Article
Oncology
Steven L. Due, David Watson, Isabell Bastian, Ann-Kathrin Eichelmann, Damian J. Hussey
Summary: This study found that variant forms of ERs exist in oesophageal adenocarcinoma and some of these variants are important for cell response to treatment. This suggests that drugs targeting ERs may be a potential therapy for patients with oesophageal adenocarcinoma in the future.
Review
Clinical Neurology
Diana N. Krause, Karin Warfvinge, Kristian Agmund Haanes, Lars Edvinsson
Summary: Reproductive hormones influence migraine in women but the basis of these effects is unknown. In this Review, the authors discuss what is known about sex hormones and their receptors in migraine-related areas of the CNS and the trigeminovascular pathway and propose a simple model to explain how hormones influence menstrual migraine.
NATURE REVIEWS NEUROLOGY
(2021)
Article
Gastroenterology & Hepatology
Dag Holmberg, Fredrik Mattsson, Shaohua Xie, Eivind Ness-Jensen, Hashem El-Serag, Jesper Lagergren
Summary: This study suggests that discontinuation of long-term use of proton-pump inhibitors may decrease the risk of gastric adenocarcinoma and oesophageal adenocarcinoma. Physicians should consider ceasing prescribing these drugs in patients without continued indication for their use.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Pernilla Lagergren, Asif Johar, Eivind Ness-Jensen, Anna Schandl
Summary: This study found that female sex, preoperative reflux, and preoperative body mass index ≥30 increased the risk of postoperative reflux. A model based on age, sex, preoperative reflux, body mass index, chronic obstructive pulmonary disease, and ventricular substitute predicted 72% of severe cases.
Article
Medicine, Research & Experimental
Meijun Pan, Jing Zhou, Xinyao Pan, Jing Wang, Qing Qi, Ling Wang
Summary: Postmenopausal symptoms are systemic symptoms associated with estrogen deficiency after menopause. Hormonal therapy (HT) and non-HT are currently used to treat these symptoms, but the best regimen for balancing the benefits and risks is still unclear. This article reviews the characteristics, regimens, and side effects of drugs used in HT and non-HT, providing valuable information for clinical drug selection.
Article
Plant Sciences
Michael Derevyanchuk, Serhii Kretynin, Yaroslava Bukhonska, Igor Pokotylo, Vladimir Khripach, Eric Ruelland, Roberta Filepova, Petre I. Dobrev, Jan Martinec, Volodymyr Kravets
Summary: This study analyzed the impact of 24-epicastasterone on hormone content in soybean leaves and found that it upregulated auxin levels while downregulating salicylic acid, jasmonic acid, and abscisic acid levels. It also activated cell metabolism's adaptation strategies to environmental challenges.
Article
Otorhinolaryngology
Michelle J. Suh, Sun Kyung Oh, Soo Bin Lee, Sung Huhn Kim
Summary: The study suggests that longer duration of lifetime estrogen exposure and the use of hormone replacement therapy may help attenuate hearing loss in postmenopausal women. These findings provide epidemiological evidence that estrogen could be beneficial in reducing age-related hearing decline.
CLINICAL OTOLARYNGOLOGY
(2021)
Review
Surgery
Steven L. Due, David I. Watson, Damian J. Hussey
Summary: Esophageal cancer, particularly adenocarcinoma, is a common malignancy with limited chemotherapeutic options. Recent efforts have been focused on targeted molecular therapies, while epidemiological evidence suggests a hormonal influence on disease development. Research on estrogen receptor expression in adenocarcinoma tissue and ER modulator therapy show promise for potential therapeutic benefit.
ANZ JOURNAL OF SURGERY
(2021)
Article
Oncology
Ben M. Eyck, Maurice P. H. M. Jansen, Bo Jan Noordman, Peggy N. Atmodimedjo, Berend J. van der Wilk, John W. M. Martens, Jean A. Helmijr, Corine M. Beaufort, Bianca Mostert, Michail Doukas, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, J. Jan B. van Lanschot, Winand N. M. Dinjens
Summary: Detection of circulating tumor DNA (ctDNA) after neoadjuvant chemoradiotherapy (nCRT) can be highly indicative of major residual disease in patients with esophageal cancer. Pre-treatment and post-nCRT ctDNA detection may help identify patients at high risk of disease progression.
JOURNAL OF PATHOLOGY
(2023)
Article
Clinical Neurology
Huy Nguyen, Aubrey L. Gilbert, Elizabeth Fortin, Ivana Vodopivec, Nurhan Torun, Bart K. Chwalisz, Dean M. Cestari, Joseph F. Rizzo
Summary: Studies have found a possible association between external hormone therapy and elevated intracranial pressure in transgender patients, prompting further investigation.
JOURNAL OF NEURO-OPHTHALMOLOGY
(2021)
Article
Endocrinology & Metabolism
Cristina Rodriguez-Varela, Maria Salvaleda-Mateu, Elena Labarta
Summary: This study retrospectively analyzed clinical results in artificial cycles over the past five years to evaluate the impact of estrogen exposure duration on reproductive outcomes and to determine if there is an optimal duration of estrogen exposure for maximizing success rates. The results suggest that the length of estrogen exposure does not affect clinical outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Engineering, Biomedical
Hui Huang, Zeyu Wang, Liang Chen, Hong Yu, Yu Chen
Summary: Catalytic therapy has shown promise in enhancing therapeutic efficacy and reducing side effects by converting less toxic or nontoxic endogenous substances into highly toxic reactive species to induce cell death. This review summarizes the recent advances in the development and use of catalytic biomaterials and nanomedicines in various biomedical applications. The study focuses on the use of endogenous activators and exogenous stimuli to improve treatment efficacy, and discusses the biosafety and biocompatibility of these materials. The challenges and future opportunities for catalytic biomaterials and nanomedicines are also highlighted.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
Romy Aarnoutse, Lars E. Hillege, Janine Ziemons, Judith De Vos-Geelen, Maaike de Boer, Elvira M. E. R. Aerts, Birgit E. P. J. Vriens, Yvonne van Riet, Jeroen Vincent, Agnes J. van de Wouw, Giang N. Le, Koen Venema, Sander S. Rensen, John Penders, Marjolein L. Smidt
Summary: The study found that there were no differences in intestinal microbiota richness, diversity, and composition between postmenopausal breast cancer patients and controls. However, an increased relative abundance of Dialister and Veillonellaceae was observed in breast cancer patients scheduled for adjuvant treatment, which may be caused by a relative decrease in other bacteria rather than an absolute increase. Further research on a more homogeneous group of treatment-naive patients is advised for future studies on the role of intestinal microbiota in breast cancer.
Article
Multidisciplinary Sciences
Kohei Shitara, Jaffer A. Ajani, Markus Moehler, Marcelo Garrido, Carlos Gallardo, Lin Shen, Kensei Yamaguchi, Lucjan Wyrwicz, Tomasz Skoczylas, Arinilda Campos Bragagnoli, Tianshu Liu, Mustapha Tehfe, Elena Elimova, Ricardo Bruges, Thomas Zander, Sergio de Azevedo, Ruben Kowalyszyn, Roberto Pazo-Cid, Michael Schenker, James M. Cleary, Patricio Yanez, Kynan Feeney, Michalis Karamouzis, Valerie Poulart, Ming Lei, Hong Xiao, Kaoru Kondo, Mingshun Li, Yelena Y. Janjigian
Summary: In patients with gastro-oesophageal adenocarcinoma, nivolumab plus chemotherapy has shown superior overall survival compared to chemotherapy alone.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jong Keon Jang, Jae Ho Byun, Ji Hun Kang, Jung Hee Son, Jin Hee Kim, Seung Soo Lee, Hyoung Jung Kim, Changhoon Yoo, Kyu-pyo Kim, Seung-Mo Hong, Dong-Wan Seo, Song Cheol Kim, Moon-Gyu Lee
Summary: The study evaluated the ability of CT-determined resectability to predict R0 resection in patients with PDAC after neoadjuvant FOLFIRINOX chemotherapy, finding a relatively low sensitivity and specificity. Low-contrast enhancement of soft tissue contacting artery may enhance the ability of CT to predict R0 resection.
EUROPEAN RADIOLOGY
(2021)
Article
Surgery
K. Van Den Heede, T. Claerhout, S. Jansen, S. Blontrock, N. Brusselaers, S. Van Slycke
Summary: This long-term follow-up study by a single surgeon in a single center confirms the safety and excellent cure rates of surgery for renal hyperparathyroidism (rHPT), while highlighting the importance of long-term follow-up.
ACTA CHIRURGICA BELGICA
(2023)
Article
Oncology
Wilhelm Leijonmarck, Johannes Asplund, Sheraz R. Markar, Fredrik Mattsson, Jesper Lagergren
Summary: This study investigated the influence of weekday of gastrectomy on long-term survival in patients with gastric adenocarcinoma in Sweden. The results showed that there was no significant impact of surgery on Thursday-Friday compared to Monday-Wednesday on 5-year all-cause mortality and 5-year disease-specific mortality.
Review
Nutrition & Dietetics
Lea Ribet, Robin Dessalles, Corinne Lesens, Nele Brusselaers, Mickael Durand-Dubief
Summary: Food fermentation using sourdough, consisting of lactic bacteria and yeasts, is considered natural and beneficial. This study reviewed clinical evidence on the effects of sourdough bread on health and found that there is currently no clear consensus on its benefits compared to other bread types. Factors such as microbial composition, fermentation parameters, and cereal and flour types may influence the nutritional properties of bread. However, specific strains and fermentation conditions showed improvements in glycemic response, satiety, and gastrointestinal comfort. Further standardization is needed to determine the clinical health benefits of sourdough.
ADVANCES IN NUTRITION
(2023)
Article
Biology
Linnea Hases, Lina Stepanauskaite, Madeleine Birgersson, Nele Brusselaers, Ina Schuppe-Koistinen, Amena Archer, Lars Engstrand, Cecilia Williams
Summary: A high-fat diet can cause gut microbiota dysbiosis, chronic intestinal inflammation, and metabolic syndrome. There are sex differences in the microbiota composition, and female mice are less affected. Estrogenic ligands can attenuate high-fat diet-induced dysbiosis and impact the microbial composition, especially in males.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
Cecilia Radkiewicz, Johannes Asplund, Jesper Lagergren
Summary: In a population-based cohort study in Sweden, the authors found differences in incidence and survival between early-onset and later-onset esophagogastric adenocarcinoma. Male predominance was higher in early-onset cases, except for noncardia gastric cancer. Early-onset patients had more advanced stages and signet ring cell morphology. Incidence trends were similar between early-onset and later-onset cases, with an increase in esophageal adenocarcinoma, stable cardia cancer, and a decrease in noncardia gastric cancer. Early-onset patients had better survival, especially in localized stages and women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Review
Oncology
Zhiqiang Liu, Yingfan Zhang, Jesper Lagergren, Shanshan Li, Jingru Li, Zhixian Zhou, Zhijian Hu, Shao-Hua Xie
Summary: This systematic review found that circulating levels of sex hormone binding globulin (SHBG) and testosterone may be associated with the risk of gastrointestinal cancer. Higher levels of SHBG were associated with increased risk of gastric and liver cancer, while higher levels of testosterone were associated with increased risk of liver cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Qiao-Li Wang, Giola Santoni, Jesper Lagergren
Summary: The association between diabetes, metformin use, and survival of esophageal cancer patients is not clear. A population-based cohort study found that diabetes was associated with increased all-cause mortality, while metformin use was associated with decreased all-cause mortality. More research is needed to determine if metformin affects survival in esophageal cancer.
JNCI CANCER SPECTRUM
(2023)
Article
Oncology
Cecilia Radkiewicz, Therese M-L Andersson, Jesper Lagergren
Summary: This study calculated years of life lost (YLL) due to the top 10 solid tumors causing the most deaths, using data from the Swedish National Cancer and Cause of Death Registers. The results showed that lung and colorectal cancer remained the leading causes of YLL, while pancreatic and breast cancer moved up in rank. Prostate cancer, on the other hand, moved down in rank. Women consistently lost more life years due to lung and pancreatic cancer, and the decline in colorectal cancer mortality was only reflected as a YLL decline in women. YLL is a simple and intuitive measure that expands our understanding of the cancer burden on society.
JNCI CANCER SPECTRUM
(2023)
Article
Cell Biology
Sanjiv Risal, Congru Li, Qing Luo, Romina Fornes, Haojiang Lu, Gustaw Eriksson, Maria Manti, Claes Ohlsson, Eva Lindgren, Nicolas Crisosto, Manuel Maliqueo, Barbara Echiburu, Sergio Recabarren, Teresa Sir Petermann, Anna Benrick, Nele Brusselaers, Jie Qiao, Qiaolin Deng, Elisabet Stener-Victorin
Summary: The transgenerational effects of PCOS in female progeny are being investigated. This study examines whether sons born to mothers with PCOS transmit reproductive and metabolic phenotypes to their male progeny. The results show that PCOS-sons are more likely to be obese and have dyslipidemia, and a mouse model confirms that these dysfunctions are passed down to multiple generations. The study highlights the potential risk of transmission of reproductive and metabolic dysfunction through the male germline.
CELL REPORTS MEDICINE
(2023)
Article
Infectious Diseases
Frank Mulindwa, Barbara Castelnuovo, Nele Brusselaers, Robert Bollinger, George Yendewa, Willington Amutuhaire, Claudine Mukashaka, Jean-Marc Schwarz
Summary: Dolutegravir (DTG) is recommended as a first and second line antiretroviral therapy due to its favorable side effect profile, but there have been reports of accelerated hyperglycemia in some patients. However, at population level, DTG has been shown to have a lower risk of incident diabetes mellitus compared to other HIV drug classes. In Uganda, there have been similar reports of hyperglycemia during DTG use, leading to a recommendation to withhold DTG in patients with diabetes. However, it remains to be demonstrated whether this recommendation should apply to all patients with incident T2DM.
BMC INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Wen Zhong, Hanna Danielsson, Nele Brusselaers, Dirk Wackernagel, Ulrika Sjobom, Karin Savman, Ingrid Hansen Pupp, David Ley, Anders K. Nilsson, Linn Fagerberg, Mathias Uhlen, Ann Hellstrom
Summary: This study investigated the changes in blood protein profiles during the first months of life in preterm infants and found that the variations in blood protein expression are mainly associated with the postnatal age of the infants. This provides an increased understanding of the development process after extremely preterm birth.
COMMUNICATIONS MEDICINE
(2023)
Letter
Public, Environmental & Occupational Health
Frank Mulindwa, Jean-Marc Schwarz, Nele Brusselaers, Simon Dujanga, George Yendewa, Barbara Castelnuovo
PAN AFRICAN MEDICAL JOURNAL
(2023)
Article
Surgery
Fien Van den Eynde, Klaas Van den Heede, Nele Brusselaers, Sam Van Slycke
Summary: The need for thyroid surgery is increasing in the elderly population due to aging, increased use of imaging studies, and higher prevalence of thyroid nodules and cancer. This study compared surgical outcomes in different age groups and found that patients aged 75 and older had a higher risk of complications, particularly bleeding, indicating that ambulatory surgery is not advisable for this age group.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
Klaas Van Den Heede, Nele Brusselaers, Esmee Breddels, Sebastien Gaujoux, Camille Buffet, Fabrice Menegaux, Nathalie Chereau
Summary: This study evaluated the prognostic impact of lymph node characteristics on patients with therapeutic neck dissection for clinically N1 classic PTC. The results showed that the number of harvested lymph node, presence of lymph node capsular rupture, and total lymph node ratio were associated with disease persistence or recurrence.
Article
Surgery
Sheraz R. Markar, Giola Santoni, Dag Holmberg, Joonas H. Kauppila, Jesper Lagergren
Summary: This study evaluated the association between annual hospital volume of bariatric surgery and long-term survival in patients with severe obesity. The results showed that higher annual hospital volume was associated with a lower risk of all-cause mortality.
BRITISH JOURNAL OF SURGERY
(2023)