ATF2 contributes to cisplatin resistance in non-small cell lung cancer and celastrol induces cisplatin resensitization through inhibition of JNK/ATF2 pathway

A Randomized Phase II Study of Pemetrexed in Combination With Cisplatin or Carboplatin as First-Line Therapy for Patients With Locally Advanced or Metastatic Non–Small-Cell Lung Cancer

(2013) Wolfgang H.W. Schuette et al.   Clinical Lung Cancer

Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

(2011) Srikumar M. Raja et al.   CANCER BIOLOGY & THERAPY

Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation

(2011) Marco Lo Iacono et al.   Journal of Translational Medicine

Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways

(2011) Haibo Mou et al.   TOXICOLOGY IN VITRO

Growth Factor Stimulation Induces Cell Survival by c-Jun·ATF2-dependent Activation of Bcl-XL

(2010) Ahmad Salameh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for ATF2 in Regulating MITF and Melanoma Development

(2010) Meera Shah et al.   PLoS Genetics

The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma

(2009) Di He et al.   BMC CANCER

Cancer Statistics, 2009

(2009) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Synergistic Anti-Cancer Activity by the Combination of TRAIL/APO-2L and Celastrol

(2009) Hong Zhu et al.   CANCER INVESTIGATION

Celastrol, a novel HSP90 inhibitor, depletes Bcr–Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation

(2009) Zhongzheng Lu et al.   CANCER LETTERS

Non-Small Cell Lung Cancer Exhibits Transcript Overexpression of Genes Associated with Homologous Recombination and DNA Replication Pathways

(2009) S. Saviozzi et al.   CANCER RESEARCH

Polymerase   mRNA Expression Predicts Survival of Non-Small Cell Lung Cancer Patients Treated with Platinum-Based Chemotherapy

(2009) P. Ceppi et al.   CLINICAL CANCER RESEARCH

Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model

(2009) Dae Yong Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Celastrol Potentiates Radiotherapy by Impairment of DNA Damage Processing in Human Prostate Cancer

(2009) Yao Dai et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Opposing Roles for ATF2 and c-Fos in c-Jun-Mediated Neuronal Apoptosis

(2009) Z. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

Celastrol causes apoptosis and cell cycle arrest in rat glioma cells

(2009) Pengfei Ge et al.   NEUROLOGICAL RESEARCH

Effect of Cigarette Smoke Extract on Dendritic Cells and Their Impact on T-Cell Proliferation

(2009) Esmaeil Mortaz et al.   PLoS One

The role of ATF-2 in oncogenesis

(2008) Spiros A. Vlahopoulos et al.   BIOESSAYS

Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression

(2008) Yulun Huang et al.   CANCER LETTERS

Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

(2008) Giorgio Vittorio Scagliotti et al.   JOURNAL OF CLINICAL ONCOLOGY

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

(2008) T. Zhang et al.   MOLECULAR CANCER THERAPEUTICS