期刊
INTERNATIONAL JOURNAL OF CANCER
卷 135, 期 12, 页码 2741-2748出版社
WILEY
DOI: 10.1002/ijc.28690
关键词
cancer initiating cells; cancer stem cells; Nanog; prognostic biomarkers; epithelial-mesenchymal transition
类别
资金
- National Institutes of Health [R01CA135096]
- Mary E. and John W. Alford Cancer Research Endowment Fund
- Michelle Theado Memorial Grant from the Joan Bisesi Fund for Head and Neck Oncology Research
- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center
Nanog is a transcription factor that is well-established as a key regulator of embryonic stem cell (ESC) maintenance. Recent evidence demonstrates that Nanog is dysregulated and intimately involved in promoting tumorigenesis in part through regulation of the cancer stem cell (CSC) population. Elevated Nanog is associated with poorer outcome in numerous epithelial malignancies. Nanog is enriched in CSCs and ablation of Nanog is sufficient to reduce the CSC pool. Nanog has also been implicated to promote chemoresistance and epithelial-mesenchymal transition (EMT). Insight into the Nanog signaling cascade, upstream regulators and downstream effectors, is beginning to emerge but remains to be fully elucidated. This review highlights the current literature on the emerging role of Nanog in tumorigenesis and CSCs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据