, Pasquale Mone, Giuseppe Paolisso, Daniela Sorriento, Gaetano Santulli
Summary: We hypothesized that exosomal microRNAs may play a role in the development of thromboembolic complications in COVID-19. We isolated circulating exosomes from COVID-19 patients and categorized them based on D-dimer levels. We found that exosomal miR-145 and miR-885 were significantly correlated with D-dimer levels. Furthermore, human endothelial cells treated with serum from COVID-19 patients showed reduced release of miR-145 and miR-885, increased apoptosis, and impaired angiogenetic properties compared to cells treated with non-COVID-19 serum.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Yu Liu, Wentao Tang, Li Ren, Tianyu Liu, Meng Yang, Ye Wei, Yijiao Chen, Meiling Ji, Guosong Chen, Wenju Chang, Jianmin Xu
Summary: miR-500a-3p is downregulated in CRC and inhibits cancer cell proliferation and glycolysis by targeting CDK6.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Farina Hanif, Ying Zhang, Collin Dube, Myron K. Gibert, Shekhar Saha, Kadie Hudson, Pawel Marcinkiewicz, Benjamin Kefas, Fadila Guessous, Roger Abounader
Summary: This study demonstrated that miR-3174 plays a tumor-suppressive role in glioblastoma (GBM) by inhibiting GBM cell growth, invasion, and neurosphere formation. It downregulates the expression of multiple tumor-promoting genes and reduces tumor volume in vivo. This suggests that miR-3174 could be a potential therapeutic target for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Shikun Yang, Fei Yu, Yang Ji, Yanjun Shen, Hao Lu, Yuan Gao, Feng Zhang, Xuehao Wang, Chuanyong Zhang
Summary: This study identified that circERBIN is upregulated in HCC, promoting cell proliferation and tumorigenesis by acting as a sponge of miR-1263 to regulate G1/S transition of HCC cells. These results highlight circERBIN as an important epigenetic regulator in HCC development.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yi-Yung Hung, Chen-Kai Chou, Yi-Chien Yang, Hung-Chun Fu, El-Wui Loh, Hong-Yo Kang
Summary: This study found that in patients with major depressive disorder, the expression levels of miR-146a in exosomes were higher, and patients who achieved remission showed lower levels of various microRNAs before treatment and increased levels after treatment. Let-7e, miR-145, and miR-146a showed acceptable discrimination between the remission and non-remission groups.
Article
Cell Biology
Yu Li, Guanghui Sun, Luqiang Wang
Summary: This study investigated the relationship between miR-21 and LPS-induced myocardial injury and its molecular mechanisms. The results showed that down-regulation or antagonism of miR-21 protected myocardial cells against LPS-induced apoptosis and inflammation by up-regulating Bcl-2 and CDK6 expression, which could provide new insights for the prevention and treatment of myocardial injury.
INFLAMMATION RESEARCH
(2022)
Article
Engineering, Biomedical
Deborah D. Chin, Christopher Poon, Jonathan Wang, Johan Joo, Victor Ong, Zhangjingyi Jiang, Kayley Cheng, Anastasia Plotkin, Gregory A. Magee, Eun Ji Chung
Summary: The delivery of miR-145 micelles to VSMCs shows promise in mitigating atherosclerosis progression by altering cell phenotypes and reducing plaque growth. In mouse experiments, miR-145 micelles significantly inhibited the advancement of atherosclerosis.
Article
Biochemistry & Molecular Biology
Viviana Costa, Marcello De Fine, Valeria Carina, Alice Conigliaro, Lavinia Raimondi, Angela De Luca, Daniele Bellavia, Francesca Salamanna, Riccardo Alessandro, Giovanni Pignatti, Milena Fini, Gianluca Giavaresi
Summary: The research focuses on the role of miR-31-5p and miR-33a-5p in osteoarthritis progression, with identification of Specificity proteins (Sp1) as common miRNA targets through bioinformatic analysis. The study evaluates the possible mechanism of how these miRNAs regulate Sp1 to affect CX43 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)